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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2009

Open Access 01-12-2009 | Research article

Articular cartilage mineralization in osteoarthritis of the hip

Authors: Martin Fuerst, Oliver Niggemeyer, Lydia Lammers, Fritz Schäfer, Christoph Lohmann, Wolfgang Rüther

Published in: BMC Musculoskeletal Disorders | Issue 1/2009

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Abstract

Background

The aim of this study was to examine the frequency of articular cartilage calcification in patients with end-stage hip OA. Further, its impact on the clinical situation and the OA severity are analyzed.

Methods

Eighty patients with OA of the hip who consecutively underwent total hip replacement were prospectively evaluated, and 10 controls were included. The patients' X-rays were analyzed for the presence of articular cartilage mineralization. A Harris Hip Score (HHS) was preoperatively calculated for every patient.
Slab specimens from the femoral head of bone and cartilage and an additional square centimeter of articular cartilage from the main chondral defect were obtained from each patient for analysis of mineralization by digital contact radiography (DCR). Histological grading was also performed. In a subset of 20 patients, minerals were characterized with an electron microscope (FE-SEM).

Results

Calcifications were seen in all OA cartilage and slab specimens using DCR, while preoperative X-rays revealed calcification in only 17.5%. None of the control cartilage specimens showed mineralization. There was a highly significant inverse correlation between articular cartilage calcification and preoperative HHS. Histological OA grade correlated positively with the amount of matrix calcification. FE-SEM analysis revealed basic calcium phosphate (BCP) as the predominant mineral; CPPD crystals were found in only two patients.

Conclusions

Articular cartilage calcification is a common event in osteoarthritis of the hip. The amount of calcification correlates with clinical symptoms and histological OA grade.
Appendix
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Literature
1.
Ryan LM, McCarthy DJ: Calcium pyrophosphate crystal deposition disease, pseudogout and articular chondrocalcinosis. Arthritis and allied conditions. Edited by: Koopman WJ. 1997, Baltimore: Wiliams & Wilkins, 2103-5.
2.
Derfus BA, Kurian JB, Butler JJ, Daft LJ, Carrera GF, Ryan LM, Rosenthal AK: The high prevalence of pathologic calcium crystals in pre-operative knees. J Rheumatol. 2002, 29 (3): 570-4.PubMed
3.
Halverson PB, McCarty DJ: Patterns of radiographic abnormalities associated with basic calcium phosphate and calcium pyrophosphate dihydrate crystal deposition in the knee. Ann Rheum Dis. 1986, 45 (7): 603-5. 10.1136/ard.45.7.603.CrossRefPubMedPubMedCentral
4.
Sokoloff L, Varma AA: Chondrocalcinosis in surgically resected joints. Arthritis Rheum. 1988, 31 (6): 750-6. 10.1002/art.1780310608.CrossRefPubMed
5.
Abreu M, Johnson K, Chung CB, De Lima JE Jr, Trudell D, Terkeltaub R, Pe S, Resnick D: Calcification in calcium pyrophosphate dihydrate (CPPD) cristalline deposits in the knee: anatomic, radiographic, MR imaging, and histologic study in cadavers. Skeletal Radiol. 2004, 33 (7): 392-8. 10.1007/s00256-004-0767-9.CrossRefPubMed
6.
Mitrovic DR, Stankovic A, Iriarte-Borda O, Uzan M, Quintero M, Miravet L, Kuntz D: The prevalence of chondrocalcinosis in the human knee joint. An autopsy survey. J Rheumatol. 1988, 15 (4): 633-41.PubMed
7.
Ishikawa K, Masuda I, Ohira T, Yokoyama M: A histological study of calcium pyrophosphate dihydrate crystal-deposition disease. J Bone Joint Surg Am. 1989, 71 (6): 875-86.PubMed
8.
Ohira T, Ishikawa K: Hydroxyapatite deposition in osteoarthritic articular cartilage of the proximal femoral head. Arthritis Rheum. 1987, 30 (6): 651-60. 10.1002/art.1780300608.CrossRefPubMed
9.
Mitsuyama H, Healey RM, Terkeltaub RA, Coutts RD, Amiel D: Calcification of human articular knee cartilage is primarily an effect of aging than osteoarthritis. Osteoarthritis cartilage. 2007, 15 (5): 559-65. 10.1016/j.joca.2006.10.017.CrossRefPubMedPubMedCentral
10.
Fuerst M, Bertrand J, Lammers L, Dreier R, Echtermeyer F, Nitschke Y, Rutsch F, Schäfer FKW, Niggemeyer O, Steinhagen J, Lohmann CH, Pap T, Rüther W: Calcification of articular cartilage in human osteoarthritis. Arthritis Rheum. 2009, 60 (9): 2694-703. 10.1002/art.24774.CrossRefPubMed
11.
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M: Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. Arthritis Rheum. 1986, 29 (8): 1039-49. 10.1002/art.1780290816.CrossRefPubMed
12.
Harris WH: Traumatic arthritis of the hip after dislocation and acetabular fractures: treatment by mold arthroplasty. An end-result study using a new method of result evaluation. J Bone Joint Surg Am. 1969, 51 (4): 737-55.PubMed
13.
14.
Mankin HJ, Dorfman H, Lipiello L, Zarins A: Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Surg Am. 1971, 53 (3): 523-37.PubMed
15.
Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, Lee J, Song YW, Herzog C, Theilmeier G, Pap T: Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med. 2009, 15 (9): 1072-6. 10.1038/nm.1998.CrossRefPubMed
16.
Neogi T, Nevitt M, Niu J, LaValley MP, Hunter DJ, Terkeltaub R, Carbone L, Chen H, Harris T, Kwoh K, Guermazi A, Felson DT: Lack of association between chondrocalcinosis and increased risk of cartilage loss in knees with osteoarthritis: results of two prospective longitudinal magnetic resonance imaging studies. Arthritis Rheum. 2006, 54 (6): 1822-8. 10.1002/art.21903.CrossRefPubMed
17.
Morgan MP, Whelan LC, Sallis JD, McCarthy CJ, Fritzgerald DJ, McCarthy GM: Basic calcium phosphate crystal-induced prostaglandin E2 production in human fibroblasts: role of cyclooxygenase 1, cyclooxygenase 2 and interleukin-1 beta. Arthritis Rheum. 2004, 50 (5): 1642-9. 10.1002/art.20223.CrossRefPubMed
18.
McCarthy GM, Mitchel PG, Struve JA, Cheung HS: Basic calcium phosphate crystals cause coordinate induction and secretion of collagenase and stromelysin. J Cell Physiol. 1992, 153: 140-146. 10.1002/jcp.1041530118.CrossRefPubMed
19.
Ea HK, Uzan B, Rey C, Lioté F: Octacalcium phosphate crystals directly stimulate expression of inducible nitric oxide synthase through p38 and JNK mitogen-activated protein kinases in articular chondrocytes. Arthritis Res Ther. 2005, 7 (5): R915-26. 10.1186/ar1763.CrossRefPubMedPubMedCentral
20.
Pritzker KP, Cheng PT, Grynpas MD, Holmyard DP: Crystal associated diseases: role of scanning electron microscopy in diagnosis. Scanning Microsc. 1988, 2 (3): 1471-8.PubMed
21.
Yavorskyy A, Hernandez-Santana A, McCarthy G, McMahon G: Detection of calcium phosphate crystals in the joint fluid of patients with osteoarthritis - analytical approaches and challenges. Analyst. 2008, 133 (3): 302-18. 10.1039/b716791a.CrossRefPubMedPubMedCentral
22.
Cheung HS, Kurup IV, Sallis JD, Ryan LM: Inhibition of calcium pyrophosphate dihydrate crystal formation in articular cartilage vesicles and cartilage by phosphocitrate. J Biol Chem. 1996, 271 (45): 28082-5. 10.1074/jbc.271.45.28485.CrossRefPubMed
23.
Russell RG, Rogers MJ: Biphosphonates: from the laboratory to the clinic and back again. Bone. 1999, 25 (1): 97-106. 10.1016/S8756-3282(99)00116-7.CrossRefPubMed
Metadata
Title
Articular cartilage mineralization in osteoarthritis of the hip
Authors
Martin Fuerst
Oliver Niggemeyer
Lydia Lammers
Fritz Schäfer
Christoph Lohmann
Wolfgang Rüther
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2009
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/1471-2474-10-166

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