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Published in: BMC Public Health 1/2009

Open Access 01-11-2009 | Research

Can we spend our way out of the AIDS epidemic? A world halting AIDS model

Authors: Robert J Smith, Jing Li, Richard Gordon, Jane M Heffernan

Published in: BMC Public Health | Special Issue 1/2009

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Abstract

Background

There has been a sudden increase in the amount of money donors are willing to spend on the worldwide HIV/AIDS epidemic. Present plans are to hold most of the money in reserve and spend it slowly. However, rapid spending may be the best strategy for halting this disease.

Methods

We develop a mathematical model that predicts eradication or persistence of HIV/AIDS on a world scale. Dividing the world into regions (continents, countries etc), we develop a linear differential equation model of infectives which has the same eradication properties as more complex models.

Results

We show that, even if HIV/AIDS can be eradicated in each region independently, travel/immigration of infectives could still sustain the epidemic. We use a continent-level example to demonstrate that eradication is possible if preventive intervention methods (such as condoms or education) reduced the infection rate to two fifths of what it is currently. We show that, for HIV/AIDS to be eradicated within five years, the total cost would be ≈ $63 billion, which is within the existing $60 billion (plus interest) amount raised by the donor community. However, if this action is spread over a twenty year period, as currently planned, then eradication is no longer possible, due to population growth, and the costs would exceed $90 billion.

Conclusion

Eradication of AIDS is feasible, using the tools that we have currently to hand, but action needs to occur immediately. If not, then HIV/AIDS will race beyond our ability to afford it.
Literature
2.
go back to reference Piot P: AIDS: from crisis management to sustained strategic response. Lancet. 2006, 368 (9534): 526-530. 10.1016/S0140-6736(06)69161-7.CrossRefPubMed Piot P: AIDS: from crisis management to sustained strategic response. Lancet. 2006, 368 (9534): 526-530. 10.1016/S0140-6736(06)69161-7.CrossRefPubMed
3.
go back to reference Stover J, Bertozzi S, Gutierrez JP, Walker N, Stanecki KA, Greener R, Gouws E, Hankins C, Garnett GP, Salomon JA, Boerma JT, De Lay P, Ghys PD: The global impact of scaling up HIV/AIDS prevention programs in low- and middle- income countries. Science. 2006, 311 (5766): 1474-1476. 10.1126/science.1121176.CrossRefPubMed Stover J, Bertozzi S, Gutierrez JP, Walker N, Stanecki KA, Greener R, Gouws E, Hankins C, Garnett GP, Salomon JA, Boerma JT, De Lay P, Ghys PD: The global impact of scaling up HIV/AIDS prevention programs in low- and middle- income countries. Science. 2006, 311 (5766): 1474-1476. 10.1126/science.1121176.CrossRefPubMed
6.
go back to reference Bloom DE, Rosenfield A: A moment in time: AIDS and business. AIDS Pat Care and STDs. 2000, 14 (9): 509-517. 10.1089/108729100438908.CrossRef Bloom DE, Rosenfield A: A moment in time: AIDS and business. AIDS Pat Care and STDs. 2000, 14 (9): 509-517. 10.1089/108729100438908.CrossRef
7.
go back to reference Bloom DE, Mahal A: Does the AIDS epidemic threaten economic growth?. J Econometrics. 1997, 1-296. Bloom DE, Mahal A: Does the AIDS epidemic threaten economic growth?. J Econometrics. 1997, 1-296.
8.
go back to reference Haaker M: The Macroeconomics of HIV/AIDS. 2004, Washington DC: International Monetary Fund Haaker M: The Macroeconomics of HIV/AIDS. 2004, Washington DC: International Monetary Fund
9.
go back to reference Tandon A: Macroeconomic Impact of HIV/AIDS in the Asian and Pacific Region. 2005, Manila: Asian Development Bank Tandon A: Macroeconomic Impact of HIV/AIDS in the Asian and Pacific Region. 2005, Manila: Asian Development Bank
10.
go back to reference Ewing T: AIDS programme faces donor fatigue. Nature. 1990, 346 (6285): 595-PubMed Ewing T: AIDS programme faces donor fatigue. Nature. 1990, 346 (6285): 595-PubMed
12.
go back to reference Okie S: Global health-the Gates-Buffett effect. N Engl J Med. 2006, 355 (11): 1084-1088. 10.1056/NEJMp068186.CrossRefPubMed Okie S: Global health-the Gates-Buffett effect. N Engl J Med. 2006, 355 (11): 1084-1088. 10.1056/NEJMp068186.CrossRefPubMed
13.
go back to reference Steinbrook R: Message from Toronto-deliver AIDS treatment and prevention. N Engl J Med. 2006, 355 (11): 1081-1084. 10.1056/NEJMp068167.CrossRefPubMed Steinbrook R: Message from Toronto-deliver AIDS treatment and prevention. N Engl J Med. 2006, 355 (11): 1081-1084. 10.1056/NEJMp068167.CrossRefPubMed
14.
go back to reference Shiffman J: Donor funding priorities for communicable disease control in the developing world. Health Policy Plan. 2006, 21 (6): 411-420. 10.1093/heapol/czl028.CrossRefPubMed Shiffman J: Donor funding priorities for communicable disease control in the developing world. Health Policy Plan. 2006, 21 (6): 411-420. 10.1093/heapol/czl028.CrossRefPubMed
16.
go back to reference Rowley JT, Anderson RM, Ng TW: Reducing the spread of HIV infection in sub-Saharan Africa: some demographic and economic implications. AIDS. 1990, 4: 47-56. 10.1097/00002030-199001000-00007.CrossRefPubMed Rowley JT, Anderson RM, Ng TW: Reducing the spread of HIV infection in sub-Saharan Africa: some demographic and economic implications. AIDS. 1990, 4: 47-56. 10.1097/00002030-199001000-00007.CrossRefPubMed
17.
go back to reference Stover J: Influence of mathematical modeling of HIV and AIDS on policies and programs in the developing world. Sex Transm Dis. 2000, 27 (10): 572-578. 10.1097/00007435-200011000-00005.CrossRefPubMed Stover J: Influence of mathematical modeling of HIV and AIDS on policies and programs in the developing world. Sex Transm Dis. 2000, 27 (10): 572-578. 10.1097/00007435-200011000-00005.CrossRefPubMed
19.
go back to reference Clark CF: AIDS and the Arrows of Pestilence. 1994, Golden, Colorado: Fulcrum Publishing Clark CF: AIDS and the Arrows of Pestilence. 1994, Golden, Colorado: Fulcrum Publishing
20.
go back to reference Bayer R, Fairchild AL: Changing the paradigm for HIV testing-the end of exceptionalism. N Engl J Med. 2006, 355 (7): 647-649. 10.1056/NEJMp068153.CrossRefPubMed Bayer R, Fairchild AL: Changing the paradigm for HIV testing-the end of exceptionalism. N Engl J Med. 2006, 355 (7): 647-649. 10.1056/NEJMp068153.CrossRefPubMed
21.
go back to reference Schwartländer B, Stover J, Walker N, Bollinger L, Gutierrez JP, McGreevey W, Opuni M, Forsythe S, Kumaranayake L, Watts C, Bertozzi S: Resource needs for HIV/AIDS. Science. 2001, 292 (5526): 2434-2436. 10.1126/science.1062876.CrossRefPubMed Schwartländer B, Stover J, Walker N, Bollinger L, Gutierrez JP, McGreevey W, Opuni M, Forsythe S, Kumaranayake L, Watts C, Bertozzi S: Resource needs for HIV/AIDS. Science. 2001, 292 (5526): 2434-2436. 10.1126/science.1062876.CrossRefPubMed
22.
go back to reference Montaner JS, Hogg R, Wood E, Kerr T, Tyndall M, Levy AR, Harrigan PR: The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet. 2006, 368 (9534): 531-536. 10.1016/S0140-6736(06)69162-9.CrossRefPubMed Montaner JS, Hogg R, Wood E, Kerr T, Tyndall M, Levy AR, Harrigan PR: The case for expanding access to highly active antiretroviral therapy to curb the growth of the HIV epidemic. Lancet. 2006, 368 (9534): 531-536. 10.1016/S0140-6736(06)69162-9.CrossRefPubMed
23.
go back to reference Moghadas SM, Gumel AB, McLeod RG, Gordon R: Could condoms stop the AIDS epidemic?. J Theor Med. 2004, 5 (3-4): 171-181. 10.1080/10273660412331315147.CrossRef Moghadas SM, Gumel AB, McLeod RG, Gordon R: Could condoms stop the AIDS epidemic?. J Theor Med. 2004, 5 (3-4): 171-181. 10.1080/10273660412331315147.CrossRef
24.
go back to reference Gordon R: A critical review of the physics and statistics of condoms and their role in individual versus societal survival of the AIDS epidemic. J Sex Marital Ther. 1989, 15: 5-30.CrossRefPubMed Gordon R: A critical review of the physics and statistics of condoms and their role in individual versus societal survival of the AIDS epidemic. J Sex Marital Ther. 1989, 15: 5-30.CrossRefPubMed
27.
go back to reference Cohen DA, Farley TA: Social marketing of condoms is great, but we need more free condoms. Lancet. 2004, 364 (9428): 13-14. 10.1016/S0140-6736(04)16611-7.CrossRefPubMed Cohen DA, Farley TA: Social marketing of condoms is great, but we need more free condoms. Lancet. 2004, 364 (9428): 13-14. 10.1016/S0140-6736(04)16611-7.CrossRefPubMed
28.
go back to reference Cohen DA, Farley TA, Mason K, Ridgeway G: The collectivity of sexual behaviour. Int J STD AIDS. 2006, 17 (3): 151-156. 10.1258/095646206775809213.CrossRefPubMed Cohen DA, Farley TA, Mason K, Ridgeway G: The collectivity of sexual behaviour. Int J STD AIDS. 2006, 17 (3): 151-156. 10.1258/095646206775809213.CrossRefPubMed
29.
go back to reference Trucco E: Studies in imitative behavior: A generalization of the Rashevsky model; Its mathematical properties. Bull Math Biol. 1954, 16 (4): 279-316. Trucco E: Studies in imitative behavior: A generalization of the Rashevsky model; Its mathematical properties. Bull Math Biol. 1954, 16 (4): 279-316.
31.
go back to reference Kremer M, Snyder CM: Why is There No AIDS Vaccine? [Working Paper]. 2004, Cambridge, MA: National Bureau of Economic Research Kremer M, Snyder CM: Why is There No AIDS Vaccine? [Working Paper]. 2004, Cambridge, MA: National Bureau of Economic Research
32.
go back to reference Smith RJ, Bodine EN, Wilson DP, Blower SM: Evaluating the potential impact of vaginal microbicides to reduce the risk of acquiring HIV in female sex workers. AIDS. 2005, 19: 413-421. 10.1097/01.aids.0000161771.44276.92.CrossRefPubMed Smith RJ, Bodine EN, Wilson DP, Blower SM: Evaluating the potential impact of vaginal microbicides to reduce the risk of acquiring HIV in female sex workers. AIDS. 2005, 19: 413-421. 10.1097/01.aids.0000161771.44276.92.CrossRefPubMed
33.
go back to reference Hethcote HW, Van Ark JW: Modeling HIV Transmission and AIDS in the United States. Lect Notes in Biomath 95. 1992, Berlin-Heidelberg-New York: Springer-Verlag Hethcote HW, Van Ark JW: Modeling HIV Transmission and AIDS in the United States. Lect Notes in Biomath 95. 1992, Berlin-Heidelberg-New York: Springer-Verlag
34.
go back to reference Huang W, Cooke KL, Castillo-Chavez C: Stability and bifurcation for a multiple group model for the dynamics of HIV transmission. SIAM J Appl Math. 1992, 52: 835-854. 10.1137/0152047.CrossRef Huang W, Cooke KL, Castillo-Chavez C: Stability and bifurcation for a multiple group model for the dynamics of HIV transmission. SIAM J Appl Math. 1992, 52: 835-854. 10.1137/0152047.CrossRef
35.
go back to reference Mode CJ, Sleeman CK: Stochastic Processes in Epidemiology. HIV/AIDS, Other Infectious Diseases and Computers. 2000, Singapore, New Jersey: World Scientific Mode CJ, Sleeman CK: Stochastic Processes in Epidemiology. HIV/AIDS, Other Infectious Diseases and Computers. 2000, Singapore, New Jersey: World Scientific
36.
go back to reference Korenromp EL, van Vliet C, Grosskurth H, Gavyole A, Ploeg van der CPB, Fransen L, Hayes RJ, Habbema JDF: Model-based evaluation of single-round mass treatment of sexually transmitted diseases for HIV control in a rural African population. AIDS. 2000, 14: 573-93. 10.1097/00002030-200003310-00013.CrossRefPubMed Korenromp EL, van Vliet C, Grosskurth H, Gavyole A, Ploeg van der CPB, Fransen L, Hayes RJ, Habbema JDF: Model-based evaluation of single-round mass treatment of sexually transmitted diseases for HIV control in a rural African population. AIDS. 2000, 14: 573-93. 10.1097/00002030-200003310-00013.CrossRefPubMed
37.
go back to reference Blower SM, Aschenbach AN, Gershengorn HB, Kahn JO: Predicting the unpredictable: Transmission of drug-resistant HIV. Nat Med. 2001, 7: 1016-1020. 10.1038/nm0901-1016.CrossRefPubMed Blower SM, Aschenbach AN, Gershengorn HB, Kahn JO: Predicting the unpredictable: Transmission of drug-resistant HIV. Nat Med. 2001, 7: 1016-1020. 10.1038/nm0901-1016.CrossRefPubMed
38.
go back to reference Boily MC, Bastos FI, Desai K, Mâsse B: Changes in the transmission dynamics of the HIV epidemic after the wide-scale use of antiretroviral therapy could explain increases in sexually transmitted infections-results from mathematical models. Sex Transm Dis. 2004, 31: 100-112. 10.1097/01.OLQ.0000112721.21285.A2.CrossRefPubMed Boily MC, Bastos FI, Desai K, Mâsse B: Changes in the transmission dynamics of the HIV epidemic after the wide-scale use of antiretroviral therapy could explain increases in sexually transmitted infections-results from mathematical models. Sex Transm Dis. 2004, 31: 100-112. 10.1097/01.OLQ.0000112721.21285.A2.CrossRefPubMed
39.
go back to reference Rapatski BL, Suppe F, Yorke JA: HIV epidemics driven by late disease stage transmission. J Acquir Immune Defic Syndr. 2005, 38: 241-253.PubMed Rapatski BL, Suppe F, Yorke JA: HIV epidemics driven by late disease stage transmission. J Acquir Immune Defic Syndr. 2005, 38: 241-253.PubMed
40.
go back to reference Vickerman P, Terris-Prestholt F, Delany S, Kumaranayake L, Rees H, Watts C: Are targeted HIV prevention activities still cost-effective in high prevalence settings? Results from an STI treatment intervention for sex workers in Hillbrow, South Africa. Sex Transm Dis. 2006, 33 (10 Suppl): S122-32.CrossRefPubMed Vickerman P, Terris-Prestholt F, Delany S, Kumaranayake L, Rees H, Watts C: Are targeted HIV prevention activities still cost-effective in high prevalence settings? Results from an STI treatment intervention for sex workers in Hillbrow, South Africa. Sex Transm Dis. 2006, 33 (10 Suppl): S122-32.CrossRefPubMed
41.
go back to reference Coffee M, Lurie MN, Garnett GP: Modelling the impact of migration on the HIV epidemic in South Africa. AIDS. 2007, 21: 343-350. 10.1097/QAD.0b013e328011dac9.CrossRefPubMed Coffee M, Lurie MN, Garnett GP: Modelling the impact of migration on the HIV epidemic in South Africa. AIDS. 2007, 21: 343-350. 10.1097/QAD.0b013e328011dac9.CrossRefPubMed
42.
go back to reference Nagelkerke NJD, Moses S, de Vlas SJ, Bailey RC: Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007, 7: 16-10.1186/1471-2334-7-16.PubMedCentralCrossRefPubMed Nagelkerke NJD, Moses S, de Vlas SJ, Bailey RC: Modelling the public health impact of male circumcision for HIV prevention in high prevalence areas in Africa. BMC Infect Dis. 2007, 7: 16-10.1186/1471-2334-7-16.PubMedCentralCrossRefPubMed
43.
go back to reference Klein E, Laxminarayan R, Smith D, Gilligan C: Economic incentives and mathematical models of disease. Environment and Development Economics. 2007, 12: 707-732. 10.1017/S1355770X0700383X.CrossRef Klein E, Laxminarayan R, Smith D, Gilligan C: Economic incentives and mathematical models of disease. Environment and Development Economics. 2007, 12: 707-732. 10.1017/S1355770X0700383X.CrossRef
44.
go back to reference Garira Mukandavire: Effects of public health educational campaigns and the role of sex workers on the spread of HIV/AIDS among heterosexuals. Theor Pop Biol. 2007, 72 (3): 346-365. 10.1016/j.tpb.2007.07.002.CrossRef Garira Mukandavire: Effects of public health educational campaigns and the role of sex workers on the spread of HIV/AIDS among heterosexuals. Theor Pop Biol. 2007, 72 (3): 346-365. 10.1016/j.tpb.2007.07.002.CrossRef
45.
go back to reference Xu Y, Xu GQ: Modeling of HIV/AIDS Transmission and Its Analysis. DCDIS Proceedings of the International Conference on Life System Modeling and Simulation. 2007, 488-492. Xu Y, Xu GQ: Modeling of HIV/AIDS Transmission and Its Analysis. DCDIS Proceedings of the International Conference on Life System Modeling and Simulation. 2007, 488-492.
46.
go back to reference Gran JM, Wasmuth L, Amundsen EJ, Lindqvist BH, Aalen OO: Growth rates in epidemic models: Application to a model for HIV/AIDS progression. Statistics in Medicine. 2008, 27 (23): 4817-4834. 10.1002/sim.3219.CrossRefPubMed Gran JM, Wasmuth L, Amundsen EJ, Lindqvist BH, Aalen OO: Growth rates in epidemic models: Application to a model for HIV/AIDS progression. Statistics in Medicine. 2008, 27 (23): 4817-4834. 10.1002/sim.3219.CrossRefPubMed
47.
go back to reference Lloyd AL, May RM: Spatial Heterogeneity in Epidemic Models. J Theor Biol. 1996, 179: 1-11. 10.1006/jtbi.1996.0042.CrossRefPubMed Lloyd AL, May RM: Spatial Heterogeneity in Epidemic Models. J Theor Biol. 1996, 179: 1-11. 10.1006/jtbi.1996.0042.CrossRefPubMed
48.
go back to reference Arino J, Davis JR, Hartley D, Jordan R, Miller JM, van den Driessche P: A multi-species epidemic model with spatial dynamics. Math Med Biol. 2005, 22 (2): 129-42. 10.1093/imammb/dqi003.CrossRefPubMed Arino J, Davis JR, Hartley D, Jordan R, Miller JM, van den Driessche P: A multi-species epidemic model with spatial dynamics. Math Med Biol. 2005, 22 (2): 129-42. 10.1093/imammb/dqi003.CrossRefPubMed
49.
go back to reference Lloyd AL, Jansen VAA: Spatiotemporal dynamics of epidemics: synchrony in metapopulation models. Math Biosci. 2004, 188 (1-2): 1-16. 10.1016/j.mbs.2003.09.003.CrossRefPubMed Lloyd AL, Jansen VAA: Spatiotemporal dynamics of epidemics: synchrony in metapopulation models. Math Biosci. 2004, 188 (1-2): 1-16. 10.1016/j.mbs.2003.09.003.CrossRefPubMed
50.
go back to reference Liebovitch LS, Schwartz IB: Migration induced epidemics: dynamics of flux-based multipatch models. Physics Letters A. 2004, 332: 256-267. 10.1016/j.physleta.2004.09.071.CrossRef Liebovitch LS, Schwartz IB: Migration induced epidemics: dynamics of flux-based multipatch models. Physics Letters A. 2004, 332: 256-267. 10.1016/j.physleta.2004.09.071.CrossRef
51.
go back to reference Arino J, van den Driessche P: A multi-city epidemic model. Math Pop Stud. 2003, 10 (3): 175-193. 10.1080/08898480306720.CrossRef Arino J, van den Driessche P: A multi-city epidemic model. Math Pop Stud. 2003, 10 (3): 175-193. 10.1080/08898480306720.CrossRef
52.
go back to reference Fitzgibbon WE, Langlais M, Morgan JJ: A mathematical model for indirectly transmitted diseases. Math Biosci. 2007, 206 (2): 233-248. 10.1016/j.mbs.2005.07.005.CrossRefPubMed Fitzgibbon WE, Langlais M, Morgan JJ: A mathematical model for indirectly transmitted diseases. Math Biosci. 2007, 206 (2): 233-248. 10.1016/j.mbs.2005.07.005.CrossRefPubMed
53.
go back to reference Hsieh YH, van den Driessche P, Wang L: Impact of Travel Between Patches for Spatial Spread of Disease. Bull Math Biol. 2007, 69: 1355-1375. 10.1007/s11538-006-9169-6.CrossRefPubMed Hsieh YH, van den Driessche P, Wang L: Impact of Travel Between Patches for Spatial Spread of Disease. Bull Math Biol. 2007, 69: 1355-1375. 10.1007/s11538-006-9169-6.CrossRefPubMed
54.
go back to reference Jacquez JA, Simon CP, Koopman J, Sattenspiel L, Perry T: Modeling and analyzing HIV transmission: the effect of contact patterns. Math Biosci. 1988, 92: 119-199. 10.1016/0025-5564(88)90031-4.CrossRef Jacquez JA, Simon CP, Koopman J, Sattenspiel L, Perry T: Modeling and analyzing HIV transmission: the effect of contact patterns. Math Biosci. 1988, 92: 119-199. 10.1016/0025-5564(88)90031-4.CrossRef
55.
go back to reference Castillo-Chavez CC, Cooke K, Huang W, Levin SA: On the role of long incubation periods in the dynamics of AIDS I: single population models. J Math Biol. 1989, 27: 373-398. 10.1007/BF00290636.CrossRefPubMed Castillo-Chavez CC, Cooke K, Huang W, Levin SA: On the role of long incubation periods in the dynamics of AIDS I: single population models. J Math Biol. 1989, 27: 373-398. 10.1007/BF00290636.CrossRefPubMed
56.
go back to reference Busenberg S, Cooke KL, Thieme HR: Demographic change and persistence of HIV/AIDS in a heterosexual population. SIAM J Appl Math. 1991, 51: 1030-1051. 10.1137/0151052.CrossRef Busenberg S, Cooke KL, Thieme HR: Demographic change and persistence of HIV/AIDS in a heterosexual population. SIAM J Appl Math. 1991, 51: 1030-1051. 10.1137/0151052.CrossRef
57.
go back to reference Thieme HR, Castillo-Chavez CC: How May Infection-Age-Dependent Infectivity Affect the Dynamics of HIV/AIDS?. SIAM J App Math. 1993, 53 (5): 1447-1479. 10.1137/0153068.CrossRef Thieme HR, Castillo-Chavez CC: How May Infection-Age-Dependent Infectivity Affect the Dynamics of HIV/AIDS?. SIAM J App Math. 1993, 53 (5): 1447-1479. 10.1137/0153068.CrossRef
58.
go back to reference Brauer F, van den Driessche P: Models for transmission of disease with immigration of infectives. Math Biosci. 2001, 171 (2): 143-154. 10.1016/S0025-5564(01)00057-8.CrossRefPubMed Brauer F, van den Driessche P: Models for transmission of disease with immigration of infectives. Math Biosci. 2001, 171 (2): 143-154. 10.1016/S0025-5564(01)00057-8.CrossRefPubMed
59.
go back to reference McCluskey CC: A model of HIV/AIDS with staged progression and amelioration. Math Biosci. 2003, 181: 1-16. 10.1016/S0025-5564(02)00149-9.CrossRefPubMed McCluskey CC: A model of HIV/AIDS with staged progression and amelioration. Math Biosci. 2003, 181: 1-16. 10.1016/S0025-5564(02)00149-9.CrossRefPubMed
60.
go back to reference Gumel AB, McCluskey CC, van den Driessche P: Mathematical Study of a Staged-Progression HIV Model with Imperfect Vaccine. Bull Math Biol. 2006, 68: 2105-2128. 10.1007/s11538-006-9095-7.CrossRefPubMed Gumel AB, McCluskey CC, van den Driessche P: Mathematical Study of a Staged-Progression HIV Model with Imperfect Vaccine. Bull Math Biol. 2006, 68: 2105-2128. 10.1007/s11538-006-9095-7.CrossRefPubMed
61.
62.
go back to reference van den Driessche P, Watmough J: Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. Math Biosci. 2002, 180: 29-48. 10.1016/S0025-5564(02)00108-6.CrossRefPubMed van den Driessche P, Watmough J: Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission. Math Biosci. 2002, 180: 29-48. 10.1016/S0025-5564(02)00108-6.CrossRefPubMed
63.
go back to reference Smith HL: Monotone Dynamical Systems. An Introduction to the Theory of Competitive and Cooperative Systems. Math Surveys Monogr. 1995, 41: 1-174. Amer. Math. Soc., Providence, R.I.CrossRef Smith HL: Monotone Dynamical Systems. An Introduction to the Theory of Competitive and Cooperative Systems. Math Surveys Monogr. 1995, 41: 1-174. Amer. Math. Soc., Providence, R.I.CrossRef
64.
go back to reference Smith HL, Waltman P: The Theory of the Chemostat. 1995, Cambrige, UK: Cambrige University PressCrossRef Smith HL, Waltman P: The Theory of the Chemostat. 1995, Cambrige, UK: Cambrige University PressCrossRef
67.
go back to reference Vijayaraghavan A, Efrusy MB, Mazonson PD, Ebrahim O, Sanne IM, Santas CC: Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. J Acquir Imme Defic Syndr. 2007, 46: 91-100. Vijayaraghavan A, Efrusy MB, Mazonson PD, Ebrahim O, Sanne IM, Santas CC: Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world. J Acquir Imme Defic Syndr. 2007, 46: 91-100.
68.
go back to reference Gordon R, Tyson JE: Fatal sexually transmitted diseases (FSTDs), such as AIDS, select for the evolution of monogamy and provide a model for background extinction. J Biol Systems. 1993, 1: 1-26. 10.1142/S0218339093000021.CrossRef Gordon R, Tyson JE: Fatal sexually transmitted diseases (FSTDs), such as AIDS, select for the evolution of monogamy and provide a model for background extinction. J Biol Systems. 1993, 1: 1-26. 10.1142/S0218339093000021.CrossRef
69.
go back to reference Burris S: Driving the epidemic underground? A new look at law and the social risk of HIV testing. AIDS Public Policy Journal. 1997, 12 (2): 66-78.PubMed Burris S: Driving the epidemic underground? A new look at law and the social risk of HIV testing. AIDS Public Policy Journal. 1997, 12 (2): 66-78.PubMed
70.
go back to reference Lopez AD, Mathers CD: Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol. 2006, 100 (5-6): 481-499. 10.1179/136485906X97417.CrossRefPubMed Lopez AD, Mathers CD: Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol. 2006, 100 (5-6): 481-499. 10.1179/136485906X97417.CrossRefPubMed
71.
go back to reference Abdullah AS, Ebrahim SH, Fielding R, Morisky DE: Sexually transmitted infections in travelers: implications for prevention and control. Clin Infect Dis. 2004, 39: 533-538. 10.1086/422721.CrossRefPubMed Abdullah AS, Ebrahim SH, Fielding R, Morisky DE: Sexually transmitted infections in travelers: implications for prevention and control. Clin Infect Dis. 2004, 39: 533-538. 10.1086/422721.CrossRefPubMed
72.
go back to reference White ND, Hill DM, Bodemeier S: Male condoms that break in use do so mostly by a "blunt puncture" mechanism. Contraception. 2008, 77: 360-365. 10.1016/j.contraception.2008.01.014.CrossRefPubMed White ND, Hill DM, Bodemeier S: Male condoms that break in use do so mostly by a "blunt puncture" mechanism. Contraception. 2008, 77: 360-365. 10.1016/j.contraception.2008.01.014.CrossRefPubMed
73.
go back to reference Barnighausen T, Bloom DE, Humair S: Human Resources for Treating HIV/AIDS: Needs, Capacities, and Gaps. AIDS Pat Care and STDs. 2007, 21 (11): 799-812. 10.1089/apc.2007.0193.CrossRef Barnighausen T, Bloom DE, Humair S: Human Resources for Treating HIV/AIDS: Needs, Capacities, and Gaps. AIDS Pat Care and STDs. 2007, 21 (11): 799-812. 10.1089/apc.2007.0193.CrossRef
74.
go back to reference Balakrishnan P, Solomon S, Kumarasamy N, Mayer KH: Low-cost monitoring of HIV infected individuals on highly active antiretroviral therapy (HAART) in developing countries. Indian J Med Res. 2005, 121: 345-355.PubMed Balakrishnan P, Solomon S, Kumarasamy N, Mayer KH: Low-cost monitoring of HIV infected individuals on highly active antiretroviral therapy (HAART) in developing countries. Indian J Med Res. 2005, 121: 345-355.PubMed
75.
go back to reference Yazdanpanah Y: Costs associated with combination therapy in HIV-infected patients. J Antimicrob Chemother. 2004, 53: 558-561. 10.1093/jac/dkh142.CrossRefPubMed Yazdanpanah Y: Costs associated with combination therapy in HIV-infected patients. J Antimicrob Chemother. 2004, 53: 558-561. 10.1093/jac/dkh142.CrossRefPubMed
76.
go back to reference Kumarasamy N, Solomon S, Chaguturu SK, Cecelia AJ, Vallabhaneni S, Flanigan TP, Mayer KH: The changing natural history of HIV disease: Before and after the introduction of generic antiretroviral therapy in southern India. Clin Infect Dis. 2005, 41: 1525-1528. 10.1086/497267.CrossRefPubMed Kumarasamy N, Solomon S, Chaguturu SK, Cecelia AJ, Vallabhaneni S, Flanigan TP, Mayer KH: The changing natural history of HIV disease: Before and after the introduction of generic antiretroviral therapy in southern India. Clin Infect Dis. 2005, 41: 1525-1528. 10.1086/497267.CrossRefPubMed
77.
go back to reference Meng X, Anderson AF, Hou X, Wang Y, Sun L, Zhang X, Li Z, Qui B, Lang Y, Zhang L: A pilot project for the effective delivery of HAART in rural China. AIDS Pat Care and STDs. 2006, 20 (3): 213-219. 10.1089/apc.2006.20.213.CrossRef Meng X, Anderson AF, Hou X, Wang Y, Sun L, Zhang X, Li Z, Qui B, Lang Y, Zhang L: A pilot project for the effective delivery of HAART in rural China. AIDS Pat Care and STDs. 2006, 20 (3): 213-219. 10.1089/apc.2006.20.213.CrossRef
78.
go back to reference Dunne M: Antiretroviral drug development: the challenge of cost and access. AIDS. 2007, 21 (suppl 4): S73-S79. 10.1097/01.aids.0000279709.47298.8a.CrossRefPubMed Dunne M: Antiretroviral drug development: the challenge of cost and access. AIDS. 2007, 21 (suppl 4): S73-S79. 10.1097/01.aids.0000279709.47298.8a.CrossRefPubMed
79.
go back to reference Hounton SH, Akonde A, Zannou DM, Bashi J, Meda N, Newlands D: Costing universal access of highly active antiretroviral therapy in Benin. AIDS Care. 2008, 20 (5): 582-587. 10.1080/09540120701868303.CrossRefPubMed Hounton SH, Akonde A, Zannou DM, Bashi J, Meda N, Newlands D: Costing universal access of highly active antiretroviral therapy in Benin. AIDS Care. 2008, 20 (5): 582-587. 10.1080/09540120701868303.CrossRefPubMed
80.
go back to reference Beaston-Blaakman A, Shepard DS, Stone N, Shevitz H: Cost-effectiveness of clinical interventions for AIDS wasting. AIDS Care. 2007, 19 (8): 996-1001. 10.1080/09540120701335238.CrossRefPubMed Beaston-Blaakman A, Shepard DS, Stone N, Shevitz H: Cost-effectiveness of clinical interventions for AIDS wasting. AIDS Care. 2007, 19 (8): 996-1001. 10.1080/09540120701335238.CrossRefPubMed
81.
go back to reference Shevitz AH, Wilson IB, McDermott AY, Spiegelman D, Skinner SC, Antonsson K, Layne JE, Beaston-Blaakman A, Shepard DS, Gorbach SL: A comparison of the clinical and cost-effectiveness of 3 intervention strategies for AIDS wasting. J Acquir Immune Defic Syndr. 2005, 38 (4): 399-406. 10.1097/01.qai.0000152647.89008.2b.CrossRefPubMed Shevitz AH, Wilson IB, McDermott AY, Spiegelman D, Skinner SC, Antonsson K, Layne JE, Beaston-Blaakman A, Shepard DS, Gorbach SL: A comparison of the clinical and cost-effectiveness of 3 intervention strategies for AIDS wasting. J Acquir Immune Defic Syndr. 2005, 38 (4): 399-406. 10.1097/01.qai.0000152647.89008.2b.CrossRefPubMed
82.
go back to reference Fieno JV: Costing adult male circumcision in high HIV prevalence, low circumcision rate countries. AIDS Care. 2008, 20 (5): 515-520. 10.1080/09540120701867149.CrossRefPubMed Fieno JV: Costing adult male circumcision in high HIV prevalence, low circumcision rate countries. AIDS Care. 2008, 20 (5): 515-520. 10.1080/09540120701867149.CrossRefPubMed
Metadata
Title
Can we spend our way out of the AIDS epidemic? A world halting AIDS model
Authors
Robert J Smith
Jing Li
Richard Gordon
Jane M Heffernan
Publication date
01-11-2009
Publisher
BioMed Central
Published in
BMC Public Health / Issue Special Issue 1/2009
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-9-S1-S15

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