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BMC Public Health
Published in: BMC Public Health 1/2008

Open Access 01-12-2008 | Research article

The epidemiology of Varicella Zoster Virus infection in Italy

Authors: Giovanni Gabutti, Maria C Rota, Marcello Guido, Antonella De Donno, Antonino Bella, Marta L Ciofi degli Atti, Pietro Crovari, the Seroepidemiology Group

Published in: BMC Public Health | Issue 1/2008

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Abstract

Background

The epidemiological importance of varicella and zoster and the availability of an efficacious and safe vaccine have led to an important international debate regarding the suitability of mass vaccination. The objective of the study was to describe the epidemiology of varicella and zoster in Italy and to determine whether there have been changes with respect to observations provided by an analogous study conducted 8 years ago, in order to define the most appropriate vaccination strategy.

Methods

A number of data sources were evaluated, a cross-sectional population-based seroprevalence study was conducted on samples collected in 2004, and the results were compared with data obtained in 1996.

Results

The data from active and passive surveillance systems confirm that varicella is a widespread infectious disease which mainly affects children. VZV seroprevalence did not substantially differ from that found in the previous study. The sero-epidemiological profile in Italy is different from that in other European countries. In particular, the percentage of susceptible adolescents is at least nearly twice as high as in other European countries and in the age group 20–39 yrs, approximately 9% of individuals are susceptible to VZV.

Conclusion

The results of this study can contribute to evaluating the options for varicella vaccination. It is possible that in a few years, in all Italian Regions, there will exist the conditions necessary for implementing a mass vaccination campaign and that the large-scale availability of MMRV tetravalent vaccines will facilitate mass vaccination.
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Literature
1.
2.
Thomas SL, Hall AJ: What does epidemiology tell us about risk factors for herpes zoster?. Lancet Infect Dis. 2004, 4: 26-33. 10.1016/S1473-3099(03)00857-0.CrossRefPubMed
3.
Bowsher D: The lifetime occurrence of herpes zoster and prevalence of post-herpetic neuralgia: a retrospective survey in an elderly population. Eur J Pain. 1999, 3: 335-342. 10.1016/S1090-3801(99)90015-0.CrossRefPubMed
4.
Volpi A: Varicella immunization and herpes zoster. Herpes. 2005, 12: 59-PubMed
5.
Grose C: Varicella vaccination of children in the United States: assessment after the first decade 1995–2005. J Clin Virol. 2005, 33: 89-95. 10.1016/j.jcv.2005.02.003.CrossRefPubMed
6.
Zhou F, Harpaz R, Jumaan AO, Winston CA, Shefer A: Impact of varicella vaccination on health care utilization. JAMA. 2005, 294: 797-802. 10.1001/jama.294.7.797.CrossRefPubMed
7.
Rentier R, Gershon AA, Members of the European Working Group on Varicella (Euro Var): Consensus: varicella vaccination of healthy children. Pediatr Infect Dis J. 2004, 23: 379-389. 10.1097/01.inf.0000122606.88429.8f.CrossRefPubMed
8.
Gabutti G, Rota MC, Salmaso S, Bruzzone BM, Bella A, Crovari P, The Serological Study Group: Epidemiology of measles, mumps and rubella in Italy. Epidemiol Infect. 2002, 129: 543-50. 10.1017/S0950268802007677.CrossRefPubMedPubMedCentral
9.
Marocco A, Assael B, Gabutti G, Guarino A, Lopalco PL, Marchetti F, Ruggeri FM, Titone L, Tozzi AE, Vitali Rosati G, Zotti C, Franco E: Ricoveri per enterite da Rotavirus in Italia valutati mediante analisi delle schede di dimissione ospedaliera negli anni 2001–2003. Ig Sanità Pubbl. 2006, 62: 215-224.PubMed
10.
Gabutti G, Penna C, Rossi M, Salmaso S, Rota MC, Bella A, Crovari C, the serological study group: The seroepidemiology of varicella in Italy. Epidemiol Infect. 2001, 126: 433-440. 10.1017/S0950268801005398.CrossRefPubMedPubMedCentral
11.
Giaquinto C, Sturkenboom M, Mannino S, Arpinelli F, Nicolosi A, Cantarutti L per il Gruppo di Studio sulla varicella in età ediatrica (Pedianet Varicella Study Group): Epidemiologia ed esiti della varicella in Italia: risultati di uno studio prospettico sui bambini (0–14 anni) seguiti dai pediatri di libera scelta (Studio Pedianet). Ann Ig. 2002, 14: 21-27.PubMed
12.
Ciofi degli Atti ML, Rota MC, Mandolini D, Bella A, Gabutti G, Crovari P, Salmaso S: Assessment of varicella underreporting in Italy. Epidemiol Infect. 2002, 128: 479-484. 10.1017/S0950268802006878.CrossRefPubMedPubMedCentral
13.
Farley CK, Miller E: Varicella-zoster virus epidemiology. A changing scene?. J Infect Dis. 1996, 174: S314-S319.CrossRef
14.
Aebi C, Fischer K, Gorgievski M, Matter L, Muhlemann K: Age-specific seroprevalence to varicella-zoster virus: study in Swiss children and analysis of European data. Vaccine. 2001, 19: 3097-3103. 10.1016/S0264-410X(01)00035-4.CrossRefPubMed
15.
Mossong N, Putz L, Schneider F: Seroprevalence and force of infection of varicella-zoster virus in Luxembourg. Epidemiol Infect. 2004, 132: 1121-1127. 10.1017/S0950268804002754.CrossRefPubMedPubMedCentral
16.
Vyse AJ, Gay NJ, Hesketh LM, Morgan-Capner P, Miller E: Seroprevalence of antibody to varicella zoster virus in England and Wales in children and young adults. Epidemiol Infect. 2004, 132: 1129-1134. 10.1017/S0950268804003140.CrossRefPubMedPubMedCentral
17.
De Melker H, Berbero G, Hahné S, Rumke H, Hof van den S, de Wit A, Boot H: The epidemiology of varicella and herpes zoster in The Netherlands: implications for varicella zoster virus vaccination. Vaccine. 2006, 24: 3946-3952. 10.1016/j.vaccine.2006.02.017.CrossRefPubMed
18.
Nardone A, de Ory F, Carton M, Cohen D, van Damme P, Davidkin I, Rota MC, de Melker H, Mossong J, Slacikova M, Tischer A, Andrews N, Berbers G, Gabutti G, Gay N, Jones L, Jokinen S, Kafatos G, Martìnez de Aragòn MV, Schenider F, Smetana Z, Vargova B, Vranckx R, Miller E: The comparative sero-epidemiology of varicella zoster virus in 11 countries in the European region. Vaccine. 2007, 25: 7866-7872. 10.1016/j.vaccine.2007.07.036.CrossRefPubMed
19.
Alfonsi V, Montomoli E, Manini I, Alberini I, Gentile C, Rota MC, Ciofi degli Atti ML: Susceptibility to varicella in childbearing age women, Central Italy: is there a need for vaccinating this population group?. Vaccine. 2007, 25: 6086-6088. 10.1016/j.vaccine.2007.05.019.CrossRefPubMed
20.
Edmunds WJ, Brisson M: The effect of vaccination on the epidemiology of varicella zoster virus. J Infect. 2002, 44: 211-219. 10.1053/jinf.2002.0988.CrossRefPubMed
21.
Di Luzio Paparatti U, Arpinelli F, Visonà G: Herpes Zoster and its complications in Italy: an observational study. J Infect. 1999, 38: 116-120. 10.1016/S0163-4453(99)90079-8.CrossRefPubMed
22.
Jumaan AO, Yu O, Jackson LA, Bohlhe K, Galil K, Seward JF: Incidence of Herpes Zoster, before and after varicella-vaccination-associated decreases in the incidence of varicella, 1992–2002. J Infect Dis. 2005, 191: 2002-2007. 10.1086/430325.CrossRefPubMed
23.
Oxman MN, Levin MJ, Johnson GR, Schmader KE, Straus SE, Gelb LD, Arbeit RD, Simberkoff MS, Gershon AA, Davis LE, Weinberg A, Boardman KD, Williams HM, Zhang JH, Peduzzi PN, Beisel CE, Morrison VA, Guatelli JC, Brooks PA, Kauffman CA, Pachucki CT, Neuzil KM, Betts RF, Wright PF, Griffin MR, Brunell P, Soto NE, Marques AR, Keay SK, Goodman RP, Cotton DJ, Gnann JW, Loutit J, Holodniy M, Keitel WA, Crawford GE, Yeh SS, Lobo Z, Toney JF, Greenberg RN, Keller PM, Harbecke R, Hayward AR, Irwin MR, Kyriakides TC, Chan CY, Chan IS, Wang WW, Annunziato PW, Silber JL, Shingles Prevention Study Group: A vaccine to prevent herpes zoster and postherpetic neuralgias in older adults. N Engl J Med. 2005, 352: 2271-2284. 10.1056/NEJMoa051016.CrossRefPubMed
24.
Conferenza permanente per i rapporti tra lo Stato, Regioni e leProvince Autonome di Trento e Bolzano: Determinazione 3 marzo2005. Accordo ai sensi dell'art 4 del decreto legislativo 28 agosto n.281, tra il Ministro della Salute e i Presidenti delleregioni e delle province autonome, concernente il Nuovo PianoNazionale Vaccini 2005–2007. GU n.86 del 14-04-2005- Suppl ordinario n.63.
25.
Ciofi degli Atti ML, Rota MC, Bella A, Salmaso S, Gruppo di Lavoro ICONA: Do changes in policy affect vaccine coverage levels? Results of a national study to evaluate childhood vaccination coverage and reasons for missed vaccination in Italy. Vaccine. 2004, 22: 4351-4357. 10.1016/j.vaccine.2004.04.026.CrossRefPubMed
Metadata
Title
The epidemiology of Varicella Zoster Virus infection in Italy
Authors
Giovanni Gabutti
Maria C Rota
Marcello Guido
Antonella De Donno
Antonino Bella
Marta L Ciofi degli Atti
Pietro Crovari
the Seroepidemiology Group
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2008
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-8-372

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