Skip to main content
Top
Published in: BMC Public Health 1/2008

Open Access 01-12-2008 | Research article

Hospitalizations associated with rotavirus gastroenteritis in Spain, 2001–2005

Authors: Ana López-de-Andrés, Rodrigo Jiménez-García, Pilar Carrasco-Garrido, Alejandro Alvaro-Meca, Patricia Graciela Galarza, Ángel Gil de Miguel

Published in: BMC Public Health | Issue 1/2008

Login to get access

Abstract

Background

This study aims to describe and analyze hospital admissions in Spain due to rotavirus infections among children aged 5 years or under during the period 2001–2005, along with the associated health cost.

Methods

To update estimates of rotavirus hospitalizations rates in Spain, we conducted a retrospective study of 5 years of national hospitalization data associated with acute gastroenteritis using the Minimum Basic Data Set.

Results

During the study period, a total of 17.1% of all admissions due to acute gastroenteritis of any etiology in children aged ≤ 5 years were attributable to rotavirus infection as determined by the rotavirus-specific International Classification of Diseases, ninth revision, Clinical Modification code. A mean incidence of 135 hospital admissions attributable to rotavirus per 100,000 children aged ≤ 5 years was found. Hospitalizations associated with rotavirus had a marked winter-time seasonality. The estimated cost of hospital admission attributable to rotavirus has risen from 3 million euros estimated for 2001 to almost 7 million euros estimated in 2005.

Conclusion

Rotavirus gastroenteritis remains an important cause of hospitalizations in Spanish children, mostly during the winter season.
Appendix
Available only for authorised users
Literature
1.
go back to reference Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI: Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003, 9: 565-572.CrossRefPubMedPubMedCentral Parashar UD, Hummelman EG, Bresee JS, Miller MA, Glass RI: Global illness and deaths caused by rotavirus disease in children. Emerg Infect Dis. 2003, 9: 565-572.CrossRefPubMedPubMedCentral
2.
go back to reference Tucker AW, Haddix AC, Bresee JS, Holman RC, Parashar UD, Glass RI: Cost-effectiveness analysis of a rotavirus immunization program for the United States. JAMA. 1998, 279: 1371-1376. 10.1001/jama.279.17.1371.CrossRefPubMed Tucker AW, Haddix AC, Bresee JS, Holman RC, Parashar UD, Glass RI: Cost-effectiveness analysis of a rotavirus immunization program for the United States. JAMA. 1998, 279: 1371-1376. 10.1001/jama.279.17.1371.CrossRefPubMed
3.
go back to reference Parashar UD, Holman RC, Clarke MJ, Bresee JS, Glass RI: Hospitalizations associated with rotavirus diarrhea in the United States, 1993 through 1995: surveillance based on the new ICD-9-CM rotavirus-specific diagnostic code. J Infect Dis. 1997, 177: 13-17.CrossRef Parashar UD, Holman RC, Clarke MJ, Bresee JS, Glass RI: Hospitalizations associated with rotavirus diarrhea in the United States, 1993 through 1995: surveillance based on the new ICD-9-CM rotavirus-specific diagnostic code. J Infect Dis. 1997, 177: 13-17.CrossRef
4.
go back to reference Charles MD, Holman RC, Curns AT, Parashar UD, Glass RI, Breese JS: Hospitalizations associated with rotavirus gastroenteritis in the United States., 1993–2002. Pediatr Infect Dis J. 2006, 25: 489-493. 10.1097/01.inf.0000215234.91997.21.CrossRefPubMed Charles MD, Holman RC, Curns AT, Parashar UD, Glass RI, Breese JS: Hospitalizations associated with rotavirus gastroenteritis in the United States., 1993–2002. Pediatr Infect Dis J. 2006, 25: 489-493. 10.1097/01.inf.0000215234.91997.21.CrossRefPubMed
5.
go back to reference Malek MA, Curns AT, Holman RC, Fischer TK, Breese JS, Glass RI, Steiner CA, Parashar UD: Diarrhea-and rotavirus-associated hospitalizations among children less than 5 years of age: United States, 1997 and 2000. Pediatrics. 2006, 117: 1887-1892. 10.1542/peds.2005-2351.CrossRefPubMed Malek MA, Curns AT, Holman RC, Fischer TK, Breese JS, Glass RI, Steiner CA, Parashar UD: Diarrhea-and rotavirus-associated hospitalizations among children less than 5 years of age: United States, 1997 and 2000. Pediatrics. 2006, 117: 1887-1892. 10.1542/peds.2005-2351.CrossRefPubMed
6.
go back to reference Soriano-Gabarro M, Mrukowicz J, Vesikari T, Verstraeten T: Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J. 2006, 7-11. Suppl 1 Soriano-Gabarro M, Mrukowicz J, Vesikari T, Verstraeten T: Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J. 2006, 7-11. Suppl 1
7.
go back to reference Rheingans RD, Heylen J, Giaquinto C: Economics of rotavirus gastroenteritis and vaccination in Europe. What makes sense?. Pediatr Infect Dis J. 2006, 48-55. Suppl 1 Rheingans RD, Heylen J, Giaquinto C: Economics of rotavirus gastroenteritis and vaccination in Europe. What makes sense?. Pediatr Infect Dis J. 2006, 48-55. Suppl 1
8.
go back to reference Giaquinto C, Van Damme P, Het F, Gothefors L, Van der Wielen M: Costs of community – acquired pediatric rotavirus gastroenteritis in 7 European countries: The REVEAL Study. J Infect Dis. 2007, 36-44. 10.1086/516716. Suppl 1 Giaquinto C, Van Damme P, Het F, Gothefors L, Van der Wielen M: Costs of community – acquired pediatric rotavirus gastroenteritis in 7 European countries: The REVEAL Study. J Infect Dis. 2007, 36-44. 10.1086/516716. Suppl 1
9.
go back to reference The Pediatric ROTavirus European CommitTee (PROTEC): The paediatric burden of rotavirus disease in Europe. Epidemiol Infect. 2006, 134: 908-916. 10.1017/S0950268806006091.CrossRef The Pediatric ROTavirus European CommitTee (PROTEC): The paediatric burden of rotavirus disease in Europe. Epidemiol Infect. 2006, 134: 908-916. 10.1017/S0950268806006091.CrossRef
10.
go back to reference Gil A, Carrasco P, Jiménez R, San-Martín M, Oyagüez I, González A: Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999–2000. Vaccine. 2004, 22: 2221-2225. 10.1016/j.vaccine.2003.11.037.CrossRefPubMed Gil A, Carrasco P, Jiménez R, San-Martín M, Oyagüez I, González A: Burden of hospitalizations attributable to rotavirus infection in children in Spain, period 1999–2000. Vaccine. 2004, 22: 2221-2225. 10.1016/j.vaccine.2003.11.037.CrossRefPubMed
15.
go back to reference Roman E, Valencia R, Fernández-Merino JC, Gallardo MV: Contribution of the microbiology laboratory to epidmeiologic surveillance. Enferm Infecc Microbiol Clin. 2003, 21: 387-388. 10.1157/13050535.CrossRefPubMed Roman E, Valencia R, Fernández-Merino JC, Gallardo MV: Contribution of the microbiology laboratory to epidmeiologic surveillance. Enferm Infecc Microbiol Clin. 2003, 21: 387-388. 10.1157/13050535.CrossRefPubMed
18.
go back to reference Giaquinto C, Van Damme P, Huet F, Gothefors L, Maxwell M, Todd P, Dal L: Clinical consequences of rotavirus acute gastroenteritis in Europe, 2004–2005: The REVEAL Study. J Infect Dis. 2007, 26-35. 10.1086/516717. Suppl 1 Giaquinto C, Van Damme P, Huet F, Gothefors L, Maxwell M, Todd P, Dal L: Clinical consequences of rotavirus acute gastroenteritis in Europe, 2004–2005: The REVEAL Study. J Infect Dis. 2007, 26-35. 10.1086/516717. Suppl 1
19.
go back to reference Ryan MJ, Ramsay M, Brown D, Gay N, Farrington CP, Wall PG: Hospital admissions attributable to rotavirus infection in England and Wales. J Infect Dis. 1996, 12-18. Suppl 1 Ryan MJ, Ramsay M, Brown D, Gay N, Farrington CP, Wall PG: Hospital admissions attributable to rotavirus infection in England and Wales. J Infect Dis. 1996, 12-18. Suppl 1
20.
go back to reference de Wit Ma, Koopmans MP, van der Blij JF, van Duynhoven YT: Hospital admissions for rotavirus infection in the Netherlands. Clin Infect Dis. 2000, 31: 698-704. 10.1086/314025.CrossRefPubMed de Wit Ma, Koopmans MP, van der Blij JF, van Duynhoven YT: Hospital admissions for rotavirus infection in the Netherlands. Clin Infect Dis. 2000, 31: 698-704. 10.1086/314025.CrossRefPubMed
21.
go back to reference Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der Wielen M, REVEAL Study Group: Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004–2005: The REVEAL study. Infect Dis. 2007, 4-16. 10.1086/516714. Suppl 1 Van Damme P, Giaquinto C, Huet F, Gothefors L, Maxwell M, Van der Wielen M, REVEAL Study Group: Multicenter prospective study of the burden of rotavirus acute gastroenteritis in Europe, 2004–2005: The REVEAL study. Infect Dis. 2007, 4-16. 10.1086/516714. Suppl 1
22.
go back to reference Vesikari T, Rautanem T, Bonsdorff CHV: Rotavirus gastroenteritis in Finland: Burden of disease and epidemiological features. Acta Paediatr. 1999, 426: 24-30. 10.1111/j.1651-2227.1999.tb14322.x.CrossRef Vesikari T, Rautanem T, Bonsdorff CHV: Rotavirus gastroenteritis in Finland: Burden of disease and epidemiological features. Acta Paediatr. 1999, 426: 24-30. 10.1111/j.1651-2227.1999.tb14322.x.CrossRef
23.
go back to reference Glass RI, Kilgore PE, Colman RC, Jin S, Smith JC, Woods PA, Clarke MJ, Ho MS, Gentsch JR: The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden. J Infect Dis. 1996, 5-11. Suppl 1 Glass RI, Kilgore PE, Colman RC, Jin S, Smith JC, Woods PA, Clarke MJ, Ho MS, Gentsch JR: The epidemiology of rotavirus diarrhea in the United States: surveillance and estimates of disease burden. J Infect Dis. 1996, 5-11. Suppl 1
24.
go back to reference Diez-Domingo J, Martín IO, Sanz AB, López AG, Martínez CC, Boronat CP, Del Barrio MJ, García DG, Pons MM, Crespo VA, Esteve PA, Armella IL, Monrabal IS, Baveira LB, López MG: Rotavirus gastroenteritis among children under five years of age in Valencia, Spain. Pediatric Infect Dis J. 2006, 25: 455-57. 10.1097/01.inf.0000217378.30444.21.CrossRef Diez-Domingo J, Martín IO, Sanz AB, López AG, Martínez CC, Boronat CP, Del Barrio MJ, García DG, Pons MM, Crespo VA, Esteve PA, Armella IL, Monrabal IS, Baveira LB, López MG: Rotavirus gastroenteritis among children under five years of age in Valencia, Spain. Pediatric Infect Dis J. 2006, 25: 455-57. 10.1097/01.inf.0000217378.30444.21.CrossRef
25.
go back to reference Nakagomi T, Nakagomi O, Takashashi Y, Enoki M, Suzuki T, Kilgore PE: Incidence and burden of rotavirus gastroenteritis in Japan, as estimated from a prospective sentinel hospital study. J Infect Dis. 2005, 106-110. 10.1086/431503. Suppl 1 Nakagomi T, Nakagomi O, Takashashi Y, Enoki M, Suzuki T, Kilgore PE: Incidence and burden of rotavirus gastroenteritis in Japan, as estimated from a prospective sentinel hospital study. J Infect Dis. 2005, 106-110. 10.1086/431503. Suppl 1
26.
go back to reference Gabutti G, Lazzara C, Marsella M, Bergamini M, Malaventura C, Borgna-Pignatti C: Burden of hospitalizations due to Rotavirus infection in Emilia Romagna, Italy. Acta Biomed. 2007, 78: 176-181.PubMed Gabutti G, Lazzara C, Marsella M, Bergamini M, Malaventura C, Borgna-Pignatti C: Burden of hospitalizations due to Rotavirus infection in Emilia Romagna, Italy. Acta Biomed. 2007, 78: 176-181.PubMed
27.
go back to reference Fischer TK, Nielsen NM, Wohlfahrt J, Paerregaard A: Incidence and cost of rotavirus hospitalizations in Denmark. Emerg Infec Dis. 2007, 13: 855-859.CrossRef Fischer TK, Nielsen NM, Wohlfahrt J, Paerregaard A: Incidence and cost of rotavirus hospitalizations in Denmark. Emerg Infec Dis. 2007, 13: 855-859.CrossRef
Metadata
Title
Hospitalizations associated with rotavirus gastroenteritis in Spain, 2001–2005
Authors
Ana López-de-Andrés
Rodrigo Jiménez-García
Pilar Carrasco-Garrido
Alejandro Alvaro-Meca
Patricia Graciela Galarza
Ángel Gil de Miguel
Publication date
01-12-2008
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2008
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-8-109

Other articles of this Issue 1/2008

BMC Public Health 1/2008 Go to the issue