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BMC Public Health
Published in: BMC Public Health 1/2007

Open Access 01-12-2007 | Research article

Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study

Authors: Marleen Vree, Nguyen T Huong, Bui D Duong, Dinh N Sy, Le N Van, Nguyen V Co, Frank GJ Cobelens, Martien W Borgdorff

Published in: BMC Public Health | Issue 1/2007

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Abstract

Background

Tuberculosis treatment failure and death rates are low in the Western Pacific Region, including Vietnam. However, failure or death may also occur among patients who did not complete treatment, i.e. reported as default or transfer-out. We aimed to assess the proportion failures and deaths among new smear-positive pulmonary tuberculosis patients with reported default or transfer-out.
Treatment outcomes rates were 1.4% default, 3.0% transfer-out, 0.4% failure and 2.6% death in northern Vietnam in 2003.

Methods

Tuberculosis patients in 32 randomly selected district tuberculosis units in northern Vietnam were followed up 1 to 3 years after treatment initiation for survival, recent treatment history and bacteriologically confirmed tuberculosis.

Results

Included were 85 transferred patients and 42 who defaulted. No information was available of 41 (32%), 28 (22%) had died. Fifty-eight were available for follow-up (46%); all had sputum smear results. Tuberculosis was recorded in 11 (13%), including 6 (7%) with positive sputum smears, 3 (3%) with negative smears but positive culture and 2 (2%) who had started re-treatment for bacteriologically confirmed tuberculosis. Fifteen (17%, 95%CI 10–27%) had died within 8 months after treatment initiation. Of 86 patients with known study outcomes, 39 (45%, 95%CI 35–56%) had died or had bacteriologically confirmed tuberculosis. This was recorded for 29/53 (55%, 95%CI 40–68%) transferred patients and 10/33 (30%, 95%CI 16–49%) patients who defaulted.

Conclusion

The total failure and death rates are 0.6% and 0.8% higher than based on routine reporting in northern Vietnam. Although this was a large proportion of treatment failures and deaths, failure and death rates were low. Defaulting and transfer carry a high risk of failure and in particular death.
Appendix
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Literature
1.
World Health Organization; International Union Against Tuberculosis and Lung Disease; Royal Netherlands Tuberculosis Association: Revised international definitions in tuberculosis control. Int J Tuberc Lung Dis. 2001, 5: 213-215.
2.
World Health Organization (WHO): Global tuberculosis control: surveillance, planning, financing. WHO report 2006. 2006, Geneva, WHO
3.
Chee CBE, Boudville IC, Chan SP, Zee YK, Wang YT: Patient and disease characteristics, and outcome of treatment defaulters from the Singapore TB control unit- a one-year retrospective survey. Int J Tuberc Lung Dis. 2000, 4: 496-503.PubMed
4.
García-García M, Ponce-de-León A, García-Sancho MC, Ferreyra-Reyes L, Palacios-Martinez M, Fuentes J, Kato-Maeda M, Bobadilla M, Small P, Sifuentes-Osornio J: Tuberculosis-related deaths within a well-functioning DOTS control program. Emerg Infect Dis. 2002, 8: 1327-1333.CrossRefPubMedCentral
5.
Verver S, Warren RM, Beyers N, Richardson M, van der Spuy GD, Borgdorff MW, Enarson DA, Behr MA, van Helden PD: Rate of reinfection tuberculosis after successful treatment is higher than rate of new tuberculosis. Am J Respir Crit Care Med. 2005, 171: 1430-1435. 10.1164/rccm.200409-1200OC.CrossRefPubMed
6.
Burman WJ, Cohn DL, Rietmeijer CA, Judson FN, Sbarbaro JA, Reves RR: Noncompliance with directly observed therapy for tuberculosis. Epidemiology and effect of the outcome of treatment. Chest. 1997, 111: 1168-1173.CrossRefPubMed
7.
World Health Organization (WHO): Global tuberculosis control: surveillance, planning, financing. WHO report 2005. 2005, Geneva, WHO
8.
Vree M, Huong NT, Duong BD, Sy DN, Van LN, Hung NV, Co NV, Borgdorff MW, Cobelens FG: Survival and relapse rate of tuberculosis patients who successfully completed treatment in Vietnam. Int J Tuberc Lung Dis. 2007, 11: 392-397.PubMed
9.
Jindani A, Nunn AJ, Enarson DA: Two 8-month regimens of chemotherapy for treatment of newly diagnosed pulmonary tuberculosis: international multicentre randomized trial. Lancet. 2004, 364: 1244-1251. 10.1016/S0140-6736(04)17141-9.CrossRefPubMed
10.
Huong NT, Duong BD, Co NV, Quy HT, Tung LB, Bosman M, Gebhardt A, Velema JP, Broekmans JF, Borgdorff MW: Establishment and development of the National Tuberculosis Control Programme in Vietnam. Int J Tuberc Lung Dis. 2005, 9: 151-156.PubMed
11.
National Tuberculosis Control Programme, National Institute of Tuberculosis and Respiratory diseases: 2004 Annual Data. Hanoi. 2005
12.
WHO/International Union Against Tuberculosis and Lung Disease: Anti-tuberculosis drug resistance in the world. 1997, Geneva: WHO
13.
14.
World Health Organization (WHO): Laboratory services in tuberculosis control. Part III: culture. 1998, Geneva, WHO
15.
World Health Organization (WHO): Guidelines for surveillance of drug resistance in tuberculosis. 2003, Geneva: WHO, 2
16.
Nguyen TH, Nguyen Tl, Trinh QH: HIV/AIDS epidemics in Vietnam: evolution and responses. AIDS Educ Prev. 2004, 16 (3 Suppl A): 137-154.PubMed
17.
World Health Organization (WHO): Laboratory services in tuberculosis control. Part I: Organization and management. 1998, Geneva, WHO, 10-
18.
Lambert ML, Hasker E, Van Deun A, Roberfroid D, Boelaert M, Van der Stuyft P: Recurrence in tuberculosis: relapse or reinfection?. Lancet Infect Dis. 2003, 3: 282-287. 10.1016/S1473-3099(03)00607-8.CrossRefPubMed
19.
Quy HT, Cobelens FGJ, Lan NTN, Buu TN, Lambregts CSB, Borgdorff MW: Treatment outcomes by drug resistance and HIV status among tuberculosis patients in Ho Chi Minh City, Vietnam. Int J Tuberc Lung Dis. 2006, 10: 45-51.PubMed
Metadata
Title
Mortality and failure among tuberculosis patients who did not complete treatment in Vietnam: a cohort study
Authors
Marleen Vree
Nguyen T Huong
Bui D Duong
Dinh N Sy
Le N Van
Nguyen V Co
Frank GJ Cobelens
Martien W Borgdorff
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2007
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-7-134

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