Top

Published in:

Open Access 01-12-2014 | Research article

Implementation of a universal rotavirus vaccination program: comparison of two delivery systems

Authors: Mitchell Zelman, Carolyn Sanford, Anne Neatby, Beth A Halperin, Donna MacDougall, Corinne Rowswell, Joanne M Langley, Scott A Halperin, Maritime Universal Rotavirus Vaccination Program (MURVP)

Published in: BMC Public Health | Issue 1/2014

Abstract

Background

Rotavirus vaccine is recommended for all infants in Canada. To evaluate the logistics of implementing a universal rotavirus vaccination program, we compared the effectiveness of program implementation in jurisdictions with either a physician-administered or public health nurse-administered program.

Methods

All infants born between October 1, 2010 and September 30, 2012 in Prince Edward Island and Nova Scotia’s Capital District Health Authority were eligible for the vaccination program. A universal rotavirus vaccination program was implemented and delivered in public health clinics in Prince Edward Island and in physicians’ offices in Nova Scotia.

Results

Engagement of vaccinators in delivery of the universal vaccination program was more successful in Prince Edward Island than in Nova Scotia. Vaccine coverage rates rose rapidly in Prince Edward Island, exceeding 90% for both doses within 3 months and remaining at those levels over the two-year program. In contrast, coverage rates in Nova Scotia rose more slowly and never exceeded 40% during the two years. Access to coverage data was more timely and accurate in Prince Edward Island than Nova Scotia.

Conclusion

A universal rotavirus vaccination program delivered through public health clinics achieved more rapid and higher levels of coverage than a program administered through physicians’ offices.

Trial registration

NCT01273077.

Available only for authorised users

World Health Organization: Estimated rotavirus deaths for children under 5 years of age. 2014, http://www.who.int/immunization/monitoring_surveillance/burden/estimates/rotavirus/en/index.html. Accessed 28 January 2014.

Parashar UD, Burton A, Lanata C, Boschi-Pinto C, Shibuya K, Steele D, Birmingham M, Glass RI: Global mortality associated with rotavirus disease among children in 2004. J Infect Dis. 2009, 200: S9-S15. 10.1086/605025.CrossRefPubMed

Tate JE, Burton AH, Boschi-Pinto C, Steele AD, Duque J, Parashar UD, WHO-coordinated Global Rotavirus Surveillance Network: 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis. Lancet. 2012, 12: 136-141. 10.1016/S1473-3099(11)70253-5.CrossRefPubMed

Bernstein DI: Rotavirus overview. Ped Infect Dis J. 2009, 29: S50-S53.CrossRef

Senecal M, Brisson M, Lebel MH, Yaremko J, Wong R, Gallant LA: Measuring the impact of rotavirus acute gastroenteritis (MIRAGE): a prospective community-based study. Can J Infect Dis Med Microbiol. 2008, 19: 397-404.PubMedPubMedCentral

Le Saux N, Bettinger JA, Halperin SA, Vaudry W, Scheifele DW, for members of the Canadian Immunization Monitoring Program, Active (IMPACT): Substantial morbidity for hospitalized children with community-acquired rotavirus infections: 2005-2007 IMPACT surveillance in Canadian hospitals. Ped Infect Dis J. 2010, 29: 879-892. 10.1097/INF.0b013e3181e20c94.CrossRef

Clark HF, Offit PA, Ellis RW, Eiden JJ, Krah D, Shaw AR, Pichichero M, Treanor JJ, Borian FE, Bell LM, Plotkin SA: The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants. J Infect Dis. 1996, 174: S73-S80. 10.1093/infdis/174.Supplement_1.S73.CrossRefPubMed

Bernstein DI, Sack DA, Rothstein E, Reisinger K, Ward RL: Efficacy of live, attenuated human rotavirus vaccine 89-12 in infants. Lancet. 1999, 354: 287-290. 10.1016/S0140-6736(98)12106-2.CrossRefPubMed

Vesikari T, Matson DO, Dennehy P, Van Damme P, Santosham M, Rodriguez Z, Dallas MJ, Heyse JF, Goveia MG, Black SB, Shinefield HR, Christie CD, Ylitalo S, Itzler RF, Coia ML, Onorato MT, Adeyi BA, Marshall GS, Gothefors L, Campens D, Karvonen A, Watt JP, O'Brien KL, DiNubile MJ, Clark HF, Boslego JW, Offit PA, Heaton PM, Rotavirus Efficacy and Safety Trial (REST) Study Team: Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med. 2006, 354: 23-33. 10.1056/NEJMoa052664.CrossRefPubMed

10.

Vesikari T, Karvonen A, Prymula R, Schuster V, Tejedor JC, Cohen R, Meurice F, Han HH, Damaso S, Bouckenooghe A: Efficacy of human rotavirus vaccine against rotavirus gastroenteritis during the first 2 years of life in European infants: randomized, double-blind controlled study. Lancet. 2007, 370: 1757-1763. 10.1016/S0140-6736(07)61744-9.CrossRefPubMed

11.

National Advisory Committee on Immunization: Rotavirus Vaccine. Canadian Immunization Guide. 2014, http://www.phac-aspc.gc.ca/publicat/cig-gci/p04-rot-eng.php. Accessed 30 January 2014

12.

Canadian Immunization Committee: Recommendations for rotavirus immunization programs. 2014, http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/14vol40/dr-rm40-02/dr-rm40-02-rota-eng.php. Accessed 30 January 2014

13.

Fisman DN, Chan CH, Lowcock E, Naus M, Lee V: Effectiveness and cost-effectiveness of pediatric rotavirus vaccination in British Columbia: a model-based evaluation. Vaccine. 2012, 30: 7601-7607. 10.1016/j.vaccine.2012.10.034.CrossRefPubMed

14.

Coyle D, Coyle K, Bettinger JA, Halperin SA, Vaudry W, Scheifele DW, Le Saux N: Cost effectiveness of infant vaccination for rotavirus in Canada. Can J Infect Dis Med Microbiol. 2012, 23: 71-77.PubMedPubMedCentral

15.

Statistics Canada: Births and total fertility rate, by province and territory. 2014, http://www.statcan.gc.ca/tables-tableaux/sum-som/l01/cst01/hlth85a-eng.htm. Accessed 9 February 2014.

16.

Statistics New Brunswick: Live Births by Age of Mother and Health Region of Residence, New Brunswick. 2011, http://www.snb.ca/e/1000/1000-01/pdf-2011/T7-1B.pdf. Accessed 9 February 2014

17.

Erickson LJ, De Wals P, Farand L: An analytical framework for immunization programs in Canada. Vaccine. 2005, 23: 2470-2476. 10.1016/j.vaccine.2004.10.029.CrossRefPubMed

18.

Parashar UD, Alexander JP, Glass RI: Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep. 2006, 55 (RR12): 1-13.PubMed

19.

Centers for Disease Control and Prevention: National, State, and Local Area Vaccination Coverage Among Children Aged 19–35 Months — United States, 2012. MMWR Morb Mortal Wkly Rep. 2013, 62: 733-740.

20.

Centers for Disease Control and Prevention: Recommendations of the Advisory Committee on Immunization Practice (ACIP). Quadrivalent human papillomavirus vaccine. MMWR Recomm Rep. 2007, 56 (RR02): 1-24.

21.

Centers for Disease Control and Prevention: National Immunization Survey-Teen Data (Adolescents-Teens 13-17 years of age. 2014, http://www.cdc.gov/vaccines/imz-managers/coverage/nis/teen/index.html. Accessed 1 March 2014.

22.

Centers for Disease Control and Prevention: Vaccine-specific coverage among children 19-35 months, National Immunization Survey, 1994-2012. 2014, http://www.dcd.gov/vaccines/imz-managers/coverage/nis/child/index.html. Accessed 1 March 2014

23.

Rapola S: National immunization program in Finland. Int J Circumpolar Health. 2007, 66: 382-389.CrossRefPubMed

24.

Leino T, Ollgren J, Salo H, Tiihonen P, Kilpi T: First year experience of rotavirus immunization program in Finland. Vaccine. 2012, 31: 176-182. 10.1016/j.vaccine.2012.10.068.CrossRefPubMed

25.

Population Health Assessment and Surveillance: School-based immunization coverage in Nova Scotia: 2008-09 to 2011-12. 2013, Nova Scotia: Department of Health and Wellness, http://novascotia.ca/dhw/populationhealth/. Accessed 1 March 2014

26.

Public Health England: Annual vaccine coverage statistics: England. NHS Immunisation Statistics England 2012-13. 2014, http://www.hscic.gov.uk/catalogue/PUB11665/nhs-immu-stat-eng-2012-13-rep.pdf. Accessed 1 March 2014

27.

Amirthalingam G, Gupta S, Campbell H: Pertussis immunisation and control in England and Wales, 1957 to 2012: a historical review. Euro Surveill. 2013, 18: 1-8.CrossRef

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/908/prepub

Title: Implementation of a universal rotavirus vaccination program: comparison of two delivery systems
Authors: Mitchell Zelman
Carolyn Sanford
Anne Neatby
Beth A Halperin
Donna MacDougall
Corinne Rowswell
Joanne M Langley
Scott A Halperin
Maritime Universal Rotavirus Vaccination Program (MURVP)
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/1471-2458-14-908

At a glance: The STEP trials

Springer Medicine

Implementation of a universal rotavirus vaccination program: comparison of two delivery systems

Abstract

Background

Methods

Results

Conclusion

Trial registration

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

Please log in to get access to this content

Other articles of this Issue 1/2014

Chronic mountain sickness in Chinese Han males who migrated to the Qinghai-Tibetan plateau: application and evaluation of diagnostic criteria for chronic mountain sickness

The association between breastfeeding and childhood obesity: a meta-analysis

Effectiveness of a school-community linked program on physical activity levels and health-related quality of life for adolescent girls

Important periods of weight development in childhood: a population-based longitudinal study

The key actors maintaining elders in functional autonomy in Bobo-Dioulasso (Burkina Faso)

The HIV epidemic and prevention response in Tigrai, Ethiopia: a synthesis at sub-national level