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Open Access 01-12-2014 | Research article

Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review

Authors: Freke R Zuure, Anouk T Urbanus, Miranda W Langendam, Charles W Helsper, Charlotte HSB van den Berg, Udi Davidovich, Maria Prins

Published in: BMC Public Health | Issue 1/2014

Abstract

Background

Effective screening programs are urgently needed to provide undiagnosed hepatitis C virus (HCV)-infected individuals with therapy. This systematic review of characteristics and outcomes of screening programs for HCV focuses on strategies to identify HCV risk groups hidden in the general population.

Methods

We conducted a comprehensive search of MEDLINE and EMBASE databases for articles published between 1991–2010, including studies that screened the general population using either a newly developed (nonintegrated) screening program or one integrated in existing health care facilities. Look-back studies, prevalence studies, and programs targeting high-risk groups in care (e.g., current drug users) were excluded.

Results

After reviewing 7052 studies, we identified 67 screening programs: 24 nonintegrated; 41 programs integrated in a variety of health care facilities (e.g., general practitioner); and 2 programs with both integrated and nonintegrated strategies. Together, these programs identified approximately 25,700 HCV-infected individuals. In general, higher HCV prevalence was found in programs in countries with intermediate to high HCV prevalence, in psychiatric clinics, and in programs that used a prescreening selection based on HCV risk factors. Only 6 programs used a comparison group for evaluation purposes, and 1 program used theory about effective promotion for screening. Comparison of the programs and their effectiveness was hampered by lack of reported data on program characteristics, clinical follow-up, and type of diagnostic test.

Conclusions

A prescreening selection based on risk factors can increase the efficiency of screening in low-prevalence populations, and we need programs with comparison groups to evaluate effectiveness. Also, program characteristics such as type of diagnostic test, screening uptake, and clinical outcomes should be reported systematically.

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Lavanchy D: The global burden of hepatitis C. Liver Int. 2009, 29 (Suppl 1): 74-81.PubMed

McHutchison JG: Understanding hepatitis C. Am J Manag Care. 2004, 10: S21-S29.PubMed

Micallef JM, Kaldor JM, Dore GJ: Spontaneous viral clearance following acute hepatitis C infection: a systematic review of longitudinal studies. J Viral Hepat. 2006, 13: 34-41. 10.1111/j.1365-2893.2005.00651.x.PubMed

Seeff LB: Natural history of chronic hepatitis C. Hepatology. 2002, 36 (5 Suppl 1): S35-S46.PubMed

Spradling PR, Rupp L, Moorman AC, Lu M, Teshale EH, Gordon SC, Nakasato C, Boscarino JA, Henkle EM, Nerenz DR, Denniston MM, Holmberg SD: Hepatitis B and C virus infection among 1.2 Million persons with access to care: factors associated with testing and infection prevalence. Clin Infect Dis. 2012, 55: 1047-1055. 10.1093/cid/cis616.PubMed

Hagan H, Campbell J, Thiede H, Strathdee S, Ouellet L, Kapadia F, Hudson S, Garfein RS: Self-reported hepatitis C virus antibody status and risk behavior in young injectors. Public Health Rep. 2006, 121: 710-719.PubMedPubMedCentral

Volk ML, Tocco R, Saini S, Lok AS: Public health impact of antiviral therapy for hepatitis C in the United States. Hepatology. 2009, 50: 1750-1755. 10.1002/hep.23220.PubMed

Grishchenko M, Grieve RD, Sweeting MJ, De Angelis D, Thomson BJ, Ryder SD, Irving WL: Cost-effectiveness of pegylated interferon and ribavirin for patients with chronic hepatitis C treated in routine clinical practice. Int J Technol Assess Health Care. 2009, 25: 171-180. 10.1017/S0266462309090229.PubMed

Siebert U, Sroczynski G, Rossol S, Wasem J, Ravens-Sieberer U, Kurth BM, Manns MP, McHutchison JG, Wong JB: Cost effectiveness of peginterferon alpha-2b plus ribavirin versus interferon alpha-2b plus ribavirin for initial treatment of chronic hepatitis C. Gut. 2003, 52: 425-432. 10.1136/gut.52.3.425.PubMedPubMedCentral

10.

Dore GJ, Matthews GV, Rockstroh J: Future of hepatitis C therapy: development of direct-acting antivirals. Curr Opin HIV AIDS. 2011, 6: 508-513. 10.1097/COH.0b013e32834b87f8.PubMed

11.

Ghany MG, Nelson DR, Strader DB, Thomas DL, Seeff LB: An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011, 54: 1433-1444. 10.1002/hep.24641.PubMedPubMedCentral

12.

Friis RH, Sellers TH: Screening for Disease in the Community. Epidemiology for Public Health Practice. 2009, Canada: Jones and Bartlett Publishers, LLC, 409-436. 4

13.

Centers for Disease Control and Prevention: Recommendations for prevention and control of hepatitis C virus (HCV) infection and HCV-related chronic disease. MMWR. 1998, 47 (No. RR-19): 20-26.

14.

Mofenson LM, Brady MT, Danner SP, Dominguez KL, Hazra R, Handelsman E, Havens P, Nesheim S, Read JS, Serchuck L, Van Dyke R: Guidelines for the Prevention and Treatment of Opportunistic Infections among HIV-exposed and HIV-infected children. MMWR Recomm Rep. 2009, 58: 1-166.PubMedPubMedCentral

15.

Lucidarme D, Decoster A, Fremaux D, Harbonnier J, Jacob C, Vosgien V, Josse P, Villeger P, Henrio C, Prouvost-Keller B, Saccardy C, Lemaire M, Vazeille G, Duchene C, Thuillier M, Colbeaux C, Lefebvre AM, Forzy G, Filoche B: Routine practice HCV infection screening with saliva samples: multicentric study in an intravenous drug user population. Gastroenterol Clin Biol. 2007, 31: 480-484. 10.1016/S0399-8320(07)89415-2.PubMed

16.

Makris M, Baglin T, Dusheiko G, Giangrande PL, Lee CA, Ludlam CA, Preston FE, Watson HG, Wilde JT, Winter M: Guidelines on the diagnosis, management and prevention of hepatitis in haemophilia. Haemophilia. 2001, 7: 339-345. 10.1046/j.1365-2516.2001.00527.x.PubMed

17.

Centers for Disease Control and Prevention: Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. MMWR. 2009, 58 (No. RR-4): 85-86. (No. RR-4)

18.

Vriend HJ, van Veen MG, Prins M, Urbanus AT, Boot HJ, Op de Coul ELM: Hepatitis C virus prevalence in the Netherlands: migrants account for most infections. Epidemiol Infect. 2013, 141 (6): 1310-1317. 10.1017/S0950268812001884.PubMed

19.

Vrielink H, Reesink HW, van den Burg PJ, Zaaijer HL, Cuypers HT, Lelie PN, van der Poel CL: Performance of three generations of anti-hepatitis C virus enzyme-linked immunosorbent assays in donors and patients. Transfusion. 1997, 37: 845-849. 10.1046/j.1537-2995.1997.37897424409.x.PubMed

20.

Glanz K, Bishop DB: The role of behavioral science theory in development and implementation of public health interventions. Annu Rev Public Health. 2010, 31: 399-418. 10.1146/annurev.publhealth.012809.103604.PubMed

21.

Alter HJ: New kit on the block: evaluation of second-generation assays for detection of antibody to the hepatitis C virus. Hepatology. 1992, 15: 350-353.PubMed

22.

Gretch DR: Diagnostic tests for hepatitis C. Hepatology. 1997, 26: 43S-47S. 10.1002/hep.510260708.PubMed

23.

Shepard CW, Finelli L, Alter MJ: Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 2005, 5: 558-567. 10.1016/S1473-3099(05)70216-4.PubMed

24.

Hao F: Prevalence of hepatitis C virus infection in pregnant women. Zhonghua Fu Chan Ke Za Zhi. 1993, 28: 668-702.PubMed

25.

Lu C: A seroepidemiological investigation on HCV infection among population in Tianjin area. Zhonghua Liu Xing Bing Xue Za Zhi. 1993, 14: 147-150.PubMed

26.

Fujimoto K, Momosaka Y, Uchida K, Ide H, Narisada H, Fujishiro K, Oda S, Okubo T: Implication of health checkups of students from developing countries in Japan. Nippon Koshu Eisei Zasshi. 1999, 46: 476-486.PubMed

27.

Fukui M: Natural history of HCV seropositive cases found in health screening. Hokkaido Igaku Zasshi. 1995, 70: 69-82.PubMed

28.

Imai Y, Tanaka H, Fukudai K, Zushi S, Yabuta T, Tujino A, Kurokawa M, Kono Y, Nishi K, Hayashi M: Present status of community-based HCV screening in Ikeda-Toyono Region, Osaka Prefecture, 2002. Acta Hepatologica Japonica. 2004, 45: 232-238. 10.2957/kanzo.45.232.

29.

Ishizuka M: Economic evaluation of health care program for hepatitis C virus antibody screening. Nippon Koshu Eisei Zasshi. 1999, 46: 447-465.PubMed

30.

Kajikawa T, Katahira Y, Ohto M, Hara K, Umezono T, Saito M, Yoshikawa M, Sugiura N, Ebara M, Saisho H: Epidemiologic aspects of cases with positive HCV antibody and clinical features of hepatocellular carcinoma with positive HCV antibody based on mass survey in a rural area of Chiba prefecture. Acta Hepatologica Japonica. 1996, 37: 13-18. 10.2957/kanzo.37.13.

31.

Kuroki T, Murai J, Fujino K, Ozaki S, Nakagishi M, Toukaiya M: The screening of hepatitis virus and its efficacy. Rinsho Byori. 1995, 43: 1095-1100.PubMed

32.

Michitaka K, Horiike N, Ohta Y: An epidemiological study of hepatitis C virus infection in a local district in Japan. Rinsho Byori. 1991, 39: 586-591.PubMed

33.

Watanabe Y, Machida K, Sato A, Ota S, Kiyosawa K: Survey for hepatitis in an isolated endemic area. Nippon Koshu Eisei Zasshi. 1996, 43: 989-996.PubMed

34.

Jonsdottir G, Briem H, Blondal T, Palsson G, Olafsson S, Gudnason T: Viral hepatitis B and C among immigrants in Iceland. Laeknabladid. 2006, 92: 669-673.PubMed

35.

Djeneva H, Aleksieva T: Screening of hepatitis markers for viral hepatitis B and C in healthy persons in the region of Stara Zagora. Bulg Med. 2003, 11: 6-8.

36.

Galetskii SA, Seniuta NB, Syrtsev AV, Abdullaev OM, Aliev DA, Kerimov AA, Yamashita M, Hayami M, Kato T, Mizokami M: Analysis of some viral infections, transmitted by parenteral and sexual routes, in the Republic of Azerbaijan. Vopr Virusol. 1999, 44: 232-236.PubMed

37.

Netesova IG, Iaroslavtseva OA, Dryga SA, Posukh OL, Osipova LP, Bronshtein EL, Zaitsev SA, Netesov SV: Frequency of encountering markers of viral hepatitis A, B, and C in the aboriginal inhabitants of the northwest region of Siberia. Vopr Virusol. 1995, 40: 172-174.PubMed

38.

Tagizadeh RK, Mammadov MK, Dadashova AE, Azimova AA: Infections caused by hepatitis virus B and C at inhabitants of Baku. Azerbaijan Med J. 2008, 1: 131-134.

39.

Ayvaz A, Nur N, Engin A, Cetinkaya S: Prevalence of hepatitis B and C in first grade primary school children living in Sivas, Turkey. Turk Pediatri Arsivi. 2010, 45: 132-136.

40.

Cagatay M, Tulek N, Koksalan H, Mert A: Prevalence of hepatitis C virus antibodies in hospital personnel. Mikrobiyol Bul. 1992, 26: 242-247.PubMed

41.

Pazdiora P, Topolcan O, Herynkova R: Hepatitis C antibodies in health personnel. Cesk Epidemiol Mikrobiol Imunol. 1994, 43: 29-31.PubMed

42.

Chen CJ, Lu SN, You SL, Wu MH, Wang LY, Lee LT, Huang GT, Yang PM, Lee HS: Community-based hepatocellular carcinoma screening in seven townships in Taiwan. J Formos Med Assoc. 1995, 94 (Suppl 2): S94-102.PubMed

43.

Tung W-C, Lu S-N, Wu M-H, Chen C-J: Screening of chronic active hepatitis from series of health examination database. J Intern Med Taiwan. 2004, 15: 65-75.

44.

Pauti MD, Simonnot N, Estecahandy P: Development of prevention programmes for HIV, hepatitis and sexually transmitted infections among migrants consulting in the doctors of the World French centers. Med Mal Infect. 2008, 38: 495-499. 10.1016/j.medmal.2008.06.028.PubMed

45.

Pauti MD, Simonnot N, Estecahandy P: Development of actions for the prevention of HIV, hepatitis and Sexually Transmitted Infections among immigrants consulting in the Doctors of the World "Missions France". Med Mal Infect. 2009, 39: 191-195. 10.1016/j.medmal.2008.12.004.PubMed

46.

Uddin G, Shoeb D, Solaiman S, Marley R, Gore C, Ramsay M, Harris R, Ushiro-Lumb I, Moreea S, Alam S, Thomas HC, Khan S, Watt B, Pugh RN, Ramaiah S, Jervis R, Hughes A, Singhal S, Cameron S, Carman WF, Foster GR: Prevalence of chronic viral hepatitis in people of south Asian ethnicity living in England: the prevalence cannot necessarily be predicted from the prevalence in the country of origin. J Viral Hepat. 2010, 17: 327-335. 10.1111/j.1365-2893.2009.01240.x.PubMed

47.

Kallman JB, Tran S, Arsalla A, Haddad D, Stepanova M, Fang Y, Wrobel VJ, Srishord M, Younossi ZM: Vietnamese community screening for hepatitis B virus and hepatitis C virus. J Viral Hepat. 2011, 18 (1): 70-76. 10.1111/j.1365-2893.2010.01278.x.PubMed

48.

Boyce DE, Tice AD, Ona FV, Akinaka KT, Lusk H: Viral hepatitis in a homeless shelter in Hawai'i. Hawaii Med J. 2009, 68: 113-115.PubMed

49.

Datta SD, Armstrong GL, Roome AJ, Alter MJ: Blood exposures and hepatitis C virus infections among emergency responders. Arch Intern Med. 2003, 163: 2605-2610. 10.1001/archinte.163.21.2605.PubMed

50.

Hwang JP, Mohseni M, Gor BJ, Wen S, Guerrero H, Vierling JM: Hepatitis B and hepatitis C prevalence and treatment referral among Asian Americans undergoing community-based hepatitis screening. Am J Public Health. 2010, 100 (Suppl 1): S118-S124.PubMedPubMedCentral

51.

Jimenez FP, Fuentes HM, Borbolla BE: Anti-HCV in patients transfused, in a health area attended by a family physician. Medical Office 19 de Abril. Acta Gastroenterol Latinoam. 2000, 30: 99-105.PubMed

52.

D'Souza RF, Glynn MJ, Alstead E, Foster GR, Ushiro-Lumb I: Improving hepatitis C services across the UK: response to a walk-in HCV testing service. Gut. 2004, 53: 1388-PubMedPubMedCentral

53.

Trepka MJ, Zhang G, Leguen F, Obiaja K, Malow RM, De La Rosa M: Benefits and adverse effects of hepatitis C screening: early results of a screening program. J Public Health Manag Pract. 2007, 13: 263-269. 10.1097/01.PHH.0000267684.23529.2c.PubMed

54.

Plard C, Shelly M, Millot J, Segouin C, Bertrand D, Le Divenah A: Anonymous and free screenings: population comparison between those conducted on-site in a testing centre and those done off-site. Sante Publique. 2007, 19: 355-362. 10.3917/spub.075.0355.PubMed

55.

Meky FA, Stoszek SK, Abdel-Hamid M, Selim S, Abdel-Wahab A, Mikhail N, El-Kafrawy S, El-Daly M, Abdel-Aziz F, Sharaf S, Mohamed MK, Engle RE, Emerson SU, Purcell RH, Fix AD, Strickland GT: Active surveillance for acute viral hepatitis in rural villages in the Nile Delta. Clin Infect Dis. 2006, 42: 628-633. 10.1086/500133.PubMed

56.

Lu SN, Chen HC, Tang CM, Wu MH, Yu ML, Chuang WL, Lu CF, Chang WY, Chen CJ: Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area. Pediatr Infect Dis J. 1998, 17: 142-145. 10.1097/00006454-199802000-00012.PubMed

57.

Aslam M, Aslam J: Seroprevalence of the antibody to hepatitis C in select groups in the Punjab region of Pakistan. J Clin Gastroenterol. 2001, 33: 407-411. 10.1097/00004836-200111000-00013.PubMed

58.

Chen CH, Yang PM, Huang GT, Lee HS, Sung JL, Sheu JC: Estimation of seroprevalence of hepatitis B virus and hepatitis C virus in Taiwan from a large-scale survey of free hepatitis screening participants. J Formos Med Assoc. 2007, 106: 148-155. 10.1016/S0929-6646(09)60231-X.PubMed

59.

D'Souza G, Arafat R, Hwang L, Cunningham C, Shah S, Reynolds K: Cross-sectional survey of the extent and indicators of hepatitis C virus infection in Houston Department of Health and Human Services' sexually transmitted disease clinics. J Viral Hepat. 2003, 10: 134-140. 10.1046/j.1365-2893.2003.00410.x.PubMed

60.

Scott C, Day S, Low E, Sullivan A, Atkins M, Asboe D: Unselected hepatitis C screening of men who have sex with men attending sexual health clinics. J Infect. 2010, 60: 351-353. 10.1016/j.jinf.2010.01.013.PubMed

61.

Weisbord JS, Trepka MJ, Zhang G, Smith IP, Brewer T: Prevalence of and risk factors for hepatitis C virus infection among STD clinic clientele in Miami, Florida. Sex Transm Infect. 2003, 79: E1-10.1136/sti.79.1.e1.PubMedPubMedCentral

62.

Gunn RA, Murray PJ, Brennan CH, Callahan DB, Alter MJ, Margolis HS: Evaluation of screening criteria to identify persons with hepatitis C virus infection among sexually transmitted disease clinic clients: results from the San Diego Viral Hepatitis Integration Project. Sex Transm Dis. 2003, 30: 340-344. 10.1097/00007435-200304000-00013.PubMed

63.

Mapagu MC, Martin SJ, Currie MJ, Bowden FJ: Screening for hepatitis C in sexual health clinic attendees. Sex Health. 2008, 5: 73-76. 10.1071/SH07034.PubMed

64.

Zimmerman R, Finley C, Rabins C, McMahon K: Integrating viral hepatitis prevention into STD clinics in Illinois (excluding Chicago), 1999–2005. Public Health Rep. 2007, 122 (Suppl 2): 18-23.PubMedPubMedCentral

65.

Subiadur J, Harris JL, Rietmeijer CA: Integrating viral hepatitis prevention services into an urban STD clinic: Denver, Colorado. Public Health Rep. 2007, 122 (Suppl 2): 12-17.PubMedPubMedCentral

66.

Heseltine G, McFarlane J: Texas statewide hepatitis C counseling and testing, 2000–2005. Public Health Rep. 2007, 122 (Suppl 2): 6-11.PubMedPubMedCentral

67.

Gunn RA, Murray PJ, Ackers ML, Hardison WG, Margolis HS: Screening for chronic hepatitis B and C virus infections in an urban sexually transmitted disease clinic: rationale for integrating services. Sex Transm Dis. 2001, 28: 166-170. 10.1097/00007435-200103000-00008.PubMed

68.

Ellks R: Hepatitis C testing should be performed routinely in all patients attending sexual health services. Abstract for the 2nd Joint Conference of the British HIV Association and the British Association for Sexual Health and HIV Manchester United Kingdom. HIV Med. 2010, 59:

69.

Tweed E, Brant L, Hurrelle M, Klapper P, Ramsay M: Hepatitis C testing in sexual health services in England, 2002–7: results from sentinel surveillance. Sex Transm Infect. 2010, 86: 126-130. 10.1136/sti.2009.036590.PubMed

70.

Monnet E, Mercet P, Woronoff-Lemsi MC, Bresson-Hadni S, Pruniaux J, Cottray P, Bouiller C, Allemand H, Miguet JP: Organized hepatitis C screening. Results and cost of a one-year campaign in a pilot area. Gastroenterol Clin Biol. 2000, 24: 541-546.PubMed

71.

Anderson EM, Mandeville RP, Hutchinson SJ, Cameron SO, Mills PR, Fox R, Ahmed S, Taylor A, Spence E, Goldberg DJ: Evaluation of a general practice based hepatitis C virus screening intervention. Scott Med J. 2009, 54: 3-7.PubMed

72.

Ouzan D, Cavailler P, Hofliger P, Mamino C, Joly H, Tran A: Modalities of care in anti HCV positive patients identified in General Medicine in the Alpes-Maritimes district. Gastroenterol Clin Biol. 2003, 27: 376-380.PubMed

73.

Josset V, Torre JP, Tavolacci MP, Van Rossem-Magnani V, Anselme K, Merle V, Godart J, Libert A, Ladner J, Czernichow P: Efficiency of hepatitis C virus screening strategies in general practice. Gastroenterol Clin Biol. 2004, 28: 351-357. 10.1016/S0399-8320(04)94935-4.PubMed

74.

Pradat P, Caillat-Vallet E, Sahajian F, Bailly F, Excler G, Sepetjan M, Trepo C, Fabry J: Prevalence of hepatitis C infection among general practice patients in the Lyon area, France. Eur J Epidemiol. 2001, 17: 47-51. 10.1023/A:1010902614443.PubMed

75.

Altman C, Lesiour A, Dunbavand A, Meyer L, de la Selle P, Buffet C: Screening of patients at risk for hepatitis C virus infection in general medicine. Gastroenterol Clin Biol. 1999, 23: 359-362.PubMed

76.

Helsper CW, van Essen GA, Bonten MJ, de Wit NJ: A support programme for primary care leads to substantial improvements in the effectiveness of a public hepatitis C campaign. Fam Pract. 2010, 27: 328-332. 10.1093/fampra/cmq006.PubMed

77.

Sahajian F, Excler G, Bailly F, Caillat-Vallet E, Trepo C, Sepetjan M, Fabry JY: Hepatitis C screening practices among private practitioners: impact of an information campaign. Gastroenterol Clin Biol. 2004, 28: 714-719. 10.1016/S0399-8320(04)95061-0.PubMed

78.

Roudot-Thoraval F, Monnet E, Mercet P, Bastie A, Dhumeaux D, Miguet JP: Strategies of hepatitis C screening in general practice. Results of a two-center randomized trial. Gastroenterol Clin Biol. 2000, 24: 1037-1041.PubMed

79.

Groom H, Dieperink E, Nelson DB, Garrard J, Johnson JR, Ewing SL, Stockley H, Durfee J, Jonk Y, Willenbring ML, Ho SB: Outcomes of a Hepatitis C screening program at a large urban VA medical center. J Clin Gastroenterol. 2008, 42: 97-106. 10.1097/MCG.0b013e31802dc56f.PubMed

80.

Mallette C, Flynn MA, Promrat K: Outcome of screening for hepatitis C virus infection based on risk factors. Am J Gastroenterol. 2008, 103: 131-137. 10.1111/j.1572-0241.2007.01522.x.PubMed

81.

Cheung RC, Cunningham BA, Cooper AD: Effectiveness of a screening program for hepatitis C. Dig Dis Sci. 2006, 51: 976-981. 10.1007/s10620-006-9100-x.PubMed

82.

Rifai MA, Moles JK, Lehman LP, Van der Linden BJ: Hepatitis C screening and treatment outcomes in patients with substance use/dependence disorders. Psychosomatics. 2006, 47: 112-121. 10.1176/appi.psy.47.2.112.PubMed

83.

Zuniga IA, Chen JJ, Lane DS, Allmer J, Jimenez-Lucho VE: Analysis of a hepatitis C screening programme for US veterans. Epidemiol Infect. 2006, 134: 249-257.PubMed

84.

Alexanian AA, Oleszkiewicz GM, Al-Chalabi T, Atabani S, Muir D, Tudor-Williams G, Brown AS: Observational outcomes in a cohort of women identified as hepatitis C (HCV) antibody positive during routine antenatal clinic (ANC) screening. Abstract for the 60th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2009 Boston, MA United States. Hepatology. 2009, 669A:

85.

Abusheikha N, Akagbosu F, Marcus S, Lass A, Cousins C, Brinsden P: Viral screening and assisted conception treatment–the Bourn Hall experience. J Assist Reprod Genet. 1999, 16: 337-339. 10.1023/A:1020414318129.PubMedPubMedCentral

86.

Leikin EL, Reinus JF, Schmell E, Tejani N: Epidemiologic predictors of hepatitis C virus infection in pregnant women. Obstet Gynecol. 1994, 84: 529-534.PubMed

87.

Ward C, Tudor-Williams G, Cotzias T, Hargreaves S, Regan L, Foster GR: Prevalence of hepatitis C among pregnant women attending an inner London obstetric department: uptake and acceptability of named antenatal testing. Gut. 2000, 47: 277-280. 10.1136/gut.47.2.277.PubMedPubMedCentral

88.

Costa ZB, Machado GC, Avelino MM, Gomes FC, Macedo Filho JV, Minuzzi AL, Turchi MD, Stefani MM, de Souza WV, Martelli CM: Prevalence and risk factors for Hepatitis C and HIV-1 infections among pregnant women in Central Brazil. BMC Infect Dis. 2009, 9: 116-10.1186/1471-2334-9-116.PubMedPubMedCentral

89.

Freudenreich O, Gandhi RT, Walsh JP, Henderson DC, Goff DC: Hepatitis C in schizophrenia: screening experience in a community-dwelling clozapine cohort. Psychosomatics. 2007, 48: 405-411. 10.1176/appi.psy.48.5.405.PubMed

90.

Gunewardene R, Lampe L, Ilchef R: Prevalence of hepatitis C in two inpatient psychiatry populations. Australas Psychiatry. 2010, 18: 330-334. 10.3109/10398561003763273.PubMed

91.

Lacey C, Ellen S, Devlin H, Wright E, Mijch A: Hepatitis C in psychiatry inpatients: testing rates, prevalence and risk behaviours. Australas Psychiatry. 2007, 15: 315-319. 10.1080/10398560701358113.PubMed

92.

Capron D, Bensousan T, Darchis JP, Barbare JC, Butel J, Bental A, Cadranel JF, Goll A, Levy P, Ink O, Autret P, Bouraya D, Thiebaut JM, Moucheron JJ, Bernard M, Lallement PY, Delobel P: Hepatitis C virus infection risk factors in patients admitted in hospital emergency departments in Picardy. Value of oriented screening based on recommendations of the 'Direction Generale de la Sante'. Eur J Gastroenterol Hepatol. 1999, 11: 643-648. 10.1097/00042737-199906000-00010.PubMed

93.

Alswaidi FM, O'Brien SS: Is there a need to include HIV, HBV and HCV viruses in the Saudi premarital screening programme on the basis of their prevalence and transmission risk factors?. J Epidemiol Community Health. 2009

94.

Dubois F, Francois M, Mariotte N, Caces E, Vol S, Roingeard P, Barin F, Goudeau A, Tichet J: Serum alanine aminotransferase measurement as a guide to selective testing for hepatitis C during medical checkup. J Hepatol. 1994, 21: 837-841. 10.1016/S0168-8278(94)80247-5.PubMed

95.

Roberts J, Cull M, Dean G, Richardson D, Fisher M: Improved but still suboptimal uptake of STI testing and vaccination in the outreach setting. Abstract for the 2nd Joint Conference of the British HIV Association and the British Association for Sexual Health and HIV Manchester United Kingdom. HIV Med. 2010, 118:

96.

Cohen DE, Russell CJ, Golub SA, Mayer KH: Prevalence of hepatitis C virus infection among men who have sex with men at a Boston community health center and its association with markers of high-risk behavior. AIDS Patient Care STDS. 2006, 20: 557-564. 10.1089/apc.2006.20.557.PubMed

97.

Campello C, Poli A, Dal MG, Besozzi-Valentini F: Seroprevalence, viremia and genotype distribution of hepatitis C virus: a community-based population study in northern Italy. Infection. 2002, 30: 7-12. 10.1007/s15010-001-1197-4.PubMed

98.

Tafuri S, Prato R, Martinelli D, Melpignano L, De Palma M, Quarto M, Germinario C: Prevalence of Hepatitis B, C, HIV and syphilis markers among refugees in Bari, Italy. BMC Infect Dis. 2010, 10: 213-10.1186/1471-2334-10-213.PubMedPubMedCentral

99.

Sahajian F, Vanhems P, Bailly F, Fabry J, Trepo C, Sepetjan M: Screening campaign of hepatitis C among underprivileged people consulting in health centres of Lyon area, France. Eur J Public Health. 2007, 17: 263-271. 10.1093/eurpub/ckl233.PubMed

100.

Sequist TD, Zaslavsky AM, Marshall R, Fletcher RH, Ayanian JZ: Patient and physician reminders to promote colorectal cancer screening: a randomized controlled trial. Arch Intern Med. 2009, 169: 364-371. 10.1001/archinternmed.2008.564.PubMedPubMedCentral

101.

Gollwitzer PM: Implementation Intentions: Strong effects of simple plans. Am Psychol. 1999, 54: 493-503.

102.

Centers for Disease Control and Prevention: Guidelines for laboratory testing and result reporting of antibody to hepatitis C virus. MMWR. 2003, 52: (No. RR-3)-

103.

Grimaudo NJ, Lado E: Hepatitis C screenings available at FNDC. Todays FDA. 2000, 12: 28-30.PubMed

104.

Wadley F: H.A.L.T. hepatitis C in Tennessee. Tenn Med. 1997, 90: 395-PubMed

105.

Nakamura J, Terajima K, Aoyagi Y, Akazawa K: Cost-effectiveness of the national screening program for hepatitis C virus in the general population and the high-risk groups. Tohoku J Exp Med. 2008, 215: 33-42. 10.1620/tjem.215.33.PubMed

106.

Coffin PO, Scott JD, Golden MR, Sullivan SD: Cost-effectiveness and population outcomes of general population screening for hepatitis C. Clin Infect Dis. 2012, 54: 1259-1271. 10.1093/cid/cis011.PubMedPubMedCentral

107.

Rein DB, Smith BD, Wittenborn JS, Lesesne SB, Wagner LD, Roblin DW, Patel N, Ward JW, Weinbaum CM: The cost-effectiveness of birth-cohort screening for hepatitis C antibody in U.S. primary care settings. Ann Intern Med. 2012, 156: 263-270. 10.7326/0003-4819-156-4-201202210-00378.PubMed

108.

Wilson JM, Jungner YG: Principles and practice of mass screening for disease. Bol Oficina Sanit Panam. 1968, 65: 281-393.PubMed

109.

Jones L, Bates G, McCoy E, Beynon C, McVeigh J, Bellis M: Centre for Public Health, Faculty of Health and Applied Social Sciences. A Systematic Review of the Effectiveness and Cost-Effectiveness of Interventions Aimed at Raising Awareness and Engaging with Groups who are at an Increased Risk of Hepatitis B and C Infection - Final Report. 2012, Liverpool: Liverpool John Moores University

110.

Smith BD, Morgan RL, Beckett GA, Falck-Ytter Y, Holtzman D, Ward JW: Hepatitis C virus testing of persons born during 1945–1965: recommendations from the Centers for Disease Control and Prevention. Ann Intern Med. 2012, 157: 817-822. 10.7326/0003-4819-157-9-201211060-00529.PubMed

111.

Hayashi J, Kishihara Y, Yamaji K, Yoshimura E, Kawakami Y, Akazawa K, Kashiwagi S: Transmission of hepatitis C virus by health care workers in a rural area of Japan. Am J Gastroenterol. 1995, 90: 794-799.PubMed

112.

Kaur S, Rybicki L, Bacon BR, Gollan JL, Rustgi VK, Carey WD: Performance characteristics and results of a large-scale screening program for viral hepatitis and risk factors associated with exposure to viral hepatitis B and C: results of the National Hepatitis Screening Survey. National Hepatitis Surveillance Group. Hepatology. 1996, 24: 979-986.PubMed

113.

Bellentani S, Tiribelli C, Saccoccio G, Sodde M, Fratti N, De Martin C, Cristianini G: Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study. Hepatology. 1994, 20: 1442-1449. 10.1002/hep.1840200611.PubMed

114.

Fagundes GD, Bonazza V, Ceretta LB, Back AJ, Bettiol J: Detection of the hepatitis C virus in a population of adults. Rev Lat Am Enfermagem. 2008, 16: 396-400.PubMed

115.

Batash S, Khaykis I, Raicht RF, Bini EJ: High prevalence of hepatitis C virus infection among immigrants from the former Soviet Union in the New York City metropolitan area: results of a community-based screening program. Am J Gastroenterol. 2008, 103: 922-927. 10.1111/j.1572-0241.2008.01789.x.PubMed

116.

ARèS 92: Intérêt d'un "parcours santé" proposé aux résidents d'un foyer Sonacotra. BEH. 2004, 43: 205-206.

117.

Goetz AM, Ndimbie OK, Wagener MM, Muder RR: Prevalence of hepatitis C infection in health care workers affiliated with a liver transplant center. Transplant. 1995, 59: 990-994. 10.1097/00007890-199504150-00012.

118.

Thomas DL, Factor SH, Kelen GD, Washington AS, Taylor E, Quinn TC: Viral hepatitis in health care personnel at The Johns Hopkins Hospital. The seroprevalence of and risk factors for hepatitis B virus and hepatitis C virus infection. Arch Intern Med. 1993, 153: 1705-1712. 10.1001/archinte.1993.00410140095011.PubMed

119.

Panlilio AL, Shapiro CN, Schable CA, Mendelson MH, Montecalvo MA, Kunches LM, Perry SW, Edwards JR, Srivastava PU, Culver DH: Serosurvey of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus infection among hospital-based surgeons. Serosurvey Study Group. J Am Coll Surg. 1995, 180: 16-24.PubMed

120.

Upfal MJ, Naylor P, Mutchnick MM: Hepatitis C screening and prevalence among urban public safety workers. J Occup Environ Med. 2001, 43: 402-411. 10.1097/00043764-200104000-00019.PubMed

121.

Gershon RR, Vlahov D, Farzadegan H, Alter MJ: Occupational risk of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus infections among funeral service practitioners in Maryland. Infect Control Hosp Epidemiol. 1995, 16: 194-197. 10.2307/30140977.PubMed

122.

Torda AJ: Vaccination and screening of medical students: results of a student health initiative. Med J Aust. 2008, 189: 484-486.PubMed

123.

Arumainayagam J, Grimshaw R, Acharya S, Chandramani S, Morrall IA, Pugh RN: Value of targeting at-risk populations at outreach venues: Findings from a local sauna. Int J STD AIDS. 2009, 20: 642-643. 10.1258/ijsa.2008.008424.PubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2458/14/66/prepub

Title: Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review
Authors: Freke R Zuure
Anouk T Urbanus
Miranda W Langendam
Charles W Helsper
Charlotte HSB van den Berg
Udi Davidovich
Maria Prins
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI: https://doi.org/10.1186/1471-2458-14-66

At a glance: The STEP trials

Springer Medicine

Outcomes of hepatitis C screening programs targeted at risk groups hidden in the general population: a systematic review

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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