Skip to main content
Top
Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

Economic burden of seasonal influenza B in France during winter 2010-2011

Authors: Maria Laura Silva, Lionel Perrier, Hans-Martin Späth, Isidore Grog, Anne Mosnier, Nathalie Havet, Jean Marie Cohen

Published in: BMC Public Health | Issue 1/2014

Login to get access

Abstract

Background

In France, 2–15% of the population is affected annually by influenza, which causes significant socioeconomic disruption. Nevertheless, despite its importance for policy makers, few published studies have evaluated the impact of influenza B. Therefore, we assessed the costs associated with influenza B during 2010–2011 in France.

Methods

Cases of lab-confirmed influenza B were analyzed as part of the Influenza B in General Practice Study. Cost calculations were based on micro-costing methods according to the French Health Insurance (FHI) perspective (in Euros, 2011). Costs were compared between age groups using the Kruskal–Wallis test, and when significant, by multiple comparisons based on rank. Moreover, uncertainties were assessed using one-way sensitivity and probabilistic analyses. Overall economic burden was estimated by multiplying cost per patient, flu attack rate, and the French population.

Results

A total of 201 patients were included in the study. We found that the mean cost associated with Influenza B was 72€ (SD: 205) per patient: 70€ (SD: 262) for younger children, 50€ (SD: 195) for older children, 126€ (SD: 180) for adults, and 42€ (SD: 18) for elderly. Thus, we observed significantly different costs between the distinct age groups (p<0.0001). Finally, the economic burden of influenza B for the FHI was estimated to be 145 million Euros (95% CI: 88–201).

Conclusions

Our findings highlight the important impact of influenza B and encourage further investigation on policy regarding vaccination strategies in France.
Appendix
Available only for authorised users
Literature
5.
go back to reference Fleming DM, Zambon M, Bartelds AI, de Jong JC: The duration and magnitude of influenza epidemics: a study of surveillance data from sentinel general practices in England, Wales and the Netherlands. Eur J Epidemiol. 1999, 15 (5): 467-473. 10.1023/A:1007525402861.CrossRefPubMed Fleming DM, Zambon M, Bartelds AI, de Jong JC: The duration and magnitude of influenza epidemics: a study of surveillance data from sentinel general practices in England, Wales and the Netherlands. Eur J Epidemiol. 1999, 15 (5): 467-473. 10.1023/A:1007525402861.CrossRefPubMed
6.
go back to reference Turner D, Wailoo A, Nicholson K, Cooper N, Sutton A, Abrams K: Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Health Technol Assess. 2003, 7 (35): 1-170. iii–iv, xi–xiiiCrossRef Turner D, Wailoo A, Nicholson K, Cooper N, Sutton A, Abrams K: Systematic review and economic decision modelling for the prevention and treatment of influenza A and B. Health Technol Assess. 2003, 7 (35): 1-170. iii–iv, xi–xiiiCrossRef
7.
go back to reference Jefferson T, Demicheli V: Socioeconomics of influenza. Textbook of influenza. Edited by: Nicholson KG, Webster RG, Hay AJ. 1998, Malden, MA: Blackwell Science, 541-547. Jefferson T, Demicheli V: Socioeconomics of influenza. Textbook of influenza. Edited by: Nicholson KG, Webster RG, Hay AJ. 1998, Malden, MA: Blackwell Science, 541-547.
8.
go back to reference Ryan J, Zoellner Y, Gradl B, Palache B, Medema J: Establishing the health and economic impact of influenza vaccination within the European Union 25 countries. Vaccine. 2006, 24 (47–48): 6812-6822.CrossRefPubMed Ryan J, Zoellner Y, Gradl B, Palache B, Medema J: Establishing the health and economic impact of influenza vaccination within the European Union 25 countries. Vaccine. 2006, 24 (47–48): 6812-6822.CrossRefPubMed
9.
go back to reference Molinari NA, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, et al: The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007, 25 (27): 5086-5096. 10.1016/j.vaccine.2007.03.046.CrossRefPubMed Molinari NA, Ortega-Sanchez IR, Messonnier ML, Thompson WW, Wortley PM, Weintraub E, et al: The annual impact of seasonal influenza in the US: measuring disease burden and costs. Vaccine. 2007, 25 (27): 5086-5096. 10.1016/j.vaccine.2007.03.046.CrossRefPubMed
10.
go back to reference Cram P, Blitz SG, Monto A, Fendrick AM: Influenza. Cost of illness and considerations in the economic evaluation of new and emerging therapies. Pharmacoeconomics. 2001, 19 (3): 223-230. 10.2165/00019053-200119030-00001.CrossRefPubMed Cram P, Blitz SG, Monto A, Fendrick AM: Influenza. Cost of illness and considerations in the economic evaluation of new and emerging therapies. Pharmacoeconomics. 2001, 19 (3): 223-230. 10.2165/00019053-200119030-00001.CrossRefPubMed
11.
go back to reference Iskander M, Booy R, Lambert S: The burden of influenza in children. Curr Opin Infect Dis. 2007, 20 (3): 259-263. 10.1097/QCO.0b013e3280ad4687.CrossRefPubMed Iskander M, Booy R, Lambert S: The burden of influenza in children. Curr Opin Infect Dis. 2007, 20 (3): 259-263. 10.1097/QCO.0b013e3280ad4687.CrossRefPubMed
12.
go back to reference Blanc P, Noel G, Dubus JC, Garnier JM, Chabrol B, Minodier P: [Pediatric features of an influenza A seasonal outbreak and its burden in pediatric emergency rooms and pediatric departments]. Arch Pediatr. 2006, 13 (1): 11-16. 10.1016/j.arcped.2005.09.028.CrossRefPubMed Blanc P, Noel G, Dubus JC, Garnier JM, Chabrol B, Minodier P: [Pediatric features of an influenza A seasonal outbreak and its burden in pediatric emergency rooms and pediatric departments]. Arch Pediatr. 2006, 13 (1): 11-16. 10.1016/j.arcped.2005.09.028.CrossRefPubMed
13.
go back to reference Narain JP, Kumar R, Bhatia R: Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects. Natl Med J India. 2009, 22 (5): 242-247.PubMed Narain JP, Kumar R, Bhatia R: Pandemic (H1N1) 2009: epidemiological, clinical and prevention aspects. Natl Med J India. 2009, 22 (5): 242-247.PubMed
14.
go back to reference Falchi A, Arena C, Andreoletti L, Jacques J, Leveque N, Blanchon T, et al: Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France. J Clin Virol. 2008, 41 (2): 148-151. 10.1016/j.jcv.2007.11.003.CrossRefPubMed Falchi A, Arena C, Andreoletti L, Jacques J, Leveque N, Blanchon T, et al: Dual infections by influenza A/H3N2 and B viruses and by influenza A/H3N2 and A/H1N1 viruses during winter 2007, Corsica Island, France. J Clin Virol. 2008, 41 (2): 148-151. 10.1016/j.jcv.2007.11.003.CrossRefPubMed
15.
go back to reference Ambrose CS, Levin MJ: The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother. 2012, 1: 8(1)-CrossRef Ambrose CS, Levin MJ: The rationale for quadrivalent influenza vaccines. Hum Vaccin Immunother. 2012, 1: 8(1)-CrossRef
16.
go back to reference Belshe RB: The need for quadrivalent vaccine against seasonal influenza. Vaccine. 2010, 28 (Suppl 4): D45-D53.CrossRefPubMed Belshe RB: The need for quadrivalent vaccine against seasonal influenza. Vaccine. 2010, 28 (Suppl 4): D45-D53.CrossRefPubMed
17.
go back to reference Fitzner KA, Shortridge KF, McGhee SM, Hedley AJ: Cost-effectiveness study on influenza prevention in Hong Kong. Health Policy. 2001, 56 (3): 215-234. 10.1016/S0168-8510(00)00140-8.CrossRefPubMed Fitzner KA, Shortridge KF, McGhee SM, Hedley AJ: Cost-effectiveness study on influenza prevention in Hong Kong. Health Policy. 2001, 56 (3): 215-234. 10.1016/S0168-8510(00)00140-8.CrossRefPubMed
18.
go back to reference Belshe RB, Coelingh K, Ambrose CS, Woo JC, Wu X: Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity. Vaccine. 2010, 28 (9): 2149-2156. 10.1016/j.vaccine.2009.11.068.CrossRefPubMed Belshe RB, Coelingh K, Ambrose CS, Woo JC, Wu X: Efficacy of live attenuated influenza vaccine in children against influenza B viruses by lineage and antigenic similarity. Vaccine. 2010, 28 (9): 2149-2156. 10.1016/j.vaccine.2009.11.068.CrossRefPubMed
19.
go back to reference Levy E: French economic evaluations of influenza and influenza vaccination. Pharmacoeconomics. 1996, 9 (Suppl 3): 62-66.CrossRefPubMed Levy E: French economic evaluations of influenza and influenza vaccination. Pharmacoeconomics. 1996, 9 (Suppl 3): 62-66.CrossRefPubMed
20.
go back to reference Carrat F, Sahler C, Rogez S, Leruez-Ville M, Freymuth F, le Gales C, et al: Influenza burden of illness: estimates from a national prospective survey of household contacts in France. Arch Intern Med. 2002, 162 (16): 1842-1848. 10.1001/archinte.162.16.1842.CrossRefPubMed Carrat F, Sahler C, Rogez S, Leruez-Ville M, Freymuth F, le Gales C, et al: Influenza burden of illness: estimates from a national prospective survey of household contacts in France. Arch Intern Med. 2002, 162 (16): 1842-1848. 10.1001/archinte.162.16.1842.CrossRefPubMed
21.
go back to reference Mosnier A: La surveillance nationale de la grippe en France: les groupes régionaux d’observation de la grippe (GROG). Arch Pediatr. 2000, 7 (Supplement 3): S472-S474.CrossRef Mosnier A: La surveillance nationale de la grippe en France: les groupes régionaux d’observation de la grippe (GROG). Arch Pediatr. 2000, 7 (Supplement 3): S472-S474.CrossRef
24.
go back to reference Drummond MF, Sulpher MJ, Torrance GW, O’Brien BG, Stoddart GL: Methods for the economic evaluation of health care programmes. 2005, New York: Oxford University Press, 3 Drummond MF, Sulpher MJ, Torrance GW, O’Brien BG, Stoddart GL: Methods for the economic evaluation of health care programmes. 2005, New York: Oxford University Press, 3
30.
go back to reference Vidal: Le Dictionnaire VIDAL 2012. 2012, Paris: du Vidal, 88 Vidal: Le Dictionnaire VIDAL 2012. 2012, Paris: du Vidal, 88
36.
go back to reference INVS, I. de veille sanitaire: Surveillance épidémiologique et virologique de la grippe en France, saison 2010–2011. Bull Épidémiologique Hebd. 2011, 37–38: 394-398. INVS, I. de veille sanitaire: Surveillance épidémiologique et virologique de la grippe en France, saison 2010–2011. Bull Épidémiologique Hebd. 2011, 37–38: 394-398.
38.
go back to reference Tuppin P, Choukroun S, Samson S, Weill A, Ricordeau P, Allemand H: Vaccination contre la grippe saisonnière en France en 2010 et 2011: diminution des taux de couverture et facteurs associés. Presse Med. 2012, 41: e568-e576. 10.1016/j.lpm.2012.05.017.CrossRefPubMed Tuppin P, Choukroun S, Samson S, Weill A, Ricordeau P, Allemand H: Vaccination contre la grippe saisonnière en France en 2010 et 2011: diminution des taux de couverture et facteurs associés. Presse Med. 2012, 41: e568-e576. 10.1016/j.lpm.2012.05.017.CrossRefPubMed
39.
go back to reference Szucs TD: Medical economics in the field of influenza–past, present and future. Virus Res. 2004, 103 (1–2): 25-30.CrossRefPubMed Szucs TD: Medical economics in the field of influenza–past, present and future. Virus Res. 2004, 103 (1–2): 25-30.CrossRefPubMed
40.
go back to reference Chiu SS, Chan K-H, So LY, Chen R, Chan ELY, Peiris JSM: The population based socioeconomic burden of pediatric influenza-associated hospitalization in Hong Kong. Vaccine. 2012, 30 (10): 1895-1900. 10.1016/j.vaccine.2011.12.027.CrossRefPubMed Chiu SS, Chan K-H, So LY, Chen R, Chan ELY, Peiris JSM: The population based socioeconomic burden of pediatric influenza-associated hospitalization in Hong Kong. Vaccine. 2012, 30 (10): 1895-1900. 10.1016/j.vaccine.2011.12.027.CrossRefPubMed
41.
go back to reference Lee BY, Bacon KM, Donohue JM, Wiringa AE, Bailey RR, Zimmerman RK: From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination. Vaccine. 2011, 29 (11): 2149-2158. 10.1016/j.vaccine.2010.12.078.CrossRefPubMedPubMedCentral Lee BY, Bacon KM, Donohue JM, Wiringa AE, Bailey RR, Zimmerman RK: From the patient perspective: the economic value of seasonal and H1N1 influenza vaccination. Vaccine. 2011, 29 (11): 2149-2158. 10.1016/j.vaccine.2010.12.078.CrossRefPubMedPubMedCentral
42.
go back to reference Mercer NJ: Cost analysis of public health influenza vaccine clinics in Ontario. Can J Public Health. 2009, 100 (5): 340-343.PubMed Mercer NJ: Cost analysis of public health influenza vaccine clinics in Ontario. Can J Public Health. 2009, 100 (5): 340-343.PubMed
Metadata
Title
Economic burden of seasonal influenza B in France during winter 2010-2011
Authors
Maria Laura Silva
Lionel Perrier
Hans-Martin Späth
Isidore Grog
Anne Mosnier
Nathalie Havet
Jean Marie Cohen
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-56

Other articles of this Issue 1/2014

BMC Public Health 1/2014 Go to the issue