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Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

No increase in new users of blood glucose-lowering drugs in Norway 2006–2011: a nationwide prescription database study

Authors: Hanne Strøm, Randi Selmer, Kåre I Birkeland, Henrik Schirmer, Tore Julsrud Berg, Anne Karen Jenum, Kristian Midthjell, Christian Berg, Lars Christian Stene

Published in: BMC Public Health | Issue 1/2014

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Abstract

Background

National estimates for the occurrence of diabetes are difficult to obtain, particularly time trends in incidence. The aim was to describe time trends in prevalent and incident use of blood glucose-lowering drugs by age group and gender in Norway during 2005–2011.

Methods

Data were obtained from the nationwide Norwegian Prescription Database. We defined prevalent users of “insulins only” as individuals having no oral antidiabetic drugs (OAD) dispensed from a pharmacy during the previous 24 months or in the subsequent 12 months. Incident users had no blood glucose-lowering drugs dispensed in the previous 24 months; incident “insulins only” users also had no OAD in the subsequent 12 months.

Results

In 2011, 3.2% of the population had blood glucose-lowering drugs dispensed, and the incidence rate was 313 per 100,000 person years. The prevalence of OAD use increased from 1.8% in 2005 to 2.4% in 2011; however a decreasing trend in incidence of OAD use was observed, particularly in those aged 70 years and older. In 2010, 0.64% of the population had insulins only dispensed, with an overall incidence rate in the total population of 33 per 100,000 person years which was stable over time.

Conclusions

In this nationwide study, we found that although the prevalent use of OAD had increased in recent years, incident use was stable or had decreased. This may indicate that the increase in diabetes occurrence in Norway is levelling off, at least temporarily.
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Literature
1.
go back to reference Shaw JE, Sicree RA, Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010, 87: 4-14. 10.1016/j.diabres.2009.10.007.CrossRefPubMed Shaw JE, Sicree RA, Zimmet PZ: Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Res Clin Pract. 2010, 87: 4-14. 10.1016/j.diabres.2009.10.007.CrossRefPubMed
2.
go back to reference Morton LM, Cahill J, Hartge P: Reporting participation in epidemiologic studies: a survey of practice. Am J Epidemiol. 2006, 163: 197-203.CrossRefPubMed Morton LM, Cahill J, Hartge P: Reporting participation in epidemiologic studies: a survey of practice. Am J Epidemiol. 2006, 163: 197-203.CrossRefPubMed
3.
go back to reference Eriksson AK, Ekbom A, Hilding A, Östenson CG: The influence of non-response in a population-based cohort study on type 2 diabetes evaluated by the Swedish prescribed drug register. Eur J Epidemiol. 2012, 27: 153-162. 10.1007/s10654-011-9630-1.CrossRefPubMed Eriksson AK, Ekbom A, Hilding A, Östenson CG: The influence of non-response in a population-based cohort study on type 2 diabetes evaluated by the Swedish prescribed drug register. Eur J Epidemiol. 2012, 27: 153-162. 10.1007/s10654-011-9630-1.CrossRefPubMed
4.
go back to reference Carstensen B, Borch-Johnsen K: Register-based studies of diabetes. Scand J Public Health. 2011, 39: 175-179. 10.1177/1403494811404279.CrossRefPubMed Carstensen B, Borch-Johnsen K: Register-based studies of diabetes. Scand J Public Health. 2011, 39: 175-179. 10.1177/1403494811404279.CrossRefPubMed
5.
go back to reference Evans JM, Barnett KN, Ogston SA, Morris AD: Increasing prevalence of type 2 diabetes in a Scottish population: effect of increasing incidence or decreasing mortality?. Diabetologia. 2007, 50: 729-732. 10.1007/s00125-006-0585-9.CrossRefPubMed Evans JM, Barnett KN, Ogston SA, Morris AD: Increasing prevalence of type 2 diabetes in a Scottish population: effect of increasing incidence or decreasing mortality?. Diabetologia. 2007, 50: 729-732. 10.1007/s00125-006-0585-9.CrossRefPubMed
6.
go back to reference Skrivarhaug T, Stene LC, Drivvoll AK, Strøm H, Joner G, Norwegian Childhood Diabetes Registry: Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian Childhood Diabetes Registry. Diabetologia. 2014, 57: 57-62. 10.1007/s00125-013-3090-y.CrossRefPubMed Skrivarhaug T, Stene LC, Drivvoll AK, Strøm H, Joner G, Norwegian Childhood Diabetes Registry: Incidence of type 1 diabetes in Norway among children aged 0-14 years between 1989 and 2012: has the incidence stopped rising? Results from the Norwegian Childhood Diabetes Registry. Diabetologia. 2014, 57: 57-62. 10.1007/s00125-013-3090-y.CrossRefPubMed
7.
go back to reference Støvring H, Andersen M, Beck-Nielsen H, Green A, Vach W: Counting drugs to understand the disease: the case of measuring the diabetes epidemic. Popul Health Metr. 2007, 5: 2-10.1186/1478-7954-5-2.CrossRefPubMedPubMedCentral Støvring H, Andersen M, Beck-Nielsen H, Green A, Vach W: Counting drugs to understand the disease: the case of measuring the diabetes epidemic. Popul Health Metr. 2007, 5: 2-10.1186/1478-7954-5-2.CrossRefPubMedPubMedCentral
11.
go back to reference Ma RC, Tong PC: Epidemiology of type 2 diabetes. Textbook of Diabetes, Volume 4. Edited by: Holt RI, Cockram CS, Flyvbjerg A, Goldstein BJ. 2010, 4 Wiley-Blackwell, Oxford, 45-68.CrossRef Ma RC, Tong PC: Epidemiology of type 2 diabetes. Textbook of Diabetes, Volume 4. Edited by: Holt RI, Cockram CS, Flyvbjerg A, Goldstein BJ. 2010, 4 Wiley-Blackwell, Oxford, 45-68.CrossRef
12.
go back to reference Dale AC, Vatten LJ, Nilsen TI, Midthjell K, Wiseth R: Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study. BMJ. 2008, 337: a236-10.1136/bmj.39582.447998.BE.CrossRefPubMed Dale AC, Vatten LJ, Nilsen TI, Midthjell K, Wiseth R: Secular decline in mortality from coronary heart disease in adults with diabetes mellitus: cohort study. BMJ. 2008, 337: a236-10.1136/bmj.39582.447998.BE.CrossRefPubMed
13.
go back to reference Tran AT, Diep LM, Cooper JG, Claudi T, Straand J, Birkeland K, Ingskog W, Jenum AK: Quality of care for patients with type 2 diabetes in general practice according to patients’ ethnic background: a cross-sectional study from Oslo. Norway BMC Health Serv Res. 2010, 10: 145-10.1186/1472-6963-10-145.CrossRefPubMed Tran AT, Diep LM, Cooper JG, Claudi T, Straand J, Birkeland K, Ingskog W, Jenum AK: Quality of care for patients with type 2 diabetes in general practice according to patients’ ethnic background: a cross-sectional study from Oslo. Norway BMC Health Serv Res. 2010, 10: 145-10.1186/1472-6963-10-145.CrossRefPubMed
14.
go back to reference Cooper JG, Claudi T, Jenum AK, Thue G, Hausken MF, Ingskog W, Sandberg S: Quality of care for patients with type 2 diabetes in primary care in Norway is improving: results of cross-sectional surveys of 33 general practices in 1995 and 2005. Diabetes Care. 2009, 32: 81-83. 10.2337/dc08-0605.CrossRefPubMedPubMedCentral Cooper JG, Claudi T, Jenum AK, Thue G, Hausken MF, Ingskog W, Sandberg S: Quality of care for patients with type 2 diabetes in primary care in Norway is improving: results of cross-sectional surveys of 33 general practices in 1995 and 2005. Diabetes Care. 2009, 32: 81-83. 10.2337/dc08-0605.CrossRefPubMedPubMedCentral
15.
go back to reference Jenssen TG, Tonstad S, Claudi T, Midthjell K, Cooper J: The gap between guidelines and practice in the treatment of type 2 diabetes A nationwide survey in Norway. Diabetes Res Clin Pract. 2008, 80: 314-320. 10.1016/j.diabres.2007.12.025.CrossRefPubMed Jenssen TG, Tonstad S, Claudi T, Midthjell K, Cooper J: The gap between guidelines and practice in the treatment of type 2 diabetes A nationwide survey in Norway. Diabetes Res Clin Pract. 2008, 80: 314-320. 10.1016/j.diabres.2007.12.025.CrossRefPubMed
17.
go back to reference Hsia Y, Dawoud D, Sutcliffe AG, Viner RM, Kinra S, Wong IC: Unlicensed use of metformin in children and adolescents in the UK. Br J Clin Pharmacol. 2012, 73: 135-139. 10.1111/j.1365-2125.2011.04063.x.CrossRefPubMedPubMedCentral Hsia Y, Dawoud D, Sutcliffe AG, Viner RM, Kinra S, Wong IC: Unlicensed use of metformin in children and adolescents in the UK. Br J Clin Pharmacol. 2012, 73: 135-139. 10.1111/j.1365-2125.2011.04063.x.CrossRefPubMedPubMedCentral
18.
go back to reference Mastorakos G, Lambrinoudaki I, Creatsas G: Polycystic ovary syndrome in adolescents: current and future treatment options. Paediatr Drugs. 2006, 8: 311-318. 10.2165/00148581-200608050-00004.CrossRefPubMed Mastorakos G, Lambrinoudaki I, Creatsas G: Polycystic ovary syndrome in adolescents: current and future treatment options. Paediatr Drugs. 2006, 8: 311-318. 10.2165/00148581-200608050-00004.CrossRefPubMed
19.
go back to reference Brufani C, Fintini D, Nobili V, Patera PI, Cappa M, Brufani M: Use of metformin in pediatric age. Pediatr Diabetes. 2011, 12: 580-588.PubMed Brufani C, Fintini D, Nobili V, Patera PI, Cappa M, Brufani M: Use of metformin in pediatric age. Pediatr Diabetes. 2011, 12: 580-588.PubMed
20.
go back to reference Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF: A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000, 85: 2434-2438.PubMed Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF: A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab. 2000, 85: 2434-2438.PubMed
21.
go back to reference Joner G, Søvik O: The incidence of type 1 (insulin-dependent) diabetes mellitus 15–29 years in Norway 1978–1982. Diabetologia. 1991, 34: 271-274. 10.1007/BF00405087.CrossRefPubMed Joner G, Søvik O: The incidence of type 1 (insulin-dependent) diabetes mellitus 15–29 years in Norway 1978–1982. Diabetologia. 1991, 34: 271-274. 10.1007/BF00405087.CrossRefPubMed
22.
go back to reference Olsson L, Ahlbom A, Grill V, Midthjell K, Carlsson S: High levels of education are associated with an increased risk of latent autoimmune diabetes in adults: results from the Nord-Trondelag health study. Diabetes Care. 2011, 34: 102-107. 10.2337/dc10-1061.CrossRefPubMed Olsson L, Ahlbom A, Grill V, Midthjell K, Carlsson S: High levels of education are associated with an increased risk of latent autoimmune diabetes in adults: results from the Nord-Trondelag health study. Diabetes Care. 2011, 34: 102-107. 10.2337/dc10-1061.CrossRefPubMed
Metadata
Title
No increase in new users of blood glucose-lowering drugs in Norway 2006–2011: a nationwide prescription database study
Authors
Hanne Strøm
Randi Selmer
Kåre I Birkeland
Henrik Schirmer
Tore Julsrud Berg
Anne Karen Jenum
Kristian Midthjell
Christian Berg
Lars Christian Stene
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-520

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