Skip to main content
Top
Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

Cost savings of reduced constipation rates attributed to increased dietary fiber intakes: a decision-analytic model

Authors: Jordana K Schmier, Paige E Miller, Jessica A Levine, Vanessa Perez, Kevin C Maki, Tia M Rains, Latha Devareddy, Lisa M Sanders, Dominik D Alexander

Published in: BMC Public Health | Issue 1/2014

Login to get access

Abstract

Background

Nearly five percent of Americans suffer from functional constipation, many of whom may benefit from increasing dietary fiber consumption. The annual constipation-related healthcare cost savings associated with increasing intakes may be considerable but have not been examined previously. The objective of the present study was to estimate the economic impact of increased dietary fiber consumption on direct medical costs associated with constipation.

Methods

Literature searches were conducted to identify nationally representative input parameters for the U.S. population, which included prevalence of functional constipation; current dietary fiber intakes; proportion of the population meeting recommended intakes; and the percentage that would be expected to respond, in terms of alleviation of constipation, to a change in dietary fiber consumption. A dose–response analysis of published data was conducted to estimate the percent reduction in constipation prevalence per 1 g/day increase in dietary fiber intake. Annual direct medical costs for constipation were derived from the literature and updated to U.S. $ 2012. Sensitivity analyses explored the impact on adult vs. pediatric populations and the robustness of the model to each input parameter.

Results

The base case direct medical cost-savings was $12.7 billion annually among adults. The base case assumed that 3% of men and 6% of women currently met recommended dietary fiber intakes; each 1 g/day increase in dietary fiber intake would lead to a reduction of 1.9% in constipation prevalence; and all adults would increase their dietary fiber intake to recommended levels (mean increase of 9 g/day). Sensitivity analyses, which explored numerous alternatives, found that even if only 50% of the adult population increased dietary fiber intake by 3 g/day, annual medical costs savings exceeded $2 billion. All plausible scenarios resulted in cost savings of at least $1 billion.

Conclusions

Increasing dietary fiber consumption is associated with considerable cost savings, potentially exceeding $12 billion, which is a conservative estimate given the exclusion of lost productivity costs in the model. The finding that $12.7 billion in direct medical costs of constipation could be averted through simple, realistic changes in dietary practices is promising and highlights the need for strategies to increase dietary fiber intakes.
Literature
1.
go back to reference IOM: Dietary Reference Intakes: energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein and amino acids. 2002, Washington, DC: National Academies Press IOM: Dietary Reference Intakes: energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein and amino acids. 2002, Washington, DC: National Academies Press
3.
go back to reference U.S. Departments of Agriculture and Health and Human Services: Dietary Guidelines for Americans, 2010. 7th Ed. 2010, Washington, DC: US Government Printing Office U.S. Departments of Agriculture and Health and Human Services: Dietary Guidelines for Americans, 2010. 7th Ed. 2010, Washington, DC: US Government Printing Office
4.
go back to reference Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H: Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med. 2007, 167: 956-965. 10.1001/archinte.167.9.956.CrossRefPubMed Schulze MB, Schulz M, Heidemann C, Schienkiewitz A, Hoffmann K, Boeing H: Fiber and magnesium intake and incidence of type 2 diabetes: a prospective study and meta-analysis. Arch Intern Med. 2007, 167: 956-965. 10.1001/archinte.167.9.956.CrossRefPubMed
5.
go back to reference Ye EQ, Chacko SA, Chou EL, Kugizaki M, Liu S: Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain. J Nutr. 2012, 142: 1304-1313. 10.3945/jn.111.155325.CrossRefPubMed Ye EQ, Chacko SA, Chou EL, Kugizaki M, Liu S: Greater whole-grain intake is associated with lower risk of type 2 diabetes, cardiovascular disease, and weight gain. J Nutr. 2012, 142: 1304-1313. 10.3945/jn.111.155325.CrossRefPubMed
6.
go back to reference Chen GC, Lv DB, Pang Z, Dong JY, Liu QF: Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2013, 67 (1): 96-100. 10.1038/ejcn.2012.158.CrossRefPubMed Chen GC, Lv DB, Pang Z, Dong JY, Liu QF: Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies. Eur J Clin Nutr. 2013, 67 (1): 96-100. 10.1038/ejcn.2012.158.CrossRefPubMed
7.
go back to reference Pereira MA, O'Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A: Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med. 2004, 164: 370-376. 10.1001/archinte.164.4.370.CrossRefPubMed Pereira MA, O'Reilly E, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, Hallmans G, Knekt P, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Ascherio A: Dietary fiber and risk of coronary heart disease: a pooled analysis of cohort studies. Arch Intern Med. 2004, 164: 370-376. 10.1001/archinte.164.4.370.CrossRefPubMed
8.
go back to reference Aune D, Chan DS, Greenwood DC, Vieira AR, Rosenblatt DA, Vieira R, Norat T: Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Ann Oncol. 2012, 23: 1394-1402. 10.1093/annonc/mdr589.CrossRefPubMed Aune D, Chan DS, Greenwood DC, Vieira AR, Rosenblatt DA, Vieira R, Norat T: Dietary fiber and breast cancer risk: a systematic review and meta-analysis of prospective studies. Ann Oncol. 2012, 23: 1394-1402. 10.1093/annonc/mdr589.CrossRefPubMed
9.
go back to reference Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, Norat T: Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose–response meta-analysis of prospective studies. BMJ. 2011, 343: d6617-10.1136/bmj.d6617.CrossRefPubMedPubMedCentral Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, Norat T: Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose–response meta-analysis of prospective studies. BMJ. 2011, 343: d6617-10.1136/bmj.d6617.CrossRefPubMedPubMedCentral
10.
go back to reference Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML: Association between dietary fiber and endometrial cancer: a dose–response meta-analysis. Am J Clin Nutr. 2007, 86: 1730-1737.PubMedPubMedCentral Bandera EV, Kushi LH, Moore DF, Gifkins DM, McCullough ML: Association between dietary fiber and endometrial cancer: a dose–response meta-analysis. Am J Clin Nutr. 2007, 86: 1730-1737.PubMedPubMedCentral
11.
go back to reference Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G: Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003, 78: 920-927.PubMed Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G: Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003, 78: 920-927.PubMed
12.
go back to reference Tucker LA, Thomas KS: Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr. 2009, 139: 576-581. 10.3945/jn.108.096685.CrossRefPubMed Tucker LA, Thomas KS: Increasing total fiber intake reduces risk of weight and fat gains in women. J Nutr. 2009, 139: 576-581. 10.3945/jn.108.096685.CrossRefPubMed
13.
go back to reference Aldoori WH, Giovannucci EL, Rockett HR, Sampson L, Rimm EB, Willett WC: A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr. 1998, 128: 714-719.PubMed Aldoori WH, Giovannucci EL, Rockett HR, Sampson L, Rimm EB, Willett WC: A prospective study of dietary fiber types and symptomatic diverticular disease in men. J Nutr. 1998, 128: 714-719.PubMed
14.
go back to reference Crowe FL, Appleby PN, Allen NE, Key TJ: Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ. 2011, 343: d4131-10.1136/bmj.d4131.CrossRefPubMedPubMedCentral Crowe FL, Appleby PN, Allen NE, Key TJ: Diet and risk of diverticular disease in Oxford cohort of European Prospective Investigation into Cancer and Nutrition (EPIC): prospective study of British vegetarians and non-vegetarians. BMJ. 2011, 343: d4131-10.1136/bmj.d4131.CrossRefPubMedPubMedCentral
15.
go back to reference Lee WT, Ip KS, Chan JS, Lui NW, Young BW: Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based study. J Paediatr Child Health. 2008, 44: 170-175. 10.1111/j.1440-1754.2007.01212.x.CrossRefPubMed Lee WT, Ip KS, Chan JS, Lui NW, Young BW: Increased prevalence of constipation in pre-school children is attributable to under-consumption of plant foods: A community-based study. J Paediatr Child Health. 2008, 44: 170-175. 10.1111/j.1440-1754.2007.01212.x.CrossRefPubMed
16.
go back to reference Jennings A, Davies GJ, Costarelli V, Dettmar PW: Dietary fibre, fluids and physical activity in relation to constipation symptoms in pre-adolescent children. J Child Health Care. 2009, 13: 116-127. 10.1177/1367493509102469.CrossRefPubMed Jennings A, Davies GJ, Costarelli V, Dettmar PW: Dietary fibre, fluids and physical activity in relation to constipation symptoms in pre-adolescent children. J Child Health Care. 2009, 13: 116-127. 10.1177/1367493509102469.CrossRefPubMed
17.
go back to reference Roma E, Adamidis D, Nikolara R, Constantopoulos A, Messaritakis J: Diet and chronic constipation in children: the role of fiber. J Pediatr Gastroenterol Nutr. 1999, 28: 169-174. 10.1097/00005176-199902000-00015.CrossRefPubMed Roma E, Adamidis D, Nikolara R, Constantopoulos A, Messaritakis J: Diet and chronic constipation in children: the role of fiber. J Pediatr Gastroenterol Nutr. 1999, 28: 169-174. 10.1097/00005176-199902000-00015.CrossRefPubMed
18.
go back to reference Dukas L, Willett WC, Giovannucci EL: Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol. 2003, 98: 1790-1796. 10.1111/j.1572-0241.2003.07591.x.CrossRefPubMed Dukas L, Willett WC, Giovannucci EL: Association between physical activity, fiber intake, and other lifestyle variables and constipation in a study of women. Am J Gastroenterol. 2003, 98: 1790-1796. 10.1111/j.1572-0241.2003.07591.x.CrossRefPubMed
19.
go back to reference Morais MB, Vitolo MR, Aguirre AN, Fagundes-Neto U: Measurement of low dietary fiber intake as a risk factor for chronic constipation in children. J Pediatr Gastroenterol Nutr. 1999, 29: 132-135. 10.1097/00005176-199908000-00007.CrossRefPubMed Morais MB, Vitolo MR, Aguirre AN, Fagundes-Neto U: Measurement of low dietary fiber intake as a risk factor for chronic constipation in children. J Pediatr Gastroenterol Nutr. 1999, 29: 132-135. 10.1097/00005176-199908000-00007.CrossRefPubMed
20.
go back to reference Slavin JL: Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc. 2008, 108: 1716-1731.CrossRefPubMed Slavin JL: Position of the American Dietetic Association: health implications of dietary fiber. J Am Diet Assoc. 2008, 108: 1716-1731.CrossRefPubMed
21.
go back to reference Higgins PD, Johanson JF: Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol. 2004, 99: 750-759. 10.1111/j.1572-0241.2004.04114.x.CrossRefPubMed Higgins PD, Johanson JF: Epidemiology of constipation in North America: a systematic review. Am J Gastroenterol. 2004, 99: 750-759. 10.1111/j.1572-0241.2004.04114.x.CrossRefPubMed
22.
go back to reference Stewart WF, Liberman JN, Sandler RS, Woods MS, Stemhagen A, Chee E, Lipton RB, Farup CE: Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol. 1999, 94: 3530-3540. 10.1111/j.1572-0241.1999.01642.x.CrossRefPubMed Stewart WF, Liberman JN, Sandler RS, Woods MS, Stemhagen A, Chee E, Lipton RB, Farup CE: Epidemiology of constipation (EPOC) study in the United States: relation of clinical subtypes to sociodemographic features. Am J Gastroenterol. 1999, 94: 3530-3540. 10.1111/j.1572-0241.1999.01642.x.CrossRefPubMed
23.
go back to reference Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006, 130: 1377-1390. 10.1053/j.gastro.2006.03.008.CrossRefPubMed Drossman DA: The functional gastrointestinal disorders and the Rome III process. Gastroenterology. 2006, 130: 1377-1390. 10.1053/j.gastro.2006.03.008.CrossRefPubMed
24.
go back to reference Burnett C, Wilkins G: Managing children with constipation: a community perspective. J Fam Health Care. 2002, 12: 127-132.PubMed Burnett C, Wilkins G: Managing children with constipation: a community perspective. J Fam Health Care. 2002, 12: 127-132.PubMed
25.
go back to reference Dennison C, Prasad M, Lloyd A, Bhattacharyya SK, Dhawan R, Coyne K: The health-related quality of life and economic burden of constipation. Pharmacoecon. 2005, 23: 461-476. 10.2165/00019053-200523050-00006.CrossRef Dennison C, Prasad M, Lloyd A, Bhattacharyya SK, Dhawan R, Coyne K: The health-related quality of life and economic burden of constipation. Pharmacoecon. 2005, 23: 461-476. 10.2165/00019053-200523050-00006.CrossRef
26.
go back to reference Sonnenberg A, Koch TR: Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989, 34: 606-611. 10.1007/BF01536339.CrossRefPubMed Sonnenberg A, Koch TR: Physician visits in the United States for constipation: 1958 to 1986. Dig Dis Sci. 1989, 34: 606-611. 10.1007/BF01536339.CrossRefPubMed
27.
go back to reference Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ: Ambulatory care for constipation in the United States, 1993–2004. Am J Gastroenterol. 2008, 103: 1746-1753. 10.1111/j.1572-0241.2008.01910.x.CrossRefPubMed Shah ND, Chitkara DK, Locke GR, Meek PD, Talley NJ: Ambulatory care for constipation in the United States, 1993–2004. Am J Gastroenterol. 2008, 103: 1746-1753. 10.1111/j.1572-0241.2008.01910.x.CrossRefPubMed
28.
go back to reference Loening-Baucke V: Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr. 2005, 146: 359-363. 10.1016/j.jpeds.2004.10.046.CrossRefPubMed Loening-Baucke V: Prevalence, symptoms and outcome of constipation in infants and toddlers. J Pediatr. 2005, 146: 359-363. 10.1016/j.jpeds.2004.10.046.CrossRefPubMed
29.
go back to reference Constipation Guideline Committee of the North American Society for Pediatric Gastroenterology H, Nutrition: Evaluation and treatment of constipation in infants and children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2006, 43: e1-13. 10.1097/01.mpg.0000233159.97667.c3.CrossRef Constipation Guideline Committee of the North American Society for Pediatric Gastroenterology H, Nutrition: Evaluation and treatment of constipation in infants and children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2006, 43: e1-13. 10.1097/01.mpg.0000233159.97667.c3.CrossRef
30.
go back to reference Voderholzer WA, Schatke W, Muhldorfer BE, Klauser AG, Birkner B, Muller-Lissner SA: Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol. 1997, 92: 95-98.PubMed Voderholzer WA, Schatke W, Muhldorfer BE, Klauser AG, Birkner B, Muller-Lissner SA: Clinical response to dietary fiber treatment of chronic constipation. Am J Gastroenterol. 1997, 92: 95-98.PubMed
31.
go back to reference Mitra D, Davis KL, Baran RW: All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome. Postgrad Med. 2011, 123: 122-132. 10.3810/pgm.2011.09.2467.CrossRefPubMed Mitra D, Davis KL, Baran RW: All-cause health care charges among managed care patients with constipation and comorbid irritable bowel syndrome. Postgrad Med. 2011, 123: 122-132. 10.3810/pgm.2011.09.2467.CrossRefPubMed
32.
go back to reference Nyrop KA, Palsson OS, Levy RL, Korff MV, Feld AD, Turner MJ, Whitehead WE: Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain. Aliment Pharmacol Ther. 2007, 26: 237-248. 10.1111/j.1365-2036.2007.03370.x.CrossRefPubMed Nyrop KA, Palsson OS, Levy RL, Korff MV, Feld AD, Turner MJ, Whitehead WE: Costs of health care for irritable bowel syndrome, chronic constipation, functional diarrhoea and functional abdominal pain. Aliment Pharmacol Ther. 2007, 26: 237-248. 10.1111/j.1365-2036.2007.03370.x.CrossRefPubMed
33.
go back to reference Liem O, Harman J, Benninga M, Kelleher K, Mousa H, Di Lorenzo C: Health utilization and cost impact of childhood constipation in the United States. J Pediatr. 2009, 154: 258-262. 10.1016/j.jpeds.2008.07.060.CrossRefPubMed Liem O, Harman J, Benninga M, Kelleher K, Mousa H, Di Lorenzo C: Health utilization and cost impact of childhood constipation in the United States. J Pediatr. 2009, 154: 258-262. 10.1016/j.jpeds.2008.07.060.CrossRefPubMed
34.
go back to reference Choung RS, Branda ME, Chitkara D, Shah ND, Katusic SK, Locke GR, Talley NJ: Longitudinal direct medical costs associated with constipation in women. Aliment Pharmacol Ther. 2011, 33: 251-260. 10.1111/j.1365-2036.2010.04513.x.CrossRefPubMed Choung RS, Branda ME, Chitkara D, Shah ND, Katusic SK, Locke GR, Talley NJ: Longitudinal direct medical costs associated with constipation in women. Aliment Pharmacol Ther. 2011, 33: 251-260. 10.1111/j.1365-2036.2010.04513.x.CrossRefPubMed
35.
go back to reference Singh G, Lingala V, Wang H, Vadhavkar S, Kahler KH, Mithal A, Triadafilopoulos G: Use of health care resources and cost of care for adults with constipation. Clin Gastroenterol Hepatol. 2007, 5: 1053-1058. 10.1016/j.cgh.2007.04.019.CrossRefPubMed Singh G, Lingala V, Wang H, Vadhavkar S, Kahler KH, Mithal A, Triadafilopoulos G: Use of health care resources and cost of care for adults with constipation. Clin Gastroenterol Hepatol. 2007, 5: 1053-1058. 10.1016/j.cgh.2007.04.019.CrossRefPubMed
36.
go back to reference Speridiao PG, Tahan S, Fagundes-Neto U, Morais MB: Dietary fiber, energy intake and nutritional status during the treatment of children with chronic constipation. Braz J Med Biol Res. 2003, 36: 753-759. 10.1590/S0100-879X2003000600011.CrossRefPubMed Speridiao PG, Tahan S, Fagundes-Neto U, Morais MB: Dietary fiber, energy intake and nutritional status during the treatment of children with chronic constipation. Braz J Med Biol Res. 2003, 36: 753-759. 10.1590/S0100-879X2003000600011.CrossRefPubMed
37.
go back to reference Markland AD, Palsson O, Goode PS, Burgio KL, Busby-Whitehead J, Whitehead WE: Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey. Am J Gastroenterol. 2013, 108: 796-803. 10.1038/ajg.2013.73.CrossRefPubMedPubMedCentral Markland AD, Palsson O, Goode PS, Burgio KL, Busby-Whitehead J, Whitehead WE: Association of low dietary intake of fiber and liquids with constipation: evidence from the National Health and Nutrition Examination Survey. Am J Gastroenterol. 2013, 108: 796-803. 10.1038/ajg.2013.73.CrossRefPubMedPubMedCentral
38.
go back to reference Hornick B, Birkett A, Liska D: The Fiber Deficit, Part 3-Beyond Traditional Fiber Sources: The Role of Adding Fiber to Food in Improving Fiber Intakes. Nutr Today. 2013, 48 (4): 168-173. 10.1097/NT.0b013e31829da149.CrossRef Hornick B, Birkett A, Liska D: The Fiber Deficit, Part 3-Beyond Traditional Fiber Sources: The Role of Adding Fiber to Food in Improving Fiber Intakes. Nutr Today. 2013, 48 (4): 168-173. 10.1097/NT.0b013e31829da149.CrossRef
39.
go back to reference O'Sullivan K: The superior benefits of wheat bran fibre in digestive health. Eur Gastroenterol Hepatol Rev. 2012, 8: 90-93. O'Sullivan K: The superior benefits of wheat bran fibre in digestive health. Eur Gastroenterol Hepatol Rev. 2012, 8: 90-93.
40.
go back to reference Marquart L, Wiemer KL, Jones JM, Jacob B: Whole grains health claims in the USA and other efforts to increase whole-grain consumption. Proc Nutr Soc. 2003, 62: 151-160. 10.1079/PNS2003242.CrossRefPubMed Marquart L, Wiemer KL, Jones JM, Jacob B: Whole grains health claims in the USA and other efforts to increase whole-grain consumption. Proc Nutr Soc. 2003, 62: 151-160. 10.1079/PNS2003242.CrossRefPubMed
41.
go back to reference Stevenson L, Phillips F, O'Sullivan K, Walton J: Wheat bran: its composition and benefits to health, a European perspective. Int J Food Sci Nutr. 2012, 63: 1001-1013. 10.3109/09637486.2012.687366.CrossRefPubMedPubMedCentral Stevenson L, Phillips F, O'Sullivan K, Walton J: Wheat bran: its composition and benefits to health, a European perspective. Int J Food Sci Nutr. 2012, 63: 1001-1013. 10.3109/09637486.2012.687366.CrossRefPubMedPubMedCentral
42.
go back to reference Suares NC, Ford AC: Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011, 106: 1582-1591. 10.1038/ajg.2011.164. quiz 1581, 1592CrossRefPubMed Suares NC, Ford AC: Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol. 2011, 106: 1582-1591. 10.1038/ajg.2011.164. quiz 1581, 1592CrossRefPubMed
43.
go back to reference Saps M, Sztainberg M, Di Lorenzo C: A prospective community-based study of gastroenterological symptoms in school-age children. J Pediatr Gastroenterol Nutr. 2006, 43: 477-482. 10.1097/01.mpg.0000235979.41947.f6.CrossRefPubMed Saps M, Sztainberg M, Di Lorenzo C: A prospective community-based study of gastroenterological symptoms in school-age children. J Pediatr Gastroenterol Nutr. 2006, 43: 477-482. 10.1097/01.mpg.0000235979.41947.f6.CrossRefPubMed
44.
go back to reference Uc A, Hyman PE, Walker LS: Functional gastrointestinal disorders in African American children in primary care. J Pediatr Gastroenterol Nutr. 2006, 42: 270-274. 10.1097/01.mpg.0000189371.29911.68.CrossRefPubMedPubMedCentral Uc A, Hyman PE, Walker LS: Functional gastrointestinal disorders in African American children in primary care. J Pediatr Gastroenterol Nutr. 2006, 42: 270-274. 10.1097/01.mpg.0000189371.29911.68.CrossRefPubMedPubMedCentral
45.
go back to reference Frank L, Schmier J, Kleinman L, Siddique R, Beck C, Schnelle J, Rothman M: Time and economic cost of constipation care in nursing homes. J Am Med Dir Assoc. 2002, 3: 215-223. 10.1016/S1525-8610(04)70481-8.CrossRefPubMed Frank L, Schmier J, Kleinman L, Siddique R, Beck C, Schnelle J, Rothman M: Time and economic cost of constipation care in nursing homes. J Am Med Dir Assoc. 2002, 3: 215-223. 10.1016/S1525-8610(04)70481-8.CrossRefPubMed
46.
go back to reference McClung HJ, Boyne L, Heitlinger L: Constipation and dietary fiber intake in children. Pediatrics. 1995, 96: 999-1000.PubMed McClung HJ, Boyne L, Heitlinger L: Constipation and dietary fiber intake in children. Pediatrics. 1995, 96: 999-1000.PubMed
47.
go back to reference Johanson JF, Kralstein J: Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007, 25: 599-608. 10.1111/j.1365-2036.2006.03238.x.CrossRefPubMed Johanson JF, Kralstein J: Chronic constipation: a survey of the patient perspective. Aliment Pharmacol Ther. 2007, 25: 599-608. 10.1111/j.1365-2036.2006.03238.x.CrossRefPubMed
Metadata
Title
Cost savings of reduced constipation rates attributed to increased dietary fiber intakes: a decision-analytic model
Authors
Jordana K Schmier
Paige E Miller
Jessica A Levine
Vanessa Perez
Kevin C Maki
Tia M Rains
Latha Devareddy
Lisa M Sanders
Dominik D Alexander
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-374

Other articles of this Issue 1/2014

BMC Public Health 1/2014 Go to the issue