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Published in: BMC Public Health 1/2014

Open Access 01-12-2014 | Research article

Common types of tuberculosis and co-infection with HIV at private health institutions in Ethiopia: a cross sectional study

Authors: Getahun Asres Alemie, Feseha Gebreselassie

Published in: BMC Public Health | Issue 1/2014

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Abstract

Background

Tuberculosis is a global emergency predominantly affecting developing countries. HIV has been the single most important reason for acquisition of tuberculosis for many patients. Conversely, tuberculosis can result in rapid progression of HIV disease. Ethiopia is a country affected seriously by HIV and tuberculosis. The main aim of this study is assessment of the types of tuberculosis and the extent of HIV infection among tuberculosis patients visiting private health institutions in Amhara region of Ethiopia.

Methods

The study used a cross sectional method with data collected using well structured pretested questionnaires containing socio-demographic and clinical variables including HIV serostatus. The setting is tuberculosis treatment sites situated at 15 private health institutions in Amhara region.

Results

A total of 1153 TB patients were included. The proportions of smear positive pulmonary TB, smear negative pulmonary TB, isolated extrapulmonary TB and disseminated TB cases were found to be 29.6%, 22.2%, 43.9% and 2.9%, respectively. TB lymphadenitis accounted for about 61% of the extrapulmonary cases followed by TB pleurisy (10.6%). Seventy percent of the patients had undergone HIV test, and 20% of them were HIV positive. Marital status, patient residence and type of TB are the major determinants of co-infection.

Conclusion

The occurrence of pulmonary tuberculosis is relatively low. Tuberculosis/HIV co-infection is also lower than other reports.
Literature
1.
go back to reference Mesfin M, Tasew T, Tareke I, Mulugeta G, Richard M: Community knowledge, attitudes and practices on pulmonary tuberculosis and their choice of treatment supervisor in Tigray, Northern Ethiopia. Ethiop J Health Dev. 2005, 19 (Special Issue): 21-27. Mesfin M, Tasew T, Tareke I, Mulugeta G, Richard M: Community knowledge, attitudes and practices on pulmonary tuberculosis and their choice of treatment supervisor in Tigray, Northern Ethiopia. Ethiop J Health Dev. 2005, 19 (Special Issue): 21-27.
2.
go back to reference Abate G: Anti-tuberculosis activity – lactam antibiotics: prospects for the treatment of multi-drug resistant tuberculosis. Ethiop J Health Dev. 2000, 14 (3): 269-276.CrossRef Abate G: Anti-tuberculosis activity – lactam antibiotics: prospects for the treatment of multi-drug resistant tuberculosis. Ethiop J Health Dev. 2000, 14 (3): 269-276.CrossRef
3.
go back to reference Mtei L, Matee M, Herfort O, Bakari M, Horsburgh CR, Waddell R, Cole BF, Vuola JM, Tvaroha S, Kreiswirth B, Pallangvo K, von Revn CF: High rates of clinical and sub-clinical tuberculosis among HIV infected ambulatory subjects in Tanzania. CID. 2005, 40: 1500-1507. 10.1086/429825.CrossRef Mtei L, Matee M, Herfort O, Bakari M, Horsburgh CR, Waddell R, Cole BF, Vuola JM, Tvaroha S, Kreiswirth B, Pallangvo K, von Revn CF: High rates of clinical and sub-clinical tuberculosis among HIV infected ambulatory subjects in Tanzania. CID. 2005, 40: 1500-1507. 10.1086/429825.CrossRef
4.
go back to reference Lawn S, Bekker L, Miler R: Immune Reconstitution Disease Associated with Mycobacterial Infections in HIV Infected Individuals Receiving Anti-Retrovirals. Lancet Infect Dis. 2005, 5: 361-373. 10.1016/S1473-3099(05)70140-7.CrossRefPubMed Lawn S, Bekker L, Miler R: Immune Reconstitution Disease Associated with Mycobacterial Infections in HIV Infected Individuals Receiving Anti-Retrovirals. Lancet Infect Dis. 2005, 5: 361-373. 10.1016/S1473-3099(05)70140-7.CrossRefPubMed
5.
go back to reference Wood R, Jiddelkoop K, Myer L, Grant AD, Whitelaw A, Lawn SD, Kaplan G, Huebner R, McIntyre J, Bekker LG: Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control. Am J Respir Crit Care Med. 2007, 157 (1): 87-93.CrossRef Wood R, Jiddelkoop K, Myer L, Grant AD, Whitelaw A, Lawn SD, Kaplan G, Huebner R, McIntyre J, Bekker LG: Undiagnosed tuberculosis in a community with high HIV prevalence: implications for tuberculosis control. Am J Respir Crit Care Med. 2007, 157 (1): 87-93.CrossRef
6.
go back to reference World Health Organization: TB/HIV A Clinical Manual. 2004, Geneva: World Health Organization, 2 World Health Organization: TB/HIV A Clinical Manual. 2004, Geneva: World Health Organization, 2
7.
go back to reference Woldehana S, Volmink J: Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2004, 1: Art No.: CD000171.pb2. doi:10.1002/14651858.CD000171.pub2 Woldehana S, Volmink J: Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2004, 1: Art No.: CD000171.pb2. doi:10.1002/14651858.CD000171.pub2
8.
go back to reference Open Society Institute: Integrating HIV/AIDS and TB Efforts. The Challenge for the President’s AIDS Initiative. Preliminary Report for the U.S. Office of the Global AIDS. 2004, New York, USA: Open Society Institute, 7- Open Society Institute: Integrating HIV/AIDS and TB Efforts. The Challenge for the President’s AIDS Initiative. Preliminary Report for the U.S. Office of the Global AIDS. 2004, New York, USA: Open Society Institute, 7-
9.
go back to reference Seifu L: Socio-demographic and clinical profile of AIDS patients in Jimma Referral Hospital, Southwest Ethiopia. Ethiop J Health Dev. 2004, 18 (3): 203-207. Seifu L: Socio-demographic and clinical profile of AIDS patients in Jimma Referral Hospital, Southwest Ethiopia. Ethiop J Health Dev. 2004, 18 (3): 203-207.
10.
go back to reference Lim H, Okwera A, Mayanja-Kizza H, Ellner JJ, Mugerwa RD, Whalen CC: Effect of tuberculosis preventive therapy on HIV disease progression and survival in HIV infected adults. HIV Clin Trials. 2006, 7 (4): 172-183. 10.1310/hct0704-172.CrossRefPubMedPubMedCentral Lim H, Okwera A, Mayanja-Kizza H, Ellner JJ, Mugerwa RD, Whalen CC: Effect of tuberculosis preventive therapy on HIV disease progression and survival in HIV infected adults. HIV Clin Trials. 2006, 7 (4): 172-183. 10.1310/hct0704-172.CrossRefPubMedPubMedCentral
11.
go back to reference Organization WH: Treatment of Tuberculosis: Guidelines for National Programs. 2003, Geneva: World Health Organization, 75-78. 3 Organization WH: Treatment of Tuberculosis: Guidelines for National Programs. 2003, Geneva: World Health Organization, 75-78. 3
12.
go back to reference PEPFAR: Tuberculosis and HIV/AIDS. 2008, Washington DC, USA: PEPFAR PEPFAR: Tuberculosis and HIV/AIDS. 2008, Washington DC, USA: PEPFAR
13.
go back to reference Berhane Y: The AIDS pandemic is still expanding its horizon: comprehensive, harmonized and large scale responses needed. Ethiop J Health Dev. 2004, 18 (2): 67-70. Berhane Y: The AIDS pandemic is still expanding its horizon: comprehensive, harmonized and large scale responses needed. Ethiop J Health Dev. 2004, 18 (2): 67-70.
14.
go back to reference Federal Ministry of Health: Tuberculosis, TB/HIV and Leprosy Prevention and Control Strategic Plan, 2007/8 – 2009/10. 2007, Addis Ababa, Ethiopia: Federal Ministry of Health Federal Ministry of Health: Tuberculosis, TB/HIV and Leprosy Prevention and Control Strategic Plan, 2007/8 – 2009/10. 2007, Addis Ababa, Ethiopia: Federal Ministry of Health
15.
16.
go back to reference Yimer S, Bjune G, Alene G: Diagnostic and treatment delay among pulmonary TB patients in Ethiopia: a cross sectional study. BMC Infect Dis. 2005, 5: 112-10.1186/1471-2334-5-112.CrossRefPubMedPubMedCentral Yimer S, Bjune G, Alene G: Diagnostic and treatment delay among pulmonary TB patients in Ethiopia: a cross sectional study. BMC Infect Dis. 2005, 5: 112-10.1186/1471-2334-5-112.CrossRefPubMedPubMedCentral
17.
go back to reference Demissie M, Zenebere B, Berhane Y, Lindtjorn B: A rapid survey to determine the prevalence of smear positive tuberculosis in Addis. Int J Tuberc Lung Dis. 2002, 6 (7): 580-584.PubMed Demissie M, Zenebere B, Berhane Y, Lindtjorn B: A rapid survey to determine the prevalence of smear positive tuberculosis in Addis. Int J Tuberc Lung Dis. 2002, 6 (7): 580-584.PubMed
18.
go back to reference Ethiopia Central Statistical Agency: Ethiopia Demographic and Health Survey. 2005, Addis Ababa, Ethiopia: CSA Ethiopia Central Statistical Agency: Ethiopia Demographic and Health Survey. 2005, Addis Ababa, Ethiopia: CSA
19.
go back to reference Asres G, Gebeyehu A: Clinical improvement and drug adverse effects among patients taking anti-tuberculosis drugs. Ethiopian J of Heal Biomed Sc. 2010, 2 (2): 103-110. Asres G, Gebeyehu A: Clinical improvement and drug adverse effects among patients taking anti-tuberculosis drugs. Ethiopian J of Heal Biomed Sc. 2010, 2 (2): 103-110.
20.
go back to reference Yassin MA, Olobo JO, Kidane D, Negesse Y, Shimeles E, Tadesse A, Demissie A, Britton S, Harboe M, Aseffa A, Abate G: Diagnosis of tuberculous lymphadenitis in Butajira, Rural Ethiopia. Scand J Infect Dis. 2003, 35 (4): 240-243. 10.1080/00365540310004027.CrossRefPubMed Yassin MA, Olobo JO, Kidane D, Negesse Y, Shimeles E, Tadesse A, Demissie A, Britton S, Harboe M, Aseffa A, Abate G: Diagnosis of tuberculous lymphadenitis in Butajira, Rural Ethiopia. Scand J Infect Dis. 2003, 35 (4): 240-243. 10.1080/00365540310004027.CrossRefPubMed
21.
go back to reference Yassin MA, Takele L, Gebresenbet S, Girma E, Lera M, Lendebo E, Cuevas LE: HIV and tuberculosis co-infection in the Southern Region of Ethiopia: a prospective epidemiological study. Scand J Infect Dis. 2004, 36 (9): 670-673. 10.1080/00365540410020848.CrossRefPubMed Yassin MA, Takele L, Gebresenbet S, Girma E, Lera M, Lendebo E, Cuevas LE: HIV and tuberculosis co-infection in the Southern Region of Ethiopia: a prospective epidemiological study. Scand J Infect Dis. 2004, 36 (9): 670-673. 10.1080/00365540410020848.CrossRefPubMed
22.
go back to reference Bruchfeld J, Aderaye G, Palme IB, Bjorvatn B, Britton S, Feleke Y, Kallenius G, Lindguist L: Evaluation of outpatients with suspected pulmonary tuberculosis in a high HIV prevalence setting in Ethiopia: clinical, diagnostic and epidemiological characteristics. Scand J Infect Dis. 2002, 34 (5): 331-337. 10.1080/00365540110080025.CrossRefPubMed Bruchfeld J, Aderaye G, Palme IB, Bjorvatn B, Britton S, Feleke Y, Kallenius G, Lindguist L: Evaluation of outpatients with suspected pulmonary tuberculosis in a high HIV prevalence setting in Ethiopia: clinical, diagnostic and epidemiological characteristics. Scand J Infect Dis. 2002, 34 (5): 331-337. 10.1080/00365540110080025.CrossRefPubMed
23.
go back to reference Network Public Health Programs, Open Society Institute: Integrating HIV/AIDS and TB Efforts: the Challenge for the President’s AIDS Initiative. 2004, New York, USA: Gist and Herlin Press Inc, 23- Network Public Health Programs, Open Society Institute: Integrating HIV/AIDS and TB Efforts: the Challenge for the President’s AIDS Initiative. 2004, New York, USA: Gist and Herlin Press Inc, 23-
24.
go back to reference Datiko DG, Yassin MA, Chekol LT, Kabeto LE, Lindtjorn B: The rate of TB HIV co-infection depends on the prevalence of HIV infection in a community. BMC Public Health. 2008, 8: 266-10.1186/1471-2458-8-266.CrossRefPubMedPubMedCentral Datiko DG, Yassin MA, Chekol LT, Kabeto LE, Lindtjorn B: The rate of TB HIV co-infection depends on the prevalence of HIV infection in a community. BMC Public Health. 2008, 8: 266-10.1186/1471-2458-8-266.CrossRefPubMedPubMedCentral
25.
go back to reference Deribew A, Tesfaye M, Hailemichael Y, Negussu N, Daba S, Wogi A, Belachew T, Apers L, Colebunders R: Tuberculosis and HIV co-infection: it’s impact on quality of life. Health Qual Life Outcomes. 2009, 7: 105-10.1186/1477-7525-7-105.CrossRefPubMedPubMedCentral Deribew A, Tesfaye M, Hailemichael Y, Negussu N, Daba S, Wogi A, Belachew T, Apers L, Colebunders R: Tuberculosis and HIV co-infection: it’s impact on quality of life. Health Qual Life Outcomes. 2009, 7: 105-10.1186/1477-7525-7-105.CrossRefPubMedPubMedCentral
26.
go back to reference Interagency Coalition on AIDS and Development: TB/HIV Co-Infection. Results Canada 2010 Report. 2010, Ottawa, Canada: Interagency Coalition on AIDS and Development Interagency Coalition on AIDS and Development: TB/HIV Co-Infection. Results Canada 2010 Report. 2010, Ottawa, Canada: Interagency Coalition on AIDS and Development
27.
go back to reference Demissie M, Lindtjorn B, Tegbaru B: Human Immunodeficiency Virus (HIV) infection in tuberculosis patients in Addis Ababa. Ethiop J Health Dev. 2000, 14 (3): 277-282. Demissie M, Lindtjorn B, Tegbaru B: Human Immunodeficiency Virus (HIV) infection in tuberculosis patients in Addis Ababa. Ethiop J Health Dev. 2000, 14 (3): 277-282.
28.
go back to reference Kassu A, Mengistu G, Ayele B, Diro E, Mekonnen F, Ketema D, Moges F, Mesfin T, Getachew A, Ergicho B, Elias D, Wondmikun Y, Aseffa A, Ota F: HIV and intestinal parasites in adult TB patients in a teaching hospital in Northwest Ethiopia. Trop Doc. 2006, 37 (4): 222-224. In PressCrossRef Kassu A, Mengistu G, Ayele B, Diro E, Mekonnen F, Ketema D, Moges F, Mesfin T, Getachew A, Ergicho B, Elias D, Wondmikun Y, Aseffa A, Ota F: HIV and intestinal parasites in adult TB patients in a teaching hospital in Northwest Ethiopia. Trop Doc. 2006, 37 (4): 222-224. In PressCrossRef
29.
go back to reference Ayenew A, Leykun A, Colebunders R, Deribew A: Predictors of HIV testing among patients with tuberculosis in Northwest Ethiopia: A Case Control Study. PLoS One. 2010, 5 (3): e9702-10.1371/journal.pone.0009702. doi:10.1371/journal.pone.009702CrossRefPubMedPubMedCentral Ayenew A, Leykun A, Colebunders R, Deribew A: Predictors of HIV testing among patients with tuberculosis in Northwest Ethiopia: A Case Control Study. PLoS One. 2010, 5 (3): e9702-10.1371/journal.pone.0009702. doi:10.1371/journal.pone.009702CrossRefPubMedPubMedCentral
Metadata
Title
Common types of tuberculosis and co-infection with HIV at private health institutions in Ethiopia: a cross sectional study
Authors
Getahun Asres Alemie
Feseha Gebreselassie
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2014
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-14-319

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