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Published in: BMC Public Health 1/2013

Open Access 01-12-2013 | Study protocol

Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada

Published in: BMC Public Health | Issue 1/2013

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Abstract

Background

Aboriginal people living in Canada have a high prevalence of obesity, type 2 diabetes, and cardiovascular disease (CVD). To better understand the pre and postnatal influences on the development of adiposity and related cardio-metabolic factors in adult Aboriginal people, we will recruit and follow prospectively Aboriginal pregnant mothers and their children – the Aboriginal Birth Cohort (ABC) study.

Methods/design

We aim to recruit 300 Aboriginal pregnant mothers and their newborns from the Six Nations Reserve, and follow them prospectively to age 3 years. Key details of environment and health including maternal nutrition, glucose tolerance, physical activity, and weight gain will be collected. At birth, cord blood and placenta samples will be collected, as well as newborn anthropometric measurements. Mothers and offspring will be followed annually with serial measurements of diet and physical activity, growth trajectory, and adiposity.

Discussion

There is an urgent need to understand maternal and child factors that underlie the early development of adiposity and type 2 diabetes in Aboriginal people. The information generated from this cohort will assist the Six Nations community in developing interventions to prevent early adiposity in Aboriginal children.
Literature
1.
2.
Anand SS, Yusuf S, Jacobs R, Davis AD, Yi Q, Gerstein H, Montague PA, Lonn E: Risk factors, atherosclerosis, and cardiovascular disease among Aboriginal people in Canada: the study of health assessment and risk evaluation in Aboriginal peoples (SHARE-AP). Lancet. 2001, 358 (9288): 1147-1153. 10.1016/S0140-6736(01)06255-9.CrossRefPubMed
3.
Amed S, Dean HJ, Panagiotopoulos C, Sellers EA, Hadjiyannakis S, Laubscher TA, Dannenbaum D, Shah BR, Booth GL, Hamilton JK: Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children. Diabetes Care. 2010, 33 (4): 786-791. 10.2337/dc09-1013.CrossRefPubMedPubMedCentral
4.
Gluckman PD, Hanson MA, Beedle AS: Early life events and their consequences for later disease: a life history and evolutionary perspective. Am J Hum Biol. 2007, 19 (1): 1-19. 10.1002/ajhb.20590.CrossRefPubMed
5.
Anand SS, Davis AD, Ahmed R, Jacobs R, Xie C, Hill A, Sowden J, Atkinson S, Blimkie C, Brouwers M, Morrison K, de Koning L, Gerstein H, Yusuf S: SHARE-AP ACTION investigators. A family-based intervention to promote healthy lifestyles in an Aboriginal community in Canada. Can J Public Health. 2007, 98 (6): 447-452.PubMed
6.
Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R, Teo K, Gerstein H, Sharma AM, Yusuf S, Anand SS: Study of the health assessment and risk evaluation; study of the health assessment and risk evaluation in Aboriginal peoples investigators. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care. 2010, 33 (7): 1629-1634. 10.2337/dc09-1392.CrossRefPubMedPubMedCentral
7.
Merchant AT, Kelemen LE, de Koning L, Lonn E, Vuksan V, Jacobs R, Davis B, Teo KK, Yusuf S, Anand SS: SHARE and SHARE-AP investigators. Interrelation of saturated fat, trans fat, alcohol intake, and subclinical atherosclerosis. Am J ClinNutr. 2008, 87 (1): 168-174.
8.
Merchant AT, Anand SS, Kelemen LE, Vuksan V, Jacobs R, Davis B, Teo K, Yusuf S: SHARE and SHARE-AP Investigators. Carbohydrate intake and HDL in a multiethnic population. Am J ClinNutr. 2007, 85 (1): 225-230.
9.
Anand SS, Razak F, Davis AD, Jacobs R, Vuksan V, Teo K, Yusuf S: Social disadvantage and cardiovascular disease: development of an index and analysis of age, sex, and ethnicity effects. Int J Epidemiol. 2006, 35 (5): 1239-1245. 10.1093/ije/dyl163.CrossRefPubMed
10.
Merchant AT, Anand SS, Vuksan V, Jacobs R, Davis B, Teo K, Yusuf S: SHARE and SHARE-AP Investigators. Protein intake is inversely associated with abdominal obesity in a multi-ethnic population. J Nutr. 2005, 135 (5): 1196-1201.PubMed
11.
Razak F, Anand S, Vuksan V, Davis B, Jacobs R, Teo KK, Yusuf S: SHARE Investigators. Ethnic differences in the relationships between obesity and glucose-metabolic abnormalities: a cross-sectional population-based study. Int J Obes. 2005, 29 (6): 656-667. 10.1038/sj.ijo.0802937.CrossRef
12.
Anand SS, Razak F, Yi Q, Davis B, Jacobs R, Vuksan V, Lonn E, Teo K, McQueen M, Yusuf S: C-reactive protein as a screening test for cardiovascular risk in a multiethnic population. Arterioscler Thromb Vasc Biol. 2004, 24 (8): 1509-1515. 10.1161/01.ATV.0000135845.95890.4e.CrossRefPubMed
13.
Anand SS, Yi Q, Gerstein H, Lonn E, Jacobs R, Vuksan V, Teo K, Davis B, Montague P, Yusuf S: Study of health assessment and risk in ethnic groups; study of health assessment and risk evaluation in Aboriginal peoples investigators. Relationship of metabolic syndrome and fibrinolytic dysfunction to cardiovascular disease. Circulation. 2003, 108 (4): 420-425. 10.1161/01.CIR.0000080884.27358.49.CrossRefPubMed
14.
Joseph P, Davis AD, Miller R, Hill K, McCarthy H, Banerjee A, Chow C, Mente A, Anand SS: Contextual determinants of health behaviours in an Aboriginal community in Canada: pilot project. BMC Publ Health. 2012, 12: 952-10.1186/1471-2458-12-952.CrossRef
15.
Franks PW, Hanson RL, Knowler WC, Sievers ML, Bennett PH, Looker HC: Childhood obesity, other cardiovascular risk factors, and premature death. N Engl J Med. 2010, 362 (6): 485-493. 10.1056/NEJMoa0904130.CrossRefPubMedPubMedCentral
16.
Barker D, Osmond C, Golding J, Kuh D, Wadsworth ME: Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989, 289 (6673): 564-567.CrossRef
17.
Lindsay RS, Cook V, Hanson RL, Salbe AD, Tataranni A, Knowler WC: Early excess weight gain of children in the Pima Indian population. Pediatrics. 2002, 109 (2): e33-10.1542/peds.109.2.e33.CrossRefPubMed
18.
Langridge AT, Li J, Nassar N, Stanley FJ: Community-level socioeconomic inequalities in infants with poor fetal growth in Western Australia, 1984 to 2006. Ann Epidemiol. 2011, 21 (7): 473-480. 10.1016/j.annepidem.2011.02.009.CrossRefPubMed
19.
Netto G, Bhopal R, Lederle N, Khatoon J, Jackson A: How can health promotion interventions be adapted for minority ethnic communities? Five principles for guiding the development of behavioural interventions. Heal Promot Int. 2010, 25 (2): 248-257. 10.1093/heapro/daq012.CrossRef
20.
Séguin L, Potvin L, St-Denis M, Loiselle J: Depressive symptoms in the late postpartum among low socioeconomic status women. Birth. 1999, 26 (3): 157-163. 10.1046/j.1523-536x.1999.00157.x.CrossRefPubMed
21.
Bohn DK, Tebben JG, Campbell JC: Influences of income, education, age, and ethnicity on physical abuse before and during pregnancy. J Obstetric Gynecol Neonatal Nurs. 2004, 33 (5): 561-571. 10.1177/0884217504269009.CrossRef
22.
Frohlich KL, Ross N, Richmond C: Health disparities in Canada today: Some evidence and a theoretical framework. Health Policy. 2006, 79 (2–3): 132-143.CrossRefPubMed
23.
Kramer MS, Séguin L, Lydon J, Goulet L: Socio-economic disparities in pregnancy outcome: why do the poor fare so poorly?. Paediatric Perinatal Epidemiol. 2000, 14 (3): 194-210. 10.1046/j.1365-3016.2000.00266.x.CrossRef
24.
Filiberto AC, Maccani MA, Koestler D, Wilhelm-Benartzi C, Avissar-Whiting M, Banister CE, Gagne LA, Marsit CJ: Birthweight is associated with DNA promoter methylation of the glucocorticoid receptor in human placenta. Epigenetics. 2011, 6 (5): 566-572. 10.4161/epi.6.5.15236.CrossRefPubMedPubMedCentral
25.
Durnin J, Womersley J: Estimates of total body fat from skinfold thickness: measurements on 481 men and women aged from 16–72 years. Br J Nutr. 1974, 32: 77-79. 10.1079/BJN19740060.CrossRefPubMed
26.
Kessler R, Andrews G, Colpe L, et al: Short screening scales to monitor population prevalence and trends in non-specific psychological distress. Psychol Med. 2002, 32: 959-976. 10.1017/S0033291702006074.CrossRefPubMed
27.
Brown JB, Lent B, Schmidt G, Sas G: Application of the woman abuse screening tool (WAST) and WAST-short in the family practice setting. J FamPract. 2000, 49 (10): 896-903.
28.
Metzger BE, Lowe LP, Dyer AR, Trimble ER, Chaovarindr U, Coustan DR, Hadden DR, McCance DR, Hod M, McIntyre HD, Oats JJ, Persson B, Rogers MS, Sacks DA, HAPO Study Cooperative Research Group: Hyperglycemia and adverse pregnancy outcomes. N Engl J Med. 2008, 358 (19): 1991-2002.CrossRefPubMed
29.
Canadian Diabetes Association Clinical Practice Guidelines Expert Committee: Canadian diabetes association 2008 clinical practice guidelines for the prevention and management of diabetes in Canada. Can J Diabetes. 2008, 32 (suppl 1): S1-S201.
30.
Slaughter M, Lohman T, Boileau R, Horswill C, Stillman R, Van Loan M, et al: Skinfold equations for estimation of body fatness in children and youth. Hum Biol. 1988, 60 (5): 709-723.PubMed
31.
Schmelzle H, Fusch C: Body fat in neonates and young infants: validation of skinfold thickness versus dual-energy X-ray absorptiometry. Am J ClinNutr. 2002, 76 (5): 1096-1100.
32.
Shaikh S, Mahalanabis D: Empirically derived new equations for calculating body fat percentage based on skinfold thickness and midarm circumference in preschool Indian children. Am J Hum Biol. 2004, 16 (3): 278-288. 10.1002/ajhb.20030.CrossRefPubMed
33.
Ness A: The Avon longitudinal study of parents and children (ALSPAC) – a resource for the study of the environmental determinants of childhood obesity. Eur J Endocrinol. 2004, 115: U141-U149.CrossRef
34.
Nickerson K: Environmental contaminants in breastmilk. Midwifery Womens Health. 2006, 51 (1): 26-34. 10.1016/j.jmwh.2005.09.006.CrossRef
35.
Anand S, Xie C, Paré G, Montpetit A, Rangarajan A, McQueen M, et al: Genetic variants associated with myocardial infarction risk factors in over 8000 individuals from five ethnic groups. Circulation: Cardiovascular Genetics. 2008, 2: 16-25.
36.
Knight R, Jansson J, Field D, Fierer N, Desai N, Fuhrman JA, Hugenholtz P, van der Lelie D, Meyer F, Stevens R, Bailey MJ, Gordon JI, Kowalchuk GA, Gilbert JA: Unlocking the potential of metagenomics through replicated experimental design. Nat Biotechnol. 2012, 30 (6): 513-520. 10.1038/nbt.2235.CrossRefPubMedPubMedCentral
37.
Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R: Diversity, stability and resilience of the human gut microbiota. Nature. 2012, 489 (7415): 220-230. 10.1038/nature11550.CrossRefPubMedPubMedCentral
38.
Human Microbiome Project Consortium: A framework for human microbiome research. Nature. 2012, 486 (7402): 215-221. 10.1038/nature11209.CrossRef
39.
La Rosa PS, Brooks JP, Deych E, Boone EL, Edwards DJ, Wang Q, Sodergen E, Weinstock G, Shannon B: Power calculations for taxonomical-based analysis of human microbiome data. PLoS ONE. 2012, 7 (12): e52078-10.1371/journal.pone.0052078. doi:10.1371/journal.pone.0052078CrossRefPubMedPubMedCentral
40.
Morrison K, Atkinson S, Yusuf S, Bourgeois J, McDonald S, McQueen M, Persadie R, Hunter B, Pogue J, Teo K: The family atherosclerosis monitoring InEarLY life (FAMILY) study: rationale, design and baseline data of a study examining the early determinants of atherosclerosis. Am Heart Jour. 2009, 158 (4): 533-539. 10.1016/j.ahj.2009.07.005.CrossRef
41.
Anand SS, Vasudevan A, Gupta M, Morrison K, Kurpad A, Teo KK, Srinivasan K: START cohort study investigators. Rationale and design of south Asian birth cohort (START): a Canada-India collaborative study. BMC Publ Health. 2013, 28: 13-79.
42.
Pomeroy J, Soderberg A, Franks P: Gene-lifestyle interactions and their consequences on human health. Med Sport Sci. 2009, 54: 110-135.CrossRefPubMed
43.
Elks C, Loos R, Sharp S, Langenberg C, Ring S, Timpson N, et al: Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 2010, 7 (5): e1000284-10.1371/journal.pmed.1000284. doi:10.1371/journal.pmed.1000284CrossRefPubMedPubMedCentral
44.
Morrison JA, Glueck CJ, Horn PS, Schreiber GB, Wang P: Pre-teen insulin resistance predicts weight gain, impaired fasting glucose, and type 2 diabetes at age 18–19 y: a 10-y prospective study of black and white girls. Am J ClinNutr. 2008, 88: 778-788.
45.
Goldstein H: Multilevel. 2010, Statistical Models: John Wiley & Sons
46.
Cohen J, Cohen P: Applied multiple regression/correlation analysis for the. 2003, L. Erlbaum Associates: Behavioral Sciences
Metadata
Title
Aboriginal birth cohort (ABC): a prospective cohort study of early life determinants of adiposity and associated risk factors among Aboriginal people in Canada
Publication date
01-12-2013
Published in
BMC Public Health / Issue 1/2013
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-13-608

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