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Published in: BMC Public Health 1/2013

Open Access 01-12-2013 | Research article

Prevalence of tuberculous lymphadenitis in Gondar University Hospital, Northwest Ethiopia

Authors: Dagnachew Muluye, Belete Biadgo, Eden Woldegerima, Andebet Ambachew

Published in: BMC Public Health | Issue 1/2013

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Abstract

Background

Tuberculous is the leading cause of death worldwide with a large number ofdeaths occurring in developing countries. Tuberculous lymphadenitis is amongthe most common presentations of extra pulmonary tuberculous. This studyattempts to determine the magnitude of tuberculous lymphadenitis frompatients with lymph node aspirate in Gondar University Hospital, NorthwestEthiopia.

Methods

Retrospective study was conducted. Data were collected from registration bookof Gondar university Hospital pathology laboratory after checking thecompleteness of patient’s necessary information like age, sex and fineneedle aspiration cytology results. Data were entered and analyzed usingSPSS version 16 statistical package. Chi-square test was done to determineassociations.

Result

A total of 3,440 lymph node aspirates were examined using fine needleaspiration cytology. Of these, 2,392 (69.5%) cases were found to havetuberculous lymphadenitis. Male 1647(47.9%) to female 1793(52.1%) ratio ofall study subjects were 0.9:1. Females (54.1%) were more affected than males(45.9%). Age, sex and site of aspiration were found to be statisticallyassociated with tuberculous lymphadenitis (p-value < 0.001).The age group of 15–24 years had the highest prevalence of tuberculouslymphadenitis followed by those of 25–34 years old. The most affectedsites were cervical lymph nodes (47.5%) followed by auxiliary (19.4%) andsubmandibular (12.9%) lymph node regions. None of the records documented theHIV status of subjects.

Conclusion

The prevalence of tuberculous from lymph node aspirate was found to be higherinvolving the frequently affected site of cervical lymph node. The HIVstatus of patients with all forms of tuberculous should have to be checkedand documented. Further prospective and advanced studies are recommended todetermine the specific etiologic agents and contributing factors.
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Literature
1.
go back to reference Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C: Tuberculous. Lancet. 2003, 362 (9387): 887-899. 10.1016/S0140-6736(03)14333-4.CrossRefPubMed Frieden TR, Sterling TR, Munsiff SS, Watt CJ, Dye C: Tuberculous. Lancet. 2003, 362 (9387): 887-899. 10.1016/S0140-6736(03)14333-4.CrossRefPubMed
5.
go back to reference WHO: Global tuberculous report. 2012, Geneva WHO: Global tuberculous report. 2012, Geneva
6.
go back to reference Ethiopian Federal Ministry of Health: First Ethiopian National Population Based Tuberculous PrevalenceSurvey. 2011, Addis Ababa, Ethiopia, Ethiopian Federal Ministry of Health: First Ethiopian National Population Based Tuberculous PrevalenceSurvey. 2011, Addis Ababa, Ethiopia,
7.
go back to reference Ishikawa N: How to cope with the global tuberculous burden--experiences and perspectivesfor Japan’s international cooperation. Kekkaku. 2005, 80 (2): 89-94.PubMed Ishikawa N: How to cope with the global tuberculous burden--experiences and perspectivesfor Japan’s international cooperation. Kekkaku. 2005, 80 (2): 89-94.PubMed
8.
go back to reference Hasan Z, Tanveer M, Kanji A, Hasan Q, Ghebremichael S, Hasan R: Spoligotyping of Mycobacterium tuberculous isolates from Pakistan revealspredominance of Central Asian Strain 1 and Beijing isolates. J Clin Microbiol. 2006, 44 (5): 1763-1768. 10.1128/JCM.44.5.1763-1768.2006.CrossRefPubMedPubMedCentral Hasan Z, Tanveer M, Kanji A, Hasan Q, Ghebremichael S, Hasan R: Spoligotyping of Mycobacterium tuberculous isolates from Pakistan revealspredominance of Central Asian Strain 1 and Beijing isolates. J Clin Microbiol. 2006, 44 (5): 1763-1768. 10.1128/JCM.44.5.1763-1768.2006.CrossRefPubMedPubMedCentral
9.
go back to reference Agarwal R, Srinivas R, Aggarwal AN: Parenchymal pseudotumoral tuberculous: Case series and systematic review ofliterature. Respir Med. 2008, 102 (3): 382-389. 10.1016/j.rmed.2007.10.017.CrossRefPubMed Agarwal R, Srinivas R, Aggarwal AN: Parenchymal pseudotumoral tuberculous: Case series and systematic review ofliterature. Respir Med. 2008, 102 (3): 382-389. 10.1016/j.rmed.2007.10.017.CrossRefPubMed
11.
go back to reference Dandapat MC, Mishra BM, Dash SP, Kar PK: Peripheral lymph node tuberculous: a review of 80 cases. Br J Surg. 1990, 77 (8): 911-912. 10.1002/bjs.1800770823.CrossRefPubMed Dandapat MC, Mishra BM, Dash SP, Kar PK: Peripheral lymph node tuberculous: a review of 80 cases. Br J Surg. 1990, 77 (8): 911-912. 10.1002/bjs.1800770823.CrossRefPubMed
12.
go back to reference Fain O, Lortholary O, Djouab M, Amoura I, Babinet P, Beaudreuil J: Lymph node tuberculous in the suburbs of Paris: 59 cases in adults notinfected by the human immunodeficiency virus. Int J Tuberc Lung Dis. 1999, 3 (2): 162-165.PubMed Fain O, Lortholary O, Djouab M, Amoura I, Babinet P, Beaudreuil J: Lymph node tuberculous in the suburbs of Paris: 59 cases in adults notinfected by the human immunodeficiency virus. Int J Tuberc Lung Dis. 1999, 3 (2): 162-165.PubMed
13.
go back to reference Majeed MM, Bukhari MH: Evaluation for granulomatous inflammation on fine needle aspiration cytologyusing special stains. Patholog Res Int. 2011, 2011: 851524-PubMedPubMedCentral Majeed MM, Bukhari MH: Evaluation for granulomatous inflammation on fine needle aspiration cytologyusing special stains. Patholog Res Int. 2011, 2011: 851524-PubMedPubMedCentral
14.
go back to reference Perenboom RM, Richter C, Swai AB, Kitinya J, Mtoni I, Chande H: Diagnosis of tuberculous lymphadenitis in an area of HIV infection andlimited diagnostic facilities. Trop Geogr Med. 1994, 46 (5): 288-292.PubMed Perenboom RM, Richter C, Swai AB, Kitinya J, Mtoni I, Chande H: Diagnosis of tuberculous lymphadenitis in an area of HIV infection andlimited diagnostic facilities. Trop Geogr Med. 1994, 46 (5): 288-292.PubMed
15.
go back to reference Cadmus SIB, Oluwasola AO, Okolo CA, Bethrand AFN: Pattern of tuberculous lymphadenitis diagnosed by fine needle aspirationcytology at the University College Hospital, Ibadan, Nigeria. Afr J Med Med Sci. 2010, 39 (3): 193-197. Cadmus SIB, Oluwasola AO, Okolo CA, Bethrand AFN: Pattern of tuberculous lymphadenitis diagnosed by fine needle aspirationcytology at the University College Hospital, Ibadan, Nigeria. Afr J Med Med Sci. 2010, 39 (3): 193-197.
16.
go back to reference Ahmed HGE, Nassar AS, Ginawi I: Screening for tuberculous and its histological pattern in patients withenlarged lymph node. Patholog Res Int. 2011, 2011: 417635-PubMedPubMedCentral Ahmed HGE, Nassar AS, Ginawi I: Screening for tuberculous and its histological pattern in patients withenlarged lymph node. Patholog Res Int. 2011, 2011: 417635-PubMedPubMedCentral
17.
go back to reference Yassin MA, Olobo JO, Kidane D, Negesse Y, Shimeles E, Tadesse A: Diagnosis of tuberculous lymphadenitis in Butajira, rural Ethiopia. Scand J Infect Dis. 2003, 35 (4): 240-243. 10.1080/00365540310004027.CrossRefPubMed Yassin MA, Olobo JO, Kidane D, Negesse Y, Shimeles E, Tadesse A: Diagnosis of tuberculous lymphadenitis in Butajira, rural Ethiopia. Scand J Infect Dis. 2003, 35 (4): 240-243. 10.1080/00365540310004027.CrossRefPubMed
18.
go back to reference Bezabih M, Mariam D, Selassie S: Fine needle aspiration cytology of suspected tuberculous lymphadenitis. Cytopathology. 2002, 13 (5): 284-290. 10.1046/j.1365-2303.2002.00418.x.CrossRefPubMed Bezabih M, Mariam D, Selassie S: Fine needle aspiration cytology of suspected tuberculous lymphadenitis. Cytopathology. 2002, 13 (5): 284-290. 10.1046/j.1365-2303.2002.00418.x.CrossRefPubMed
19.
go back to reference Weiler Z, Nelly P, Baruchin AM, Oren S: Diagnosis and treatment of cervical tuberculous lymphadenitis. J Oral Maxillofac Surg. 2000, 58 (5): 477-481. 10.1016/S0278-2391(00)90004-1.CrossRefPubMed Weiler Z, Nelly P, Baruchin AM, Oren S: Diagnosis and treatment of cervical tuberculous lymphadenitis. J Oral Maxillofac Surg. 2000, 58 (5): 477-481. 10.1016/S0278-2391(00)90004-1.CrossRefPubMed
20.
go back to reference Kakkar S, Kapila K, Singh MK, Verma K: Tuberculous of the Breast. Acta Cytol. 2000, 44 (3): 292-296. 10.1159/000328467.CrossRefPubMed Kakkar S, Kapila K, Singh MK, Verma K: Tuberculous of the Breast. Acta Cytol. 2000, 44 (3): 292-296. 10.1159/000328467.CrossRefPubMed
21.
go back to reference Arora B, Arora DR: Fine needle aspiration cytology in diagnosis of tuberculous lymphadenitis. Indian J Med Res. 1990, 91: 189-192.PubMed Arora B, Arora DR: Fine needle aspiration cytology in diagnosis of tuberculous lymphadenitis. Indian J Med Res. 1990, 91: 189-192.PubMed
22.
go back to reference Perlman DC, D’Amico R, Salomon N: Mycobacterial infections of the head and neck. Curr Infect Dis Rep. 2001, 3 (3): 233-241. 10.1007/s11908-001-0025-4.CrossRefPubMed Perlman DC, D’Amico R, Salomon N: Mycobacterial infections of the head and neck. Curr Infect Dis Rep. 2001, 3 (3): 233-241. 10.1007/s11908-001-0025-4.CrossRefPubMed
Metadata
Title
Prevalence of tuberculous lymphadenitis in Gondar University Hospital, Northwest Ethiopia
Authors
Dagnachew Muluye
Belete Biadgo
Eden Woldegerima
Andebet Ambachew
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2013
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-13-435

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