Skip to main content
Top
Published in: BMC Public Health 1/2013

Open Access 01-12-2013 | Research article

Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial

Authors: Linda C Tapsell, Marijka J Batterham, Karen E Charlton, Elizabeth P Neale, Yasmine C Probst, Jane E O’Shea, Rebecca L Thorne, Qingsheng Zhang, Jimmy Chun Yu Louie

Published in: BMC Public Health | Issue 1/2013

Login to get access

Abstract

Background

There is some evidence in the literature that emphasising fish consumption may assist with weight loss. The aim was to assess the effects of advice to consume 2 fish meals per week in a weight loss diet.

Methods

A parallel randomised placebo-controlled trial was conducted in 118 obese Australian adults (mean BMI ± SD 31.3 ± 3.5 kg/m2; mean age ± SD 45 ± 10 y; 28% male). Participants received low calorie dietary advice + placebo (1 g olive oil; Control), low calorie dietary advice emphasising fish + placebo (Fish), or low calorie dietary advice emphasising fish diet + LCn3PUFA supplements (Fish + S). Individualised advice targeted 2 MJ energy deficit (30%E fat, 45%E carbohydrate and 25%E protein) with or without two servings (180 g) fatty fish/wk.

Results

All groups lost weight at 12 months (Control −4.5 kg vs. Fish −4.3 kg vs. Fish + S −3.3 kg; p < 0.001) and percentage body fat (Control: -1.5% vs. Fish: -1.4% vs. Fish + S: -0.7%; p < 0.001) but there were no significant differences between groups. Cardiovascular disease risk factors changed as expected from weight loss.

Conclusions

Advice to consume 2 fish meals per week did not enhance the effects on weight loss of a healthy low calorie diet.

Trial registration

Appendix
Available only for authorised users
Literature
1.
go back to reference National Health and Medical Research Council: Australian dietary guidelines. 2013, Canberra: National Health and Medical Research Council National Health and Medical Research Council: Australian dietary guidelines. 2013, Canberra: National Health and Medical Research Council
2.
go back to reference U.S. Department of Agriculture and U.S. Department of Health and Human Services: Dietary Guidelines for Americans. 2010, Washington D.C: US Government Printing Office, December 2010, 7 U.S. Department of Agriculture and U.S. Department of Health and Human Services: Dietary Guidelines for Americans. 2010, Washington D.C: US Government Printing Office, December 2010, 7
3.
go back to reference Mozaffarian D, Ludwig D: Dietary guidelines in the 21st century - a time for food. J Am Med Assoc. 2010, 304 (6): 681-10.1001/jama.2010.1116.CrossRef Mozaffarian D, Ludwig D: Dietary guidelines in the 21st century - a time for food. J Am Med Assoc. 2010, 304 (6): 681-10.1001/jama.2010.1116.CrossRef
4.
go back to reference Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, et al: Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009, 360 (9): 859-873. 10.1056/NEJMoa0804748.CrossRefPubMedPubMedCentral Sacks FM, Bray GA, Carey VJ, Smith SR, Ryan DH, Anton SD, McManus K, Champagne CM, Bishop LM, Laranjo N, et al: Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates. N Engl J Med. 2009, 360 (9): 859-873. 10.1056/NEJMoa0804748.CrossRefPubMedPubMedCentral
5.
go back to reference National Health and Medical Research Council: A review of the evidence to address targeted questions to inform the revision of the Australian Dietary Guidelines - Evidence Statements. 2011, Canberra: Commonwealth of Australia National Health and Medical Research Council: A review of the evidence to address targeted questions to inform the revision of the Australian Dietary Guidelines - Evidence Statements. 2011, Canberra: Commonwealth of Australia
6.
go back to reference Micallef M, Munro I, Phang M, Garg M: Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity. Br J Nutr. 2009, 102: 1370-1374. 10.1017/S0007114509382173.CrossRefPubMed Micallef M, Munro I, Phang M, Garg M: Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity. Br J Nutr. 2009, 102: 1370-1374. 10.1017/S0007114509382173.CrossRefPubMed
7.
go back to reference Garaulet M, Perez-Llamas F, Perez-Ayala M, Martinez P, de Medina FS, Tebar FJ, Zamora S: Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr. 2001, 74 (5): 585-591.PubMed Garaulet M, Perez-Llamas F, Perez-Ayala M, Martinez P, de Medina FS, Tebar FJ, Zamora S: Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity. Am J Clin Nutr. 2001, 74 (5): 585-591.PubMed
8.
go back to reference Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quingard-Boulane A, Vidal H, Slama G, Clement K, et al: Treatment for 2 mo with n-3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr. 2007, 86: 1670-1679.PubMed Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quingard-Boulane A, Vidal H, Slama G, Clement K, et al: Treatment for 2 mo with n-3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr. 2007, 86: 1670-1679.PubMed
9.
go back to reference Couet C, Delarue J, Ritz P, Antoine J, Lamisse F: Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes. 1997, 21: 637-643. 10.1038/sj.ijo.0800451.CrossRef Couet C, Delarue J, Ritz P, Antoine J, Lamisse F: Effect of dietary fish oil on body fat mass and basal fat oxidation in healthy adults. Int J Obes. 1997, 21: 637-643. 10.1038/sj.ijo.0800451.CrossRef
10.
go back to reference Kunesova M, Braunerova R, Hlavaty P, Tvrzicka E, Stankova B, Skrrha J, Hilgertova J, Hill M, Kopecky J, Wagenknecht M, et al: The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol Res. 2006, 55: 63-72.PubMed Kunesova M, Braunerova R, Hlavaty P, Tvrzicka E, Stankova B, Skrrha J, Hilgertova J, Hill M, Kopecky J, Wagenknecht M, et al: The influence of n-3 polyunsaturated fatty acids and very low calorie diet during a short-term weight reducing regimen on weight loss and serum fatty acid composition in severely obese women. Physiol Res. 2006, 55: 63-72.PubMed
11.
go back to reference de Fina L, Marcoux L, Devers S, Cleaver J, Willis B: Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. Am J Clin Nutr. 2011, 93: 455-462. 10.3945/ajcn.110.002741.CrossRef de Fina L, Marcoux L, Devers S, Cleaver J, Willis B: Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. Am J Clin Nutr. 2011, 93: 455-462. 10.3945/ajcn.110.002741.CrossRef
12.
go back to reference Kratz M, Callahan H, Yang P, Matthys C, Weigle D: Dietary n-3 polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial. Nutr Metab. 2009, 6: 24-10.1186/1743-7075-6-24.CrossRef Kratz M, Callahan H, Yang P, Matthys C, Weigle D: Dietary n-3 polyunsaturated fatty acids and energy balance in overweight or moderately obese men and women: a randomized controlled trial. Nutr Metab. 2009, 6: 24-10.1186/1743-7075-6-24.CrossRef
13.
go back to reference Thorsdottir I, Tomasson H, Gunnarsdottir I, Gisladottir E, Kiely M, Parra M, Bandarra N, Schaafsma G, Martinez J: Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content. Int J Obes. 2007, 31: 1560-1566. 10.1038/sj.ijo.0803643.CrossRef Thorsdottir I, Tomasson H, Gunnarsdottir I, Gisladottir E, Kiely M, Parra M, Bandarra N, Schaafsma G, Martinez J: Randomized trial of weight-loss-diets for young adults varying in fish and fish oil content. Int J Obes. 2007, 31: 1560-1566. 10.1038/sj.ijo.0803643.CrossRef
14.
go back to reference Mann JI, Morenga LT: Diet and diabetes revisited, yet again. Am J Clin Nutr. 2013, 97 (3): 453-454. 10.3945/ajcn.112.057547.CrossRefPubMed Mann JI, Morenga LT: Diet and diabetes revisited, yet again. Am J Clin Nutr. 2013, 97 (3): 453-454. 10.3945/ajcn.112.057547.CrossRefPubMed
15.
go back to reference Jebb SA, Ahern AL, Olson AD, Aston LM, Holzapfel C, Stoll J, Amann-Gassner U, Simpson AE, Fuller NR, Pearson S, et al: Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet. 2011, 378 (9801): 1485-1495. 10.1016/S0140-6736(11)61344-5.CrossRefPubMedPubMedCentral Jebb SA, Ahern AL, Olson AD, Aston LM, Holzapfel C, Stoll J, Amann-Gassner U, Simpson AE, Fuller NR, Pearson S, et al: Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial. Lancet. 2011, 378 (9801): 1485-1495. 10.1016/S0140-6736(11)61344-5.CrossRefPubMedPubMedCentral
16.
go back to reference Allison PD: Missing Data. 2001, Thousand Oaks, CA: Sage University Papers Series Allison PD: Missing Data. 2001, Thousand Oaks, CA: Sage University Papers Series
17.
go back to reference National Health and Medical Research Council: Nutrient reference values for Australia and New Zealand including recommended dietary intakes. 2006, Canberra: NHMRC National Health and Medical Research Council: Nutrient reference values for Australia and New Zealand including recommended dietary intakes. 2006, Canberra: NHMRC
18.
go back to reference Mifflin M, St Jeor S, Hill L, Scott B, Daugherty SA, Koh Y: A new predictive equation for testing energy expenditure in healthy individuals. Am J Clin Nutr. 1990, 51: 241-247.PubMed Mifflin M, St Jeor S, Hill L, Scott B, Daugherty SA, Koh Y: A new predictive equation for testing energy expenditure in healthy individuals. Am J Clin Nutr. 1990, 51: 241-247.PubMed
19.
go back to reference Department of Health and Ageing: Australian guide to healthy eating. 1998, Canberra: Commonwealth of Australia Department of Health and Ageing: Australian guide to healthy eating. 1998, Canberra: Commonwealth of Australia
20.
go back to reference Martin GS, Tapsell LC, Batterham M,J, Russell KG: Relative validity of a diet history interview in an intervention trial manipulating dietary fat in the management of type 2 diabetes mellitus. Prev Med. 2003, 36: 420-428. 10.1016/S0091-7435(02)00054-3.CrossRefPubMed Martin GS, Tapsell LC, Batterham M,J, Russell KG: Relative validity of a diet history interview in an intervention trial manipulating dietary fat in the management of type 2 diabetes mellitus. Prev Med. 2003, 36: 420-428. 10.1016/S0091-7435(02)00054-3.CrossRefPubMed
21.
go back to reference Food Standards Australia New Zealand: AUSNUT - Australian Food and Nutrient Database 1999. 1999, Canberra: Food Standards Australia New Zealand Food Standards Australia New Zealand: AUSNUT - Australian Food and Nutrient Database 1999. 1999, Canberra: Food Standards Australia New Zealand
22.
go back to reference Food Standards Australia New Zealand: AUSNUT 2007 - Australian Food, Supplement and Nutrient Database for Estimation of Population Nutrient Intakes. 2008, Canberra: Food Standards Australia New Zealand Food Standards Australia New Zealand: AUSNUT 2007 - Australian Food, Supplement and Nutrient Database for Estimation of Population Nutrient Intakes. 2008, Canberra: Food Standards Australia New Zealand
23.
go back to reference Neale E, Probst Y, Batterham M, Tapsell L: Development and Validation of an Australian Database for estimating the Seafood Content of Canned Products. Food and Nutrition Sciences. 2011, 2 (7): 759-763. 10.4236/fns.2011.27104.CrossRef Neale E, Probst Y, Batterham M, Tapsell L: Development and Validation of an Australian Database for estimating the Seafood Content of Canned Products. Food and Nutrition Sciences. 2011, 2 (7): 759-763. 10.4236/fns.2011.27104.CrossRef
24.
go back to reference Baecke J, Burema J, Frijters J: A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982, 36: 936-942.PubMed Baecke J, Burema J, Frijters J: A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982, 36: 936-942.PubMed
25.
go back to reference Patel P, Sharp S, Jansen E, Luben R, Khaw K, Wareham N, NG F: Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Am J Clin Nutr. 2010, 92: 1214-1222. 10.3945/ajcn.2010.29182.CrossRefPubMed Patel P, Sharp S, Jansen E, Luben R, Khaw K, Wareham N, NG F: Fatty acids measured in plasma and erythrocyte-membrane phospholipids and derived by food-frequency questionnaire and the risk of new-onset type 2 diabetes: a pilot study in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort. Am J Clin Nutr. 2010, 92: 1214-1222. 10.3945/ajcn.2010.29182.CrossRefPubMed
26.
go back to reference Harris WS: The omega-3 index as a risk factor for coronary heart disease. Am J Clin Nutr. 2008, 87 (6): 1997S-2002S.PubMed Harris WS: The omega-3 index as a risk factor for coronary heart disease. Am J Clin Nutr. 2008, 87 (6): 1997S-2002S.PubMed
27.
go back to reference Levy J, Matthews D, Hermans M: Correct Homeostasis Model Assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998, 21: 2191-2192. 10.2337/diacare.21.12.2191.CrossRefPubMed Levy J, Matthews D, Hermans M: Correct Homeostasis Model Assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998, 21: 2191-2192. 10.2337/diacare.21.12.2191.CrossRefPubMed
28.
go back to reference Alhassan S, Kim S, Bersamin A, King A, Gardner C: Dietary adherence and weight loss success among overweight women: results from the A to Z weight loss study. Int J Obes. 2008, 32: 985-991. 10.1038/ijo.2008.8.CrossRef Alhassan S, Kim S, Bersamin A, King A, Gardner C: Dietary adherence and weight loss success among overweight women: results from the A to Z weight loss study. Int J Obes. 2008, 32: 985-991. 10.1038/ijo.2008.8.CrossRef
29.
go back to reference Tapsell L, Batterham M, Huang XF, Tan SY, Teuss G, Charlton K, O’ Shea J, Warensjö E: Short term effects of energy restriction and dietary fat sub-type on weight loss and disease risk factors. Nutr Metab Cardiovasc Dis. 2010, 20 (5): 317-325. 10.1016/j.numecd.2009.04.007.CrossRefPubMed Tapsell L, Batterham M, Huang XF, Tan SY, Teuss G, Charlton K, O’ Shea J, Warensjö E: Short term effects of energy restriction and dietary fat sub-type on weight loss and disease risk factors. Nutr Metab Cardiovasc Dis. 2010, 20 (5): 317-325. 10.1016/j.numecd.2009.04.007.CrossRefPubMed
30.
go back to reference Elobeid MA, Padilla MA, McVie T, Thomas O, Brock DW, Musser B, Lu K, Coffey CS, Desmond RA, St-Onge M-P, et al: Missing Data in Randomized Clinical Trials for Weight Loss: Scope of the Problem, State of the Field, and Performance of Statistical Methods. PLOS One. 2009, 4 (8): e6624-10.1371/journal.pone.0006624.CrossRefPubMedPubMedCentral Elobeid MA, Padilla MA, McVie T, Thomas O, Brock DW, Musser B, Lu K, Coffey CS, Desmond RA, St-Onge M-P, et al: Missing Data in Randomized Clinical Trials for Weight Loss: Scope of the Problem, State of the Field, and Performance of Statistical Methods. PLOS One. 2009, 4 (8): e6624-10.1371/journal.pone.0006624.CrossRefPubMedPubMedCentral
31.
go back to reference National Health and Medical Research Council: Reference values for Australia and New Zealand, including recommended dietary intakes. 2006, Canberra: NHMRC National Health and Medical Research Council: Reference values for Australia and New Zealand, including recommended dietary intakes. 2006, Canberra: NHMRC
32.
go back to reference Aihaud F, Guesnet P, Cunnane C: An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?. Br J Nutr. 2008, 100: 461-470. 10.1017/S0007114508911569.CrossRef Aihaud F, Guesnet P, Cunnane C: An emerging risk factor for obesity: does disequilibrium of polyunsaturated fatty acid metabolism contribute to excessive adipose tissue development?. Br J Nutr. 2008, 100: 461-470. 10.1017/S0007114508911569.CrossRef
33.
go back to reference Sanders TA, Hall WL, Maniou Z, Lewis F, Seed PT, Chowienczyk PJ: Effect of low doses of long-chain n − 3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. Am J Clin Nutr. 2011, 94 (4): 973-980. 10.3945/ajcn.111.018036.CrossRefPubMed Sanders TA, Hall WL, Maniou Z, Lewis F, Seed PT, Chowienczyk PJ: Effect of low doses of long-chain n − 3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial. Am J Clin Nutr. 2011, 94 (4): 973-980. 10.3945/ajcn.111.018036.CrossRefPubMed
34.
go back to reference Harris WS, Klurfeld DM: Twentieth-century trends in essential fatty acid intakes and the predicted omega-3 index: evidence versus estimates. Am J Clin Nutr. 2011, 93 (5): 907-908. 10.3945/ajcn.111.014365.CrossRefPubMed Harris WS, Klurfeld DM: Twentieth-century trends in essential fatty acid intakes and the predicted omega-3 index: evidence versus estimates. Am J Clin Nutr. 2011, 93 (5): 907-908. 10.3945/ajcn.111.014365.CrossRefPubMed
35.
go back to reference Chan J, Mantzoros C: Role of leptin in energy deprivation states:normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet. 2005, 366: 74-85. 10.1016/S0140-6736(05)66830-4.CrossRefPubMed Chan J, Mantzoros C: Role of leptin in energy deprivation states:normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa. Lancet. 2005, 366: 74-85. 10.1016/S0140-6736(05)66830-4.CrossRefPubMed
36.
go back to reference Carpenter JR, Kenward MG: Missing data in randomised controlled trials - a practical guide. 2008, Birmingham: National Institute for Health Research, Publication RM03/JH17/MK Carpenter JR, Kenward MG: Missing data in randomised controlled trials - a practical guide. 2008, Birmingham: National Institute for Health Research, Publication RM03/JH17/MK
37.
go back to reference Ludwig DS, Ebbeling CB: Weight-loss maintenance - mind over matter?. N Eng J Med. 2010, 363: 2159-2161. 10.1056/NEJMe1011361.CrossRef Ludwig DS, Ebbeling CB: Weight-loss maintenance - mind over matter?. N Eng J Med. 2010, 363: 2159-2161. 10.1056/NEJMe1011361.CrossRef
38.
go back to reference Melanson E, Astrup A, Donahoo W: The relationship between dietary fat and fatty acid intake and body weight, diabetes, and the metabolic syndrome. Ann Nutr Metab. 2009, 55: 229-243. 10.1159/000229004.CrossRefPubMed Melanson E, Astrup A, Donahoo W: The relationship between dietary fat and fatty acid intake and body weight, diabetes, and the metabolic syndrome. Ann Nutr Metab. 2009, 55: 229-243. 10.1159/000229004.CrossRefPubMed
Metadata
Title
Foods, nutrients or whole diets: effects of targeting fish and LCn3PUFA consumption in a 12mo weight loss trial
Authors
Linda C Tapsell
Marijka J Batterham
Karen E Charlton
Elizabeth P Neale
Yasmine C Probst
Jane E O’Shea
Rebecca L Thorne
Qingsheng Zhang
Jimmy Chun Yu Louie
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2013
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-13-1231

Other articles of this Issue 1/2013

BMC Public Health 1/2013 Go to the issue