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Published in: BMC Public Health 1/2012

Open Access 01-12-2012 | Research article

Diagnostic work-up and loss of tuberculosis suspects in Jogjakarta, Indonesia

Authors: Riris Andono Ahmad, Francine Matthys, Bintari Dwihardiani, Ning Rintiswati, Sake J de Vlas, Yodi Mahendradhata, Patrick van der Stuyft

Published in: BMC Public Health | Issue 1/2012

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Abstract

Background

Early and accurate diagnosis of pulmonary tuberculosis (TB) is critical for successful TB control. To assist in the diagnosis of smear-negative pulmonary TB, the World Health Organisation (WHO) recommends the use of a diagnostic algorithm. Our study evaluated the implementation of the national tuberculosis programme's diagnostic algorithm in routine health care settings in Jogjakarta, Indonesia. The diagnostic algorithm is based on the WHO TB diagnostic algorithm, which had already been implemented in the health facilities.

Methods

We prospectively documented the diagnostic work-up of all new tuberculosis suspects until a diagnosis was reached. We used clinical audit forms to record each step chronologically. Data on the patient's gender, age, symptoms, examinations (types, dates, and results), and final diagnosis were collected.

Results

Information was recorded for 754 TB suspects; 43.5% of whom were lost during the diagnostic work-up in health centres, 0% in lung clinics. Among the TB suspects who completed diagnostic work-ups, 51.1% and 100.0% were diagnosed without following the national TB diagnostic algorithm in health centres and lung clinics, respectively. However, the work-up in the health centres and lung clinics generally conformed to international standards for tuberculosis care (ISTC). Diagnostic delays were significantly longer in health centres compared to lung clinics.

Conclusions

The high rate of patients lost in health centres needs to be addressed through the implementation of TB suspect tracing and better programme supervision. The national TB algorithm needs to be revised and differentiated according to the level of care.
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Literature
1.
go back to reference Dye C: Tuberculosis 2000-2010: control, but not elimination. Int J Tuberc Lung Dis. 2000, 4 (Supl): 146-152. Dye C: Tuberculosis 2000-2010: control, but not elimination. Int J Tuberc Lung Dis. 2000, 4 (Supl): 146-152.
2.
go back to reference Reid MJA, Shah NS: Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings. Lancet Infect Dis. 2009, 9: 173-184. 10.1016/S1473-3099(09)70043-X.CrossRefPubMed Reid MJA, Shah NS: Approaches to tuberculosis screening and diagnosis in people with HIV in resource-limited settings. Lancet Infect Dis. 2009, 9: 173-184. 10.1016/S1473-3099(09)70043-X.CrossRefPubMed
3.
go back to reference Anthony RM, Cobelens FGJ, Gebhard A, et al: Liquid culture for Mycobacterium tuberculosis: proceed, but with caution. Int J Tuberc Lung Dis. 2009, 13: 1051-1053.PubMed Anthony RM, Cobelens FGJ, Gebhard A, et al: Liquid culture for Mycobacterium tuberculosis: proceed, but with caution. Int J Tuberc Lung Dis. 2009, 13: 1051-1053.PubMed
4.
go back to reference WHO: Treatment of Tuberculosis Guidelines. 2009, Geneva: WHO, (WHO/HTM/TB/2009.420), 4 WHO: Treatment of Tuberculosis Guidelines. 2009, Geneva: WHO, (WHO/HTM/TB/2009.420), 4
5.
go back to reference WHO: Implementing the WHO stop TB strategy: a handbook for national TB control programme. 2008, Geneva: WHO, (WHO/HTM/TB/2008.401) WHO: Implementing the WHO stop TB strategy: a handbook for national TB control programme. 2008, Geneva: WHO, (WHO/HTM/TB/2008.401)
6.
go back to reference WHO: Improving the diagnosis and treatment of smear-negative pulmonary and extra-pulmonary tuberculosis among adults and adolescents: recommendations for HIV-prevalent and resource-constrained settings. 2007, Geneva: WHO, (WHO/HTM/TB/2007.379; WHO/HIV/2007.1) WHO: Improving the diagnosis and treatment of smear-negative pulmonary and extra-pulmonary tuberculosis among adults and adolescents: recommendations for HIV-prevalent and resource-constrained settings. 2007, Geneva: WHO, (WHO/HTM/TB/2007.379; WHO/HIV/2007.1)
7.
go back to reference Getahun H, Harrington M, O'Brien R, Nunn P: Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet. 2007, 369: 2042-2049. 10.1016/S0140-6736(07)60284-0.CrossRefPubMed Getahun H, Harrington M, O'Brien R, Nunn P: Diagnosis of smear-negative pulmonary tuberculosis in people with HIV infection or AIDS in resource-constrained settings: informing urgent policy changes. Lancet. 2007, 369: 2042-2049. 10.1016/S0140-6736(07)60284-0.CrossRefPubMed
8.
go back to reference Saranchuk P, Boulle A, Hilderbrand K: Evaluation of a diagnostic algorithm for smear negative pulmonary tuberculosis in HIV-infected adults. S Afr Med J. 2007, 97: 517-523.PubMed Saranchuk P, Boulle A, Hilderbrand K: Evaluation of a diagnostic algorithm for smear negative pulmonary tuberculosis in HIV-infected adults. S Afr Med J. 2007, 97: 517-523.PubMed
9.
go back to reference Cain KP, McCarthy KD, Heilig CM, et al: An algorithm for tuberculosis screening and diagnosis in people with HIV. N Engl J Med. 2010, 362: 707-716. 10.1056/NEJMoa0907488.CrossRefPubMed Cain KP, McCarthy KD, Heilig CM, et al: An algorithm for tuberculosis screening and diagnosis in people with HIV. N Engl J Med. 2010, 362: 707-716. 10.1056/NEJMoa0907488.CrossRefPubMed
10.
go back to reference Wilkinson D, Newman W, Reid A, Squire SB, Sturm AW, Gilks CF: Trial-of-antibiotic algorithm for the diagnosis of tuberculosis in a district hospital in a developing country with high HIV prevalence. Int J Tuberc Lung Dis. 2000, 4: 513-518.PubMed Wilkinson D, Newman W, Reid A, Squire SB, Sturm AW, Gilks CF: Trial-of-antibiotic algorithm for the diagnosis of tuberculosis in a district hospital in a developing country with high HIV prevalence. Int J Tuberc Lung Dis. 2000, 4: 513-518.PubMed
11.
go back to reference Siddiqi K, Walley J, Khan MA, Shah K, Safdar N: Clinical guidelines to diagnose smear negative pulmonary tuberculosis in Pakistan, a country with low-HIV prevalence. Trop Med Int Health. 2006, 2: 323-331.CrossRef Siddiqi K, Walley J, Khan MA, Shah K, Safdar N: Clinical guidelines to diagnose smear negative pulmonary tuberculosis in Pakistan, a country with low-HIV prevalence. Trop Med Int Health. 2006, 2: 323-331.CrossRef
12.
go back to reference Soto A, Solari L, Gotuzzo E, Acinelli R, Vargas D, Van der Stuyft P: Performance of an algorithm based on WHO recommendations for the diagnosis of s pulmonary tuberculosis in patients without HIV infection. Trop Med Int Health. 2011, 16: 424-430. 10.1111/j.1365-3156.2010.02715.x.CrossRefPubMed Soto A, Solari L, Gotuzzo E, Acinelli R, Vargas D, Van der Stuyft P: Performance of an algorithm based on WHO recommendations for the diagnosis of s pulmonary tuberculosis in patients without HIV infection. Trop Med Int Health. 2011, 16: 424-430. 10.1111/j.1365-3156.2010.02715.x.CrossRefPubMed
13.
go back to reference Soto A, Solari L, Díaz J, Mantilla A, Matthys F, Van der Stuyft P: Validation of a Clinical-Radiographic Score to Assess the Probability of Pulmonary Tuberculosis in Suspect Patients with Negative Sputum Smears. PLoS One. 2011, 6: e18486-10.1371/journal.pone.0018486.CrossRefPubMedPubMedCentral Soto A, Solari L, Díaz J, Mantilla A, Matthys F, Van der Stuyft P: Validation of a Clinical-Radiographic Score to Assess the Probability of Pulmonary Tuberculosis in Suspect Patients with Negative Sputum Smears. PLoS One. 2011, 6: e18486-10.1371/journal.pone.0018486.CrossRefPubMedPubMedCentral
14.
go back to reference Soemantri S, Lolong DS, Senewe FE, et al: Tuberculosis Prevalence Survey in Indonesia 2004. 2005, Jakarta: National Institute of Health Research and Development Ministry of Health Republic of Indonesia Soemantri S, Lolong DS, Senewe FE, et al: Tuberculosis Prevalence Survey in Indonesia 2004. 2005, Jakarta: National Institute of Health Research and Development Ministry of Health Republic of Indonesia
15.
go back to reference Mahendradhata Y, Ahmad RA, Kusuma T, et al: VCT uptake and HIV prevalence amongst TB patients in Jogjakarta, Indonesia. Trans R Soc Trop Med Hyg. 2008, 102: 1003-1010. 10.1016/j.trstmh.2008.04.042.CrossRefPubMed Mahendradhata Y, Ahmad RA, Kusuma T, et al: VCT uptake and HIV prevalence amongst TB patients in Jogjakarta, Indonesia. Trans R Soc Trop Med Hyg. 2008, 102: 1003-1010. 10.1016/j.trstmh.2008.04.042.CrossRefPubMed
16.
go back to reference MoH-RoI: National Guideline for Tuberculosis Control. 2007, Jakarta: Ministry of Health, Republic of Indonesia MoH-RoI: National Guideline for Tuberculosis Control. 2007, Jakarta: Ministry of Health, Republic of Indonesia
17.
go back to reference Lambert ML, Sugulle H, Seyoum D: How can detection of infectious tuberculosis be improved? Experience in the Somali region of Ethiopia. Int J Tuberc Lung Dis. 2003, 7: 485-488.PubMed Lambert ML, Sugulle H, Seyoum D: How can detection of infectious tuberculosis be improved? Experience in the Somali region of Ethiopia. Int J Tuberc Lung Dis. 2003, 7: 485-488.PubMed
18.
go back to reference Mesfin MM, Tasew TW, Richard MJ: The Quality of tuberculosis diagnosis in district of Tigray region of Northern Ethiopia. Ethi J Health Dev. 2005, 19: 13-20. Mesfin MM, Tasew TW, Richard MJ: The Quality of tuberculosis diagnosis in district of Tigray region of Northern Ethiopia. Ethi J Health Dev. 2005, 19: 13-20.
19.
go back to reference Thomas A, Gopi PG, Santha T, et al: Course of action taken by smear-negative chest symptomatics: a report from a rural area in South India. Ind J Tuberc. 2006, 53: 4-6. Thomas A, Gopi PG, Santha T, et al: Course of action taken by smear-negative chest symptomatics: a report from a rural area in South India. Ind J Tuberc. 2006, 53: 4-6.
20.
go back to reference Khan MS, Khan S, Godfrey-Faussett P: Default during TB diagnosis: quantifying the problem. Trop Med Int Health. 2009, 14: 1437-1441. 10.1111/j.1365-3156.2009.02406.x.CrossRefPubMed Khan MS, Khan S, Godfrey-Faussett P: Default during TB diagnosis: quantifying the problem. Trop Med Int Health. 2009, 14: 1437-1441. 10.1111/j.1365-3156.2009.02406.x.CrossRefPubMed
21.
go back to reference Buu TN, Lonnroth K, Quy HT: Initial defaulting in the National Tuberculosis Programme in Ho Chi Minh City Vietnam: a survey of extent reasons and alternative actions taken following default. Int J Tuberc Lung Dis. 2003, 7: 735-741.PubMed Buu TN, Lonnroth K, Quy HT: Initial defaulting in the National Tuberculosis Programme in Ho Chi Minh City Vietnam: a survey of extent reasons and alternative actions taken following default. Int J Tuberc Lung Dis. 2003, 7: 735-741.PubMed
22.
go back to reference Rao NA, Anwer T, Saleem M: Magnitude of initial default in pulmonary tuberculosis. J Pak Med Assoc. 2009, 59: 223-225.PubMed Rao NA, Anwer T, Saleem M: Magnitude of initial default in pulmonary tuberculosis. J Pak Med Assoc. 2009, 59: 223-225.PubMed
23.
go back to reference Budiono Wahyuni CU, Rahariyani LD, et al: Obstacles for optimal tuberculosis case detection in primary health centers (PHC) in Sidoarjo district, East Java, Indonesia. BMC Health Serv Res. 2007, 7: 135-10.1186/1472-6963-7-135.CrossRefPubMedPubMedCentral Budiono Wahyuni CU, Rahariyani LD, et al: Obstacles for optimal tuberculosis case detection in primary health centers (PHC) in Sidoarjo district, East Java, Indonesia. BMC Health Serv Res. 2007, 7: 135-10.1186/1472-6963-7-135.CrossRefPubMedPubMedCentral
24.
go back to reference Hopewell PC, Pai M, Maher D, Uplekar M, Raviglione MC: International Standards for Tuberculosis Care. Lancet Infect Dis. 2006, 6: 710-725. 10.1016/S1473-3099(06)70628-4.CrossRefPubMed Hopewell PC, Pai M, Maher D, Uplekar M, Raviglione MC: International Standards for Tuberculosis Care. Lancet Infect Dis. 2006, 6: 710-725. 10.1016/S1473-3099(06)70628-4.CrossRefPubMed
25.
go back to reference Tuberculosis Coalition for Technical Assistance: International Standards for Tuberculosis Care (ISTC). 2006, The Hague: Tuberculosis Coalition for Technical Assistance Tuberculosis Coalition for Technical Assistance: International Standards for Tuberculosis Care (ISTC). 2006, The Hague: Tuberculosis Coalition for Technical Assistance
26.
go back to reference Boehme CC, Nabeta P, Hillemann D, et al: Rapid Molecular Detection of Tuberculosis and Rifampin Resistance. N Engl J Med. 2010, 363: 1005-1015. 10.1056/NEJMoa0907847.CrossRefPubMedPubMedCentral Boehme CC, Nabeta P, Hillemann D, et al: Rapid Molecular Detection of Tuberculosis and Rifampin Resistance. N Engl J Med. 2010, 363: 1005-1015. 10.1056/NEJMoa0907847.CrossRefPubMedPubMedCentral
27.
go back to reference WHO: Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF SYSTEM Policy statement. 2011, Geneva: WHO, (WHO/HTM/TB/2011.4) WHO: Automated real-time nucleic acid amplification technology for rapid and simultaneous detection of tuberculosis and rifampicin resistance: Xpert MTB/RIF SYSTEM Policy statement. 2011, Geneva: WHO, (WHO/HTM/TB/2011.4)
Metadata
Title
Diagnostic work-up and loss of tuberculosis suspects in Jogjakarta, Indonesia
Authors
Riris Andono Ahmad
Francine Matthys
Bintari Dwihardiani
Ning Rintiswati
Sake J de Vlas
Yodi Mahendradhata
Patrick van der Stuyft
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2012
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-12-132

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