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Published in: BMC Public Health 1/2010

Open Access 01-12-2010 | Research article

What 'outliers' tell us about missed opportunities for tuberculosis control: a cross-sectional study of patients in Mumbai, India

Authors: Anagha Pradhan, Karina Kielmann, Himanshu Gupte, Arun Bamne, John DH Porter, Sheela Rangan

Published in: BMC Public Health | Issue 1/2010

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Abstract

Background

India's Revised National Tuberculosis Control Programme (RNTCP) is deemed highly successful in terms of detection and cure rates. However, some patients experience delays in accessing diagnosis and treatment. Patients falling between the 96th and 100th percentiles for these access indicators are often ignored as atypical 'outliers' when assessing programme performance. They may, however, provide clues to understanding why some patients never reach the programme. This paper examines the underlying vulnerabilities of patients with extreme values for delays in accessing the RNTCP in Mumbai city, India.

Methods

We conducted a cross-sectional study with 266 new sputum positive patients registered with the RNTCP in Mumbai. Patients were classified as 'outliers' if patient, provider and system delays were beyond the 95th percentile for the respective variable. Case profiles of 'outliers' for patient, provider and system delays were examined and compared with the rest of the sample to identify key factors responsible for delays.

Results

Forty-two patients were 'outliers' on one or more of the delay variables. All 'outliers' had a significantly lower per capita income than the remaining sample. The lack of economic resources was compounded by social, structural and environmental vulnerabilities. Longer patient delays were related to patients' perception of symptoms as non-serious. Provider delays were incurred as a result of private providers' failure to respond to tuberculosis in a timely manner. Diagnostic and treatment delays were minimal, however, analysis of the 'outliers' revealed the importance of social support in enabling access to the programme.

Conclusion

A proxy for those who fail to reach the programme, these case profiles highlight unique vulnerabilities that need innovative approaches by the RNTCP. The focus on 'outliers' provides a less resource- and time-intensive alternative to community-based studies for understanding the barriers to reaching public health programmes.
Literature
1.
go back to reference World Health Organization: WHO Report. 2006, Geneva: WHO/HTM/TB/2006.362, : Global tuberculosis control, surveillance, planning, financing World Health Organization: WHO Report. 2006, Geneva: WHO/HTM/TB/2006.362, : Global tuberculosis control, surveillance, planning, financing
3.
go back to reference Singh V, Jaiswal A, Porter JDH, Ogden JA, Sarin R, Sharma PP, Arora VK, Jain RC: TB control, poverty, and vulnerability in Delhi, India. Trop Med Int Health. 2002, 7 (8): 693-700. 10.1046/j.1365-3156.2002.00909.x.CrossRefPubMed Singh V, Jaiswal A, Porter JDH, Ogden JA, Sarin R, Sharma PP, Arora VK, Jain RC: TB control, poverty, and vulnerability in Delhi, India. Trop Med Int Health. 2002, 7 (8): 693-700. 10.1046/j.1365-3156.2002.00909.x.CrossRefPubMed
4.
go back to reference Jaiswal A, Singh V, Ogden JA, Porter JDH, Sharma PP, Sarin R, Arora VK, Jain RC: Adherence to tuberculosis treatment: lessons from the urban setting of Delhi, India. Trop Med Int Health. 2003, 8 (7): 625-633. 10.1046/j.1365-3156.2003.01061.x.CrossRefPubMed Jaiswal A, Singh V, Ogden JA, Porter JDH, Sharma PP, Sarin R, Arora VK, Jain RC: Adherence to tuberculosis treatment: lessons from the urban setting of Delhi, India. Trop Med Int Health. 2003, 8 (7): 625-633. 10.1046/j.1365-3156.2003.01061.x.CrossRefPubMed
5.
go back to reference Ashford LS, Gwatkin DR, Yazbeck AS: Designing health and population programs to reach the poor. 2006, Washington, D.C.: Population Reference Bureau Ashford LS, Gwatkin DR, Yazbeck AS: Designing health and population programs to reach the poor. 2006, Washington, D.C.: Population Reference Bureau
9.
go back to reference Coker R, McKee M, Atun R, Dimitrova B, Dodonova E, Kuznetsov S, Drobniewski F: Risk factors for pulmonary tuberculosis in Russia: case-control study. BMJ. 2006, 332: 85-87. 10.1136/bmj.38684.687940.80.CrossRefPubMedPubMedCentral Coker R, McKee M, Atun R, Dimitrova B, Dodonova E, Kuznetsov S, Drobniewski F: Risk factors for pulmonary tuberculosis in Russia: case-control study. BMJ. 2006, 332: 85-87. 10.1136/bmj.38684.687940.80.CrossRefPubMedPubMedCentral
10.
go back to reference Jackson S, Sleigh AC, Wang GJ, Liu XL: Poverty and the economic effects of TB in rural China. Int J Tuberc Lung Dis. 2006, 10 (10): 1104-1110.PubMed Jackson S, Sleigh AC, Wang GJ, Liu XL: Poverty and the economic effects of TB in rural China. Int J Tuberc Lung Dis. 2006, 10 (10): 1104-1110.PubMed
11.
go back to reference David AM, Mercado SP, Becker KE, Mugisha F: The prevention and control of HIV/AIDS, TB and vector-borne diseases in informal settlements: Challenges, opportunities and insights. J Urban Health. 2007, 84 (1): i65-i74. 10.1007/s11524-007-9183-5.CrossRefPubMed David AM, Mercado SP, Becker KE, Mugisha F: The prevention and control of HIV/AIDS, TB and vector-borne diseases in informal settlements: Challenges, opportunities and insights. J Urban Health. 2007, 84 (1): i65-i74. 10.1007/s11524-007-9183-5.CrossRefPubMed
12.
go back to reference Kemp JR, Mann G, Nhlema Simwaka B, Salaniponi FML, Squire SB: Can Malawi's poor afford free tuberculosis services? Patient and household costs associated with a tuberculosis diagnosis in Lilongwe. Bull World Health Organ. 2007, 85: 580-585. 10.2471/BLT.06.033167.CrossRefPubMedPubMedCentral Kemp JR, Mann G, Nhlema Simwaka B, Salaniponi FML, Squire SB: Can Malawi's poor afford free tuberculosis services? Patient and household costs associated with a tuberculosis diagnosis in Lilongwe. Bull World Health Organ. 2007, 85: 580-585. 10.2471/BLT.06.033167.CrossRefPubMedPubMedCentral
13.
go back to reference Rangan S, Ambe G, Borremans N, Zallocco D, Porter J: The Mumbai experience in building field level partnerships for DOTS implementation. Tuberculosis. 2003, 83: 165-172. 10.1016/S1472-9792(02)00070-7.CrossRefPubMed Rangan S, Ambe G, Borremans N, Zallocco D, Porter J: The Mumbai experience in building field level partnerships for DOTS implementation. Tuberculosis. 2003, 83: 165-172. 10.1016/S1472-9792(02)00070-7.CrossRefPubMed
14.
go back to reference Ambe G, Lonnroth K, Dholakia J, Copreaux J, Zignol M, Borremans N, Uplekar M: Every provider counts: effect of a comprehensive public-private mix approach for TB control in a large metropolitan area in India. Int J of Tuberc Lung Dis. 2005, 9 (5): 562-568. Ambe G, Lonnroth K, Dholakia J, Copreaux J, Zignol M, Borremans N, Uplekar M: Every provider counts: effect of a comprehensive public-private mix approach for TB control in a large metropolitan area in India. Int J of Tuberc Lung Dis. 2005, 9 (5): 562-568.
15.
go back to reference Rajeswari R, Chandrasekaran V, Suhadev M, Sivasubramaniam S, Sudha G, Renu G: Factors associated with patient and health system delays in the diagnosis of tuberculosis in South India. Int J Tuberc Lung Dis. 2005, 6 (9): 789-795. Rajeswari R, Chandrasekaran V, Suhadev M, Sivasubramaniam S, Sudha G, Renu G: Factors associated with patient and health system delays in the diagnosis of tuberculosis in South India. Int J Tuberc Lung Dis. 2005, 6 (9): 789-795.
16.
go back to reference Balasubramanian R, Garg R, Santha T, Gopi PG, Subramani R, Chandrasekaran V, Thomas A, Rajeswari R, Anandakrishnan S, Perumal M, Niruparani C, Sudha G, Jaggarajamma K, Frieden TR, Narayanan PR: Gender disparities in tuberculosis: report from a rural DOTS programme in South India. Int J Tuberc Lung Dis. 2004, 8 (3): 323-332.PubMed Balasubramanian R, Garg R, Santha T, Gopi PG, Subramani R, Chandrasekaran V, Thomas A, Rajeswari R, Anandakrishnan S, Perumal M, Niruparani C, Sudha G, Jaggarajamma K, Frieden TR, Narayanan PR: Gender disparities in tuberculosis: report from a rural DOTS programme in South India. Int J Tuberc Lung Dis. 2004, 8 (3): 323-332.PubMed
17.
go back to reference Eastwood SV, Hill PC: A gender-focused qualitative study of barriers to accessing tuberculosis treatment in The Gambia, West Africa. Int J Tuberc Lung Dis. 2004, 8 (1): 70-75.PubMed Eastwood SV, Hill PC: A gender-focused qualitative study of barriers to accessing tuberculosis treatment in The Gambia, West Africa. Int J Tuberc Lung Dis. 2004, 8 (1): 70-75.PubMed
18.
go back to reference Cambanis A, Yassin MA, Ramsay A, Squire SB, Abride I, Cuevas LE: Rural poverty and delayed presentation to tuberculosis services in Ethiopia. Trop Med Int Health. 2005, 10 (4): 330-335. 10.1111/j.1365-3156.2005.01393.x.CrossRefPubMed Cambanis A, Yassin MA, Ramsay A, Squire SB, Abride I, Cuevas LE: Rural poverty and delayed presentation to tuberculosis services in Ethiopia. Trop Med Int Health. 2005, 10 (4): 330-335. 10.1111/j.1365-3156.2005.01393.x.CrossRefPubMed
19.
go back to reference Chiang CY, Chang CT, Chang RE, Li CT, Huang RM: Patient and health system delays in the diagnosis and treatment of tuberculosis in Southern Taiwan. Int J Tuberc Lung Dis. 2005, 9 (9): 1006-1012.PubMed Chiang CY, Chang CT, Chang RE, Li CT, Huang RM: Patient and health system delays in the diagnosis and treatment of tuberculosis in Southern Taiwan. Int J Tuberc Lung Dis. 2005, 9 (9): 1006-1012.PubMed
20.
go back to reference Karim F, Islam MA, Chowdhury AMR, Johansson E, Diwan VK: Gender differences in delays in diagnosis and treatment of tuberculosis. Health Policy and Planning. 2007, 22: 329-334. 10.1093/heapol/czm026.CrossRefPubMed Karim F, Islam MA, Chowdhury AMR, Johansson E, Diwan VK: Gender differences in delays in diagnosis and treatment of tuberculosis. Health Policy and Planning. 2007, 22: 329-334. 10.1093/heapol/czm026.CrossRefPubMed
21.
go back to reference Tobgay KJ, Sarma PS, Thankappan KR: Predictors of treatment delays for tuberculosis in Sikkim. Natl Med J India. 2006, 19 (2): 60-63.PubMed Tobgay KJ, Sarma PS, Thankappan KR: Predictors of treatment delays for tuberculosis in Sikkim. Natl Med J India. 2006, 19 (2): 60-63.PubMed
22.
go back to reference Buu TN, Lonnroth K, Quy HT: Initial defaulting in the National Tuberculosis Programme in Ho Chi Minh City, Vietnam: a survey of extent, reasons and alternative actions taken following default. Int J Tuberc Lung Dis. 2003, 7 (8): 735-741.PubMed Buu TN, Lonnroth K, Quy HT: Initial defaulting in the National Tuberculosis Programme in Ho Chi Minh City, Vietnam: a survey of extent, reasons and alternative actions taken following default. Int J Tuberc Lung Dis. 2003, 7 (8): 735-741.PubMed
23.
go back to reference Santha T, Garg R, Frieden TR, Subramani R, Gopi PG, Chandrasekaran V, Selvakumar N, Thomas A, Rajeswari R, Balasubramanian R, Kolappan C, Narayanan PR: Are community surveys to detect tuberculosis in high prevalence areas useful? Results of a comparative study from Tiruvallur District, South India. Int J Tuberc Lung Dis. 2003, 7 (3): 258-265.PubMed Santha T, Garg R, Frieden TR, Subramani R, Gopi PG, Chandrasekaran V, Selvakumar N, Thomas A, Rajeswari R, Balasubramanian R, Kolappan C, Narayanan PR: Are community surveys to detect tuberculosis in high prevalence areas useful? Results of a comparative study from Tiruvallur District, South India. Int J Tuberc Lung Dis. 2003, 7 (3): 258-265.PubMed
24.
go back to reference Dandona R, Dandona L, Mishra A, Dhingra S, Venkatagopalakrishna K, Chauhan LS: Utilization of and barriers to public sector tuberculosis services in India. The Natl Med J India. 2004, 17 (6): 292-299.PubMed Dandona R, Dandona L, Mishra A, Dhingra S, Venkatagopalakrishna K, Chauhan LS: Utilization of and barriers to public sector tuberculosis services in India. The Natl Med J India. 2004, 17 (6): 292-299.PubMed
25.
go back to reference Porter JDH: Epidemiological reflections of the contribution of anthropology to public health policy and practice. J Biosoc Sci. 2006, 38: 133-144. 10.1017/S0021932005001070.CrossRefPubMed Porter JDH: Epidemiological reflections of the contribution of anthropology to public health policy and practice. J Biosoc Sci. 2006, 38: 133-144. 10.1017/S0021932005001070.CrossRefPubMed
27.
go back to reference Salaniponi FML, Harries AD, Banda HT, Kang'ombe C, Mphasa N, Mwale A, Upindi B, Nyirenda TE, Banerjee A, Boeree MJ: Care seeking behaviour and diagnostic processes in patients with smear-positive pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis. 2000, 4 (4): 327-332.PubMed Salaniponi FML, Harries AD, Banda HT, Kang'ombe C, Mphasa N, Mwale A, Upindi B, Nyirenda TE, Banerjee A, Boeree MJ: Care seeking behaviour and diagnostic processes in patients with smear-positive pulmonary tuberculosis in Malawi. Int J Tuberc Lung Dis. 2000, 4 (4): 327-332.PubMed
28.
go back to reference MacKian S: A review of health seeking behaviour: problems and prospects. DfID Health Systems Development Programme, Working Paper HSD/WP/0503. 2001, University of Manchester MacKian S: A review of health seeking behaviour: problems and prospects. DfID Health Systems Development Programme, Working Paper HSD/WP/0503. 2001, University of Manchester
29.
go back to reference Lienhardt C, Ogden JA: Tuberculosis control in resource-poor countries: have we reached the limits of the universal paradigm?. Trop Med Int Health. 2004, 9 (7): 833-841. 10.1111/j.1365-3156.2004.01273.x.CrossRefPubMed Lienhardt C, Ogden JA: Tuberculosis control in resource-poor countries: have we reached the limits of the universal paradigm?. Trop Med Int Health. 2004, 9 (7): 833-841. 10.1111/j.1365-3156.2004.01273.x.CrossRefPubMed
30.
go back to reference Lonnroth K, Thuong LM, Linh PD, Diwan VK: Delay and discontinuity-a survey of TB patients' search of a diagnosis in a diversified health care system. Int J Tuberc Lung Dis. 1999, 3 (11): 992-1000.PubMed Lonnroth K, Thuong LM, Linh PD, Diwan VK: Delay and discontinuity-a survey of TB patients' search of a diagnosis in a diversified health care system. Int J Tuberc Lung Dis. 1999, 3 (11): 992-1000.PubMed
31.
go back to reference Kielmann K, Bentley M: Thresholds of perceived morbidity among women in a peri-urban community of Maharashtra, India: Conceptual and methodological issues. Journal of Health Psychology. 2003, 8: 525-538. 10.1177/13591053030085005.CrossRefPubMed Kielmann K, Bentley M: Thresholds of perceived morbidity among women in a peri-urban community of Maharashtra, India: Conceptual and methodological issues. Journal of Health Psychology. 2003, 8: 525-538. 10.1177/13591053030085005.CrossRefPubMed
32.
go back to reference Auer C, Sarol J, Tanner M, Weiss M: Health seeking and perceived causes of tuberculosis among patients in Manila, Philippines. Trop Med Int Health. 2000, 5 (9): 648-656. 10.1046/j.1365-3156.2000.00615.x.CrossRefPubMed Auer C, Sarol J, Tanner M, Weiss M: Health seeking and perceived causes of tuberculosis among patients in Manila, Philippines. Trop Med Int Health. 2000, 5 (9): 648-656. 10.1046/j.1365-3156.2000.00615.x.CrossRefPubMed
33.
go back to reference Lonnroth K, Tran TU, Thuong LM, Quy HT, Diwan V: Can I afford free treatment?: Perceived consequences of health care provider choices among people with tuberculosis in Ho Chi Minh City, Vietnam. Soc Sci Med. 2001, 52: 935-948. 10.1016/S0277-9536(00)00195-7.CrossRefPubMed Lonnroth K, Tran TU, Thuong LM, Quy HT, Diwan V: Can I afford free treatment?: Perceived consequences of health care provider choices among people with tuberculosis in Ho Chi Minh City, Vietnam. Soc Sci Med. 2001, 52: 935-948. 10.1016/S0277-9536(00)00195-7.CrossRefPubMed
34.
go back to reference Arora VK, Sarin R, Lonnroth K: Feasibility and effectiveness of a public-private mix project for improved TB control in Delhi, India. Int J Tuberc Lung Dis. 2003, 7 (12): 1131-1138.PubMed Arora VK, Sarin R, Lonnroth K: Feasibility and effectiveness of a public-private mix project for improved TB control in Delhi, India. Int J Tuberc Lung Dis. 2003, 7 (12): 1131-1138.PubMed
35.
go back to reference Arora VK, Gupta R: Public-Private Mix: A prioritisation under RNTCP - An Indian perspective. Indian J Chest Dis Allied Sci. 2004, 46: 27-37.PubMed Arora VK, Gupta R: Public-Private Mix: A prioritisation under RNTCP - An Indian perspective. Indian J Chest Dis Allied Sci. 2004, 46: 27-37.PubMed
36.
go back to reference Rangan S: The Public-Private Mix in India's Revised National Tuberculosis Control Programme - An Update. J Indian Med Assoc. 2003, 101 (3): 161-163.PubMed Rangan S: The Public-Private Mix in India's Revised National Tuberculosis Control Programme - An Update. J Indian Med Assoc. 2003, 101 (3): 161-163.PubMed
37.
go back to reference Sudha G, Nirupa C, Rajasakthivel M, Sivasubramanian S, Sundaram V, Bhatt S, Subramaniam K, Thiruvalluvan E, Mathew R, Renu G, Santha T: Factors influencing the care-seeking behaviour of chest symptomatics : a communitybased study involving rural and urban population in Tamil Nadu, South India. Trop Med Int Health. 2003, 8 (4): 336-341. 10.1046/j.1365-3156.2003.01010.x.CrossRefPubMed Sudha G, Nirupa C, Rajasakthivel M, Sivasubramanian S, Sundaram V, Bhatt S, Subramaniam K, Thiruvalluvan E, Mathew R, Renu G, Santha T: Factors influencing the care-seeking behaviour of chest symptomatics : a communitybased study involving rural and urban population in Tamil Nadu, South India. Trop Med Int Health. 2003, 8 (4): 336-341. 10.1046/j.1365-3156.2003.01010.x.CrossRefPubMed
38.
go back to reference Needham DM, Foster SD, Tomlinson G, Godfrey-Faussett P: Socio-economic, gender and health services factors affecting diagnostic delay for tuberculosis patients in urban Zambia. Tro Med Int Health. 2001, 6 (4): 256-259. 10.1046/j.1365-3156.2001.00709.x.CrossRef Needham DM, Foster SD, Tomlinson G, Godfrey-Faussett P: Socio-economic, gender and health services factors affecting diagnostic delay for tuberculosis patients in urban Zambia. Tro Med Int Health. 2001, 6 (4): 256-259. 10.1046/j.1365-3156.2001.00709.x.CrossRef
39.
go back to reference Kiwuwa MS, Charles K, Harriet MK: Patient and health service delay in pulmonary tuberculosis patients attending a referral hospital: a cross-sectional study. BMC Public Health. 2005, 5: 122-10.1186/1471-2458-5-122.CrossRefPubMedPubMedCentral Kiwuwa MS, Charles K, Harriet MK: Patient and health service delay in pulmonary tuberculosis patients attending a referral hospital: a cross-sectional study. BMC Public Health. 2005, 5: 122-10.1186/1471-2458-5-122.CrossRefPubMedPubMedCentral
40.
go back to reference Kelkar-Khambete A, Kielmann K, Pawar S, Porter J, Inamdar V, Datye A, Rangan S: India's Revised National Tuberculosis Control Programme: looking beyond detection and cure. Int J Tuberc Lung Dis. 2008, 12 (1): 1-6. Kelkar-Khambete A, Kielmann K, Pawar S, Porter J, Inamdar V, Datye A, Rangan S: India's Revised National Tuberculosis Control Programme: looking beyond detection and cure. Int J Tuberc Lung Dis. 2008, 12 (1): 1-6.
Metadata
Title
What 'outliers' tell us about missed opportunities for tuberculosis control: a cross-sectional study of patients in Mumbai, India
Authors
Anagha Pradhan
Karina Kielmann
Himanshu Gupte
Arun Bamne
John DH Porter
Sheela Rangan
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2010
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-10-263

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