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Published in: BMC Psychiatry 1/2009

Open Access 01-12-2009 | Research article

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

Authors: Xiaohui Xu, Jonathan Mill, Bo Sun, Chih-Ken Chen, Yu-Shu Huang, Yu-Yu Wu, Philip Asherson

Published in: BMC Psychiatry | Issue 1/2009

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Abstract

Background

Attention deficit hyperactivity disorder (ADHD) is a complex neurobehavioral disorder. The dopamine transporter gene (DAT1/SLC6A3) has been considered a good candidate for ADHD. Most association studies with ADHD have investigated the 40-base-pair variable number of tandem repeat (VNTR) polymorphism in the 3'-untranslated region of DAT1. Only few studies have reported association between promoter polymorphisms of the gene and ADHD.

Methods

To investigate the association between the polymorphisms -67A/T (rs2975226) and -839C/T (rs2652511) in promoter region of DAT1 in ADHD, two samples of ADHD patients from the UK (n = 197) and Taiwan (n = 212) were genotyped, and analysed using within-family transmission disequilibrium test (TDT).

Results

A significant association was found between the T allele of promoter polymorphism -67A/T and ADHD in the Taiwanese population (P = 0.001). There was also evidence of preferential transmission of the T allele of -67A/T polymorphism in combined samples from the UK and Taiwan (P = 0.003). No association was detected between the -839C/T polymorphism and ADHD in either of the two populations.

Conclusion

The finding suggests that genetic variation in the promoter region of DAT1 may be a risk factor in the development of ADHD.
Literature
1.
go back to reference Burd L, Klug MG, Coumbe MJ, Kerbeshian J: Children and adolescents with attention deficit-hyperactivity disorder: 1. Prevalence and cost of care. J Child Neurol. 2003, 18: 555-561. 10.1177/08830738030180080101.CrossRefPubMed Burd L, Klug MG, Coumbe MJ, Kerbeshian J: Children and adolescents with attention deficit-hyperactivity disorder: 1. Prevalence and cost of care. J Child Neurol. 2003, 18: 555-561. 10.1177/08830738030180080101.CrossRefPubMed
2.
go back to reference Kessler RC, Adler L, Ames M, Barkley RA, Birnbaum H, Greenberg P, Johnston JA, Spencer T, Ustün TB: The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med. 2005, 47: 565-572. 10.1097/01.jom.0000166863.33541.39.CrossRefPubMed Kessler RC, Adler L, Ames M, Barkley RA, Birnbaum H, Greenberg P, Johnston JA, Spencer T, Ustün TB: The prevalence and effects of adult attention deficit/hyperactivity disorder on work performance in a nationally representative sample of workers. J Occup Environ Med. 2005, 47: 565-572. 10.1097/01.jom.0000166863.33541.39.CrossRefPubMed
3.
go back to reference Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P: Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57: 1313-1323. 10.1016/j.biopsych.2004.11.024.CrossRefPubMed Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P: Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005, 57: 1313-1323. 10.1016/j.biopsych.2004.11.024.CrossRefPubMed
4.
go back to reference Asherson P, the IMAGE Consortium: Attention-deficit hyperactivity disorder in the post-genomic era. Eur Child Adolesc Psychiatry. 2004, 13: 50-70. 10.1007/s00787-004-1006-6.CrossRef Asherson P, the IMAGE Consortium: Attention-deficit hyperactivity disorder in the post-genomic era. Eur Child Adolesc Psychiatry. 2004, 13: 50-70. 10.1007/s00787-004-1006-6.CrossRef
5.
go back to reference Faraone SV, Khan SA: Candidate gene studies of attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2006, 67 (Suppl 8): 13-20.PubMed Faraone SV, Khan SA: Candidate gene studies of attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2006, 67 (Suppl 8): 13-20.PubMed
6.
go back to reference Thapar A, Langley K, Owen MJ, O'donovan MC: Avances in genetic findings on attention deficit hyperactivity disorder. Psychol Med. 2007, 37: 1681-1692. 10.1017/S0033291707000773.CrossRefPubMed Thapar A, Langley K, Owen MJ, O'donovan MC: Avances in genetic findings on attention deficit hyperactivity disorder. Psychol Med. 2007, 37: 1681-1692. 10.1017/S0033291707000773.CrossRefPubMed
7.
go back to reference Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL: Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet. 1995, 56: 993-998.PubMedPubMedCentral Cook EH, Stein MA, Krasowski MD, Cox NJ, Olkon DM, Kieffer JE, Leventhal BL: Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet. 1995, 56: 993-998.PubMedPubMedCentral
8.
go back to reference Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M: Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry. 1997, 2: 311-313. 10.1038/sj.mp.4000290.CrossRefPubMed Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M: Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry. 1997, 2: 311-313. 10.1038/sj.mp.4000290.CrossRefPubMed
9.
go back to reference Daly G, Hawi Z, Fitzgerald M, Gill M: Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry. 1999, 4: 192-196. 10.1038/sj.mp.4000510.CrossRefPubMed Daly G, Hawi Z, Fitzgerald M, Gill M: Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry. 1999, 4: 192-196. 10.1038/sj.mp.4000510.CrossRefPubMed
10.
go back to reference Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, Ozbay F, Yazgan Y, Simonoff E, Thompson M, Taylor E, Asherson P: Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry. 2001, 6: 425-428. 10.1038/sj.mp.4000914.CrossRefPubMed Curran S, Mill J, Tahir E, Kent L, Richards S, Gould A, Huckett L, Sharp J, Batten C, Fernando S, Ozbay F, Yazgan Y, Simonoff E, Thompson M, Taylor E, Asherson P: Association study of a dopamine transporter polymorphism and attention deficit hyperactivity disorder in UK and Turkish samples. Mol Psychiatry. 2001, 6: 425-428. 10.1038/sj.mp.4000914.CrossRefPubMed
11.
go back to reference Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P: The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry. 2003, 8: 393-396. 10.1038/sj.mp.4001238.CrossRefPubMed Chen CK, Chen SL, Mill J, Huang YS, Lin SK, Curran S, Purcell S, Sham P, Asherson P: The dopamine transporter gene is associated with attention deficit hyperactivity disorder in a Taiwanese sample. Mol Psychiatry. 2003, 8: 393-396. 10.1038/sj.mp.4001238.CrossRefPubMed
12.
go back to reference Galili-Weisstub E, Levy S, Frisch A, Gross-Tsur V, Michaelovsky E, Kosov A, Meltzer A, Goltser T, Serretti A, Cusin C, Darvasi A, Inbar E, Weizman A, Segman RH: Dopamine transporter haplotype and attention-deficit hyperactivity disorder. Mol Psychiatry. 2005, 10: 617-618. 10.1038/sj.mp.4001655.CrossRefPubMed Galili-Weisstub E, Levy S, Frisch A, Gross-Tsur V, Michaelovsky E, Kosov A, Meltzer A, Goltser T, Serretti A, Cusin C, Darvasi A, Inbar E, Weizman A, Segman RH: Dopamine transporter haplotype and attention-deficit hyperactivity disorder. Mol Psychiatry. 2005, 10: 617-618. 10.1038/sj.mp.4001655.CrossRefPubMed
13.
go back to reference Yang B, Chan RC, Jing J, Li T, Sham P, Chen RY: A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B (4): 541-550. 10.1002/ajmg.b.30453.CrossRefPubMed Yang B, Chan RC, Jing J, Li T, Sham P, Chen RY: A meta-analysis of association studies between the 10-repeat allele of a VNTR polymorphism in the 3'-UTR of dopamine transporter gene and attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B (4): 541-550. 10.1002/ajmg.b.30453.CrossRefPubMed
14.
go back to reference Palmer CG, Bailey JN, Ramsey C, Cantwell D, Sinsheimer JS, Del'Homme M, McGough J, Woodward JA, Asarnow R, Asarnow J, Nelson S, Smalley SL: No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatr Genet. 1999, 9: 157-160. 10.1097/00041444-199909000-00009.CrossRefPubMed Palmer CG, Bailey JN, Ramsey C, Cantwell D, Sinsheimer JS, Del'Homme M, McGough J, Woodward JA, Asarnow R, Asarnow J, Nelson S, Smalley SL: No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatr Genet. 1999, 9: 157-160. 10.1097/00041444-199909000-00009.CrossRefPubMed
15.
go back to reference Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, Zarrabian Comings D, Sellers EM, Tyndale RF, George SR, O'Dowd BF, Uhl GR: Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Mol Psychiatry. 2000, 5: 283-292. 10.1038/sj.mp.4000701.CrossRefPubMed Vandenbergh DJ, Thompson MD, Cook EH, Bendahhou E, Nguyen T, Krasowski MD, Zarrabian Comings D, Sellers EM, Tyndale RF, George SR, O'Dowd BF, Uhl GR: Human dopamine transporter gene: coding region conservation among normal, Tourette's disorder, alcohol dependence and attention-deficit hyperactivity disorder populations. Mol Psychiatry. 2000, 5: 283-292. 10.1038/sj.mp.4000701.CrossRefPubMed
16.
go back to reference Roman T, Schmitz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH: Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet. 2001, 105: 471-478. 10.1002/ajmg.1408.CrossRefPubMed Roman T, Schmitz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH: Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet. 2001, 105: 471-478. 10.1002/ajmg.1408.CrossRefPubMed
17.
go back to reference Langley K, Turic D, Peirce TR, Mills S, Bree Van Den MB, Owen MJ, O'Donovan MC, Thapar A: No support for association between the dopamine transporter (DAT1) gene and ADHD. Am J Med Genet B Neuropsychiatr Genet. 2005, 139B (1): 7-10. 10.1002/ajmg.b.30206.CrossRefPubMed Langley K, Turic D, Peirce TR, Mills S, Bree Van Den MB, Owen MJ, O'Donovan MC, Thapar A: No support for association between the dopamine transporter (DAT1) gene and ADHD. Am J Med Genet B Neuropsychiatr Genet. 2005, 139B (1): 7-10. 10.1002/ajmg.b.30206.CrossRefPubMed
18.
go back to reference Feng Y, Wigg KG, Makkar R, Ickowicz A, Pathare T, Tannock R, Roberts W, Malone M, Kennedy JL, Schachar R, Barr CL: Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD). Am J Med Genet B Neuropsychiatr Genet. 2005, 139B (1): 1-6. 10.1002/ajmg.b.30190.CrossRefPubMed Feng Y, Wigg KG, Makkar R, Ickowicz A, Pathare T, Tannock R, Roberts W, Malone M, Kennedy JL, Schachar R, Barr CL: Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD). Am J Med Genet B Neuropsychiatr Genet. 2005, 139B (1): 1-6. 10.1002/ajmg.b.30190.CrossRefPubMed
19.
go back to reference Hebebrand J, Dempfle A, Saar K, Thiele H, Herpertz-Dahlmann B, Linder M, Kiefl H, Remschmidt H, Hemminger U, Warnke A, Knölker U, Heiser P, Friedel S, Hinney A, Schäfer H, Nürnberg P, Konrad K: A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry. 2006, 11: 196-205. 10.1038/sj.mp.4001761.CrossRefPubMed Hebebrand J, Dempfle A, Saar K, Thiele H, Herpertz-Dahlmann B, Linder M, Kiefl H, Remschmidt H, Hemminger U, Warnke A, Knölker U, Heiser P, Friedel S, Hinney A, Schäfer H, Nürnberg P, Konrad K: A genome-wide scan for attention-deficit/hyperactivity disorder in 155 German sib-pairs. Mol Psychiatry. 2006, 11: 196-205. 10.1038/sj.mp.4001761.CrossRefPubMed
20.
go back to reference Genro JP, Zeni C, Polanczyk GV, Roman T, Rohde LA, Hutz MH: A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B (2): 215-219. 10.1002/ajmg.b.30428.CrossRefPubMed Genro JP, Zeni C, Polanczyk GV, Roman T, Rohde LA, Hutz MH: A promoter polymorphism (-839 C > T) at the dopamine transporter gene is associated with attention deficit/hyperactivity disorder in Brazilian children. Am J Med Genet B Neuropsychiatr Genet. 2007, 144B (2): 215-219. 10.1002/ajmg.b.30428.CrossRefPubMed
21.
go back to reference Banoei MM, Majidizadeh T, Shirazi E, Moghimi N, Ghadiri M, Najmabadi H, Ohadi M: No association between the DAT1 10-repeat allele and ADHD in the Iranian population. Am J Med Genet B Neuropsychiatr Genet. 2007, 147B (1): 110-111.CrossRef Banoei MM, Majidizadeh T, Shirazi E, Moghimi N, Ghadiri M, Najmabadi H, Ohadi M: No association between the DAT1 10-repeat allele and ADHD in the Iranian population. Am J Med Genet B Neuropsychiatr Genet. 2007, 147B (1): 110-111.CrossRef
22.
go back to reference Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P: A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry. 2006, 63: 74-81. 10.1001/archpsyc.63.1.74.CrossRefPubMed Brookes KJ, Mill J, Guindalini C, Curran S, Xu X, Knight J, Chen CK, Huang YS, Sethna V, Taylor E, Chen W, Breen G, Asherson P: A common haplotype of the dopamine transporter gene associated with attention-deficit/hyperactivity disorder and interacting with maternal use of alcohol during pregnancy. Arch Gen Psychiatry. 2006, 63: 74-81. 10.1001/archpsyc.63.1.74.CrossRefPubMed
23.
go back to reference Cornish KM, Manly T, Savage R, Swanson J, Morisano D, Butler N, Grant C, Cross G, Bentley L, Hollis CP: Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. Mol Psychiatry. 2005, 10: 686-698. 10.1038/sj.mp.4001641.CrossRefPubMed Cornish KM, Manly T, Savage R, Swanson J, Morisano D, Butler N, Grant C, Cross G, Bentley L, Hollis CP: Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample. Mol Psychiatry. 2005, 10: 686-698. 10.1038/sj.mp.4001641.CrossRefPubMed
24.
go back to reference Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P: Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. Am J Med Genet B Neuropsychiatr Genet. 2005, 133B (1): 68-73. 10.1002/ajmg.b.30107.CrossRefPubMed Mill J, Xu X, Ronald A, Curran S, Price T, Knight J, Craig I, Sham P, Plomin R, Asherson P: Quantitative trait locus analysis of candidate gene alleles associated with attention deficit hyperactivity disorder (ADHD) in five genes: DRD4, DAT1, DRD5, SNAP-25, and 5HT1B. Am J Med Genet B Neuropsychiatr Genet. 2005, 133B (1): 68-73. 10.1002/ajmg.b.30107.CrossRefPubMed
25.
go back to reference Mill J, Asherson P, Browes C, D'Souza U, Craig I: Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet. 2002, 114: 975-979. 10.1002/ajmg.b.10948.CrossRefPubMed Mill J, Asherson P, Browes C, D'Souza U, Craig I: Expression of the dopamine transporter gene is regulated by the 3' UTR VNTR: Evidence from brain and lymphocytes using quantitative RT-PCR. Am J Med Genet. 2002, 114: 975-979. 10.1002/ajmg.b.10948.CrossRefPubMed
26.
go back to reference VanNess SH, Owens MJ, Kilts CD: The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet. 2005, 6: 55-10.1186/1471-2156-6-55.CrossRefPubMedPubMedCentral VanNess SH, Owens MJ, Kilts CD: The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density. BMC Genet. 2005, 6: 55-10.1186/1471-2156-6-55.CrossRefPubMedPubMedCentral
27.
go back to reference Rubie C, Schmidt F, Knapp M, Sprandel J, Wiegand C, Meyer J, Jungkunz G, Riederer P, Stöber G: The human dopamine transporter gene: the 5'-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample. Neurosci Lett. 2001, 297: 125-128. 10.1016/S0304-3940(00)01685-2.CrossRefPubMed Rubie C, Schmidt F, Knapp M, Sprandel J, Wiegand C, Meyer J, Jungkunz G, Riederer P, Stöber G: The human dopamine transporter gene: the 5'-flanking region reveals five diallelic polymorphic sites in a Caucasian population sample. Neurosci Lett. 2001, 297: 125-128. 10.1016/S0304-3940(00)01685-2.CrossRefPubMed
28.
go back to reference Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Anney R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Korn-Lubetzki I, Johansson L, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin P, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P: The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 genes. Molecular Psychiatry. 2006, 11: 934-953. 10.1038/sj.mp.4001869.CrossRefPubMed Brookes K, Xu X, Chen W, Zhou K, Neale B, Lowe N, Anney R, Franke B, Gill M, Ebstein R, Buitelaar J, Sham P, Campbell D, Knight J, Andreou P, Altink M, Arnold R, Boer F, Buschgens C, Butler L, Christiansen H, Feldman L, Fleischman K, Fliers E, Howe-Forbes R, Goldfarb A, Heise A, Gabriëls I, Korn-Lubetzki I, Johansson L, Marco R, Medad S, Minderaa R, Mulas F, Müller U, Mulligan A, Rabin K, Rommelse N, Sethna V, Sorohan J, Uebel H, Psychogiou L, Weeks A, Barrett R, Craig I, Banaschewski T, Sonuga-Barke E, Eisenberg J, Kuntsi J, Manor I, McGuffin P, Miranda A, Oades RD, Plomin R, Roeyers H, Rothenberger A, Sergeant J, Steinhausen HC, Taylor E, Thompson M, Faraone SV, Asherson P: The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 genes. Molecular Psychiatry. 2006, 11: 934-953. 10.1038/sj.mp.4001869.CrossRefPubMed
29.
go back to reference Ohadi M, Shirazi E, Tehranidoosti M, Moghimi N, Keikhaee MR, Ehssani S, Aghajani A, Najmabadi H: Attention-deficit/hyperactivity disorder (ADHD) association with the DAT1 core promoter -67 T allele. Brain Res. 2006, 1101: 1-4. 10.1016/j.brainres.2006.05.024.CrossRefPubMed Ohadi M, Shirazi E, Tehranidoosti M, Moghimi N, Keikhaee MR, Ehssani S, Aghajani A, Najmabadi H: Attention-deficit/hyperactivity disorder (ADHD) association with the DAT1 core promoter -67 T allele. Brain Res. 2006, 1101: 1-4. 10.1016/j.brainres.2006.05.024.CrossRefPubMed
30.
go back to reference Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M: The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med. 1995, 25: 739-753.CrossRefPubMed Angold A, Prendergast M, Cox A, Harrington R, Simonoff E, Rutter M: The Child and Adolescent Psychiatric Assessment (CAPA). Psychol Med. 1995, 25: 739-753.CrossRefPubMed
31.
go back to reference Conners CK: The Conners Rating Scales: Instruments for Assessments of Childhood Psychopathology. 1995, Duke University: Durham, USA Conners CK: The Conners Rating Scales: Instruments for Assessments of Childhood Psychopathology. 1995, Duke University: Durham, USA
32.
go back to reference Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moneci P, Williamson D, Ryan N: Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997, 36: 980-988. 10.1097/00004583-199707000-00021.CrossRefPubMed Kaufman J, Birmaher B, Brent D, Rao U, Flynn C, Moneci P, Williamson D, Ryan N: Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry. 1997, 36: 980-988. 10.1097/00004583-199707000-00021.CrossRefPubMed
33.
go back to reference Dudbridge F: Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol. 2003, 25: 115-121. 10.1002/gepi.10252.CrossRefPubMed Dudbridge F: Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol. 2003, 25: 115-121. 10.1002/gepi.10252.CrossRefPubMed
Metadata
Title
Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder
Authors
Xiaohui Xu
Jonathan Mill
Bo Sun
Chih-Ken Chen
Yu-Shu Huang
Yu-Yu Wu
Philip Asherson
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2009
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-9-3

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