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Open Access 01-12-2014 | Study protocol

The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design

Authors: Marco A Bottelier, Marieke LJ Schouw, Anne Klomp, Hyke GH Tamminga, Anouk GM Schrantee, Cheima Bouziane, Michiel B de Ruiter, Frits Boer, Henricus G Ruhé, Damiaan Denys, Roselyne Rijsman, Ramon JL Lindauer, Hans B Reitsma, Hilde M Geurts, Liesbeth Reneman

Published in: BMC Psychiatry | Issue 1/2014

Abstract

Background

Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans.

Methods/Design

Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques. In addition, we set up two double-blind placebo controlled clinical trials with MPH in 50 boys (10–12 years) and 50 young men (23–40 years) suffering from ADHD (ePOD-MPH) and with FLX in 40 girls (12–14 years) and 40 young women (23–40 years) suffering from depression and anxiety disorders (ePOD-SSRI). Trial registration numbers are: Nederlands Trial Register NTR3103 and NTR2111. A cross-sectional cohort study on age-related effects of these psychotropic medications in patients who have been treated previously with MPH or FLX (ePOD-Pharmo) is also ongoing. The effects of psychotropic drugs on the developing brain are studied using neuroimaging techniques together with neuropsychological and psychiatric assessments of cognition, behavior and emotion. All assessments take place before, during (only in case of MPH) and after chronic treatment.

Discussion

The combined results of these approaches will provide new insight into the modulating effect of MPH and FLX on brain development.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/14/48/prepub

Title: The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design
Authors: Marco A Bottelier
Marieke LJ Schouw
Anne Klomp
Hyke GH Tamminga
Anouk GM Schrantee
Cheima Bouziane
Michiel B de Ruiter
Frits Boer
Henricus G Ruhé
Damiaan Denys
Roselyne Rijsman
Ramon JL Lindauer
Hans B Reitsma
Hilde M Geurts
Liesbeth Reneman
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/1471-244X-14-48

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design

Abstract

Background

Methods/Design

Discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods/Design

Discussion

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