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Open Access 01-12-2014 | Correspondence

Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression

Authors: Terrie E Moffitt, Avshalom Caspi

Published in: BMC Psychiatry | Issue 1/2014

Excerpt

We are delighted to see pre-study publication in BMC Psychiatry[1] of the research design and plans for meta-analysis of the literature on the interaction between serotonin transporter genotype and life stress, predicting depression [2]. However, we recommend two changes: dropping “Primary Analysis Plan 2” and including studies in the meta-analysis with sample sizes under 300 participants. In mid-2012 we wrote to the group of researchers involved in the meta-analysis, expressing these two concerns with the plan. Because these concerns have not been adequately addressed in the published protocol, we submit this correspondence. …

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-244X/14/179/prepub

Title: Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression
Authors: Terrie E Moffitt
Avshalom Caspi
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/1471-244X-14-179

At a glance: The STEP trials

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Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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