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BMC Psychiatry
Published in: BMC Psychiatry 1/2014

Open Access 01-12-2014 | Study protocol

Study protocol: the Whitehall II imaging sub-study

Authors: Nicola Filippini, Enikő Zsoldos, Rita Haapakoski, Claire E Sexton, Abda Mahmood, Charlotte L Allan, Anya Topiwala, Vyara Valkanova, Eric J Brunner, Martin J Shipley, Edward Auerbach, Steen Moeller, Kâmil Uğurbil, Junqian Xu, Essa Yacoub, Jesper Andersson, Janine Bijsterbosch, Stuart Clare, Ludovica Griffanti, Aaron T Hess, Mark Jenkinson, Karla L Miller, Gholamreza Salimi-Khorshidi, Stamatios N Sotiropoulos, Natalie L Voets, Stephen M Smith, John R Geddes, Archana Singh-Manoux, Clare E Mackay, Mika Kivimäki, Klaus P Ebmeier

Published in: BMC Psychiatry | Issue 1/2014

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Abstract

Background

The Whitehall II (WHII) study of British civil servants provides a unique source of longitudinal data to investigate key factors hypothesized to affect brain health and cognitive ageing. This paper introduces the multi-modal magnetic resonance imaging (MRI) protocol and cognitive assessment designed to investigate brain health in a random sample of 800 members of the WHII study.

Methods/design

A total of 6035 civil servants participated in the WHII Phase 11 clinical examination in 2012–2013. A random sample of these participants was included in a sub-study comprising an MRI brain scan, a detailed clinical and cognitive assessment, and collection of blood and buccal mucosal samples for the characterisation of immune function and associated measures. Data collection for this sub-study started in 2012 and will be completed by 2016. The participants, for whom social and health records have been collected since 1985, were between 60–85 years of age at the time the MRI study started. Here, we describe the pre-specified clinical and cognitive assessment protocols, the state-of-the-art MRI sequences and latest pipelines for analyses of this sub-study.

Discussion

The integration of cutting-edge MRI techniques, clinical and cognitive tests in combination with retrospective data on social, behavioural and biological variables during the preceding 25 years from a well-established longitudinal epidemiological study (WHII cohort) will provide a unique opportunity to examine brain structure and function in relation to age-related diseases and the modifiable and non-modifiable factors affecting resilience against and vulnerability to adverse brain changes.
Appendix
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Metadata
Title
Study protocol: the Whitehall II imaging sub-study
Authors
Nicola Filippini
Enikő Zsoldos
Rita Haapakoski
Claire E Sexton
Abda Mahmood
Charlotte L Allan
Anya Topiwala
Vyara Valkanova
Eric J Brunner
Martin J Shipley
Edward Auerbach
Steen Moeller
Kâmil Uğurbil
Junqian Xu
Essa Yacoub
Jesper Andersson
Janine Bijsterbosch
Stuart Clare
Ludovica Griffanti
Aaron T Hess
Mark Jenkinson
Karla L Miller
Gholamreza Salimi-Khorshidi
Stamatios N Sotiropoulos
Natalie L Voets
Stephen M Smith
John R Geddes
Archana Singh-Manoux
Clare E Mackay
Mika Kivimäki
Klaus P Ebmeier
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Psychiatry / Issue 1/2014
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-14-159

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