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BMC Psychiatry
Published in: BMC Psychiatry 1/2011

Open Access 01-12-2011 | Research article

The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits

Published in: BMC Psychiatry | Issue 1/2011

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Abstract

Background

A genetic liability for anxiety-related personality traits in healthy subjects has been associated with the functional serotonin transporter promoter polymorphism (5-HTTLPR), although the data are somewhat conflicting. Moreover, only one study has investigated the functional significance of the 5-HTTLPR/rs25531 haplotypes in relation to anxiety traits in healthy subjects. We tested whether the 5-HTTLPR polymorphism and the 5-HTTLPR/rs25531 haplotypes are linked to Harm Avoidance (HA) using an association study (STUDY I) and a meta-analytic approach (STUDY II).

Methods

STUDY I: A total of 287 unrelated Italian volunteers were screened for DSM-IV Axis I disorders and genotyped for the 5-HTTLPR and rs25531 (A/G) polymorphisms. Different functional haplotype combinations were also analyzed. STUDY II: A total of 44 studies were chosen for a meta-analysis of the putative association between 5-HTTLPR and anxiety-related personality traits.

Results

STUDY I: In the whole sample of 287 volunteers, we found that the SS genotype and S'S' haplotypes were associated with higher scores on HA. However, because the screening assessed by Mini-International Neuropsychiatric Interview (M.I.N.I.) showed the presence of 55 volunteers affected by depression or anxiety disorders, we analyzed the two groups ("disordered" and "healthy") separately. The data obtained did indeed confirm that in the "healthy" group, the significant effects of the SS genotype and S'S' haplotypes were lost, but they remained in the "disordered" group. STUDY II: The results of the 5-HTTLPR meta-analysis with anxiety-related traits in the whole sample confirmed the association of the SS genotype with higher anxiety-related traits scores in Caucasoids; however, when we analyzed only those studies that used structured psychiatric screening, no association was found.

Conclusions

This study demonstrates the relevance to perform analyses on personality traits only in DSM-IV axis I disorder-free subjects. Furthermore, we did not find an association between functional serotonin transporter gene polymorphisms and anxiety traits in healthy subjects screened through a structured psychiatric interview.
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Literature
1.
Bouchard TJ, Loehlin JC: Genes, evolution, and personality. Behav Genet. 2001, 31 (3): 243-273. 10.1023/A:1012294324713.CrossRefPubMed
2.
Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP: Allelic variation of human serotonin transporter gene expression. J Neurochem. 1996, 66 (6): 2621-2624. 10.1046/j.1471-4159.1996.66062621.x.CrossRefPubMed
3.
Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL: Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996, 274 (5292): 1527-1531. 10.1126/science.274.5292.1527.CrossRefPubMed
4.
Hu XZ, Lipsky RH, Zhu G, Akhtar LA, Taubman J, Greenberg BD, Xu K, Arnold PD, Richter MA, Kennedy JL, et al: Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet. 2006, 78 (5): 815-826. 10.1086/503850.CrossRefPubMedPubMedCentral
5.
Zandi PP, Judy JT: The promise and reality of pharmacogenetics in psychiatry. Clin Lab Med. 30 (4): 931-974. 10.1016/j.cll.2010.07.004.
6.
Serretti A, Kato M, De Ronchi D, Kinoshita T: Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients. Mol Psychiatry. 2007, 12 (3): 247-257.PubMed
7.
Horstmann S, Binder EB: Pharmacogenomics of antidepressant drugs. Pharmacol Ther. 2009, 124 (1): 57-73. 10.1016/j.pharmthera.2009.06.007.CrossRefPubMed
8.
Bonvicini C, Minelli A, Scassellati C, Bortolomasi M, Segala M, Sartori R, Giacopuzzi M, Gennarelli M: Serotonin transporter gene polymorphisms and treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry. 34 (6): 934-939. 10.1016/j.pnpbp.2010.04.020.
9.
Uher R, McGuffin P: The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry. 15 (1): 18-22. 10.1038/mp.2009.123.
10.
Wankerl M, Wust S, Otte C: Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression?. Curr Opin Psychiatry. 23 (6): 582-587. 10.1097/YCO.0b013e32833f0e3a.
11.
Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE: Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. 167 (5): 509-527. 10.1176/appi.ajp.2010.09101452.
12.
Lipsky RH, Hu XZ, Goldman D: Additional functional variation at the SLC6A4 gene. Am J Med Genet B Neuropsychiatr Genet. 2009, 150B (1): 153-10.1002/ajmg.b.30766.CrossRefPubMedPubMedCentral
13.
Wendland JR, Moya PR, Kruse MR, Ren-Patterson RF, Jensen CL, Timpano KR, Murphy DL: A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet. 2008, 17 (5): 717-723. 10.1093/hmg/ddm343.CrossRefPubMed
14.
Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S: Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry. 2007, 12 (5): 421-422. 10.1038/sj.mp.4001952.CrossRefPubMed
15.
Costa PT, McCrae RR: Revised NEO personality inventory (NEO-PI-R) and NEO five-factor inventory (NEO-FFI) professional manual. 1992, Odessa, FL: Psychological Assessment Resources
16.
Cloninger CR, Svrakic DM, Przybeck TR: A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993, 50 (12): 975-990.CrossRefPubMed
17.
Zuckerman M, Cloninger CR: Relationships between Cloninger's, Zuckerman's, and Eysenck's dimension of personality. Pers Individ Differ. 1996, 21 (2): 283-285. 10.1016/0191-8869(96)00042-6.CrossRef
18.
Sher KJ, Bartholow BD, Wood MD: Personality and substance use disorders: a prospective study. J Consult Clin Psychol. 2000, 68 (5): 818-829. 10.1037/0022-006X.68.5.818.CrossRefPubMed
19.
De Fruyt F, De Clercq BJ, van de Wiele L, Van Heeringen K: The validity of Cloninger's psychobiological model versus the five-factor model to predict DSM-IV personality disorders in a heterogeneous psychiatric sample: domain facet and residualized facet descriptions. J Pers. 2006, 74 (2): 479-510. 10.1111/j.1467-6494.2006.00382.x.CrossRefPubMed
20.
Munafo MR, Clark TG, Moore LR, Payne E, Walton R, Flint J: Genetic polymorphisms and personality in healthy adults: a systematic review and meta-analysis. Mol Psychiatry. 2003, 8 (5): 471-484. 10.1038/sj.mp.4001326.CrossRefPubMed
21.
Munafo MR, Clark T, Flint J: Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis. Mol Psychiatry. 2005, 10 (4): 415-419. 10.1038/sj.mp.4001627.CrossRefPubMed
22.
Munafo MR, Freimer NB, Ng W, Ophoff R, Veijola J, Miettunen J, Jarvelin MR, Taanila A, Flint J: 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet B Neuropsychiatr Genet. 2009, 150B (2): 271-281. 10.1002/ajmg.b.30808.CrossRefPubMedPubMedCentral
23.
Schinka JA, Busch RM, Robichaux-Keene N: A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry. 2004, 9 (2): 197-202. 10.1038/sj.mp.4001405.CrossRefPubMed
24.
Sen S, Burmeister M, Ghosh D: Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am J Med Genet B Neuropsychiatr Genet. 2004, 127B (1): 85-89. 10.1002/ajmg.b.20158.CrossRefPubMed
25.
Smith DJ, Duffy L, Stewart ME, Muir WJ, Blackwood DH: High harm avoidance and low self-directedness in euthymic young adults with recurrent, early-onset depression. J Affect Disord. 2005, 87 (1): 83-89. 10.1016/j.jad.2005.03.014.CrossRefPubMed
26.
Matsudaira T, Kitamura T: Personality traits as risk factors of depression and anxiety among Japanese students. J Clin Psychol. 2006, 62 (1): 97-109. 10.1002/jclp.20215.CrossRefPubMed
27.
Jylha P, Isometsa E: Temperament, character and symptoms of anxiety and depression in the general population. Eur Psychiatry. 2006, 21 (6): 389-395. 10.1016/j.eurpsy.2005.09.003.CrossRefPubMed
28.
de Winter RF, Wolterbeek R, Spinhoven P, Zitman FG, Goekoop JG: Character and temperament in major depressive disorder and a highly anxious-retarded subtype derived from melancholia. Compr Psychiatry. 2007, 48 (5): 426-435. 10.1016/j.comppsych.2007.04.002.CrossRefPubMed
29.
Holsboer F: How can we realize the promise of personalized antidepressant medicines?. Nat Rev Neurosci. 2008, 9 (8): 638-646. 10.1038/nrn2453.CrossRefPubMed
30.
Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC: The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998, 59 (Suppl 20): 22-33. quiz 34-57PubMed
31.
Martinotti G, Mandelli L, Di Nicola M, Serretti A, Fossati A, Borroni S, Cloninger CR, Janiri L: Psychometric characteristic of the Italian version of the Temperament and Character Inventory--revised, personality, psychopathology, and attachment styles. Compr Psychiatry. 2008, 49 (5): 514-522. 10.1016/j.comppsych.2007.11.002.CrossRefPubMed
32.
Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975, 12 (3): 189-198. 10.1016/0022-3956(75)90026-6.CrossRefPubMed
33.
Hirano S, Sato T, Narita T, Kusunoki K, Ozaki N, Kimura S, Takahashi T, Sakado K, Uehara T: Evaluating the state dependency of the Temperament and Character Inventory dimensions in patients with major depression: a methodological contribution. J Affect Disord. 2002, 69 (1-3): 31-38. 10.1016/S0165-0327(00)00329-3.CrossRefPubMed
34.
Marijnissen G, Tuinier S, Sijben AE, Verhoeven WM: The temperament and character inventory in major depression. J Affect Disord. 2002, 70 (2): 219-223. 10.1016/S0165-0327(01)00364-0.CrossRefPubMed
35.
Farmer A, Mahmood A, Redman K, Harris T, Sadler S, McGuffin P: A sib-pair study of the Temperament and Character Inventory scales in major depression. Arch Gen Psychiatry. 2003, 60 (5): 490-496. 10.1001/archpsyc.60.5.490.CrossRefPubMed
36.
Abrams KY, Yune SK, Kim SJ, Jeon HJ, Han SJ, Hwang J, Sung YH, Lee KJ, Lyoo IK: Trait and state aspects of harm avoidance and its implication for treatment in major depressive disorder, dysthymic disorder, and depressive personality disorder. Psychiatry Clin Neurosci. 2004, 58 (3): 240-248. 10.1111/j.1440-1819.2004.01226.x.CrossRefPubMed
37.
Strobel A, Brocke B, Ebstein RP: Interektionseffekte monoaminrelevanter genetischer polymorphismen mit traits des TPQ [Interaction effects of monoamine-relevant genetic polymorphisms with traits of the TPQ]. Z Different Diagnost Psychol. 2000, 21: 194-199.CrossRef
38.
39.
DerSimonian R, Laird N: Meta-analysis in clinical trials. Control Clin Trials. 1986, 7 (3): 177-188. 10.1016/0197-2456(86)90046-2.CrossRefPubMed
40.
Ebstein RP, Gritsenko I, Nemanov L, Frisch A, Osher Y, Belmaker RH: No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance. Mol Psychiatry. 1997, 2 (3): 224-226. 10.1038/sj.mp.4000275.CrossRefPubMed
41.
Nakamura T, Muramatsu T, Ono Y, Matsushita S, Higuchi S, Mizushima H, Yoshimura K, Kanba S, Asai M: Serotonin transporter gene regulatory region polymorphism and anxiety-related traits in the Japanese. Am J Med Genet. 1997, 74 (5): 544-545. 10.1002/(SICI)1096-8628(19970919)74:5<544::AID-AJMG18>3.0.CO;2-C.CrossRefPubMed
42.
Mazzanti CM, Lappalainen J, Long JC, Bengel D, Naukkarinen H, Eggert M, Virkkunen M, Linnoila M, Goldman D: Role of the serotonin transporter promoter polymorphism in anxiety-related traits. Arch Gen Psychiatry. 1998, 55 (10): 936-940. 10.1001/archpsyc.55.10.936.CrossRefPubMed
43.
Monteleone P, Santonastaso P, Mauri M, Bellodi L, Erzegovesi S, Fuschino A, Favaro A, Rotondo A, Castaldo E, Maj M: Investigation of the serotonin transporter regulatory region polymorphism in bulimia nervosa: relationships to harm avoidance, nutritional parameters, and psychiatric comorbidity. Psychosom Med. 2006, 68 (1): 99-103. 10.1097/01.psy.0000195746.52074.63.CrossRefPubMed
44.
Ricketts MH, Hamer RM, Sage JI, Manowitz P, Feng F, Menza MA: Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population. Psychiatr Genet. 1998, 8 (2): 41-44. 10.1097/00041444-199800820-00001.CrossRefPubMed
45.
Flory JD, Manuck SB, Ferrell RE, Dent KM, Peters DG, Muldoon MF: Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism. Mol Psychiatry. 1999, 4 (1): 93-96. 10.1038/sj.mp.4000466.CrossRefPubMed
46.
Hamer DH, Greenberg BD, Sabol SZ, Murphy DL: Role of the serotonin transporter gene in temperament and character. J Pers Disord. 1999, 13 (4): 312-327.CrossRefPubMed
47.
Katsuragi S, Kunugi H, Sano A, Tsutsumi T, Isogawa K, Nanko S, Akiyoshi J: Association between serotonin transporter gene polymorphism and anxiety-related traits. Biol Psychiatry. 1999, 45 (3): 368-370. 10.1016/S0006-3223(98)00090-0.CrossRefPubMed
48.
Kazantseva AV, Gaysina DA, Faskhutdinova GG, Noskova T, Malykh SB, Khusnutdinova EK: Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia. Psychiatr Genet. 2008, 18 (4): 167-176. 10.1097/YPG.0b013e328304deb8.CrossRefPubMed
49.
Kumakiri C, Kodama K, Shimizu E, Yamanouchi N, Okada S, Noda S, Okamoto H, Sato T, Shirasawa H: Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population. Neurosci Lett. 1999, 263 (2-3): 205-207. 10.1016/S0304-3940(99)00098-1.CrossRefPubMed
50.
Benjamin J, Osher Y, Kotler M, Gritsenko I, Nemanov L, Belmaker RH, Ebstein RP: Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT). Mol Psychiatry. 2000, 5 (1): 96-100. 10.1038/sj.mp.4000640.CrossRefPubMed
51.
Du L, Bakish D, Hrdina PD: Gender differences in association between serotonin transporter gene polymorphism and personality traits. Psychiatr Genet. 2000, 10 (4): 159-164. 10.1097/00041444-200010040-00002.CrossRefPubMed
52.
Greenberg BD, Li Q, Lucas FR, Hu S, Sirota LA, Benjamin J, Lesch KP, Hamer D, Murphy DL: Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am J Med Genet. 2000, 96 (2): 202-216. 10.1002/(SICI)1096-8628(20000403)96:2<202::AID-AJMG16>3.0.CO;2-J.CrossRefPubMed
53.
Herbst JH, Zonderman AB, McCrae RR, Costa PT: Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. Am J Psychiatry. 2000, 157 (8): 1285-1290. 10.1176/appi.ajp.157.8.1285.CrossRefPubMed
54.
Hu S, Brody CL, Fisher C, Gunzerath L, Nelson ML, Sabol SZ, Sirota LA, Marcus SE, Greenberg BD, Murphy DL, et al: Interaction between the serotonin transporter gene and neuroticism in cigarette smoking behavior. Mol Psychiatry. 2000, 5 (2): 181-188. 10.1038/sj.mp.4000690.CrossRefPubMed
55.
Osher Y, Hamer D, Benjamin J: Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Mol Psychiatry. 2000, 5 (2): 216-219. 10.1038/sj.mp.4000660.CrossRefPubMed
56.
Schmidt NB, Storey J, Greenberg BD, Santiago HT, Li Q, Murphy DL: Evaluating gene × psychological risk factor effects in the pathogenesis of anxiety: a new model approach. J Abnorm Psychol. 2000, 109 (2): 308-320. 10.1037/0021-843X.109.2.308.CrossRefPubMed
57.
Samochowiec J, Rybakowski F, Czerski P, Zakrzewska M, Stepien G, Pelka-Wysiecka J, Horodnicki J, Rybakowski JK, Hauser J: Polymorphisms in the dopamine, serotonin, and norepinephrine transporter genes and their relationship to temperamental dimensions measured by the Temperament and Character Inventory in healthy volunteers. Neuropsychobiology. 2001, 43 (4): 248-253. 10.1159/000054898.CrossRefPubMed
58.
Tsai SJ, Hong CJ, Cheng CY: Serotonin transporter genetic polymorphisms and harm avoidance in the Chinese. Psychiatr Genet. 2002, 12 (3): 165-168. 10.1097/00041444-200209000-00008.CrossRefPubMed
59.
Samochowiec J, Syrek S, Michal P, Ryzewska-Wodecka A, Samochowiec A, Horodnicki J, Zakrzewska M, Kucharska-Mazur J: Polymorphisms in the serotonin transporter and monoamine oxidase A genes and their relationship to personality traits measured by the Temperament and Character Inventory and NEO Five-Factor Inventory in healthy volunteers. Neuropsychobiology. 2004, 50 (2): 174-181. 10.1159/000079111.CrossRefPubMed
60.
Sen S, Villafuerte S, Nesse R, Stoltenberg SF, Hopcian J, Gleiberman L, Weder A, Burmeister M: Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biol Psychiatry. 2004, 55 (3): 244-249. 10.1016/j.biopsych.2003.08.006.CrossRefPubMed
61.
Szekely A, Ronai Z, Nemoda Z, Kolmann G, Gervai J, Sasvari-Szekely M: Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet B Neuropsychiatr Genet. 2004, 126B (1): 106-110. 10.1002/ajmg.b.20134.CrossRefPubMed
62.
Thierry N, Willeit M, Praschak-Rieder N, Zill P, Hornik K, Neumeister A, Lenzinger E, Stastny J, Hilger E, Konstantinidis A, et al: Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls. Eur Neuropsychopharmacol. 2004, 14 (1): 53-58. 10.1016/S0924-977X(03)00064-6.CrossRefPubMed
63.
Park JW, Kim JS, Lee HK, Kim YI, Lee KS: Serotonin transporter polymorphism and harm avoidance personality in chronic tension-type headache. Headache. 2004, 44 (10): 1005-1009. 10.1111/j.1526-4610.2004.04194.x.CrossRefPubMed
64.
Umekage T, Tochigi M, Marui T, Kato C, Hibino H, Otani T, Kohda K, Kato N, Sasaki T: Serotonin transporter-linked promoter region polymorphism and personality traits in a Japanese population. Neurosci Lett. 2003, 337 (1): 13-16. 10.1016/S0304-3940(02)01291-0.CrossRefPubMed
65.
Lanzagorta N, Alexanderson-Rosas E, Ricalde A, Gomez Caudillo L, Sosa A, Camarena B, Aguilar A, Fresan A, Apiquian R, Nicolini H: [Effect to the serotonin transporter gene (5-HTT) on personality dimensions in individuals without psychopathology]. Actas Esp Psiquiatr. 2006, 34 (5): 303-308.PubMed
66.
Lang UE, Bajbouj M, Wernicke C, Rommelspacher H, Danker-Hopfe H, Gallinat J: No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits. Neuropsychobiology. 2004, 49 (4): 182-184. 10.1159/000077363.CrossRefPubMed
67.
Kim SJ, Kim YS, Choi NK, Hong HJ, Lee HS, Kim CH: Serotonin transporter gene polymorphism and personality traits in a Korean population. Neuropsychobiology. 2005, 51 (4): 243-247. 10.1159/000085819.CrossRefPubMed
68.
Kremer I, Bachner-Melman R, Reshef A, Broude L, Nemanov L, Gritsenko I, Heresco-Levy U, Elizur Y, Ebstein RP: Association of the serotonin transporter gene with smoking behavior. Am J Psychiatry. 2005, 162 (5): 924-930. 10.1176/appi.ajp.162.5.924.CrossRefPubMed
69.
Jacob CP, Strobel A, Hohenberger K, Ringel T, Gutknecht L, Reif A, Brocke B, Lesch KP: Association between allelic variation of serotonin transporter function and neuroticism in anxious cluster C personality disorders. Am J Psychiatry. 2004, 161 (3): 569-572. 10.1176/appi.ajp.161.3.569.CrossRefPubMed
70.
Ham BJ, Kim YH, Choi MJ, Cha JH, Choi YK, Lee MS: Serotonergic genes and personality traits in the Korean population. Neurosci Lett. 2004, 354 (1): 2-5. 10.1016/S0304-3940(03)00753-5.CrossRefPubMed
71.
Hariri AR, Drabant EM, Munoz KE, Kolachana BS, Mattay VS, Egan MF, Weinberger DR: A susceptibility gene for affective disorders and the response of the human amygdala. Arch Gen Psychiatry. 2005, 62 (2): 146-152. 10.1001/archpsyc.62.2.146.CrossRefPubMed
72.
Dragan WL, Oniszczenko W: Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population. Neuropsychobiology. 2006, 54 (1): 45-50. 10.1159/000095741.CrossRefPubMed
73.
Brummett BH, Siegler IC, McQuoid DR, Svenson IK, Marchuk DA, Steffens DC: Associations among the NEO Personality Inventory, Revised and the serotonin transporter gene-linked polymorphic region in elders: effects of depression and gender. Psychiatr Genet. 2003, 13 (1): 13-18. 10.1097/00041444-200303000-00002.CrossRefPubMed
74.
Cohen H, Buskila D, Neumann L, Ebstein RP: Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5-HTTLPR) polymorphism, and relationship to anxiety-related personality traits. Arthritis Rheum. 2002, 46 (3): 845-847. 10.1002/art.10103.CrossRefPubMed
75.
Gonda X, Fountoulakis KN, Juhasz G, Rihmer Z, Lazary J, Laszik A, Akiskal HS, Bagdy G: Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population. Eur Arch Psychiatry Clin Neurosci. 2009, 259 (2): 106-113. 10.1007/s00406-008-0842-7.CrossRefPubMed
76.
Lee YS, Han DH, Yang KC, Daniels MA, Na C, Kee BS, Renshaw PF: Depression like characteristics of 5HTTLPR polymorphism and temperament in excessive internet users. J Affect Disord. 2008, 109 (1-2): 165-169. 10.1016/j.jad.2007.10.020.CrossRefPubMed
77.
Joo YH, Oh HB, Kim B, Jung SH, Chung JK, Hong JP, Kim CY: No association between 5-HTTLPR and harm avoidance in Korean college students. J Korean Med Sci. 2007, 22 (1): 138-141. 10.3346/jkms.2007.22.1.138.CrossRefPubMedPubMedCentral
78.
Hunnerkopf R, Strobel A, Gutknecht L, Brocke B, Lesch KP: Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharmacology. 2007, 32 (12): 2552-2560. 10.1038/sj.npp.1301383.CrossRefPubMed
79.
Nilsson KW, Damberg M, Ohrvik J, Leppert J, Lindstrom L, Anckarsater H, Oreland L: Genes encoding for AP-2beta and the Serotonin Transporter are associated with the Personality Character Spiritual Acceptance. Neurosci Lett. 2007, 411 (3): 233-237. 10.1016/j.neulet.2006.10.051.CrossRefPubMed
80.
Serretti A, Mandelli L, Lorenzi C, Landoni S, Calati R, Insacco C, Cloninger CR: Temperament and character in mood disorders: influence of DRD4, SERTPR, TPH and MAO-A polymorphisms. Neuropsychobiology. 2006, 53 (1): 9-16. 10.1159/000089916.CrossRefPubMed
81.
Stein MB, Schork NJ, Gelernter J: Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology. 2008, 33 (2): 312-319. 10.1038/sj.npp.1301422.CrossRefPubMed
82.
Suzuki A, Matsumoto Y, Oshino S, Kamata M, Goto K, Otani K: Combination of the serotonin transporter and norepinephrine transporter gene promoter polymorphisms might influence harm avoidance and novelty seeking in healthy females. Neurosci Lett. 2008, 439 (1): 52-55. 10.1016/j.neulet.2008.04.088.CrossRefPubMed
83.
Terracciano A, Balaci L, Thayer J, Scally M, Kokinos S, Ferrucci L, Tanaka T, Zonderman AB, Sanna S, Olla N, et al: Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Am J Med Genet B Neuropsychiatr Genet. 2009
84.
Vormfelde SV, Hoell I, Tzvetkov M, Jamrozinski K, Sehrt D, Brockmoller J, Leibing E: Anxiety- and novelty seeking-related personality traits and serotonin transporter gene polymorphisms. J Psychiatr Res. 2006, 40 (6): 568-576. 10.1016/j.jpsychires.2005.10.002.CrossRefPubMed
85.
Schmitz A, Hennig J, Kuepper Y, Reuter M: The association between neuroticism and the serotonin tranporter polymorphism depends on structural differences between personality measures. Pers Individ Differ. 2007, 42 (4): 789-799. 10.1016/j.paid.2006.08.023.CrossRef
86.
Bachner-Melman R, Dina C, Zohar AH, Constantini N, Lerer E, Hoch S, Sella S, Nemanov L, Gritsenko I, Lichtenberg P, et al: AVPR1a and SLC6A4 gene polymorphisms are associated with creative dance performance. PLoS Genet. 2005, 1 (3): e42-10.1371/journal.pgen.0010042.CrossRefPubMedPubMedCentral
87.
Comings DE, Gade-Andavolu R, Gonzalez N, Wu S, Muhleman D, Blake H, Mann MB, Dietz G, Saucier G, MacMurray JP: A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory. Clin Genet. 2000, 58 (5): 375-385. 10.1034/j.1399-0004.2000.580508.x.CrossRefPubMed
88.
Saiz PA, Garcia-Portilla MP, Herrero R, Arango C, Corcoran P, Morales B, Bascaran MT, Alvarez V, Coto E, Paredes B, et al: Interactions between functional serotonergic polymorphisms and demographic factors influence personality traits in healthy Spanish Caucasians. Psychiatr Genet.
89.
Minelli A, Pedrini L, Magni LR, Rotondo A: Personality traits in an italian sample: relationship with anxiety and depression. Clin Pract Epidemiol Ment Health. 2009, 5: 26-30. 10.2174/1745017900905010026.CrossRefPubMedPubMedCentral
90.
Goldman N, Glei DA, Lin YH, Weinstein M: The serotonin transporter polymorphism (5-HTTLPR): allelic variation and links with depressive symptoms. Depress Anxiety. 27 (3): 260-269. 10.1002/da.20660.
Metadata
Title
The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits
Publication date
01-12-2011
Published in
BMC Psychiatry / Issue 1/2011
Electronic ISSN: 1471-244X
DOI
https://doi.org/10.1186/1471-244X-11-50

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