Skip to main content
Top
Published in: BMC Pediatrics 1/2014

Open Access 01-12-2014 | Case report

Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent

Authors: Maria Koliou, Evaggelia Karaoli, Elpidoforos S Soteriades, Sylvie Pavlides, Stavros Bashiardes, Christina Christodoulou

Published in: BMC Pediatrics | Issue 1/2014

Login to get access

Abstract

Background

Erythema infectiosum is the most common clinical manifestation of Parvovirus B19 infection although it has also been associated with rheumatologic diseases and various types of systemic vasculitides. Acute hepatitis and benign myositis however are rarely reported in association with Parvovirus B19 infection.

Case presentation

Here we report a 14-year old male, who developed acute hepatitis and benign myositis associated with erythema infectiosum following Parvovirus B19 infection.

Conclusion

Parvovirus B19 infection has rarely been associated with acute hepatitis and exceptionally rarely with benign myositis. Parvovirus B19 should be considered in the differential diagnosis of acute non-A to E hepatitis and in the case of acute benign myositis presenting with a rash especially in children.
Literature
1.
2.
go back to reference Anderson MJ, Higgins PG, Davis LR, Willman JS, Jones SE, Kidd IM, Pattison JR, Tyrrell DA: Experimental parvoviral infection in humans. J Infect Dis. 1985, 152: 257-265. 10.1093/infdis/152.2.257.CrossRefPubMed Anderson MJ, Higgins PG, Davis LR, Willman JS, Jones SE, Kidd IM, Pattison JR, Tyrrell DA: Experimental parvoviral infection in humans. J Infect Dis. 1985, 152: 257-265. 10.1093/infdis/152.2.257.CrossRefPubMed
3.
go back to reference Broliden K, Tolfvenstam T, Norbeck O: Clinical aspects of parvovirus B19 infection. J Intern Med. 2006, 260: 285-304. 10.1111/j.1365-2796.2006.01697.x.CrossRefPubMed Broliden K, Tolfvenstam T, Norbeck O: Clinical aspects of parvovirus B19 infection. J Intern Med. 2006, 260: 285-304. 10.1111/j.1365-2796.2006.01697.x.CrossRefPubMed
4.
go back to reference Hatakka A, Klein J, He R, Piper J, Tam E, Walkty A: Acute hepatitis as a manifestation of parvovirus B19 infection. J Clin Microbiol. 2011, 49: 3422-3424. 10.1128/JCM.00575-11.CrossRefPubMedPubMedCentral Hatakka A, Klein J, He R, Piper J, Tam E, Walkty A: Acute hepatitis as a manifestation of parvovirus B19 infection. J Clin Microbiol. 2011, 49: 3422-3424. 10.1128/JCM.00575-11.CrossRefPubMedPubMedCentral
5.
go back to reference Pinho JR, Alves VA, Vieira AF, Moralez MO, Fonseca LE, Guz B, Wakamatsu A, Cançado EL, Carrilho FJ, da Silva LC, Bernardini AP, Durigon EL: Detection of human parvovirus B19 in a patient with hepatitis. Detection of human parvovirus B19 in a patient with hepatitis. Braz J Med Biol Res. 2001, 34: 1131-1138.CrossRefPubMed Pinho JR, Alves VA, Vieira AF, Moralez MO, Fonseca LE, Guz B, Wakamatsu A, Cançado EL, Carrilho FJ, da Silva LC, Bernardini AP, Durigon EL: Detection of human parvovirus B19 in a patient with hepatitis. Detection of human parvovirus B19 in a patient with hepatitis. Braz J Med Biol Res. 2001, 34: 1131-1138.CrossRefPubMed
6.
go back to reference Pardi DS, Romero Y, Mertz LE, Douglas DD: Hepatitis-associated aplastic anemia and acute parvovirus B19 infection: a report of two cases and a review of the literature. Am J Gastroenterol. 1998, 93: 468-470.CrossRefPubMed Pardi DS, Romero Y, Mertz LE, Douglas DD: Hepatitis-associated aplastic anemia and acute parvovirus B19 infection: a report of two cases and a review of the literature. Am J Gastroenterol. 1998, 93: 468-470.CrossRefPubMed
7.
go back to reference Bousvaros A, Sundel R, Thorne GM, McIntosh K, Cohen M, Erdman DD, Perez-Atayde A, Finkel TH, Colin AA: Parvovirus B19-associated interstitial lung disease, hepatitis, and myositis. Pediatr Pulmonol. 1998, 26: 365-369. 10.1002/(SICI)1099-0496(199811)26:5<365::AID-PPUL11>3.0.CO;2-4.CrossRefPubMed Bousvaros A, Sundel R, Thorne GM, McIntosh K, Cohen M, Erdman DD, Perez-Atayde A, Finkel TH, Colin AA: Parvovirus B19-associated interstitial lung disease, hepatitis, and myositis. Pediatr Pulmonol. 1998, 26: 365-369. 10.1002/(SICI)1099-0496(199811)26:5<365::AID-PPUL11>3.0.CO;2-4.CrossRefPubMed
8.
go back to reference Kishore J, Singh J: Detection of parvovirus B19 in a case of erythema infectiosum with myositis. Indian Pediatr. 2006, 43: 814-817.PubMed Kishore J, Singh J: Detection of parvovirus B19 in a case of erythema infectiosum with myositis. Indian Pediatr. 2006, 43: 814-817.PubMed
9.
go back to reference Watzinger F, Suda M, Preuner S, Baumgartinger R, Ebner K, Baskova L, Niesters HGM, Lawitschka A, Lion T: Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients. J Clin Microbiol. 2004, 42: 5189-5198. 10.1128/JCM.42.11.5189-5198.2004.CrossRefPubMedPubMedCentral Watzinger F, Suda M, Preuner S, Baumgartinger R, Ebner K, Baskova L, Niesters HGM, Lawitschka A, Lion T: Real-time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients. J Clin Microbiol. 2004, 42: 5189-5198. 10.1128/JCM.42.11.5189-5198.2004.CrossRefPubMedPubMedCentral
10.
go back to reference Bihari C, Rastogi A, Rangegowda D, Chowdhury A, Saxena P, Garg H, Sarin SK: Parvovirus B19 associated acute hepatitis and hepatosplenomegaly. Clin Res Hepatol Gastroenterol. 2013, 10. [Epub ahead of print] Bihari C, Rastogi A, Rangegowda D, Chowdhury A, Saxena P, Garg H, Sarin SK: Parvovirus B19 associated acute hepatitis and hepatosplenomegaly. Clin Res Hepatol Gastroenterol. 2013, 10. [Epub ahead of print]
11.
go back to reference Etienne MS, Melchior M, Cornu C, Vandenbroucke AT, Buts JP, Cohen BJ, Burtonboy G: Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Lancet. 1998, 352: 1739-1741. 10.1016/S0140-6736(98)06165-0.CrossRef Etienne MS, Melchior M, Cornu C, Vandenbroucke AT, Buts JP, Cohen BJ, Burtonboy G: Acute parvovirus B19 infection associated with fulminant hepatitis of favourable prognosis in young children. Lancet. 1998, 352: 1739-1741. 10.1016/S0140-6736(98)06165-0.CrossRef
12.
go back to reference Wong S, Young NS, Brown KE: Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. J Infect Dis. 2003, 187: 1581-1586. 10.1086/374781.CrossRefPubMed Wong S, Young NS, Brown KE: Prevalence of parvovirus B19 in liver tissue: no association with fulminant hepatitis or hepatitis-associated aplastic anemia. J Infect Dis. 2003, 187: 1581-1586. 10.1086/374781.CrossRefPubMed
13.
14.
go back to reference Díaz F, Collazos J: Hepatic dysfunction due to parvovirus B19 infection. J Infect Chemother. 2000, 6: 63-64. 10.1007/s101560050052.CrossRefPubMed Díaz F, Collazos J: Hepatic dysfunction due to parvovirus B19 infection. J Infect Chemother. 2000, 6: 63-64. 10.1007/s101560050052.CrossRefPubMed
15.
go back to reference Brown KE, Anderson SM, Young NS: Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science. 1993, 262: 114-117. 10.1126/science.8211117.CrossRefPubMed Brown KE, Anderson SM, Young NS: Erythrocyte P antigen: cellular receptor for B19 parvovirus. Science. 1993, 262: 114-117. 10.1126/science.8211117.CrossRefPubMed
16.
go back to reference Rouger P, Gane P, Salmon C: Tissue distribution of H, Lewis and P antigens as shown by a panel of 18 monoclonal antibodies. Rev Fr Transfus Immunohematol. 1987, 30: 699-708. 10.1016/S0338-4535(87)80138-1.CrossRefPubMed Rouger P, Gane P, Salmon C: Tissue distribution of H, Lewis and P antigens as shown by a panel of 18 monoclonal antibodies. Rev Fr Transfus Immunohematol. 1987, 30: 699-708. 10.1016/S0338-4535(87)80138-1.CrossRefPubMed
17.
go back to reference Jordan JA, Butchko AR: Apoptotic activity in villous trophoblast cells during B19 infection correlates with clinical outcome: assessment by the caspase-related M30 Cytodeath antibody. Placenta. 2002, 23 (7): 547-553. 10.1053/plac.2002.0843.CrossRefPubMed Jordan JA, Butchko AR: Apoptotic activity in villous trophoblast cells during B19 infection correlates with clinical outcome: assessment by the caspase-related M30 Cytodeath antibody. Placenta. 2002, 23 (7): 547-553. 10.1053/plac.2002.0843.CrossRefPubMed
18.
go back to reference Ho JM, Juurlink DN: Considerations when prescribing trimethoprim-sulfamethoxazole. CMAJ. 2011, 183 (16): 1851-1858. 10.1503/cmaj.111152. doi: 10.1503/cmaj.111152. Epub 2011 Oct 11CrossRefPubMedPubMedCentral Ho JM, Juurlink DN: Considerations when prescribing trimethoprim-sulfamethoxazole. CMAJ. 2011, 183 (16): 1851-1858. 10.1503/cmaj.111152. doi: 10.1503/cmaj.111152. Epub 2011 Oct 11CrossRefPubMedPubMedCentral
19.
go back to reference Andrade RJ, Tulkens PM: Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother. 2011, 66 (7): 1431-1446. 10.1093/jac/dkr159. doi: 10.1093/jac/dkr159. Epub 2011 May 17CrossRefPubMedPubMedCentral Andrade RJ, Tulkens PM: Hepatic safety of antibiotics used in primary care. J Antimicrob Chemother. 2011, 66 (7): 1431-1446. 10.1093/jac/dkr159. doi: 10.1093/jac/dkr159. Epub 2011 May 17CrossRefPubMedPubMedCentral
20.
go back to reference Kouklakis G, Mpoumponaris A, Zezos P, Moschos J, Koulaouzidis A, Nakos A, Pehlivanidis A, Iosiphidis M, Molyvas E, Nikolaidis N: Cholestatic hepatitis with severe systemic reactions induced by trimethoprim-sulfamethoxazole. Ann Hepatol. 2007, 6 (1): 63-65.PubMed Kouklakis G, Mpoumponaris A, Zezos P, Moschos J, Koulaouzidis A, Nakos A, Pehlivanidis A, Iosiphidis M, Molyvas E, Nikolaidis N: Cholestatic hepatitis with severe systemic reactions induced by trimethoprim-sulfamethoxazole. Ann Hepatol. 2007, 6 (1): 63-65.PubMed
21.
go back to reference Kucers A, Crowe S, Grayson ML, Hoy J: The Use of Antibiotics. A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs. 1997, Oxford, UK: Butterworth-Heinemann, 5 Kucers A, Crowe S, Grayson ML, Hoy J: The Use of Antibiotics. A Clinical Review of Antibacterial, Antifungal and Antiviral Drugs. 1997, Oxford, UK: Butterworth-Heinemann, 5
22.
go back to reference Nocton JJ, Miller LC, Tucker LB, Schaller JG: Human parvovirus B19-associated arthritis in children. J Pediatr. 1993, 122: 186-190. 10.1016/S0022-3476(06)80111-3.CrossRefPubMed Nocton JJ, Miller LC, Tucker LB, Schaller JG: Human parvovirus B19-associated arthritis in children. J Pediatr. 1993, 122: 186-190. 10.1016/S0022-3476(06)80111-3.CrossRefPubMed
23.
go back to reference Oliver ND, Millar A, Pendleton A: A case report on parvovirus b19 associated myositis. Case Rep Rheumatol. 2012, 2012: 250537-doi: 10.1155/2012/250537. Epub 2012 Dec 10PubMedPubMedCentral Oliver ND, Millar A, Pendleton A: A case report on parvovirus b19 associated myositis. Case Rep Rheumatol. 2012, 2012: 250537-doi: 10.1155/2012/250537. Epub 2012 Dec 10PubMedPubMedCentral
24.
go back to reference Koliou M, Hadjiloizou S, Ourani S, Demosthenous A, Hadjidemetriou A: A case of benign acute childhood myositis associated with influenza A (H1N1) virus infection. Clin Microbiol Infect. 2010, 16: 193-195. 10.1111/j.1469-0691.2009.03064.x.CrossRefPubMed Koliou M, Hadjiloizou S, Ourani S, Demosthenous A, Hadjidemetriou A: A case of benign acute childhood myositis associated with influenza A (H1N1) virus infection. Clin Microbiol Infect. 2010, 16: 193-195. 10.1111/j.1469-0691.2009.03064.x.CrossRefPubMed
25.
go back to reference Davis LE, Kornfeld M: Experimental influenza B viral myositis. J Neurol Sci. 2001, 187: 61-67. 10.1016/S0022-510X(01)00526-3.CrossRefPubMed Davis LE, Kornfeld M: Experimental influenza B viral myositis. J Neurol Sci. 2001, 187: 61-67. 10.1016/S0022-510X(01)00526-3.CrossRefPubMed
26.
go back to reference Mackay MT, Kornberg AJ, Shield LK, Dennett X: Benign acute childhood myositis: laboratory and clinical features. Neurology. 1999, 53: 2127-2131. 10.1212/WNL.53.9.2127.CrossRefPubMed Mackay MT, Kornberg AJ, Shield LK, Dennett X: Benign acute childhood myositis: laboratory and clinical features. Neurology. 1999, 53: 2127-2131. 10.1212/WNL.53.9.2127.CrossRefPubMed
Metadata
Title
Acute hepatitis and myositis associated with Erythema infectiosum by Parvovirus B19 in an adolescent
Authors
Maria Koliou
Evaggelia Karaoli
Elpidoforos S Soteriades
Sylvie Pavlides
Stavros Bashiardes
Christina Christodoulou
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Pediatrics / Issue 1/2014
Electronic ISSN: 1471-2431
DOI
https://doi.org/10.1186/1471-2431-14-6

Other articles of this Issue 1/2014

BMC Pediatrics 1/2014 Go to the issue