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BMC Ophthalmology

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Open Access 01-12-2014 | Research article

A hyporeflective space between hyperreflective materials in pigment epithelial detachment and Bruch’s membrane in neovascular age-related macular degeneration

Authors: Ryo Mukai, Taku Sato, Shoji Kishi

Published in: BMC Ophthalmology | Issue 1/2014

Abstract

Background

The purpose of this study was to investigate the clinical characteristics of a hyporeflective space between hyperreflective materials in pigment epithelial detachment (PED) and Bruch’s membrane in neovascular age-related macular degeneration (AMD) using spectral-domain optical coherence tomography (SD-OCT) or swept source optical coherence tomography (SS-OCT).

Methods

Among 223 patients with neovascular AMD, 227 eyes were studied retrospectively. Using SD-OCT or SS-OCT, we reviewed clinical characteristics of the space.

Results

Twenty-two (10%) of the 227 eyes showed a space between hyperreflective materials in PED and Bruch’s membrane. In all spaces, fibrovascular changes of the choroidal neovascularization (CNV) membrane were seen on funduscopy, with OCT images showing the retinal pigment epithelium (RPE) above the space adhering tightly and continuously to the CNV membranes. Nineteen (86%) of the 22 eyes with this cleft also had serous retinal detachment or cystoid macular edema. Five eyes (23%) had an RPE tear during follow-up.

Conclusions

A hyporeflective space between hyperreflective materials in PED and Bruch’s membrane sometimes appears in neovascular AMD. The appearance of such a space may indicate residual activities of the hyperreflective materials.

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Friedman DS, O’Colmain BJ, Munoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J, Eye Diseases Prevalence Research G: Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004, 122 (4): 564-572.CrossRefPubMed

Yasuda M, Kiyohara Y, Hata Y, Arakawa S, Yonemoto K, Doi Y, Iida M, Ishibashi T: Nine-year incidence and risk factors for age-related macular degeneration in a defined Japanese population the Hisayama study. Ophthalmology. 2009, 116 (11): 2135-2140. 10.1016/j.ophtha.2009.04.017.CrossRefPubMed

Spaide RF: Enhanced depth imaging optical coherence tomography of retinal pigment epithelial detachment in age-related macular degeneration. Am J Ophthalmol. 2009, 147 (4): 644-652. 10.1016/j.ajo.2008.10.005.CrossRefPubMed

Coscas G: Optical Coherence Tomography in Age-Related Macular Degeneration. 2009, Berlin, Heidelberg: SpringerCrossRef

Bloch SB, Lund-Andersen H, Sander B, Larsen M: Subfoveal fibrosis in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab. Am J Ophthalmol. 2013, 156 (1): 116-124. 10.1016/j.ajo.2013.02.012.CrossRefPubMed

Yannuzzi LA, Ciardella A, Spaide RF, Rabb M, Freund KB, Orlock DA: The expanding clinical spectrum of idiopathic polypoidal choroidal vasculopathy. Arch Ophthalmol. 1997, 115 (4): 478-485. 10.1001/archopht.1997.01100150480005.CrossRefPubMed

Maruko I, Iida T, Saito M, Nagayama D, Saito K: Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol. 2007, 144 (1): 15-22. 10.1016/j.ajo.2007.03.047.CrossRefPubMed

Singerman LJ, Brucker AJ, Jampol LM, Lim JI, Rosenfeld P, Schachat AP, Spaide RF: Neovascular age-related macular degeneration: roundtable. Retina. 2005, 25 (7 Suppl): S1-S22.CrossRefPubMed

Spaide RF, Yannuzzi LA, Slakter JS, Sorenson J, Orloch DA: Indocyanine green videoangiography of idiopathic polypoidal choroidal vasculopathy. Retina. 1995, 15 (2): 100-110. 10.1097/00006982-199515020-00003.CrossRefPubMed

10.

Sato T, Kishi S, Watanabe G, Matsumoto H, Mukai R: Tomographic features of branching vascular networks in polypoidal choroidal vasculopathy. Retina. 2007, 27 (5): 589-594. 10.1097/01.iae.0000249386.63482.05.CrossRefPubMed

11.

Khan S, Engelbert M, Imamura Y, Freund KB: Polypoidal choroidal vasculopathy: simultaneous indocyanine green angiography and eye-tracked spectral domain optical coherence tomography findings. Retina. 2012, 32 (6): 1057-1068. 10.1097/IAE.0b013e31823beb14.CrossRefPubMed

12.

Nagiel A, Freund KB, Spaide RF, Munch IC, Larsen M, Sarraf D: Mechanism of retinal pigment epithelium tear formation following intravitreal anti-vascular endothelial growth factor therapy revealed by spectral-domain optical coherence tomography. Am J Ophthalmol. 2013, 156 (5): 981-988 e982-CrossRef

13.

Mukai R, Sato T, Kishi S: Precursor stage of retinal pigment epithelial tear in age-related macular degeneration. Acta ophthalmologica. 2014, [Epub ahead of print]

14.

Bressler NM, Treatment of Age-Related Macular Degeneration with Photodynamic Therapy Study G: Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin: two-year results of 2 randomized clinical trials-tap report 2. Arch Ophthalmol. 2001, 119 (2): 198-207.PubMed

15.

Leitritz M, Gelisken F, Inhoffen W, Voelker M, Ziemssen F: Can the risk of retinal pigment epithelium tears after bevacizumab treatment be predicted? An optical coherence tomography study. Eye (Lond). 2008, 22 (12): 1504-1507. 10.1038/eye.2008.145.CrossRef

16.

Chang LK, Sarraf D: Tears of the retinal pigment epithelium: an old problem in a new era. Retina. 2007, 27 (5): 523-534. 10.1097/IAE.0b013e3180a032db.CrossRefPubMed

17.

Chan CK, Abraham P, Meyer CH, Kokame GT, Kaiser PK, Rauser ME, Gross JG, Nuthi AS, Lin SG, Daher NS: Optical coherence tomography-measured pigment epithelial detachment height as a predictor for retinal pigment epithelial tears associated with intravitreal bevacizumab injections. Retina. 2010, 30 (2): 203-211. 10.1097/IAE.0b013e3181babda5.CrossRefPubMed

18.

Giovannini A, Amato G, Mariotti C, Scassellati-Sforzolini B: Optical coherence tomography in the assessment of retinal pigment epithelial tear. Retina. 2000, 20 (1): 37-40. 10.1097/00006982-200001000-00007.CrossRefPubMed

19.

Bressler SB, Silva JC, Bressler NM, Alexander J, Green WR: Clinicopathologic correlation of occult choroidal neovascularization in age-related macular degeneration. Arch Ophthalmol. 1992, 110 (6): 827-832. 10.1001/archopht.1992.01080180099035.CrossRefPubMed

20.

Tsujikawa A, Sasahara M, Otani A, Gotoh N, Kameda T, Iwama D, Yodoi Y, Tamura H, Mandai M, Yoshimura N: Pigment epithelial detachment in polypoidal choroidal vasculopathy. Am J Ophthalmol. 2007, 143 (1): 102-111. 10.1016/j.ajo.2006.08.025.CrossRefPubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2415/14/159/prepub

Title: A hyporeflective space between hyperreflective materials in pigment epithelial detachment and Bruch’s membrane in neovascular age-related macular degeneration
Authors: Ryo Mukai
Taku Sato
Shoji Kishi
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Ophthalmology / Issue 1/2014
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/1471-2415-14-159

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A hyporeflective space between hyperreflective materials in pigment epithelial detachment and Bruch’s membrane in neovascular age-related macular degeneration

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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