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BMC Cancer
Published in: BMC Cancer 1/2009

Open Access 01-12-2009 | Research article

The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study

Authors: Jae Jeong Yang, Kwang-Pil Ko, Lisa Y Cho, Aesun Shin, Jin Gwack, Soung-Hoon Chang, Hai-Rim Shin, Keun-Young Yoo, Daehee Kang, Sue K Park

Published in: BMC Cancer | Issue 1/2009

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Abstract

Background

The aim of this study was to investigate the role of TNF genetic variants and the combined effect between TNF gene and cigarette smoking in the development of gastric cancer in the Korean population.

Methods

We selected 84 incident gastric cancer cases and 336 matched controls nested within the Korean Multi-Center Cancer Cohort. Six SNPs on the TNF gene, TNF-α-238 G/A, -308 G/A, -857 C/T, -863 C/A, -1031 T/C, and TNF-β 252 A/G were genotyped. The ORs (95% CIs) were calculated using unconditional logistic regression model to detect each SNP and haplotype-pair effects for gastric cancer. The combined effects between the TNF gene and smoking on gastric cancer risk were also evaluated. Multi dimensionality reduction (MDR) analyses were performed to explore the potential TNF gene-gene interactions.

Results

TNF-α-857 C/T containing the T allele was significantly associated with an increased risk of gastric cancer and a linear trend effect was observed in the additive model (OR = 1.6, 95% CI 1.0–2.5 for CT genotype; OR = 2.6, 95% CI 1.0–6.4 for TT genotype). All haplotype-pairs that contained TCT or CCC of TNF-α-1031 T/C, TNF-α-863 C/A, and TNF-α-857 C/T were associated with a significantly higher risk for gastric cancer only among smokers. In the MDR analysis, regardless of smoking status, TNF-α-857 C/T was included in the first list of SNPs with a significant main effect.

Conclusion

TNF-α-857 C/T polymorphism may play an independent role in gastric carcinogenesis and the risk for gastric cancer by TNF genetic effect is pronounced by cigarette smoking.
Appendix
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Metadata
Title
The role of TNFgenetic variants and the interaction with cigarette smoking for gastric cancer risk: a nested case-control study
Authors
Jae Jeong Yang
Kwang-Pil Ko
Lisa Y Cho
Aesun Shin
Jin Gwack
Soung-Hoon Chang
Hai-Rim Shin
Keun-Young Yoo
Daehee Kang
Sue K Park
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2009
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-9-238

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