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Open Access 01-12-2008 | Research article

Activity of chemotherapy in mucinous ovarian cancer with a recurrence free interval of more than 6 months: results from the SOCRATES retrospective study

Authors: Sandro Pignata, Gabriella Ferrandina, Giovanna Scarfone, Paolo Scollo, Franco Odicino, Gennaro Cormio, Dionyssios Katsaros, Antonella Villa, Liliana Mereu, Fabio Ghezzi, Luigi Manzione, Rossella Lauria, Enrico Breda, Desiderio Gueli Alletti, Michela Ballardini, Alessandra Vernaglia Lombardi, Roberto Sorio, Giorgia Mangili, Domenico Priolo, Giovanna Magni, Alessandro Morabito

Published in: BMC Cancer | Issue 1/2008

Abstract

Background

Mucinous ovarian carcinoma have a poorer prognosis compared with other histological subtypes. The aim of this study was to evaluate, retrospectively, the activity of chemotherapy in patients with platinum sensitive recurrent mucinous ovarian cancer.

Methods

The SOCRATES study retrospectively assessed the pattern of care of a cohort of patients with recurrent platinum-sensitive ovarian cancer observed in the years 2000–2002 in 37 Italian centres. Data were collected between April and September 2005. Patients with recurrent ovarian cancer with > 6 months of platinum free interval were considered eligible.

Results

Twenty patients with mucinous histotype and 388 patients with other histotypes were analyzed. At baseline, mucinous tumours differed from the others for an higher number of patients with lower tumor grading (p = 0.0056) and less advanced FIGO stage (p = 0.025). At time of recurrence, a statistically significant difference was found in performance status (worse in mucinous, p = 0.024). About 20% of patients underwent secondary cytoreduction in both groups, but a lower number of patients were optimally debulked in the mucinous group (p = 0.03). Patients with mucinous cancer received more frequently single agent platinum than platinum based-combination therapy or other non-platinum schedules as second line therapy (p = 0.026), with a response rate lower than in non-mucinous group (36.4% vs 62.6%, respectively, p = 0.04). Median time to progression and overall survival were worse for mucinous ovarian cancer. Finally, mucinous cancer received a lower number of chemotherapy lines (p = 0.0023).

Conclusion

This analysis shows that platinum sensitive mucinous ovarian cancer has a poor response to chemotherapy. Studies dedicated to this histological subgroup are needed.

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Harrison ML, Jameson G, Gore ME: Mucinous ovarian cancer. Int J Gynecol Oncol. 2007

du Bois A, Quinn M, Thigpen T, Vermorken J, Avall-Lundqvist E, Bookman M, Bowtell D, Brady M, Casado A, Cervantes A, Eisenhauer E, Friedlaender M, Fujiwara K, Grenman S, Guastalla JP, Harper P, Hogberg T, Kaye S, Kitchener H, Kristensen G, Mannel R, Meier W, Miller B, Neijt JP, Oza A, Ozols R, Parmar M, Pecorelli S, Pfisterer J, Poveda A, Provencher D, Pujade-Lauraine E, Randall M, Rochon J, Rustin G, Sagae S, Stehman F, Stuart G, Trimble E, Vasey P, Vergote I, Verheijen R, Wagner U, Gynecologic Cancer Intergroup; AGO-OVAR; ANZGOG; EORTC; GEICO; GINECO; GOG; JGOG; MRC/NCRI; NCIC-CTG; NCI-US; NSGO; RTOG; SGCTG; IGCS; Organizational team of the two prior International OCC: 2004 consensus statements on the management of ovarian cancer: final document of the 3rd International Gynecologic Cancer Intergroup Ovarian Cancer Consensus Conference (GCIG OCCC 2004). Ann Oncol. 2005, viii7-12. 10.1093/annonc/mdi961. Suppl 8

Hess V, A'Hern R, Nasiri N, King DM, Blake PR, Barton DP, Shepherd JH, Ind T, Bridges J, Harrington K, Kaye SB, Gore ME: Mucinous epithelial ovarian cancer: a separate entity requiring specific treatment. J Clin Oncol. 2004, 22: 1040-1044. 10.1200/JCO.2004.08.078.CrossRefPubMed

Pisano C, Greggi S, Tambaro R, Losito S, Iodice F, Di Maio M, Ferrari E, Falanga M, Formato R, Iaffaioli VR, Pignata S: Activity of chemotherapy in mucinous epithelial ovarian cancer: a retrospective study. Anticancer Res. 2005, 25: 3501-3505.PubMed

Enomoto T, Kuragakin C, Yamasaki M: Is clear cell carcinoma and mucinous carcinoma of ovary sensitive to combination chemotherapy with paclitaxel and carboplatin?. Proc Am Soc Clin Oncol. 2003, 22 (A1797): 447-

Pectasides D, Fonutrilas G, Aravantinos G, Kalofanos HP, Efstathion E, Salamalekis E: stage mucinous epithelial ovarian cancer; the Hellenic Cooperative Oncology Group experience. Gynecol Oncol. 2005, 99: 788-790. 10.1016/j.ygyno.2005.07.022.CrossRef

Pignata S, Ferrandina G, Scarfone G, Scollo P, Odicino F, Selvaggi L, Katsaros D, Frigerio L, Mereu L, Grezzi F, Manzione L, Lauria R, Breda E, Martorio G, Ballardini M, Vernaglia Lombardi A, Sorio R, Tumolo S, Costa B, Magni G, Perrone F, Favalli G: Extending the platinum-free interval with a non platinum therapy in platinum sensitive recurrent ovarian cancer: results from the SOCRATES retrospective study. Oncology. 2007, 71: 320-326. 10.1159/000108592.CrossRef

Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC, Gwyther SG: New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst. 2000, 92: 205-216. 10.1093/jnci/92.3.205.CrossRefPubMed

Rustin GJ, Nelstrop AE, McClean P, Brady MF, McGuire WP, Hoskins WJ, Mitchell H, Lambert HE: Defining response of ovarian carcinoma to initial chemotherapy according to serum Ca 125. J Clin Oncol. 1996, 14: 1545-1550.PubMed

10.

Kaplan EL, Meier P: Non parametric estimation from incomplete observation. J Am Stat Assoc. 1958, 53: 457-481. 10.2307/2281868.CrossRef

11.

Kikkawa F, Nawa A, Kajiyama H, Shibata K, Ino K, Nomura S: Clinical Charcateristics and prognosis of mucinous tumours of the ovary. Gynecol Oncol. 2006, 103: 171-175. 10.1016/j.ygyno.2006.02.015.CrossRefPubMed

12.

McGuire V, Jesser CA, Whittemore AS: Survival among U.S. women with invasive epithelial ovarian cancer. Gynecol Oncol. 2002, 84: 399-403. 10.1006/gyno.2001.6536.CrossRefPubMed

13.

Omura GA, Brady MF, Homesley HD, Yordan E, Major FJ, Buchsbaum HJ, Park RC: Long-term follow-up and prognostic factor analysis in advanced ovarian carcinoma: The Ginecologic Oncology Group experience. J Clin Oncol. 1991, 9: 1138-1150.PubMed

14.

Cloven NG, Kyshtoobayeva A, Burger RA, Yu IR, Fruehauf JP: In vitro chemoresistance and biomarker profiles are unique for histologic subtypes of epithelial ovariancancer. Gynecol Oncol. 2004, 92: 160-6. 10.1016/j.ygyno.2003.09.030.CrossRefPubMed

15.

Parmar MK, Ledermann JA, Colombo N, du Bois A, Delaloye JF, Kristensen GB, Wheeler S, Swart AM, Qian W, Torri V, Floriani I, Jayson G, Lamont A, Trope C, ICON and AGO Collaborators: Paclitaxel plus platinum-based chemotherapy versus conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. Lancet. 2003, 361: 2099-2106. 10.1016/S0140-6736(03)13718-X.CrossRefPubMed

16.

Pfisterer J, Plante M, Vergote I, du Bois A, Hirte H, Lacave AJ, Wagner U, Stahle A, Stuart G, Kimmig R, Olbricht S, Le T, Emerich J, Kuhn W, Bentley J, Jackisch C, Luck HJ, Rochon J, Zimmermann AH, Eisenhauer E, AGO-OVAR; NCIC CTG; EORTC GCG: Gemcitabine/carboplatin (GC) vs. carboplatin (C) in platinum sensitive recurrent ovarian cancer (OVCA). J Clin Oncol. 2006, 24: 4699-707. 10.1200/JCO.2006.06.0913.CrossRefPubMed

17.

Enomoto T, Weghorst CM, Inoue M, Tanizawa O, Rice JM: K-ras activation occur frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the ovary. J Pathol. 1991, 139: 777-85.

18.

Ichikawa Y, Nishida M, Suzuki H, Yoshida S, Tsunoda H, Kubo T, Uchida K, Miwa M: Mutation of K-ras protooncogene is associated with histological subtype in human mucinous ovarian tumors. Cancer Res. 1994, 54: 33-5.PubMed

19.

Cuatrecasas M, Villanueva A, Matias-Guiu X, Prat J: K-ras mutations in mucinous ovarian tumors: a clinicopathologic and molecular study of 95 cases. Cancer. 1997, 79: 1581-6. 10.1002/(SICI)1097-0142(19970415)79:8<1581::AID-CNCR21>3.0.CO;2-T.CrossRefPubMed

20.

Reles A, Wen WH, Schmider A, Gee C, Runnebaum IB, Kilian U, Jones LA, El-Naggar A, Minguillon C, Schönborn I, Reich O, Kreienberg R, Lichtenegger W, Press MF: Correlation of p53 mutation to platinum-based chemotherapy and shortened survival in ovarian cancer. Clin Cancer Res. 2001, 7 (10): 2984-2997.PubMed

21.

Matsumoto Y, Ishiko O, Deguchi M, Nakagawa E, Ogita S: Cyclooxigenase-2 expression in normal ovaries and epithelial ovarian neoplasm. Int J Mol Med. 2001, 8: 31-6.PubMed

22.

Denkert C, Köbel M, Pest S, Koch I, Berger S, Schwabe M, Siegert A, Reles A, Klosterhalfen B, Hauptmann S: Expression of cyclooxygenase 2 is an independent prognostic factor in human ovarian carcinoma. Am J Pathol. 2002, 160: 893-903.CrossRefPubMedPubMedCentral

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/8/252/prepub

Title: Activity of chemotherapy in mucinous ovarian cancer with a recurrence free interval of more than 6 months: results from the SOCRATES retrospective study
Authors: Sandro Pignata
Gabriella Ferrandina
Giovanna Scarfone
Paolo Scollo
Franco Odicino
Gennaro Cormio
Dionyssios Katsaros
Antonella Villa
Liliana Mereu
Fabio Ghezzi
Luigi Manzione
Rossella Lauria
Enrico Breda
Desiderio Gueli Alletti
Michela Ballardini
Alessandra Vernaglia Lombardi
Roberto Sorio
Giorgia Mangili
Domenico Priolo
Giovanna Magni
Alessandro Morabito
Publication date: 01-12-2008
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2008
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-8-252

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