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BMC Cancer
Published in: BMC Cancer 1/2007

Open Access 01-12-2007 | Research article

Non-alcoholic beverages and risk of bladder cancer in Uruguay

Authors: Eduardo De Stefani, Paolo Boffetta, Hugo Deneo-Pellegrini, Pelayo Correa, Alvaro L Ronco, Paul Brennan, Gilles Ferro, Giselle Acosta, María Mendilaharsu

Published in: BMC Cancer | Issue 1/2007

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Abstract

Background

Bladder cancer is the fourth most frequent malignancy among Uruguayan men. A previous study from Uruguay suggested a high risk of bladder cancer associated with maté drinking. We conducted an additional case-control study in order to further explore the role of non-alcoholic beverages in bladder carcinogenesis.

Methods

In the time period 1996–2000, 255 incident cases with transitional cell carcinoma of the bladder and 501 patients treated in the same hospitals and in the same time period were frequency matched on age, sex, and residence. Both cases and controls were face-to-face interviewed on occupation, tobacco smoking, alcohol drinking and intake of maté, coffee, tea, and soft drinks. Statistical analysis was carried out by unconditional multiple logistic regression.

Results

Ever maté drinking was positively associated with bladder cancer (odds ratio [OR] 2.2, 95% confidence interval [CI] 1.2–3.9) and the risk increased for increasing duration and amount of maté drinking. Both coffee and tea were strongly associated with bladder cancer risk (OR for coffee drinking 1.6, 95% CI 1.2–2.3; OR for tea drinking 2.3, 95% CI 1.5–3.4). These results were confirmed in a separate analysis of never-smokers.

Conclusion

Our results suggest that drinking of maté, coffee and tea may be risk factors for bladder carcinoma in Uruguay.
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Metadata
Title
Non-alcoholic beverages and risk of bladder cancer in Uruguay
Authors
Eduardo De Stefani
Paolo Boffetta
Hugo Deneo-Pellegrini
Pelayo Correa
Alvaro L Ronco
Paul Brennan
Gilles Ferro
Giselle Acosta
María Mendilaharsu
Publication date
01-12-2007
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2007
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-7-57

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