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BMC Cancer

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Open Access 01-12-2014 | Research article

¹⁸F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution ¹⁸F-FDG-directed surgery experience: feasibility and quantification of ¹⁸F-FDG accumulation within ¹⁸F-FDG-avid lesions and background tissues

Authors: Stephen P Povoski, Douglas A Murrey Jr, Sabrina M Smith, Edward W Martin Jr, Nathan C Hall

Published in: BMC Cancer | Issue 1/2014

Abstract

Background

¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography/computed tomography (PET/CT) is a well-established imaging modality for a wide variety of solid malignancies. Currently, only limited data exists regarding the utility of PET/CT imaging at very extended injection-to-scan acquisition times. The current retrospective data analysis assessed the feasibility and quantification of diagnostic ¹⁸F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals.

Methods

¹⁸F-FDG-avid lesions (not surgically manipulated or altered during ¹⁸F-FDG-directed surgery, and visualized both on preoperative and postoperative ¹⁸F-FDG PET/CT imaging) and corresponding background tissues were assessed for ¹⁸F-FDG accumulation on same-day preoperative and postoperative ¹⁸F-FDG PET/CT imaging. Multiple patient variables and ¹⁸F-FDG-avid lesion variables were examined.

Results

For the 32 ¹⁸F-FDG-avid lesions making up the final ¹⁸F-FDG-avid lesion data set (from among 7 patients), the mean injection-to-scan times of the preoperative and postoperative ¹⁸F-FDG PET/CT scans were 73 (±3, 70-78) and 530 (±79, 413-739) minutes, respectively (P < 0.001). The preoperative and postoperative mean ¹⁸F-FDG-avid lesion SUV_max values were 7.7 (±4.0, 3.6-19.5) and 11.3 (±6.0, 4.1-29.2), respectively (P < 0.001). The preoperative and postoperative mean background SUV_max values were 2.3 (±0.6, 1.0-3.2) and 2.1 (±0.6, 1.0-3.3), respectively (P = 0.017). The preoperative and postoperative mean lesion-to-background SUV_max ratios were 3.7 (±2.3, 1.5-9.8) and 5.8 (±3.6, 1.6-16.2), respectively, (P < 0.001).

Conclusions

¹⁸F-FDG PET/CT oncologic imaging can be successfully performed at extended injection-to-scan acquisition time intervals of up to approximately 5 half-lives for ¹⁸F-FDG while maintaining good/adequate diagnostic image quality. The resultant increase in the ¹⁸F-FDG-avid lesion SUV_max values, decreased background SUV_max values, and increased lesion-to-background SUV_max ratios seen from preoperative to postoperative ¹⁸F-FDG PET/CT imaging have great potential for allowing for the integrated, real-time use of ¹⁸F-FDG PET/CT imaging in conjunction with ¹⁸F-FDG-directed interventional radiology biopsy and ablation procedures and ¹⁸F-FDG-directed surgical procedures, as well as have far-reaching impact on potentially re-shaping future thinking regarding the “most optimal” injection-to-scan acquisition time interval for all routine diagnostic ¹⁸F-FDG PET/CT oncologic imaging.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2407/14/453/prepub

Title: 18F-FDG PET/CT oncologic imaging at extended injection-to-scan acquisition time intervals derived from a single-institution 18F-FDG-directed surgery experience: feasibility and quantification of 18F-FDG accumulation within 18F-FDG-avid lesions and background tissues
Authors: Stephen P Povoski
Douglas A Murrey Jr
Sabrina M Smith
Edward W Martin Jr
Nathan C Hall
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/1471-2407-14-453

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