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BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Research article

Primary small cell carcinoma of the esophagus: clinicopathological study of 44 cases

Authors: Wei-Wei Chen, Feng Wang, Dong-Sheng Zhang, Hui-Yan Luo, Zhi-Qiang Wang, Feng-Hua Wang, Miao-Zhen Qiu, Chao Ren, Xiao-Li Wei, Wen-Jing Wu, Yu-Hong Li, Rui-Hua Xu

Published in: BMC Cancer | Issue 1/2014

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Abstract

Background

Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive disease characterized by early dissemination and poor prognosis. Because of the rarity of this disease, few previous studies have investigated the biomarkers associated with its prognosis. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is a stem cell marker and a member of the canonical Wnt-signaling cascade. However, the clinical role of Lgr5 in SCCE remains unknown.

Methods

Tissue sections were obtained from 44 patients diagnosed with SCCE and expression of Lgr5 was examined by immunohistochemistry. The correlations between Lgr5 expression, and clinical parameters and prognostic significance were evaluated.

Results

Lgr5 was expressed in SCCE cancer tissues. High Lgr5 expression was significantly correlated with lymph node metastasis (p = 0.003), late stage (p = 0.003) and unfavorable response to chemotherapy (p = 0.013) according to RECIST 1.0 criteria. Patients with higher Lgr5 expression levels had shorter overall survival times than those with lower expression levels.

Conclusions

These results demonstrated that overexpression of Lgr5 was significantly correlated with lymph node metastasis, tumor stage, and response to chemotherapy. Furthermore, high levels of Lgr5 expression appeared to be associated with poorer survival in patients with SCCE.
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Metadata
Title
Primary small cell carcinoma of the esophagus: clinicopathological study of 44 cases
Authors
Wei-Wei Chen
Feng Wang
Dong-Sheng Zhang
Hui-Yan Luo
Zhi-Qiang Wang
Feng-Hua Wang
Miao-Zhen Qiu
Chao Ren
Xiao-Li Wei
Wen-Jing Wu
Yu-Hong Li
Rui-Hua Xu
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-222

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