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BMC Cancer
Published in: BMC Cancer 1/2014

Open Access 01-12-2014 | Research article

Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study

Authors: Yulan Ren, Boer Shan, Daren Shi, Huaying Wang

Published in: BMC Cancer | Issue 1/2014

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Abstract

Background

Salvage cytoreductive surgery (SCR) has been shown to improve the survival of cancer patients. This study aimed to determine the survival benefits of SCR for recurrent endometrial cancer in Chinese population.

Methods

Between January 1995 and May 2012, 75 Chinese patients with recurrent endometrial cancer undergoing SCR were retrospectively analyzed.

Results

43 patients (57.3%) had R0 (no visible disease), 15 patients (20.0%) had R1 (residual disease ≤1 cm), and 17 (22.7%) had R2 (residual disease >1 cm) Resection. 35 patients (46.7%) had single, and 40 (53.3%) had multiple sites of recurrence. The median survival time was 18 months, and 5-year overall survival (OS) rate were 42.0%. Multivariate analysis showed that residual disease ≤1 cm and high histology grade were significantly associated with a better OS. The size of the largest recurrent tumors (≤6 cm), solitary recurrent tumor, and age at recurrence (≤56 years old) were associated with optimal SCR.

Conclusion

Optimal SCR and high histology grade are associated with prolonged overall survival for patients with recurrent endometrial cancer. Patients with young age, tumor size < 6 cm, and solitary recurrent tumor are more likely to benefit from optimal cytoreductive surgery.
Appendix
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Literature
1.
Fung-Kee-Fung M, Dodge J, Elit L, Lukka H, Chambers A, Oliver T: Follow-up after primary therapy for endometrial cancer: a systematic review. Gynecol Oncol. 2006, 101 (3): 520-9. 10.1016/j.ygyno.2006.02.011.CrossRefPubMed
2.
Aalders J, Abeler V, Kolstad P: Recurrent adenocarcinoma of the endometrium: a clinical and histopathological study of 379 patients. Gynecol Oncol. 1984, 17 (1): 85-103. 10.1016/0090-8258(84)90063-5.CrossRefPubMed
3.
Wylie J, Irwin C, Pintilie M, Levin W, Manchul L, Milosevic M, Fyles A: Results of radical radiotherapy for recurrent endometrial cancer. Gynecol Oncol. 2000, 77 (1): 66-72. 10.1006/gyno.2000.5727.CrossRefPubMed
4.
Jereczek-Fossa B, Badzio A, Jassem J: Recurrent endometrial cancer after surgery alone: results of salvage radiotherapy. Int J Radiat Oncol Biol Phys. 2000, 48 (2): 405-13. 10.1016/S0360-3016(00)00642-8.CrossRefPubMed
5.
Morris M, Alvarez RD, Kinney WK, Wilson TO: Treatment of recurrent adenocarcinoma of the endometrium with pelvic exenteration. Gynecol Oncol. 1996, 60 (2): 288-91. 10.1006/gyno.1996.0040.CrossRefPubMed
6.
Barakat RR, Goldman NA, Patel DA, Venkatraman ES, Curtin JP: Pelvic exenteration for recurrent endometrial cancer. Gynecol Oncol. 1999, 75 (1): 99-102. 10.1006/gyno.1999.5536.CrossRefPubMed
7.
Scarabelli C, Campagnutta E, Giorda G, DePiero G, Sopracordevole F, Quaranta M, DeMarco L: Maximal cytoreductive surgery as a reasonable therapeutic alternative for recurrent endometrial carcinoma. Gynecol Oncol. 1998, 70 (1): 90-3. 10.1006/gyno.1998.5017.CrossRefPubMed
8.
Campagnutta E, Giorda G, De Piero G, Sopracordevole F, Visentin MC, Martella L, Scarabelli C: Surgical treatment of recurrent endometrial carcinoma. Cancer. 2004, 100 (1): 89-96. 10.1002/cncr.11868.CrossRefPubMed
9.
Bristow RE, Santillan A, Zahurak ML, Gardner GJ, Giuntoli RL, Armstrong DK: Salvage cytoreductive surgery for recurrent endometrial cancer. Gynecol Oncol. 2006, 103 (1): 281-7. 10.1016/j.ygyno.2006.03.011.CrossRefPubMed
10.
Awtrey CS, Cadungog MG, Leitao MM, Alektiar KM, Aghajanian C, Hummer AJ, Barakat RR, Chi DS: Surgical resection of recurrent endometrial carcinoma. Gynecol Oncol. 2006, 102 (3): 480-8. 10.1016/j.ygyno.2006.01.007.CrossRefPubMed
11.
Pecorelli S: Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium. Int J Gynaecol Obstet. 2009, 105 (2): 103-4. 10.1016/j.ijgo.2009.02.012.CrossRefPubMed
12.
Curran WJ, Whittington R, Peters AJ, Fanning J: Vaginal recurrences of endometrial carcinoma: the prognostic value of staging by a primary vaginal carcinoma system. Int J Radiat Oncol Biol Phys. 1988, 15 (4): 803-8. 10.1016/0360-3016(88)90110-1.CrossRefPubMed
13.
Sears JD, Greven KM, Hoen HM, Randall ME: Prognostic factors and treatment outcome for patients with locally recurrent endometrial cancer. Cancer. 1994, 74 (4): 1303-8. 10.1002/1097-0142(19940815)74:4<1303::AID-CNCR2820740420>3.0.CO;2-G.CrossRefPubMed
14.
Wadler S, Levy DE, Lincoln ST, Soori GS, Schink JC, Goldberg G: Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma: Eastern Cooperative Oncology Group study E3E93. J Clin Oncol. 2003, 21 (11): 2110-4. 10.1200/JCO.2003.12.093.CrossRefPubMed
15.
Lincoln S, Blessing JA, Lee RB, Rocereto TF: Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2003, 88 (3): 277-81. 10.1016/S0090-8258(02)00068-9.CrossRefPubMed
16.
Burke TW, Munkarah A, Kavanagh JJ, Morris M, Levenback C, Tornos C, Gershenson DM: Treatment of advanced or recurrent endometrial carcinoma with single-agent carboplatin. Gynecol Oncol. 1993, 51 (3): 397-400. 10.1006/gyno.1993.1310.CrossRefPubMed
17.
Thigpen JT, Blessing JA, Homesley H, Creasman WT, Sutton G: Phase II trial of cisplatin as first-line chemotherapy in patients with advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 1989, 33 (1): 68-70. 10.1016/0090-8258(89)90605-7.CrossRefPubMed
18.
Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, Kline R, Burger RA, Goodman A, Burks RT: Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filfrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2004, 22 (11): 2159-66. 10.1200/JCO.2004.07.184.CrossRefPubMed
19.
Thigpen T, Brady MF, Homesley HD, Soper JT, Bell J: Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2001, 19 (2): 364-7.PubMed
20.
Asbury RF, Brunetto VL, Lee RB, Reid G, Rocereto TF: Goserelin acetate as treatment for recurrent endometrial carcinoma: a Gynecologic Oncology Group study. Am J Clin Oncol. 2002, 25 (6): 557-60. 10.1097/00000421-200212000-00004.CrossRefPubMed
21.
Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W: Phase II trial of alternating courses of Megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004, 92 (1): 10-4. 10.1016/j.ygyno.2003.11.008.CrossRefPubMed
22.
Barlin JN, Puri I, Bristow RE: Cytoreductive surgery for advanced or recurrent endometrial cancer: a meta-analysis. Gynecol Oncol. 2010, 118 (1): 14-8. 10.1016/j.ygyno.2010.04.005.CrossRefPubMed
23.
Otsuka I, Uno M, Wakabayashi A, Kameda S, Udagawa H, Kubota T: Predictive factors for prolonged survival in recurrent endometrial carcinoma: implications for follow-up protocol. Gynecol Oncol. 2010, 119 (3): 506-10. 10.1016/j.ygyno.2010.08.013.CrossRefPubMed
Metadata
Title
Salvage cytoreductive surgery for patients with recurrent endometrial cancer: a retrospective study
Authors
Yulan Ren
Boer Shan
Daren Shi
Huaying Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2014
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-14-135

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