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BMC Cancer
Published in: BMC Cancer 1/2013

Open Access 01-12-2013 | Research article

Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study

Authors: Loredana Radoï, Sophie Paget-Bailly, Florence Guida, Diane Cyr, Gwenn Menvielle, Annie Schmaus, Matthieu Carton, Sylvie Cénée, Marie Sanchez, Anne-Valérie Guizard, Brigitte Trétarre, Isabelle Stücker, Danièle Luce

Published in: BMC Cancer | Issue 1/2013

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Abstract

Background

The aim of this study was to evaluate the role of family history of cancer and personal history of other medical conditions in the aetiology of the oral cavity cancer in France.

Methods

We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls included in a population-based case–control study, the ICARE study. Odds-ratios (ORs) associated with family history of cancer and personal medical conditions and their 95% confidence intervals (95% CI) were estimated by unconditional logistic regression and were adjusted for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking.

Results

Personal history of oral candidiasis was related to a significantly increased risk of oral cavity cancer (OR 5.0, 95% CI 2.1-12.1). History of head and neck cancers among the first-degree relatives was associated with an OR of 1.9 (95% CI 1.2-2.8). The risk increased with the number of first-degree relatives with head and neck cancer.

Conclusion

A family history of head and neck cancer is a marker of an increased risk of oral cavity cancer and should be taken into account to target prevention efforts and screening. Further studies are needed to clarify the association between oral cavity cancer and personal history of candidiasis.
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Metadata
Title
Family history of cancer, personal history of medical conditions and risk of oral cavity cancer in France: the ICARE study
Authors
Loredana Radoï
Sophie Paget-Bailly
Florence Guida
Diane Cyr
Gwenn Menvielle
Annie Schmaus
Matthieu Carton
Sylvie Cénée
Marie Sanchez
Anne-Valérie Guizard
Brigitte Trétarre
Isabelle Stücker
Danièle Luce
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2013
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-13-560

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