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BMC Cancer
Published in: BMC Cancer 1/2013

Open Access 01-12-2013 | Research article

A pri-miR-218variant and risk of cervical carcinoma in Chinese women

Authors: Ting-Yan Shi, Xiao-Jun Chen, Mei-Ling Zhu, Meng-Yun Wang, Jing He, Ke-Da Yu, Zhi-Ming Shao, Meng-Hong Sun, Xiao-Yan Zhou, Xi Cheng, Xiaohua Wu, Qingyi Wei

Published in: BMC Cancer | Issue 1/2013

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Abstract

Background

MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma.

Methods

In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women.

Results

We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015). However, this association was not observed for the miR-218 binding site SNP (rs2566) on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma.

Conclusions

The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.
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Metadata
Title
A pri-miR-218variant and risk of cervical carcinoma in Chinese women
Authors
Ting-Yan Shi
Xiao-Jun Chen
Mei-Ling Zhu
Meng-Yun Wang
Jing He
Ke-Da Yu
Zhi-Ming Shao
Meng-Hong Sun
Xiao-Yan Zhou
Xi Cheng
Xiaohua Wu
Qingyi Wei
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2013
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-13-19

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