Expression and significance of histone H3K27 demethylases in renal cell carcinoma

go back to reference Rini BI, Campbell SC, Escudier B: Renal cell carcinoma. Lancet. 2009, 373: 1119-1132. 10.1016/S0140-6736(09)60229-4.CrossRefPubMed Rini BI, Campbell SC, Escudier B: Renal cell carcinoma. Lancet. 2009, 373: 1119-1132. 10.1016/S0140-6736(09)60229-4.CrossRefPubMed

go back to reference Giubellino A, Linehan WM, Bottaro DP: Targeting the Met signaling pathway in renal cancer. Expert Rev Anticancer Ther. 2009, 9: 785-793. 10.1586/era.09.43.CrossRefPubMedPubMedCentral Giubellino A, Linehan WM, Bottaro DP: Targeting the Met signaling pathway in renal cancer. Expert Rev Anticancer Ther. 2009, 9: 785-793. 10.1586/era.09.43.CrossRefPubMedPubMedCentral

go back to reference Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007, 18: 581-592.CrossRefPubMed Ferlay J, Autier P, Boniol M, Heanue M, Colombet M, Boyle P: Estimates of the cancer incidence and mortality in Europe in 2006. Ann Oncol. 2007, 18: 581-592.CrossRefPubMed

go back to reference Basu B, Eisen T: Perspectives in drug development for metastatic renal cell cancer. Target Oncol. 2010, 5: 139-156. 10.1007/s11523-010-0149-2.CrossRefPubMed Basu B, Eisen T: Perspectives in drug development for metastatic renal cell cancer. Target Oncol. 2010, 5: 139-156. 10.1007/s11523-010-0149-2.CrossRefPubMed

go back to reference Suárez C, Morales R, Muñoz E, Rodón J, Valverde CM, Carles J: Molecular basis for the treatment of renal cell carcinoma. Clin Transl Oncol. 2010, 12: 15-21. 10.1007/s12094-010-0461-4.CrossRefPubMed Suárez C, Morales R, Muñoz E, Rodón J, Valverde CM, Carles J: Molecular basis for the treatment of renal cell carcinoma. Clin Transl Oncol. 2010, 12: 15-21. 10.1007/s12094-010-0461-4.CrossRefPubMed

go back to reference Banumathy G, Cairns P: Signaling pathways in renal cell carcinoma. Cancer Biol Ther. 2010, 10: 658-864. 10.4161/cbt.10.7.13247.CrossRefPubMedPubMedCentral Banumathy G, Cairns P: Signaling pathways in renal cell carcinoma. Cancer Biol Ther. 2010, 10: 658-864. 10.4161/cbt.10.7.13247.CrossRefPubMedPubMedCentral

go back to reference Mohammed A, Shergill I, Little B: Management of metastatic renal cell carcinoma: current trends. Expert Rev Mol Diagn. 2009, 9: 75-83. 10.1586/14737159.9.1.75.CrossRefPubMed Mohammed A, Shergill I, Little B: Management of metastatic renal cell carcinoma: current trends. Expert Rev Mol Diagn. 2009, 9: 75-83. 10.1586/14737159.9.1.75.CrossRefPubMed

go back to reference Chin AI, Lam JS, Figlin RA, Belldegrun AS: Surveillance strategies for renal cell carcinoma patients following nephrectomy. Rev Urol. 2006, 8: 1-7.PubMedPubMedCentral Chin AI, Lam JS, Figlin RA, Belldegrun AS: Surveillance strategies for renal cell carcinoma patients following nephrectomy. Rev Urol. 2006, 8: 1-7.PubMedPubMedCentral

go back to reference Eichelberg C, Junker K, Ljungberg B, Moch H: Diagnostic and prognostic molecular markers for renal cell carcinoma: a critical appraisal of the current state of research and clinical applicability. Eur Urol. 2009, 55: 851-863. 10.1016/j.eururo.2009.01.003.CrossRefPubMed Eichelberg C, Junker K, Ljungberg B, Moch H: Diagnostic and prognostic molecular markers for renal cell carcinoma: a critical appraisal of the current state of research and clinical applicability. Eur Urol. 2009, 55: 851-863. 10.1016/j.eururo.2009.01.003.CrossRefPubMed

go back to reference Hatziapostolou M, Iliopoulos D: Epigenetic aberrations during oncogenesis. Cell Mol Life Sci. 2011, 68: 1681-1702. 10.1007/s00018-010-0624-z.CrossRefPubMed Hatziapostolou M, Iliopoulos D: Epigenetic aberrations during oncogenesis. Cell Mol Life Sci. 2011, 68: 1681-1702. 10.1007/s00018-010-0624-z.CrossRefPubMed

go back to reference Chi P, Allis CD, Wang GG: Covalent histone modifications–miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer. 2010, 10: 457-469. 10.1038/nrc2876.CrossRefPubMedPubMedCentral Chi P, Allis CD, Wang GG: Covalent histone modifications–miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer. 2010, 10: 457-469. 10.1038/nrc2876.CrossRefPubMedPubMedCentral

go back to reference Hübner MR, Spector DL: Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol. 2010, 75: 43-49.CrossRefPubMed Hübner MR, Spector DL: Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb Symp Quant Biol. 2010, 75: 43-49.CrossRefPubMed

go back to reference Simon JA, Lange CA: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008, 647: 21-29. 10.1016/j.mrfmmm.2008.07.010.CrossRefPubMed Simon JA, Lange CA: Roles of the EZH2 histone methyltransferase in cancer epigenetics. Mutat Res. 2008, 647: 21-29. 10.1016/j.mrfmmm.2008.07.010.CrossRefPubMed

go back to reference Wagener N, Macher-Goeppinger S, Pritsch M, Hüsing J, Hoppe-Seyler K, Schirmacher P, Pfitzenmaier J, Haferkamp A, Hoppe-Seyler F, Hohenfellner M: Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma. BMC Cancer. 2010, 10: 524-10.1186/1471-2407-10-524.CrossRefPubMedPubMedCentral Wagener N, Macher-Goeppinger S, Pritsch M, Hüsing J, Hoppe-Seyler K, Schirmacher P, Pfitzenmaier J, Haferkamp A, Hoppe-Seyler F, Hohenfellner M: Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma. BMC Cancer. 2010, 10: 524-10.1186/1471-2407-10-524.CrossRefPubMedPubMedCentral

go back to reference Hinz S, Weikert S, Magheli A, Hoffmann M, Engers R, Miller K, Kempkensteffen C: Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma. J Urol. 2009, 182: 2920-2925. 10.1016/j.juro.2009.08.014.CrossRefPubMed Hinz S, Weikert S, Magheli A, Hoffmann M, Engers R, Miller K, Kempkensteffen C: Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma. J Urol. 2009, 182: 2920-2925. 10.1016/j.juro.2009.08.014.CrossRefPubMed

go back to reference Swigut T, Wysocka J: H3K27 demethylases, at long last. Cell. 2007, 131: 29-32. 10.1016/j.cell.2007.09.026.CrossRefPubMed Swigut T, Wysocka J: H3K27 demethylases, at long last. Cell. 2007, 131: 29-32. 10.1016/j.cell.2007.09.026.CrossRefPubMed

go back to reference Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K: UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 2007, 449: 731-7314. 10.1038/nature06145.CrossRefPubMed Agger K, Cloos PA, Christensen J, Pasini D, Rose S, Rappsilber J, Issaeva I, Canaani E, Salcini AE, Helin K: UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature. 2007, 449: 731-7314. 10.1038/nature06145.CrossRefPubMed

go back to reference Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R: Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007, 318: 447-450. 10.1126/science.1149042.CrossRefPubMed Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R: Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007, 318: 447-450. 10.1126/science.1149042.CrossRefPubMed

go back to reference Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y: A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007, 449: 689-694. 10.1038/nature06192.CrossRefPubMed Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y: A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007, 449: 689-694. 10.1038/nature06192.CrossRefPubMed

go back to reference Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD: JMJD3 is a histone H3K27 demethylase. Cell Res. 2007, 17: 850-857. 10.1038/cr.2007.83.CrossRefPubMed Xiang Y, Zhu Z, Han G, Lin H, Xu L, Chen CD: JMJD3 is a histone H3K27 demethylase. Cell Res. 2007, 17: 850-857. 10.1038/cr.2007.83.CrossRefPubMed

go back to reference van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O’Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA: Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009, 41: 521-523. 10.1038/ng.349.CrossRefPubMedPubMedCentral van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G, Greenman C, Edkins S, Hardy C, O’Meara S, Teague J, Butler A, Hinton J, Latimer C, Andrews J, Barthorpe S, Beare D, Buck G, Campbell PJ, Cole J, Forbes S, Jia M, Jones D, Kok CY, Leroy C, Lin ML, McBride DJ, Maddison M, Maquire S, McLay K, Menzies A, Mironenko T, Mulderrig L, Mudie L, Pleasance E, Shepherd R, Smith R, Stebbings L, Stephens P, Tang G, Tarpey PS, Turner R, Turrell K, Varian J, West S, Widaa S, Wray P, Collins VP, Ichimura K, Law S, Wong J, Yuen ST, Leung SY, Tonon G, DePinho RA, Tai YT, Anderson KC, Kahnoski RJ, Massie A, Khoo SK, Teh BT, Stratton MR, Futreal PA: Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet. 2009, 41: 521-523. 10.1038/ng.349.CrossRefPubMedPubMedCentral

go back to reference Fuhrman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982, 6: 655-663. 10.1097/00000478-198210000-00007.CrossRefPubMed Fuhrman SA, Lasky LC, Limas C: Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol. 1982, 6: 655-663. 10.1097/00000478-198210000-00007.CrossRefPubMed

go back to reference Wu S, Wang Y, Sun L, Zhang Z, Jiang Z, Qin Z, Han H, Liu Z, Li X, Tang A, Gui Y, Cai Z, Zhou F: Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer. 2011, 11: 413-10.1186/1471-2407-11-413.CrossRefPubMedPubMedCentral Wu S, Wang Y, Sun L, Zhang Z, Jiang Z, Qin Z, Han H, Liu Z, Li X, Tang A, Gui Y, Cai Z, Zhou F: Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma. BMC Cancer. 2011, 11: 413-10.1186/1471-2407-11-413.CrossRefPubMedPubMedCentral

go back to reference Kampranis SC, Tsichlis PN: Histone demethylases and cancer. Adv Cancer Res. 2009, 102: 103-169.CrossRefPubMedPubMedCentral Kampranis SC, Tsichlis PN: Histone demethylases and cancer. Adv Cancer Res. 2009, 102: 103-169.CrossRefPubMedPubMedCentral

go back to reference Guo X, Shi M, Sun L, Wang Y, Gui Y, Cai Z, Duan X: The expression of histone demethylase JMJD1A in renal cell carcinoma. Neoplasma. 2011, 58: 153-157. 10.4149/neo_2011_02_153.CrossRefPubMed Guo X, Shi M, Sun L, Wang Y, Gui Y, Cai Z, Duan X: The expression of histone demethylase JMJD1A in renal cell carcinoma. Neoplasma. 2011, 58: 153-157. 10.4149/neo_2011_02_153.CrossRefPubMed

go back to reference Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010, 30: 344-353. 10.1128/MCB.00444-09.CrossRefPubMed Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010, 30: 344-353. 10.1128/MCB.00444-09.CrossRefPubMed

go back to reference Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K: The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 2009, 23: 1171-1176. 10.1101/gad.510809.CrossRefPubMedPubMedCentral Agger K, Cloos PA, Rudkjaer L, Williams K, Andersen G, Christensen J, Helin K: The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence. Genes Dev. 2009, 23: 1171-1176. 10.1101/gad.510809.CrossRefPubMedPubMedCentral

go back to reference Tsai MC, Wang JK, Chang HY: Tumor suppression by the histone demethylase UTX. Cell Cycle. 2010, 9: 2043-2044. 10.4161/cc.9.11.11845.CrossRefPubMedPubMedCentral Tsai MC, Wang JK, Chang HY: Tumor suppression by the histone demethylase UTX. Cell Cycle. 2010, 9: 2043-2044. 10.4161/cc.9.11.11845.CrossRefPubMedPubMedCentral

go back to reference Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J: Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009, 23: 1177-1182. 10.1101/gad.511109.CrossRefPubMedPubMedCentral Barradas M, Anderton E, Acosta JC, Li S, Banito A, Rodriguez-Niedenführ M, Maertens G, Banck M, Zhou MM, Walsh MJ, Peters G, Gil J: Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. Genes Dev. 2009, 23: 1177-1182. 10.1101/gad.511109.CrossRefPubMedPubMedCentral

go back to reference Campisi J: Cancer and ageing: rival demons?. Nat Rev Cancer. 2003, 3: 339-349. 10.1038/nrc1073.CrossRefPubMed Campisi J: Cancer and ageing: rival demons?. Nat Rev Cancer. 2003, 3: 339-349. 10.1038/nrc1073.CrossRefPubMed

go back to reference Gil J, Peters G: Regulation of the INK4b–ARF–INK4a tumour suppressor locus: All for one or one for all. Nat Rev Mol Cell Biol. 2006, 7: 667-677.CrossRefPubMed Gil J, Peters G: Regulation of the INK4b–ARF–INK4a tumour suppressor locus: All for one or one for all. Nat Rev Mol Cell Biol. 2006, 7: 667-677.CrossRefPubMed

go back to reference Collado M, Serrano M: The power and the promise of oncogene induced senescence markers. Nat Rev Cancer. 2006, 6: 472-476. 10.1038/nrc1884.CrossRefPubMed Collado M, Serrano M: The power and the promise of oncogene induced senescence markers. Nat Rev Cancer. 2006, 6: 472-476. 10.1038/nrc1884.CrossRefPubMed

go back to reference Campisi J, D’Adda Di Fagagna F: Cellular senescence: When bad things happen to good cells. Nat Rev Mol Cell Biol. 2007, 8: 729-740.CrossRefPubMed Campisi J, D’Adda Di Fagagna F: Cellular senescence: When bad things happen to good cells. Nat Rev Mol Cell Biol. 2007, 8: 729-740.CrossRefPubMed

go back to reference Popov N, Gil J: Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health. Epigenetics. 2010, 5: 685-690. 10.4161/epi.5.8.12996.CrossRefPubMedPubMedCentral Popov N, Gil J: Epigenetic regulation of the INK4b-ARF-INK4a locus: In sickness and in health. Epigenetics. 2010, 5: 685-690. 10.4161/epi.5.8.12996.CrossRefPubMedPubMedCentral

go back to reference Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y: pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev. 2007, 21: 49-54. 10.1101/gad.1499407.CrossRefPubMedPubMedCentral Kotake Y, Cao R, Viatour P, Sage J, Zhang Y, Xiong Y: pRB family proteins are required for H3K27 trimethylation and Polycomb repression complexes binding to and silencing p16INK4alpha tumor suppressor gene. Genes Dev. 2007, 21: 49-54. 10.1101/gad.1499407.CrossRefPubMedPubMedCentral

go back to reference Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21: 525-530. 10.1101/gad.415507.CrossRefPubMedPubMedCentral Bracken AP, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, Theilgaard-Mönch K, Minucci S, Porse BT, Marine JC, Hansen KH, Helin K: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007, 21: 525-530. 10.1101/gad.415507.CrossRefPubMedPubMedCentral

go back to reference Anderton JA, Bose S, Vockerodt M, Vrzalikova K, Wei W, Kuo M, Helin K, Christensen J, Rowe M, Murray PG, Woodman CB: The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin’s Lymphoma. Oncogene. 2011, 30: 2037-2043. 10.1038/onc.2010.579.CrossRefPubMed Anderton JA, Bose S, Vockerodt M, Vrzalikova K, Wei W, Kuo M, Helin K, Christensen J, Rowe M, Murray PG, Woodman CB: The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin’s Lymphoma. Oncogene. 2011, 30: 2037-2043. 10.1038/onc.2010.579.CrossRefPubMed

go back to reference Kasahara T, Bilim V, Hara N, Takahashi K, Tomita Y: Homozygous deletions of the INK4a/ARF locus in renal cell cancer. Anticancer Res. 2006, 26: 4299-4305.PubMed Kasahara T, Bilim V, Hara N, Takahashi K, Tomita Y: Homozygous deletions of the INK4a/ARF locus in renal cell cancer. Anticancer Res. 2006, 26: 4299-4305.PubMed

go back to reference Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, Shi Y, Chang HY: The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 2010, 24: 327-332. 10.1101/gad.1882610.CrossRefPubMedPubMedCentral Wang JK, Tsai MC, Poulin G, Adler AS, Chen S, Liu H, Shi Y, Chang HY: The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev. 2010, 24: 327-332. 10.1101/gad.1882610.CrossRefPubMedPubMedCentral

go back to reference Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T: The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase. Biochem Biophys Res Commun. 2010, 399: 238-244. 10.1016/j.bbrc.2010.07.061.CrossRefPubMed Terashima M, Ishimura A, Yoshida M, Suzuki Y, Sugano S, Suzuki T: The tumor suppressor Rb and its related Rbl2 genes are regulated by Utx histone demethylase. Biochem Biophys Res Commun. 2010, 399: 238-244. 10.1016/j.bbrc.2010.07.061.CrossRefPubMed

go back to reference Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A: The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010, 30: 2485-2497. 10.1128/MCB.01633-09.CrossRefPubMedPubMedCentral Herz HM, Madden LD, Chen Z, Bolduc C, Buff E, Gupta R, Davuluri R, Shilatifard A, Hariharan IK, Bergmann A: The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol. 2010, 30: 2485-2497. 10.1128/MCB.01633-09.CrossRefPubMedPubMedCentral

go back to reference He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D: Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer. 2009, 9: 461-10.1186/1471-2407-9-461.CrossRefPubMedPubMedCentral He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D: Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer. 2009, 9: 461-10.1186/1471-2407-9-461.CrossRefPubMedPubMedCentral

go back to reference Varier RA, Timmers HT: Histone lysine methylation and demethylation pathways in cancer. Biochim Biophys Acta. 2011, 1815: 75-89.PubMed Varier RA, Timmers HT: Histone lysine methylation and demethylation pathways in cancer. Biochim Biophys Acta. 2011, 1815: 75-89.PubMed

go back to reference Rotili D, Mai A: Targeting histone demethylases: a new avenue for the fight against cancer. Genes Cancer. 2011, 2: 663-679. 10.1177/1947601911417976.CrossRefPubMedPubMedCentral Rotili D, Mai A: Targeting histone demethylases: a new avenue for the fight against cancer. Genes Cancer. 2011, 2: 663-679. 10.1177/1947601911417976.CrossRefPubMedPubMedCentral