Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2011

Open Access 01-12-2011 | Research article

Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer

Authors: Chen-Hsi Hsieh, Ying-Shiung Kuo, Li-Jen Liao, Kawang-Yu Hu, Shih-Chiang Lin, Le-Jung Wu, Yu-Chin Lin, Yu-Jen Chen, Li-Ying Wang, Yen-Ping Hsieh, Shoei Long Lin, Chun-Yi Chen, Chien-An Chen, Pei-Wei Shueng

Published in: BMC Cancer | Issue 1/2011

Login to get access

Abstract

Background

The aim of this study was to assess the treatment results and toxicity profiles of helical tomotherapy (HT) for postoperative high-risk oral cavity cancer.

Methods

From December 6, 2006 through October 9, 2009, 19 postoperative high-risk oral cavity cancer patients were enrolled. All of the patients received HT with (84%) or without (16%) chemotherapy.

Results

The median follow-up time was 17 months. The 2-year overall survival, disease-free survival, locoregional control, and distant metastasis-free rates were 94%, 84%, 92%, and 94%, respectively. The package of overall treatment time > 13 wk, the interval between surgery and radiation ≤ 6 wk, and the overall treatment time of radiation ≤ 7 wk was 21%, 84%, and 79%, respectively. The percentage of grade 3 mucositis, dermatitis, and leucopenia was 42%, 5% and 5%, respectively.

Conclusions

HT achieved encouraging clinical outcomes for postoperative high-risk oral cavity cancer patients with high compliance. A long-term follow-up study is needed to confirm these preliminary findings.
Appendix
Available only for authorised users
Literature
1.
Amdur RJ, Parsons JT, Mendenhall WM, Million RR, Stringer SP, Cassisi NJ: Postoperative irradiation for squamous cell carcinoma of the head and neck: an analysis of treatment results and complications. Int J Radiat Oncol Biol Phys. 1989, 16 (1): 25-36. 10.1016/0360-3016(89)90006-0.CrossRefPubMed
2.
Peters LJ, Goepfert H, Ang KK, Byers RM, Maor MH, Guillamondegui O, Morrison WH, Weber RS, Garden AS, Frankenthaler RA, et al: Evaluation of the dose for postoperative radiation therapy of head and neck cancer: first report of a prospective randomized trial. Int J Radiat Oncol Biol Phys. 1993, 26 (1): 3-11. 10.1016/0360-3016(93)90167-T.CrossRefPubMed
3.
Eisbruch A, Marsh LH, Dawson LA, Bradford CR, Teknos TN, Chepeha DB, Worden FP, Urba S, Lin A, Schipper MJ, et al: Recurrences near base of skull after IMRT for head-and-neck cancer: implications for target delineation in high neck and for parotid gland sparing. Int J Radiat Oncol Biol Phys. 2004, 59 (1): 28-42. 10.1016/j.ijrobp.2003.10.032.CrossRefPubMed
4.
Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, Kim HE, Cmelak AJ, Rotman M, et al: Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004, 350 (19): 1937-1944. 10.1056/NEJMoa032646.CrossRefPubMed
5.
Bernier J, Domenge C, Ozsahin M, Matuszewska K, Lefebvre JL, Greiner RH, Giralt J, Maingon P, Rolland F, Bolla M, et al: Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer. N Engl J Med. 2004, 350 (19): 1945-1952. 10.1056/NEJMoa032641.CrossRefPubMed
6.
Ang KK, Trotti A, Brown BW, Garden AS, Foote RL, Morrison WH, Geara FB, Klotch DW, Goepfert H, Peters LJ: Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2001, 51 (3): 571-578. 10.1016/S0360-3016(01)01690-X.CrossRefPubMed
7.
Langendijk JA, de Jong MA, Leemans CR, de Bree R, Smeele LE, Doornaert P, Slotman BJ: Postoperative radiotherapy in squamous cell carcinoma of the oral cavity: the importance of the overall treatment time. Int J Radiat Oncol Biol Phys. 2003, 57 (3): 693-700. 10.1016/S0360-3016(03)00624-2.CrossRefPubMed
8.
Mackie TR, Holmes T, Swerdloff S, Reckwerdt P, Deasy JO, Yang J, Paliwal B, Kinsella T: Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys. 1993, 20 (6): 1709-1719. 10.1118/1.596958.CrossRefPubMed
9.
Shueng PW, Wu LJ, Chen SY, Hsiao CH, Tien HJ, Cheng PW, Kuo YS, Chen YJ, Chen CA, Hsieh PY, et al: Concurrent Chemoradiotherapy with Helical Tomotherapy for Oropharyngeal Cancer: A Preliminary Result. Int J Radiat Oncol Biol Phys. 2010, 77 (3): 715-721. 10.1016/j.ijrobp.2009.06.026.CrossRefPubMed
10.
Chao KS, Wippold FJ, Ozyigit G, Tran BN, Dempsey JF: Determination and delineation of nodal target volumes for head-and-neck cancer based on patterns of failure in patients receiving definitive and postoperative IMRT. Int J Radiat Oncol Biol Phys. 2002, 53 (5): 1174-1184. 10.1016/S0360-3016(02)02881-X.CrossRefPubMed
11.
Gregoire V, Coche E, Cosnard G, Hamoir M, Reychler H: Selection and delineation of lymph node target volumes in head and neck conformal radiotherapy. Proposal for standardizing terminology and procedure based on the surgical experience. Radiother Oncol. 2000, 56 (2): 135-150. 10.1016/S0167-8140(00)00202-4.CrossRefPubMed
12.
Forrest LJ, Mackie TR, Ruchala K, Turek M, Kapatoes J, Jaradat H, Hui S, Balog J, Vail DM, Mehta MP: The utility of megavoltage computed tomography images from a helical tomotherapy system for setup verification purposes. Int J Radiat Oncol Biol Phys. 2004, 60 (5): 1639-1644. 10.1016/j.ijrobp.2004.08.016.CrossRefPubMed
13.
Kaplan E, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958, 53: 457-481. 10.2307/2281868.CrossRef
14.
Rosenthal DI, Harris J, Forastiere AA, Weber RS, Ridge JA, Myers JN, Garden AS, Kuettel MR, Sidhu K, Schultz CJ, et al: Early postoperative paclitaxel followed by concurrent paclitaxel and cisplatin with radiation therapy for patients with resected high-risk head and neck squamous cell carcinoma: report of the phase II trial RTOG 0024. J Clin Oncol. 2009, 27 (28): 4727-4732. 10.1200/JCO.2008.21.4197.CrossRefPubMedPubMedCentral
15.
16.
Chao KS, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA: Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2003, 55 (2): 312-321. 10.1016/S0360-3016(02)03940-8.CrossRefPubMed
17.
Chen WC, Hwang TZ, Wang WH, Lu CH, Chen CC, Chen CM, Weng HH, Lai CH, Chen MF: Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. Oral Oncol. 2009, 45 (6): 505-510. 10.1016/j.oraloncology.2008.07.002.CrossRefPubMed
18.
Yao M, Chang K, Funk GF, Lu H, Tan H, Wacha J, Dornfeld KJ, Buatti JM: The failure patterns of oral cavity squamous cell carcinoma after intensity-modulated radiotherapy-the university of iowa experience. Int J Radiat Oncol Biol Phys. 2007, 67 (5): 1332-1341. 10.1016/j.ijrobp.2006.11.030.CrossRefPubMed
19.
Gomez DR, Zhung JE, Gomez J, Chan K, Wu AJ, Wolden SL, Pfister DG, Shaha A, Shah JP, Kraus DH, et al: Intensity-modulated radiotherapy in postoperative treatment of oral cavity cancers. Int J Radiat Oncol Biol Phys. 2009, 73 (4): 1096-1103. 10.1016/j.ijrobp.2008.05.024.CrossRefPubMed
20.
Hinerman RW, Mendenhall WM, Morris CG, Amdur RJ, Werning JW, Villaret DB: Postoperative irradiation for squamous cell carcinoma of the oral cavity: 35-year experience. Head Neck. 2004, 26 (11): 984-994. 10.1002/hed.20091.CrossRefPubMed
21.
Muriel VP, Tejada MR, de Dios Luna del Castillo J: Time-dose-response relationships in postoperatively irradiated patients with head and neck squamous cell carcinomas. Radiother Oncol. 2001, 60 (2): 137-145. 10.1016/S0167-8140(01)00381-4.CrossRefPubMed
22.
Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR: An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity. Int J Radiat Oncol Biol Phys. 1997, 39 (1): 137-148. 10.1016/S0360-3016(97)00152-1.CrossRefPubMed
23.
Yu P, Robb GL: Pharyngoesophageal reconstruction with the anterolateral thigh flap: a clinical and functional outcomes study. Plast Reconstr Surg. 2005, 116 (7): 1845-1855. 10.1097/01.prs.0000191179.58054.80.CrossRefPubMed
24.
Jeremic B, Shibamoto Y, Stanisavljevic B, Milojevic L, Milicic B, Nikolic N: Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: a prospective randomized trial. Radiother Oncol. 1997, 43 (1): 29-37. 10.1016/S0167-8140(97)00048-0.CrossRefPubMed
25.
Capuano G, Grosso A, Gentile PC, Battista M, Bianciardi F, Di Palma A, Pavese I, Satta F, Tosti M, Palladino A, et al: Influence of weight loss on outcomes in patients with head and neck cancer undergoing concomitant chemoradiotherapy. Head Neck. 2008, 30 (4): 503-508. 10.1002/hed.20737.CrossRefPubMed
26.
Eisbruch A, Dawson LA, Kim HM, Bradford CR, Terrell JE, Chepeha DB, Teknos TN, Anzai Y, Marsh LH, Martel MK, et al: Conformal and intensity modulated irradiation of head and neck cancer: the potential for improved target irradiation, salivary gland function, and quality of life. Acta Otorhinolaryngol Belg. 1999, 53 (3): 271-275.PubMed
Metadata
Title
Image-guided intensity modulated radiotherapy with helical tomotherapy for postoperative treatment of high-risk oral cavity cancer
Authors
Chen-Hsi Hsieh
Ying-Shiung Kuo
Li-Jen Liao
Kawang-Yu Hu
Shih-Chiang Lin
Le-Jung Wu
Yu-Chin Lin
Yu-Jen Chen
Li-Ying Wang
Yen-Ping Hsieh
Shoei Long Lin
Chun-Yi Chen
Chien-An Chen
Pei-Wei Shueng
Publication date
01-12-2011
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2011
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-11-37

Other articles of this Issue 1/2011

BMC Cancer 1/2011 Go to the issue

Research article

A study of head and neck cancer treatment and survival among indigenous and non-indigenous people in Queensland, Australia, 1998 to 2004

Research article

Phase II study of weekly paclitaxel and capecitabine in patients with metastatic or recurrent esophageal squamous cell carcinoma

Research article

Constitutive phosphorylation of the FOXO1 transcription factor in gastric cancer cells correlates with microvessel area and the expressions of angiogenesis-related molecules

Research article

Modulation of TRAIL resistance in colon carcinoma cells: Different contributions of DR4 and DR5

Research article

Acceptability of the Distress Thermometer and Problem List to community-based telephone cancer helpline operators, and to cancer patients and carers

Research article

Re-expression of ARHI (DIRAS3) induces autophagy in breast cancer cells and enhances the inhibitory effect of paclitaxel
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits