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BMC Cancer
Published in: BMC Cancer 1/2001

Open Access 01-12-2001 | Research article

Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival

Authors: Masaki Tomita, Takanori Ayabe, Yasunori Matsuzaki, Masao Edagawa, Masayuki Maeda, Tetsuya Shimizu, Masaki Hara, Toshio Onitsuka

Published in: BMC Cancer | Issue 1/2001

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Abstract

Background

We assessed the nm23-H1 gene product expression and its relationship with lymphatic and blood vessel invasion in patients with esophageal squamous cell carcinoma.

Methods

Formalin-fixed and paraffin-embedded tissue sections from 45 patients who were treated surgically were used in this study. Pathologists graded lymphatic and blood vessel invasion in each of the tissue samples. Expression of nm23-Hl gene product was determined using a specific monoclonal antibody.

Results

Expression of nm23-H1 gene product was present in 17 (37.8%) cases. We found an inverse correlation between nm23-H1 gene product expression and lymphatic vessel invasion, whereas no correlation between nm23-H1 gene product expression and blood vessel invasion. Overall survival rate was not different between nm23-H1 gene product positive and negative patients (p = 0.21). However, reduced expression of nm23-H1 gene product was associated with shorter overall survival in patients with involved lymph nodes (p < 0.05), but not in patients without involved lymph nodes (p = 0.87).

Conclusions

In patients with esophageal squamous cell carcinoma, there appears to be an inverse relationship between nm23-H1 gene product expression and lymphatic vessel invasion. Furthermore, nm23-H1 gene product expression might be a prognostic marker in patients with involved lymph nodes. Our data does not demonstrate any correlation between nm23-H1 gene product expression and blood vessel invasion.
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Metadata
Title
Expression of nm23-H1 gene product in esophageal squamous cell carcinoma and its association with vessel invasion and survival
Authors
Masaki Tomita
Takanori Ayabe
Yasunori Matsuzaki
Masao Edagawa
Masayuki Maeda
Tetsuya Shimizu
Masaki Hara
Toshio Onitsuka
Publication date
01-12-2001
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2001
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/1471-2407-1-3

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