Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
BMC Pregnancy and Childbirth
Published in: BMC Pregnancy and Childbirth 1/2007

Open Access 01-06-2007 | Proceedings

Inflammatory pathways in the mechanism of parturition

Authors: Jane E Norman, Shrikant Bollapragada, Mei Yuan, Scott M Nelson

Published in: BMC Pregnancy and Childbirth | Special Issue 1/2007

Login to get access

Abstract

Increasing evidence suggests that parturition is an inflammatory process. In this brief overview, inflammatory events occurring in association with parturition, and the mechanism by which they may contribute to labour and delivery will be discussed. Mention will be made of how this information may be of use in regulating the timing and the onset of parturition.
Literature
1.
2.
Thomson A, Telfer J, Young A, Campbell S, Stewart C, Cameron I, Greer I, Norman J: Leukocytes infiltrate the myometrium during human parturtion: further evidence that labour is an inflammatory process. Human Reproduction. 1999, 14: 229-236. 10.1093/humrep/14.1.229.CrossRefPubMed
3.
Osman I, Young A, Ledingham M, Thomson A, Jordan F, Greer I, Norman J: Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term. Molecular Human Reproduction. 2003, 9: 41-45. 10.1093/molehr/gag001.CrossRefPubMed
4.
Young A, Jordan F, Ledingham M, Thomson A, Norman J, Greer I: Quantification of pro-inflammatory cytokines in myometrium, cervix and fetal membranes during human parturition. Journal of the Society of Gynecologic Investigation. 2002, 9: 137A-10.1016/S1071-5576(02)00142-9.CrossRef
5.
Ledingham MA, Thomson AJ, Jordan F, Young A, Crawford M, Norman JE: Cell adhesion molecule expression in cervix and myometrium during pregnancy and parturition. Obstet Gynecol. 2001, 97: 235-242. 10.1016/S0029-7844(00)01126-1.CrossRefPubMed
6.
Tribe RM, Moriarty P, Dalrymple A, Hassoni AA, Poston L: Interleukin-1beta induces calcium transients and enhances basal and store operated calcium entry in human myometrial smooth muscle. Biol Reprod. 2003, 68 (5): 1842-1849. 10.1095/biolreprod.102.011403.CrossRefPubMed
7.
Oger S, Mehats C, Dallot E, Ferre F, Leroy MJ: Interleukin-1beta induces phosphodiesterase 4B2 expression in human myometrial cells through a prostaglandin E2- and cyclic adenosine 3',5'-monophosphate-dependent pathway. J Clin Endocrinol Metab. 2002, 87 (12): 5524-5531. 10.1210/jc.2002-020575.CrossRefPubMed
8.
Rauk PN, Chiao JP: Interleukin-1 stimulates human uterine prostaglandin production through induction of cyclooxygenase-2 expression. Am J Reprod Immunol. 2000, 43 (3): 152-159. 10.1111/j.8755-8920.2000.430304.x.CrossRefPubMed
9.
Roh CR, Oh WJ, Yoon BK, Lee JH: Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Molecular Human Reproduction. 2000, 6 (1): 96-102. 10.1093/molehr/6.1.96.CrossRefPubMed
10.
Ledingham M, Thomson A, Macara L, Young A, Greer I, Norman J: Changes in the expression of nitric oxide synthase in the human uterine cervix during pregnancy and parturition. Molecular Human Reproduction. 2000, 6: 1041-1048. 10.1093/molehr/6.11.1041.CrossRefPubMed
11.
Tschugguel W, Schneeberger C, Lass H, Stonek F, Zaghlula M, Czerwenka K, Schatten C, Kaider A, Husslein P, Huber J: Human cervical ripening is associated with an increase in cervical inducible nitric oxide synthase expression. Biology of Reproduction. 1999, 60: 1367-1372. 10.1095/biolreprod60.6.1367.CrossRefPubMed
12.
Thomson AJ, Lunan CB, Cameron AD, Cameron IT, Greer IA, Norman JE: Nitric oxide donors induce ripening of the human uterine cervix: a randomised controlled trial. Br J Obstet and Gynaecol. 1997, 104: 1054-1057.CrossRef
13.
Nicoll AE, Mackenzie F, Greer IA, Norman J: Vaginal application of the nitric oxide donor isosorbide mononitrate for preinduction cervical ripening: a randomised controlled trial to determine effects on maternal and fetal haemodynamics. Am J Obstet Gynecol. 2001, 184: 958-964. 10.1067/mob.2001.111797.CrossRefPubMed
14.
Osman I, MacKenzie F, Norrie J, Murray HM, Greer IA, Norman JE: The "PRIM" study: a randomized comparison of prostaglandin E2 gel with the nitric oxide donor isosorbide mononitrate for cervical ripening before the induction of labor at term. Am J Obstet Gynecol. 2006, 194 (4): 1012-1021. 10.1016/j.ajog.2005.10.812.CrossRefPubMed
15.
Bollapragada S, Mackenzie F, Norrie J, Petrou S, Reid M, Greer I, Osman I, JE N: IMOP: randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour – clinical trial with analyses of efficacy, cost effectiveness and acceptability. BMC Pregnancy Childbirth. 2006, 6: 25-10.1186/1471-2393-6-25.PubMedCentralCrossRefPubMed
16.
Osman I, Young A, Jordan F, Greer IA, Norman JE: Leukocyte density and proinflammatory mediator expression in regional human fetal membranes and decidua before and during labor at term. J Soc Gynecol Investig. 2006, 13 (2): 97-103. 10.1016/j.jsgi.2005.12.002.CrossRefPubMed
17.
Haddad R, Tromp G, Kuivaniemi H, Chaiworapongsa T, Kim YM, Mazor M, Romero R: Human spontaneous labor without histologic chorioamnionitis is characterized by an acute inflammation gene expression signature. Am J Obstet Gynecol. 2006, 195 (2): e1-e24. 10.1016/j.ajog.2005.08.057.PubMed
Metadata
Title
Inflammatory pathways in the mechanism of parturition
Authors
Jane E Norman
Shrikant Bollapragada
Mei Yuan
Scott M Nelson
Publication date
01-06-2007
Publisher
BioMed Central
Published in
BMC Pregnancy and Childbirth / Issue Special Issue 1/2007
Electronic ISSN: 1471-2393
DOI
https://doi.org/10.1186/1471-2393-7-S1-S7

Other articles of this Special Issue 1/2007

BMC Pregnancy and Childbirth 1/2007 Go to the issue

Proceedings

Tocolytic effect of a selective FP receptor antagonist in rodent models reveals an innovative approach to the treatment of preterm labor

Proceedings

Barusiban suppresses oxytocin-induced preterm labour in non-human primates

Proceedings

A translational approach to studying preterm labour

Proceedings

New research models and novel signal analysis in studies on preterm labor: a key to progress?

Proceedings

PDE4 as a target in preterm labour

Proceedings

Towards understanding the myometrial physiome: approaches for the construction of a virtual physiological uterus