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Open Access 01-12-2014 | Research article

Sero-positivity rate of rubella and associated factors among pregnant women attending antenatal care in Mwanza, Tanzania

Authors: Berno Mwambe, Mariam M Mirambo, Stephen E Mshana, Anthony N Massinde, Benson R Kidenya, Denna Michael, Domenica Morona, Charles Majinge, Uwe Groß

Published in: BMC Pregnancy and Childbirth | Issue 1/2014

Abstract

Background

Sero-positivity rates of the rubella virus among pregnant women vary widely throughout the world. In Tanzania, rubella vaccination is not included in the national immunization schedule and there is therefore no antenatal screening for this viral disease. So far, there are no reports on the sero-prevalence of rubella among pregnant women in Tanzania. As a result, this study was undertaken to establish the sero-positivity rate of rubella and rubella risk factors among pregnant women attending antenatal care clinics in Mwanza, Tanzania.

Methods

From November 2012 to May 2013 a total of 350 pregnant women were enrolled and their serum samples collected and analyzed using the AXSYM anti-rubella virus IgG/IgM-MEIA test. Demographic and clinical data were collected using a standardized data collection tool. Data analysis was done using STATA version 12.

Results

Of 342 pregnant women tested for rubella antibodies, 317 (92.6%) were positive for anti-rubella IgG while only 1 (0.3%) was positive for IgM. Higher sero-positivity rates were found in the age group of 25–44 years. Furthermore, it was observed that with each year increase in age, the risk of contracting rubella increases by 12% (OR = 1.12, 95% CI: 1.02-1.22, P = 0.019). Women involved in farming and business women were at a higher risk of contracting rubella infection compared to formally employed women (OR: 4.9, P = 0.011; OR 7.1, p = 0.003 respectively). In univariate analysis, the risk of contracting rubella virus infection was found to increase with gestational age with a statistical significance.

Conclusions

Sero-positivity rates of rubella are high in Mwanza and are significantly associated with an increase in age and being a farmer or a business woman. Screening of rubella and immunization of women at risk are highly recommended in this area with a high non-immune rate against rubella virus.

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Shah I, Bhatnagar S: Antenatal diagnostic problem of congenital rubella. Indian J Pediatr. 2010, 77: 450-451. 10.1007/s12098-009-0312-x.CrossRefPubMed

WHO: Rubella vaccines: WHO position paper. Wkly Epidemiol Rec. 2011, 86 (29): 301-316.

Binnicker MJ, Jespersen JD, Harring JA: Multiplex detection of IgM and IgG class antibodies to Toxoplasma gondii, rubella virus, and cytomegalovirus using a novel multiplex flow immunoassay. Clin Vaccine Immunol. 2010, 17 (11): 1734-1738. 10.1128/CVI.00332-10.CrossRefPubMedPubMedCentral

Linguissi LS, Nagalo BM, Bisseye C, Kagone TS, Sanou M, Tao I, Benao V, Simpore J, Kone B: Seroprevalence of toxoplasmosis and rubella in pregnant women attending antenatal private clinic at Ouagadougou, Burkina Faso. Asian Pac J Trop Med. 2012, 5 (10): 810-813. 10.1016/S1995-7645(12)60148-5.CrossRefPubMed

Uyar Y, Balci A, Akcali A: Prevalence of rubella and cytomegalovirus antibodies among pregnant women in Northern Turkey. New Microbiol. 2008, 31: 451-455.PubMed

Usonis V, Anca I, Andre F: Rubella revisited: where are we on the road to disease elimination in Central Europe?. Vaccine. 2011, 29: 9141-9147. 10.1016/j.vaccine.2011.09.104.CrossRefPubMed

Cochran WG: Sampling Techniques. 1963, New York: John Wiley and Sons, Inc, 2

Doehring E, Reiter-Owona I, Bauer O, Kaisi M, Hlobil H, Quade G, Hamudu NA, Seitz HM: Toxoplasma gondii antibodies in pregnant women and their newborns in Dar es Salaam, Tanzania. Am J Trop Med Hyg. 1995, 52: 546-548.PubMed

Calimeri CA, La Fauci V, Squeri R, Grillo OC, Lo Giudice D: Prevalence of serum anti-rubella virus antibodies among pregnant women in southern Italy. Int J Gynaecol Obstet. 2012, 116 (3): 211-213. 10.1016/j.ijgo.2011.10.029.CrossRefPubMed

10.

Onakewhor JU, Chiwuzie J: Seroprevalence survey of rubella infection in pregnancy at the University of Benin Teaching Hospital, Benin City, Nigeria. Niger J Clin Pract. 2011, 14 (2): 140-145. 10.4103/1119-3077.84002.CrossRefPubMed

11.

Hamdan HZ, Abdelbagi IE, Nasser NM, Adam I: Seroprevalence of cytomegalovirus and rubella among pregnant women in western Sudan. Virol J. 2011, 11 (8): 217-CrossRef

12.

Lin C, Yang C, Shih Y, Hsu H, Yang T, Cheng Y, Chang CF, Hsieh LC, Chen BH, Lee CH, Huang YL: Rubella Seroepidemiologic and estimations of the catch-up immunisation rate and persistence of antibody titers in pregnant women in Taiwan. BJOG. 2011, 118: 706-712. 10.1111/j.1471-0528.2011.02903.x.CrossRefPubMed

13.

Bukbuk DN, el Nafaty AU, Obed JY: Prevalence of rubella-specific IgG antibody in non-immunized pregnant women in Maiduguri, north eastern Nigeria. Cent Eur J Public Health. 2002, 10 (1–2): 21-23.PubMed

14.

Kombich JJ, Muchai PC, Tukei P, Borus PK: Rubella seroprevalence among primary and pre- primary school pupils at Moi’s Bridge location, Uasin Gishu District, Kenya. BMC Public Health. 2009, 29 (9): 269-CrossRef

15.

Lewis RF, Braka F, Mbabazi W, Makumbi I, Kasasa S, Nanyunja M: Exposure of Ugandan health personnel to measles and rubella: evidence of the need for health worker vaccination. Vaccine. 2006, 24 (47–48): 6924-6929.CrossRefPubMed

16.

Tahita MC, Hübschen JM, Tarnagda Z, Ernest D, Charpentier E, Kremer JR, Muller CP, Ouedraogo JB: Rubella seroprevalence among pregnant women in Burkina Faso. BMC Infect Dis. 2013, 13: 164-10.1186/1471-2334-13-164.CrossRefPubMedPubMedCentral

17.

Schoub BD, Harris BN, McAnerney J, Blumberg L: Rubella in South Africa: an impending Greek tragedy?. S Afr Med J. 2009, 99: 7-

18.

Robertson SE, Featherstone DA, Gacic-Dobo M, Hersh BS: Rubella and congenital rubella syndrome: global update. Rev Panam Salud Publica. 2003, 14 (5): 306-315.CrossRefPubMed

19.

Kombich JJ, Muchai PC, Borus PK: Seroprevalence of natural rubella antibodies among antenatal attendees at Moi teaching and Referral Hospital, Eldoret, Kenya. J Immunol Tech Infect Dis. 2012, 1: 1-doi:10.4172/2325-9752.1000102

20.

Corcoran C, Hardie DR: Seroprevalence of rubella antibodies among antenatal patients in the Western Cape. S Afr Med J. 2005, 95 (9): 688-690.PubMed

The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2393/14/95/prepub

Title: Sero-positivity rate of rubella and associated factors among pregnant women attending antenatal care in Mwanza, Tanzania
Authors: Berno Mwambe
Mariam M Mirambo
Stephen E Mshana
Anthony N Massinde
Benson R Kidenya
Denna Michael
Domenica Morona
Charles Majinge
Uwe Groß
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: BMC Pregnancy and Childbirth / Issue 1/2014
Electronic ISSN: 1471-2393
DOI: https://doi.org/10.1186/1471-2393-14-95

ACC 2024 Congress

Springer Medicine

Sero-positivity rate of rubella and associated factors among pregnant women attending antenatal care in Mwanza, Tanzania

Abstract

Background

Methods

Results

Conclusions

ACC 2024 Congress

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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