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BMC Neurology
Published in: BMC Neurology 1/2006

Open Access 01-12-2006 | Research article

Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?

Authors: Constanze Boesenberg-Grosse, Walter J Schulz-Schaeffer, Monika Bodemer, Barbara Ciesielczyk, Bettina Meissner, Anna Krasnianski, Mario Bartl, Uta Heinemann, Daniela Varges, Sabina Eigenbrod, Hans A Kretzschmar, Alison Green, Inga Zerr

Published in: BMC Neurology | Issue 1/2006

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Abstract

Background

Brain derived proteins such as 14-3-3, neuron-specific enolase (NSE), S 100b, tau, phosphorylated tau and Aβ1–42 were found to be altered in the cerebrospinal fluid (CSF) in Creutzfeldt-Jakob disease (CJD) patients. The pathogenic mechanisms leading to these abnormalities are not known, but a relation to rapid neuronal damage is assumed. No systematic analysis on brain-derived proteins in the CSF and neuropathological lesion profiles has been performed.

Methods

CSF protein levels of brain-derived proteins and the degree of spongiform changes, neuronal loss and gliosis in various brain areas were analyzed in 57 CJD patients.

Results

We observed three different patterns of CSF alteration associated with the degree of cortical and subcortical changes. NSE levels increased with lesion severity of subcortical areas. Tau and 14-3-3 levels increased with minor pathological changes, a negative correlation was observed with severity of cortical lesions. Levels of the physiological form of the prion protein (PrPc) and Aβ1–42 levels correlated negatively with cortical pathology, most clearly with temporal and occipital lesions.

Conclusion

Our results indicate that the alteration of levels of brain-derived proteins in the CSF does not only reflect the degree of neuronal damage, but it is also modified by the localization on the brain pathology. Brain specific lesion patterns have to be considered when analyzing CSF neuronal proteins.
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Metadata
Title
Brain-derived proteins in the CSF, do they correlate with brain pathology in CJD?
Authors
Constanze Boesenberg-Grosse
Walter J Schulz-Schaeffer
Monika Bodemer
Barbara Ciesielczyk
Bettina Meissner
Anna Krasnianski
Mario Bartl
Uta Heinemann
Daniela Varges
Sabina Eigenbrod
Hans A Kretzschmar
Alison Green
Inga Zerr
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2006
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-6-35

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