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BMC Neurology
Published in: BMC Neurology 1/2014

Open Access 01-12-2014 | Study protocol

The effect of obstructive sleep apnea and treatment with continuous positive airway pressure on stroke rehabilitation: rationale, design and methods of the TOROS study

Authors: Justine A Aaronson, Coen AM van Bennekom, Winni F Hofman, Tijs van Bezeij, Joost G van den Aardweg, Erny Groet, Wytske A Kylstra, Ben A Schmand

Published in: BMC Neurology | Issue 1/2014

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Abstract

Background

Obstructive sleep apnea is a common sleep disorder in stroke patients. Obstructive sleep apnea is associated with stroke severity and poor functional outcome. Continuous positive airway pressure seems to improve functional recovery in stroke rehabilitation. To date, the effect of continuous positive airway pressure on cognitive functioning in stroke patients is not well established. The current study will investigate the effectiveness of continuous positive airway pressure on both cognitive and functional outcomes in stroke patients with obstructive sleep apnea.

Methods/Design

A randomized controlled trial will be conducted on the neurorehabilitation unit of Heliomare, a rehabilitation center in the Netherlands. Seventy stroke patients with obstructive sleep apnea will be randomly allocated to an intervention or control group (n = 2×35). The intervention will consist of four weeks of continuous positive airway pressure treatment. Patients allocated to the control group will receive four weeks of treatment as usual. Outcomes will be assessed at baseline, immediately after the intervention and at two-month follow-up.
In a supplementary study, these 70 patients with obstructive sleep apnea will be compared to 70 stroke patients without obstructive sleep apnea with respect to cognitive and functional status at rehabilitation admission. Additionally, the societal participation of both groups will be assessed at six months and one year after inclusion.

Discussion

This study will provide novel information on the effects of obstructive sleep apnea and its treatment with continuous positive airway pressure on rehabilitation outcomes after stroke.

Trial registration

Trial registration number: Dutch Trial Register NTR3412
Appendix
Available only for authorised users
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Metadata
Title
The effect of obstructive sleep apnea and treatment with continuous positive airway pressure on stroke rehabilitation: rationale, design and methods of the TOROS study
Authors
Justine A Aaronson
Coen AM van Bennekom
Winni F Hofman
Tijs van Bezeij
Joost G van den Aardweg
Erny Groet
Wytske A Kylstra
Ben A Schmand
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2014
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-14-36

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