Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Neurology
Published in: BMC Neurology 1/2013

Open Access 01-12-2013 | Study protocol

COMBIT: protocol of a randomised comparison trial of COMbined modified constraint induced movement therapy and bimanual intensive training with distributed model of standard upper limb rehabilitation in children with congenital hemiplegia

Authors: Roslyn N Boyd, Jenny Ziviani, Leanne Sakzewski, Laura Miller, Joanne Bowden, Ross Cunnington, Robert Ware, Andrea Guzzetta, Richard AL Macdonell, Graeme D Jackson, David F Abbott, Stephen Rose

Published in: BMC Neurology | Issue 1/2013

Login to get access

Abstract

Introduction

Children with congenital hemiplegia often present with limitations in using their impaired upper limb which impacts on independence in activities of daily living, societal participation and quality of life. Traditional therapy has adopted a bimanual training approach (BIM) and more recently, modified constraint induced movement therapy (mCIMT) has emerged as a promising unimanual approach. Evidence of enhanced neuroplasticity following mCIMT suggests that the sequential application of mCIMT followed by bimanual training may optimise outcomes (Hybrid CIMT). It remains unclear whether more intensely delivered group based interventions (hCIMT) are superior to distributed models of individualised therapy. This study aims to determine the optimal density of upper limb training for children with congenital hemiplegia.

Methods and analyses

A total of 50 children (25 in each group) with congenital hemiplegia will be recruited to participate in this randomized comparison trial. Children will be matched in pairs at baseline and randomly allocated to receive an intensive block group hybrid model of combined mCIMT followed by intensive bimanual training delivered in a day camp model (COMBiT; total dose 45 hours direct, 10 hours of indirect therapy), or a distributed model of standard occupational therapy and physiotherapy care (SC) over 12 weeks (total 45 hours direct and indirect therapy). Outcomes will be assessed at 13 weeks after commencement, and retention of effects tested at 26 weeks. The primary outcomes will be bimanual coordination and unimanual upper-limb capacity. Secondary outcomes will be participation and quality of life. Advanced brain imaging will assess neurovascular changes in response to treatment. Analysis will follow standard principles for RCTs, using two-group comparisons on all participants on an intention-to-treat basis. Comparisons will be between treatment groups using generalized linear models.

Trial registration

ACTRN12613000181​707
Appendix
Available only for authorised users
Literature
1.
Stanley F, Blair E, Alberman E: Cerebral palsies: Epidemiology and causal pathways. 2000, London: Mac Keith
2.
Wiklund LM, Uvebrant P: Hemiplegic cerebral palsy. Correlation between CT morphology and clinical findings. Dev. Med & Child Neurology. 1991, 33: 512-523.
3.
Sakzewski L, Boyd R, Ziviani J: Clinimetric properties of participation measures for 5- to 13-year-old children with cerebral palsy: a systematic review. Dev. Med. & Child Neurology. 2007, 49: 232-240.
4.
Sakzewski L, Ziviani J, Boyd R: Systematic review and meta-analysis of therapeutic management of upper limb dysfunction in children with congenital hemiplegia. Pediatrics. 2009, 123: E1111-E1122.PubMed
5.
Taub E, Ramey SL, DeLuca S, Echols K: Efficacy of constraint-induced movement therapy for children with cerebral palsy with asymmetric motor impairment. Pediatrics. 2004, 113: 305-312.PubMed
6.
Wolf S, Winstein C, Miller J, Taub E, Uswatte G, Morris D, Giuliani C, Light K, Nichols-Larsen D: Effect of constraint-induced movement therapy on upper extremity function 3 to 9 months after stroke. JAMA. 2006, 296: 2095-2104.PubMed
7.
Taub E, Griffin A, Uswatte G, Gammons K, Nick J, Law CR: Treatment of congenital hemiparesis with pediatric constraint-induced movement therapy. J Child Neurol. 2011, 26: 1163-1173.PubMedPubMedCentral
8.
Deluca SC, Case-Smith J, Stevenson R, Ramey SL: Constraint-induced movement therapy (CIMT) for young children with cerebral palsy: Effects of therapeutic dosage. J Pediatr Rehabil Med. 2012, 5: 133-142.PubMed
9.
Charles JC, Wolf SL, Schneider JA, Gordon AM: Efficacy of a child-friendly form of constraint-induced movement therapy in hemiplegic cerebral palsy: a randomized control trial. Dev Med & Child Neurology. 2006, 48: 635-642.
10.
Gordon AM, Hung YC, Brandao M, Ferre CL, Kuo HC, Friel K, Petra E, Chinnan A, Charles JR: Bimanual training and constraint-induced movement therapy in children with hemiplegic cerebral palsy: a randomized trial. Neurorehab and Neural Repair. 2011, 25: 692-702.
11.
Sakzewski L, Ziviani J, Abbott DF, Macdonell RA, Jackson GD, Boyd RN: Randomized trial of constraint-induced movement therapy and bimanual training on activity outcomes for children with congenital hemiplegia. Dev Med Child Neurol. 2011, 53: 313-320.PubMed
12.
Xu K, Wang L, Mai J, He L: Efficacy of constraint-induced movement therapy and electrical stimulation on hand function of children with hemiplegic cerebral palsy: a controlled clinical trial. Disabil Rehabil. 2012, 34: 337-346.PubMed
13.
Facchin P, Rosa-Rizzotto M, Visona Dalla Pozza L, Turconi AC, Pagliano E, Signorini S, Tornetta L, Trabacca A, Fedrizzi E: Multisite trial comparing the efficacy of constraint-induced movement therapy with that of bimanual Intensive training in children with hemiplegic cerebral palsy: post intervention results. Is J of Phys Med and Rehab. 2011, 90: 539-553.
14.
Rostami HR, Malamiri RA: Effect of treatment environment on modified constraint-induced movement therapy results in children with spastic hemiplegic cerebral palsy: a randomized controlled trial. Disabil Rehabil. 2012, 34: 40-44.PubMed
15.
Al-Oraibi S, Eliasson AC: Implementation of constraint-induced movement therapy for young children with unilateral cerebral palsy in Jordan: a home-based model. Disabil Rehabil. 2011, 33: 2006-2012.PubMed
16.
Eliasson AC, Shaw K, Berg E, Krumlinde-Sundholm L: An ecological approach of Constraint Induced Movement Therapy for 2-3-year-old children: a randomized control trial. Research in Dev. Disabilities. 2011, 32: 2820-8.
17.
Hsin YJ, Chen FC, Lin KC, Kang LJ, Chen CL, Chen CY: Efficacy of constraint-induced therapy on functional performance and health-related quality of life for children with cerebral palsy: a randomized controlled trial. J of Child Neurology. 2012, 27: 992-999.
18.
Smania N, Aglioti SM, Cosentino A, Camin M, Gandolfi M, Tinazzi M, Fiaschi A, Faccioli S: A modified constraint-induced movement therapy (CIT) program improves paretic arm use and function in children with cerebral palsy. Euro J Physical & Rehab Med. 2009, 45: 493-500.
19.
Wallen M, Ziviani J, Naylor O, Evans R, Novak I, Herbert RD: Modified constraint-induced therapy for children with hemiplegic cerebral palsy: a randomized trial. Dev Med & Child Neuro. 2011, 53: 1091-1099.
20.
Chen CL, Kang LJ, Hong WH, Chen FC, Chen HC, Wu CY: Effect of therapist-based constraint-induced therapy at home on motor control, motor performance and daily function in children with cerebral palsy: a randomized controlled study. Clin Rehabil. 2013, 27: 236-245.PubMed
21.
Lin KC, Wang TN, Wu CY, Chen CL, Chang KC, Lin YC, Chen YJ: Effects of home-based constraint-induced therapy versus dose-matched control intervention on functional outcomes and caregiver well-being in children with cerebral palsy. Res Dev Disabil. 2011, 32: 1483-1491.PubMed
22.
Aarts PB, Jongerius PH, Geerdink YA, van Limbeek J, Geurts AC: Effectiveness of modified constraint-induced movement therapy in children with unilateral spastic cerebral palsy: a randomized controlled trial. Neurorehabil Neural Repair. 2010, 24: 509-518.PubMed
23.
De Brandão Brito M, Mancini MC, Vaz DV, Pereira de Melo AP, Fonseca ST: Adapted version of constraint-induced movement therapy promotes functioning in children with cerebral palsy: a randomized controlled trial. Clin Rehabil. 2010, 24: 639-647.
24.
Case-Smith J, DeLuca SC, Stevenson R, Ramey SL: Multicenter randomized controlled trial of pediatric constraint-induced movement therapy: 6-month follow-up. Am J Occup Ther. 2012, 66: 15-23.PubMed
25.
Boyd R, Sakzewski L, Ziviani J, Abbott DF, Badawy R, Gilmore R, Provan K, Tournier JD, Macdonell RA, Jackson GD: INCITE: a randomised trial comparing constraint induced movement therapy and bimanual training in children with congenital hemiplegia. BMC Neurol. 2010, 10: 4-PubMedPubMedCentral
26.
Novak I, Cusick A, Lannin N: Occupational therapy home programs for cerebral palsy: double-blind, randomized, controlled trial. Pediatrics. 2009, 124: e606-e614.PubMed
27.
Johnson LM, Randall MJ, Reddihough DS, Oke LE, Byrt TA, Bach TM: Development of a clinical assessment of quality of movement for unilateral upper-limb function. Dev Med Child Neurol. 1994, 36: 965-973.PubMed
28.
Randall M, Carlin JB, Chondros P, Reddihough D: Reliability of the Melbourne Assessment of Unilateral Upper Limb Function. Dev Med Child Neurol. 2001, 43: 761-767.PubMed
29.
Loubinoux I, Carel C, Alary F, Boulanouar K, Viallard G, Manelfe C, Rascol O, Celsis P, Chollet F: Within-session and between-session reproducibility of cerebral sensorimotor activation: a test-retest effect evidenced with functional magnetic resonance imaging. J Cereb Blood Flow Metab. 2001, 21: 592-607.PubMed
30.
Eliasson AC, Krumlinde-Sundholm L, Rosblad B, Beckung E, Arner M, Ohrvall AM, Rosenbaum P: The Manual Ability Classification System (MACS) for children with cerebral palsy: scale development and evidence of validity and reliability. Dev Med Child Neurol. 2006, 48: 549-554.PubMed
31.
Palisano RJ, Rosenbaum P, Walter S, Russell D, Wood EP, Galuppi BE: Development and reliability of a system to classify gross motor function in children with cerebral palsy. Dev Med Child Neurol. 1997, 39: 214-223.PubMed
32.
Palisano RJ, Hanna SE, Rosenbaum PL, Russell DJ, Walter SD, Wood EP, Raina PS, Galuppi BE: Validation of a model of gross motor function for children with cerebral palsy. Phys Ther. 2000, 80: 974-985.PubMed
33.
Morris C, Galuppi BE, Rosenbaum PL: Reliability of family report for the gross motor function classification system. Dev Med Child Neurol. 2004, 46: 455-460.PubMed
34.
Morris C, Kurinczuk JJ, Fitzpatrick RB, Rosenbaum PL: Reliability of the manual ability classification system for children with cerebral palsy. Dev Med Child Neurol. 2006, 48: 950-953.PubMed
35.
Zancolli E: Surgical management of the hemiplegic spastic hand in cerebral palsy. Surg Clin N Am. 1981, 61: 395-406.PubMed
36.
House J, Gwathmey F, Fidler M: A dynamic approach to the thumb-in palm deformity in cerebral palsy. Evaluation and results in fifty-six patients. J of Bone & Jt Surgery. 1981, 63: 216-225.
37.
Barkovich AJM, Kuzniecky RIM, Jackson GDM, Guerrini RM, Dobyns WBM: Classification system for malformations of cortical development: update 2001. Neurology. 2001, 57: 2168-2178.PubMed
38.
Krägeloh-Mann I, Helber A, Mader I, Staudt M, Wolff M, Groenendaal F, DeVries L: Bilateral lesions of thalamus and basal ganglia: origin and outcome. Dev Med & Child Neuro. 2002, 44: 477-484.
39.
Guzzetta A, Sinclair K, Clarke D, Boyd RN: A novel semi-quantitative scale for classification of brain MRI for children with cerebral palsy. Dev Med & Child Neuro. 2010, 52: 74-
40.
Holmes CJ, Hoge R, Collins L, Woods R, Toga AW, Evans AC: Enhancement of MR Images Using Registration for Signal Averaging. J of Computer Assisted Tomography. 1998, 22: 324-333. March/April
41.
Abbott D, Jackson G: iBrain™ — Software for analysis and visualisation of functional MR images. Neuroimage. 2001, 13: S59-
42.
Briellmann RS, Abbott DF, Caflisch U, Archer JS, Jackson GD: Brain reorganisation in cerebral palsy: a high-field functional MRI study. Neuropediatrics. 2002, 33: 162-165.PubMed
43.
Logothetis N, Pauls J, Augath M, Trinath T, Oeltermann A: Neurophysiological investigation of the basis of the fMRI signal. Nature. 2001, 412: 150-157.PubMed
44.
Lehéricy S, Bardinet E, Tremblay L, Van de Moortele P-F, Pochon J-B, Dormont D, Kim D-S, Yelnik J, Ugurbil K: Motor control in basal ganglia circuits using fMRI and brain atlas approaches. Cereb Cortex. 2006, 16: 149-161.PubMed
45.
Waites AB, Stanislavsky A, Abbott DF, Jackson GD: The effect of prior cognitive state on resting state networks measured with functional connectivity. Hum Brain Mapp. 2005, 24: 59-68.PubMed
46.
Abbott DF, Masterton RAJ, Waites AB, Bhaganagarapu K, Pell GS, Harvey MR, Sharma GJ, Jackson GD: The iBrain™ Analysis Toolbox for SPM. 2011, Canada: In Proceedings of the 17th Annual Meeting of the Organisation for Human Brain Mapping; Quebec City, 364 WTh. (available at http://​www.​brain.​org.​au/​software)
47.
Wilson SJ, Abbott DF, Lusher D, Gentle EC, Jackson GD: Finding your voice: a singing lesson from functional imaging. Hum Brain Mapp. 2011, 32: 2115-2130.PubMed
48.
Frackowiak R, Friston K, Frith C, Dolan R, Price C, Zeki S, Ashburner J, Penny W: Human Brain Function. 2003, San Diego: Academic Press, 2
49.
Lemieux L, Salek-Haddadi A, Lund TE, Laufs H, Carmichael D: Modelling large motion events in fMRI studies of patients with epilepsy. Magn Reson Imaging. 2007, 25: 894-901.PubMed
50.
Power JD, Barnes KA, Snyder AZ, Schlaggar BL, Petersen SE: Spurious but systematic conditions in functional connectivity MRI networks arise from subject motion. Neuroimage. 2012, 59: 2141-2154.
51.
Abbott DF, Waites AB, Lillywhite LM, Jackson GD: fMRI assessment of language lateralization: an objective approach. Neuroimage. 2010, 50: 1446-1455.PubMed
52.
Tournier J, Calamante F, Connelly A: Robust determination of the fibre orientation distribution in diffusion MRI: non-negativity constrained super-resolved spherical deconvolution. Neuroimage. 2007, 35: 1459-1472.PubMed
53.
Tournier JD, Calamante F, Connelly A: MRtrix: Diffusion tractography in crossing fiber regions. Int J Imaging Syst Technol. 2012, 22: 53-66.
54.
Farquharson S, Tournier JD, Calamante F, Fabinyi G, Schneider-Kolsky M, Jackson GD, Connelly A: White matter fiber tractography: why we need to move beyond DTI. J Neurosurg. 2013, 6: 1367-1377.
55.
Raffelt D, Tournier JD, Rose S, Ridgway GR, Henderson R, Crozier S, Salvado O, Connelly A: Apparent Fibre Density: a novel measure for the analysis of diffusion-weighted magnetic resonance images. Neuroimage. 2012, 59: 3976-3994.PubMed
56.
Rose S, Guzzetta A, Pannek K, Boyd R: MRI structural connectivity, disruption of primary sensorimotor pathways, and hand function in cerebral palsy. Brain Connectivity. 2011, 1: 309-316.PubMed
57.
Rose S, Pannek K, Bell C, Baumann F, Hutchinson N, Coulthard A, McCombe P, Henderson R: Direct evidence of intra- and interhemispheric corticomotor network degeneration in amyotrophic lateral sclerosis: an automated MRI structural connectivity study. Neuroimage. 2012, 59: 2661-2669.PubMed
58.
Rose S, Rowland T, Pannek K, Baumann F, Coulthard A, McCombe P, Henderson R: Structural hemispheric asymmetries in the human precentral gyrus hand representation. Neuroscience. 2012, 210: 211-221.PubMed
59.
Behrens TE, Johansen-Berg H, Woolrich MW, Smith SM, Wheeler-Kingshott CA, Boulby PA, Barker GJ, Sillery EL, Sheehan K, Ciccarelli O, et al: Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging. Nat Neurosci. 2003, 6: 750-757.PubMed
60.
Pannek K, Mathias JL, Bigler ED, Brown G, Taylor JD, Rose S: An automated strategy for the delineation and parcellation of commissural pathways suitable for clinical populations utilising high angular resolution diffusion imaging tractography. Neuroimage. 2010, 50: 1044-1053.PubMed
61.
Boyd RN: The central and peripheral effects of botulinum toxin A in children with cerebral palsy. 2004, Melbourne, Australia: PhD Thesis, School of Physiotherapy, Faculty of Health Sciences Library. La Trobe University
62.
Boyd R, Graham H: Objective measurement of clinical findings in the use of botulinum toxin type A for the management of children with cerebral palsy. Eur J Neurol. 1999, 6: S23-S35.
63.
Ashworth B: Preliminary trial of carisoprodol in multiple sclerosis. Practitioner. 1964, 192: 540-542.PubMed
64.
Bohannon R, Smith M: Interrater reliability of a modified Ashworth scale of muscle spasticity. Phys Ther. 1987, 67: 206-207.PubMed
65.
Feys H, Klingels K, Desloovere K, Huenaerts C, Eyssen M, Molenaers G, De Cock P: Reliability of a clinical assessment of sensory function for the upper limb in children with hemiplegic cerebral palsy. Dev Med & Child Neuro. 2005, 47: 20-
66.
Auld ML, Boyd RN, Moseley GL, Ware RS, Johnston LM: Impact of tactile dysfunction on upper-limb motor performance in children with unilateral cerebral palsy. Arch of Phys Med & Rehab. 2012, 93: 696-702.
67.
Klingels K, De Cock P, Molenaers G, Desloovere K, Huenaerts C, Jaspers E, Feys H: Upper limb motor and sensory impairments in children with hemiplegic cerebral palsy. Can they be measured reliably?. Disabil Rehabil. 2010, 32: 409-416.PubMed
68.
Mackinnon S, Dellon A: Two-point discrimination tester. J of Hand Surgery American. 1985, 10A: 906-907.
69.
Gordon A: Relation between clinical measures and fine manipulative control in children with hemiplegic cerebral palsy. Dev Med & Child Neuro. 1999, 41: 586-591.
70.
Miller KJ, Phillips BA, Martin CL, Wheat HE, Goodwin AW, Galea MP: The AsTex®: clinimetric properties of a new tool for evaluating hand sensation following stroke. Clin Rehabil. 2009, 23: 1104-1115.PubMed
71.
Mathiowetz V, Weber K, Volland G, Kashman N: Reliability and validity of grip and pinch strength evaluations. J of Hand Surgery American. 1984, 9: 222-226.
72.
Woods BT, Teuber HL: Mirror movements after childhood hemiparesis. Neurology. 1978, 28: 1152-1158.PubMed
73.
Krumlinde-Sundholm L, Eliasson A: Development of the Assisting Hand Assessment: a Rasch-built measure intended for children with unilateral upper limb impairments. Scandanavian J of Occ Th. 2003, 10: 16-26.
74.
Eliasson AC, Krumlinde-sundholm L, Shaw K, Wang C: Effects of constraint-induced movement therapy in young children with hemiplegic cerebral palsy: an adapted model. Dev Med & Child Neuro. 2005, 47: 266-275.
75.
Gordon AM, Schneider JA, Chinnan A, Charles JR: Efficacy of a hand-arm bimanual intensive therapy (HABIT) in children with hemiplegic cerebral palsy: a randomized control trial. Dev Med & Child Neuro. 2007, 49: 830-838.
76.
Holmefur M, Aarts P, Hoare B, Krumlinde-Sundholm L: Retest and alternate forms reliability of the Assisting Hand Assessment. 2009, Stockholm, Sweden: PhD Thesis. Karolinska Univeristy
77.
Randall M, Johnson I, Reddihough D: The Test Administration Manual: Melbourne Assessment of Unilateral Upper Limb Function. 1999, Melbourne: Royal Childrens Hospital
78.
Sakzewski L, Ziviani J, Boyd RN: Best responders after intensive upper-limb training for children with unilateral cerebral palsy. Arch of Phy Med & Rehab. 2011, 92: 578-584.
79.
Klingels K, De Cock P, Desloovere K, Huenaerts C, Molenaers G, Van Nuland I, Huysmans A, Feys H: Comparison of the Melbourne Assessment of Unilateral Upper Limb Function and the Quality of Upper Extremity Skills Test in hemiplegic CP. Dev Med & Child Neuro. 2008, 50: 904-909.
80.
Randall M, Imms C, Carey L: Further evidence of validity of the Modified Melbourne Assessment for neurologically impaired children aged 2 to 4 years. Dev Med & Child Neuro. 2012, 54: 424-428.
81.
Taylor N, Sand P, Jebsen R: Evaluation of hand function in children. Arch of Phys Med & Rehab. 1973, 54: 129-135.
82.
Charles JC, Gordon AM: Development of hand-arm bimanual intensive training (HABIT) for improving bimanual coordination in children with hemiplegic cerebral palsy. Dev Med & Child Neuro. 2006, 48: 931-936.
83.
Eliasson A, Shaw K, Ponten E, Boyd R, Krumlinde-Sundholm L: Feasibility of a day-camp model of modified constraint induced movement therapy with and without Botulinum Toxin A injections for children with hemiplegia. Phys & Occ Therapy in Pediatrics. 2009, 29: 311-333.
84.
Mathiowetz V, Federman S, Wiemer D: Box and blocks test of manual dexterity: Norms for 6–19 year olds. Can J Occup Ther. 1985, 52: 241-245.
85.
Mathiowetz V, Volland G, Kashman N, Weber K: Adults norms for the box and blocks test of manual dexterity. Am J Occup Ther. 1985, 39: 386-391.PubMed
86.
SkÖLd A, Hermansson LN, Krumlinde-Sundholm L, Eliasson A-C: Development and evidence of validity for the Children’s Hand-use Experience Questionnaire (CHEQ). Dev Med & Child Neuro. 2011, 53: 436-442.
87.
88.
Noreau L, Lepage C, Boissiere L, Picard R, Fougeyrollas P, Mathieu J, Desmarais G, Nadeau L: Social participation in children with cerebral palsy: measurement issues and applications. Dev Med & Child Neuro. 2004, 45: 43-44.
89.
Noreau L, Lepage C, Boissiere L, Picard R, Fougeyrollas P, Mathieu J, Desmarais G, Nadeau L: Measuring participation in children with disabilities using the assessment of life habits. Dev Med & Child Neuro. 2007, 49: 666-671.
90.
Waters E, Davis E, Boyd R, Reddihough D, Mackinnon A, Graham H, Lo S, Wolfe R, Stevenson R, Bjornson K: Cerebral Palsy Quality of Life Questionnaire for Children (CP QOL-Child) Manual. 2006, Melbourne, Australia: McCaughey Centre, The University of Melbourne, http://​www.​cpqol.​org.​au,
91.
Waters E, Davis E, Mackinnon A, Boyd R, Graham HK, Kai Lo S, Wolfe R, Stevenson R, Bjornson K, Blair E, et al: Psychometric properties of the quality of life questionnaire for children with CP. Dev Med & Child Neuro. 2007, 49: 49-55.
92.
Davis E, Mackinnon A, Davern M, Boyd R, Bohanna I, Waters E, Graham HK, Reid S, Reddihough D: Description and psychometric properties of the CP QOL-Teen: A quality of life questionnaire for adolescents with cerebral palsy. Res Dev Disabilities. 2013, 34: 344-352.
93.
Davis E, Shelly A, Waters E, Davern M: Measuring the quality of life of children with cerebral palsy: comparing the conceptual differences and psychometric properties of three instruments. Dev Med & Child Neuro. 2009
94.
Law M, Baptiste S, Carswell A: McColl M, Polatajko HJ, Pollock N: Canadian Occupational Performance Measure. 2005, Ottawa, Ontario: CAOT Publications, 3
95.
Dedding C, Cardol M, Eyssen I, Dekker J, Beelen A: Validity of the Canadian occupational performance measure: a client-centred outcome measurement. Clin Rehabil. 2004, 18: 660-667.PubMed
96.
Law M, Polatajko HJ, Pollock N, McColl M, Carswell A, Baptiste S: Pilot testing of the Canadian Occupational Performance Measure: clinical and measurement issues. Canadian J of Occ Therapy. 1994, 61: 191-197.
97.
McColl M, Paterson M, Davies D, Doubt L, Law M: Validity and community utility of the Canadian Occupational Performance Measure. Canadian J of Occ Therapy. 2000, 67: 22-30.
98.
Cup E, Reimer W, Thijssen M, van Kuyk-Minis M: Reliability and validity of the Canadian Occupational Performance Measure in stroke patients. Clin Rehabil. 2003, 17: 402-409.PubMed
99.
Sewell L, Singh S: The Canadian Occupational Performance Measure: is it a reliable measure in clients with chronic obstructive pulmonary disease?. British J of Occ Therapy. 2001, 64: 305-310.
100.
Lowe K, Novak I, Cusick A: Low-dose/high-concentration localized botulinum toxin A improves upper limb movement and function in children with hemiplegic cerebral palsy. Dev Med & Child Neuro. 2006, 48: 170-175.
101.
Wallen M, O' Flaherty SJ, Waugh MCA: Functional outcomes of intramuscular botulinum toxin type A and occupational therapy in the upper limbs of children with cerebral palsy: a randomized controlled trial. Arch of Phys Med and Rehabilitation. 2004, 88: 1-10.
102.
Arnold DS, O'Leary SG, Wolff LS, Acker MM: The Parenting Scale: a measure of dysfunctional parenting in discipline situations. Psychol Assess. 1993, 5: 137-144.
103.
Rhoades KA, O'Leary SG: Factor Structure and Validity of the Parenting Scale. J of Clinical Child & Adolescent Psychology. 2007, 36: 137-146.
104.
Freeman AR, Decourcey W: Further analysis of the discriminate vailidity of the parenting scale. J of Psychopathology and Behavioural Assessment. 2007, 29: 169-176.
105.
Morgan GA, Busch-Rossnagel NA, Barrett KC, Wang J: The Dimensions of Mastery Questionnaire (DMQ): a manual about its development, psychometrics, and use. 2009, USA: Colorado State University
106.
Igoe D, Peralta C, Jean L, Vo S, Yep LN, Zabjek K, Wright FV: A pilot evaluation of the test-retest score reliability of the Dimensions of Mastery Questionnaire in preschool-aged children. Infants & Young Children. 2011, 24 (3): 280-291. July-Sept
107.
Miller L, Ziviani J, Boyd RN: A systematic review of clinimetric properties of measurements of motivation for children aged 5–16 years with a physical disability or motor delay. Phys & Occ Therapy in Pediatrics. 2013, early online
108.
Basu S, Kafkes A, Schatz R, Kiraly A, Kielhofner G: A user's manual for the Pediatric Volitional Questionnaire. 2008, Chicago: Model of Human Occupation Clearinghouse, Department of Occupational Therapy, University of Illinois of Chicago, 21
109.
Andersen S, Kielhofner G, Lai J: An examination of the measurement properties of the Pediatric Volitional Questionnaire. Phys Occup Ther Pediatr. 2005, 25: 39-57.PubMed
110.
Metadata
Title
COMBIT: protocol of a randomised comparison trial of COMbined modified constraint induced movement therapy and bimanual intensive training with distributed model of standard upper limb rehabilitation in children with congenital hemiplegia
Authors
Roslyn N Boyd
Jenny Ziviani
Leanne Sakzewski
Laura Miller
Joanne Bowden
Ross Cunnington
Robert Ware
Andrea Guzzetta
Richard AL Macdonell
Graeme D Jackson
David F Abbott
Stephen Rose
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2013
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-13-68

Other articles of this Issue 1/2013

BMC Neurology 1/2013 Go to the issue

Research article

Results from the 5-year, phase IV RENEW (Registry to Evaluate Novantrone Effects in Worsening Multiple Sclerosis) study

Research article

Eleven years of experience with the neurologic complications in Korean patients with acute aortic dissection: a retrospective study

Case report

Abdominal wall hemorrhage after intravenous thrombolysis for acute ischemic stroke

Debate

Neuromarketing and consumer neuroscience: contributions to neurology

Research article

Change in heart rate variability precedes the occurrence of periodic leg movements during sleep: an observational study

Research article

Modifications of longitudinally extensive transverse myelitis and brainstem lesions in the course of neuromyelitis optica (NMO): a population-based, descriptive study