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BMC Neurology
Published in: BMC Neurology 1/2012

Open Access 01-12-2012 | Review

Clinical correlates of grey matter pathology in multiple sclerosis

Authors: Dana Horakova, Tomas Kalincik, Jana Blahova Dusankova, Ondrej Dolezal

Published in: BMC Neurology | Issue 1/2012

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Abstract

Traditionally, multiple sclerosis has been viewed as a disease predominantly affecting white matter. However, this view has lately been subject to numerous changes, as new evidence of anatomical and histological changes as well as of molecular targets within the grey matter has arisen. This advance was driven mainly by novel imaging techniques, however, these have not yet been implemented in routine clinical practice. The changes in the grey matter are related to physical and cognitive disability seen in individuals with multiple sclerosis. Furthermore, damage to several grey matter structures can be associated with impairment of specific functions. Therefore, we conclude that grey matter damage - global and regional - has the potential to become a marker of disease activity, complementary to the currently used magnetic resonance markers (global brain atrophy and T2 hyperintense lesions). Furthermore, it may improve the prediction of the future disease course and response to therapy in individual patients and may also become a reliable additional surrogate marker of treatment effect.
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Metadata
Title
Clinical correlates of grey matter pathology in multiple sclerosis
Authors
Dana Horakova
Tomas Kalincik
Jana Blahova Dusankova
Ondrej Dolezal
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2012
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-12-10

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