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BMC Neurology
Published in: BMC Neurology 1/2010

Open Access 01-12-2010 | Research article

Protective effect of rifampicin and clindamycin impregnated devices against Staphylococcusspp. infection after cerebrospinal fluid diversion procedures

Authors: Raquel Gutiérrez-González, Gregorio R Boto, Cristina Fernández-Pérez, Náyade del Prado

Published in: BMC Neurology | Issue 1/2010

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Abstract

Background

Infection is a major complication of cerebrospinal fluid shunting procedures. The present report assesses the efficacy of such catheters in both shunts and external ventricular drains (EVDs) against infection and particularly against Staphylococcus spp. infection.

Methods

All shunt and EVD procedures performed by means of antibiotic-impregnated catheters (AICs) and non-AICs during the period of study were registered. In cases of shunt procedures, a minimal follow-up of 90 days was considered, as well as de novo insertion and catheter revisions. Single valve revisions were not included. In cases of EVD procedures, those catheters removed before the fifth post-insertion day were not included. A total of 119 cerebrospinal fluid shunting procedures performed with AICs were studied in comparison with 112 procedures performed by means of non-AICs.

Results

Antibiotic-impregnated catheters were associated with a significant decrease in both overall and staphylococcal infection (p = 0.030 and p = 0.045, respectively). The number needed to treat for AICs was 8 to prevent one infection and 14 to prevent one staphylococcal infection. When comparing with shunts, the use of EVDs was associated with a 37-fold increased likelihood of infection.

Conclusions

Antibiotic-impregnated catheters are a safe and helpful tool to reduce CSF shunting device-related infections.
Appendix
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Metadata
Title
Protective effect of rifampicin and clindamycin impregnated devices against Staphylococcusspp. infection after cerebrospinal fluid diversion procedures
Authors
Raquel Gutiérrez-González
Gregorio R Boto
Cristina Fernández-Pérez
Náyade del Prado
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2010
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-10-93

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