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BMC Medical Imaging
Published in: BMC Medical Imaging 1/2014

Open Access 01-12-2014 | Research article

Determination of regional lung air volume distribution at mid-tidal breathing from computed tomography: a retrospective study of normal variability and reproducibility

Authors: John Fleming, Joy Conway, Caroline Majoral, Michael Bennett, Georges Caillibotte, Spyridon Montesantos, Ira Katz

Published in: BMC Medical Imaging | Issue 1/2014

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Abstract

Background

Determination of regional lung air volume has several clinical applications. This study investigates the use of mid-tidal breathing CT scans to provide regional lung volume data.

Methods

Low resolution CT scans of the thorax were obtained during tidal breathing in 11 healthy control male subjects, each on two separate occasions. A 3D map of air volume was derived, and total lung volume calculated. The regional distribution of air volume from centre to periphery of the lung was analysed using a radial transform and also using one dimensional profiles in three orthogonal directions.

Results

The total air volumes for the right and left lungs were 1035 +/− 280 ml and 864 +/− 315 ml, respectively (mean and SD). The corresponding fractional air volume concentrations (FAVC) were 0.680 +/− 0.044 and 0.658 +/− 0.062. All differences between the right and left lung were highly significant (p < 0.0001). The coefficients of variation of repeated measurement of right and left lung air volumes and FAVC were 6.5% and 6.9% and 2.5% and 3.6%, respectively. FAVC correlated significantly with lung space volume (r = 0.78) (p < 0.005). FAVC increased from the centre towards the periphery of the lung. Central to peripheral ratios were significantly higher for the right (0.100 +/− 0.007 SD) than the left (0.089 +/− 0.013 SD) (p < 0.0001).

Conclusion

A technique for measuring the distribution of air volume in the lung at mid-tidal breathing is described. Mean values and reproducibility are described for healthy male control subjects. Fractional air volume concentration is shown to increase with lung size.
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Metadata
Title
Determination of regional lung air volume distribution at mid-tidal breathing from computed tomography: a retrospective study of normal variability and reproducibility
Authors
John Fleming
Joy Conway
Caroline Majoral
Michael Bennett
Georges Caillibotte
Spyridon Montesantos
Ira Katz
Publication date
01-12-2014
Publisher
BioMed Central
Published in
BMC Medical Imaging / Issue 1/2014
Electronic ISSN: 1471-2342
DOI
https://doi.org/10.1186/1471-2342-14-25

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