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Published in: BMC Primary Care 1/2013

Open Access 01-12-2013 | Research article

Improvement in the management of gout is vital and overdue: an audit from a UK primary care medical practice

Authors: Elizabeth Cottrell, Valerie Crabtree, John J Edwards, Edward Roddy

Published in: BMC Primary Care | Issue 1/2013

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Abstract

Background

Gout is estimated to affect 1.4% of adults in the UK. Appropriate and timely management is essential to reduce the risk of further flares, complications, and to reduce cardiovascular disease risk. The British Society for Rheumatology and British Health Professionals in Rheumatology (BSR/BHPR) and the European League Against Rheumatism (EULAR) have published guidance regarding the management of gout, thereby providing standards against which performance can be measured. This audit was designed to assess the extent to which patients diagnosed with gout in one primary care medical practice in North Staffordshire, UK, are managed in accordance with current best practice guidelines, and to identify strategies for improvement where appropriate.

Methods

Audit criteria were derived from the EULAR and BSR/BHPR guidelines; standards were set arbitrarily, but with consideration of patient comorbidity and other factors which may influence concordance. An electronic search of the practice records was performed to identify adults with a diagnosis of gout. Medical record review with a descriptive analysis was undertaken to assess the extent to which medical management adhered to the predefined standards.

Results

Of the total ≥18 year-old practice population (n = 8686), 305 (3%) patient records included a diagnosis of gout. Of these, 74% (n = 226) had an electronic record of serum uric acid (SUA), and 11% (n = 34) and 53% (n = 162) a measure of estimated glomerular filtration rate (eGFR) ever and serum glucose since diagnosis respectively. 34% (n = 105) of patients had ever taken urate-lowering therapy with 25% (n = 77) currently prescribed this at the time of data extraction. Dose adjustment and monitoring of treatment according to SUA was found to be inadequate. Provision of lifestyle advice and consideration of comorbidities was also lacking.

Conclusions

The primary care management of gout in this practice was not concordant with national and international guidance, a finding consistent with previous studies. This demonstrates that the provision of guidelines alone is not sufficient to improve the quality of gout management and we identify possible strategies to increase guideline adherence.
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Literature
1.
go back to reference Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki F, Perez-Ruiz F, Pignone A, Pimentão , Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I, Extended report: EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT). Ann Rheum Dis. 2006, 65: 1301-1311. 10.1136/ard.2006.055251. doi: 10.1136/ard.2006.055251CrossRefPubMedPubMedCentral Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki F, Perez-Ruiz F, Pignone A, Pimentão , Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I, Extended report: EULAR evidence based recommendations for gout. Part I: Diagnosis. Report of a task force of the standing committee for international clinical studies including therapeutics (ESCISIT). Ann Rheum Dis. 2006, 65: 1301-1311. 10.1136/ard.2006.055251. doi: 10.1136/ard.2006.055251CrossRefPubMedPubMedCentral
2.
go back to reference Mikuls TR, Farrar JT, Biker WB, Fernandes S, Schumacher HR, Saag KG: Gout epidemiology: results from the UK general practice research database, 1990–1999. Ann Rheum Dis. 2005, 64: 267-272. 10.1136/ard.2004.024091.CrossRefPubMedPubMedCentral Mikuls TR, Farrar JT, Biker WB, Fernandes S, Schumacher HR, Saag KG: Gout epidemiology: results from the UK general practice research database, 1990–1999. Ann Rheum Dis. 2005, 64: 267-272. 10.1136/ard.2004.024091.CrossRefPubMedPubMedCentral
4.
go back to reference Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki F, Perez-Ruiz F, Pignone A, Pimentão , Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I: EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2006, 65: 1312-1324. 10.1136/ard.2006.055269. doi: 10.1136/ard.2006.055269CrossRefPubMedPubMedCentral Zhang W, Doherty M, Bardin T, Pascual E, Barskova V, Conaghan P, Gerster J, Jacobs J, Leeb B, Lioté F, McCarthy G, Netter P, Nuki F, Perez-Ruiz F, Pignone A, Pimentão , Punzi L, Roddy E, Uhlig T, Zimmermann-Gòrska I: EULAR evidence based recommendations for gout. Part II: Management. Report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2006, 65: 1312-1324. 10.1136/ard.2006.055269. doi: 10.1136/ard.2006.055269CrossRefPubMedPubMedCentral
5.
go back to reference Waldron JL, Ashby HL, Razavi C, Thomas OL, Chugh S, Deshpande S, Ford C, Gama R: The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on serum uric acid in patients without gout: a prospective study. Rheumatology. 2013, 52 (4): 676-678. 10.1093/rheumatology/kes327.CrossRefPubMed Waldron JL, Ashby HL, Razavi C, Thomas OL, Chugh S, Deshpande S, Ford C, Gama R: The effect of the systemic inflammatory response, as provoked by elective orthopaedic surgery, on serum uric acid in patients without gout: a prospective study. Rheumatology. 2013, 52 (4): 676-678. 10.1093/rheumatology/kes327.CrossRefPubMed
6.
go back to reference Dessein PH, Shipton EA, Stanwix AE, Joffe BI, Ramokgadi J: Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Ann Rheum Dis. 2000, 59: 539-543. 10.1136/ard.59.7.539.CrossRefPubMedPubMedCentral Dessein PH, Shipton EA, Stanwix AE, Joffe BI, Ramokgadi J: Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study. Ann Rheum Dis. 2000, 59: 539-543. 10.1136/ard.59.7.539.CrossRefPubMedPubMedCentral
7.
go back to reference Kullich W, Ulreich A, Klein G: [Changes in uric acid and blood lipids in patients with asymptomatic hyperuricemia treated with diet therapy in a rehabilitation procedure]. Rehabilitation (Stuttg). 1989, 28: 134-137. Kullich W, Ulreich A, Klein G: [Changes in uric acid and blood lipids in patients with asymptomatic hyperuricemia treated with diet therapy in a rehabilitation procedure]. Rehabilitation (Stuttg). 1989, 28: 134-137.
8.
go back to reference Pal B, Foxall M, Dysart T, Carey F, Whittaker M: How is gout managed in primary care? A review of current practice and proposed guidelines. Clin Rheumatol. 2000, 19: 21-25. 10.1007/s100670050005.CrossRefPubMed Pal B, Foxall M, Dysart T, Carey F, Whittaker M: How is gout managed in primary care? A review of current practice and proposed guidelines. Clin Rheumatol. 2000, 19: 21-25. 10.1007/s100670050005.CrossRefPubMed
9.
go back to reference Roddy E, Zhang W, Doherty M: Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations. Ann Rheum Dis. 2007, 66: 1311-1315. 10.1136/ard.2007.070755. doi: 10.1136/ard.2007.070755CrossRefPubMedPubMedCentral Roddy E, Zhang W, Doherty M: Concordance of the management of chronic gout in a UK primary-care population with the EULAR gout recommendations. Ann Rheum Dis. 2007, 66: 1311-1315. 10.1136/ard.2007.070755. doi: 10.1136/ard.2007.070755CrossRefPubMedPubMedCentral
10.
go back to reference Wall GC, Koenigsfield CF, Hegge KA, Bottenberg MM: Adherence to treatment guidelines in two primary care populations with gout. Rheumatol Int. 2010, 30: 749-753. 10.1007/s00296-009-1056-7.CrossRefPubMed Wall GC, Koenigsfield CF, Hegge KA, Bottenberg MM: Adherence to treatment guidelines in two primary care populations with gout. Rheumatol Int. 2010, 30: 749-753. 10.1007/s00296-009-1056-7.CrossRefPubMed
12.
go back to reference McCarty DJ: Gout without hyperuricemia. JAMA. 1994, 271 (4): 302-303. 10.1001/jama.1994.03510280064034.CrossRefPubMed McCarty DJ: Gout without hyperuricemia. JAMA. 1994, 271 (4): 302-303. 10.1001/jama.1994.03510280064034.CrossRefPubMed
13.
go back to reference Taylor TH, Mecchella JN, Larson RJ, et al: Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med. 2012, 125 (11): 1126-1134. 10.1016/j.amjmed.2012.05.025. doi: 10.1016/j.amjmed.2012.05.025. (Original) PMID: 23098865CrossRefPubMed Taylor TH, Mecchella JN, Larson RJ, et al: Initiation of allopurinol at first medical contact for acute attacks of gout: a randomized clinical trial. Am J Med. 2012, 125 (11): 1126-1134. 10.1016/j.amjmed.2012.05.025. doi: 10.1016/j.amjmed.2012.05.025. (Original) PMID: 23098865CrossRefPubMed
14.
go back to reference Sarawate CA, Patel PA, Schumacher HR, Yang W, Brewer KK, Bakst AW: Serum urate levels and gout flares: analysis from managed care data. J Clin Rheumatol. 2006, 12 (2): 61-65. 10.1097/01.rhu.0000209882.50228.9f.CrossRefPubMed Sarawate CA, Patel PA, Schumacher HR, Yang W, Brewer KK, Bakst AW: Serum urate levels and gout flares: analysis from managed care data. J Clin Rheumatol. 2006, 12 (2): 61-65. 10.1097/01.rhu.0000209882.50228.9f.CrossRefPubMed
15.
16.
go back to reference Owens D, Whelan B, McCarthy G: A survey of the management of gout in primary care in Ireland. Ir Med J. 2008, 10: 147-149. Owens D, Whelan B, McCarthy G: A survey of the management of gout in primary care in Ireland. Ir Med J. 2008, 10: 147-149.
17.
go back to reference Ludt S, Petek D, Laux G, van Lieshout J, Campbell SM, Kϋnzi B, Glehr M, Wensing M: Recording of risk-factors and lifestyle counselling in patients at high risk for cardiovascular diseases in European primary care. Eur J Prev Cardiol. 2012, 19 (2): 258-266. 10.1177/1741826711400510.CrossRefPubMed Ludt S, Petek D, Laux G, van Lieshout J, Campbell SM, Kϋnzi B, Glehr M, Wensing M: Recording of risk-factors and lifestyle counselling in patients at high risk for cardiovascular diseases in European primary care. Eur J Prev Cardiol. 2012, 19 (2): 258-266. 10.1177/1741826711400510.CrossRefPubMed
18.
go back to reference Rees F, Jenkins W, Doherty M: Patients with gout adhere to curative treatment if informed appropriately: proof-of-concept observational study. Ann Rheum Dis. 2012,  -Epub 2012 Jun 7. doi: 10.1136/annrheumdis-2012-201676 Rees F, Jenkins W, Doherty M: Patients with gout adhere to curative treatment if informed appropriately: proof-of-concept observational study. Ann Rheum Dis. 2012,  -Epub 2012 Jun 7. doi: 10.1136/annrheumdis-2012-201676
19.
go back to reference Hueskes BA, Roovers EA, Mantel-Teeuwisse AK, Janssens HJ, van de Lisdonk EH, Janssen M: Use of diuretics and the risk of gouty arthritis: a systematic review. Semin Arthritis Rheum. 2012, 41 (6): 879-889. 10.1016/j.semarthrit.2011.11.008. Epub 2012 Jan 4CrossRefPubMed Hueskes BA, Roovers EA, Mantel-Teeuwisse AK, Janssens HJ, van de Lisdonk EH, Janssen M: Use of diuretics and the risk of gouty arthritis: a systematic review. Semin Arthritis Rheum. 2012, 41 (6): 879-889. 10.1016/j.semarthrit.2011.11.008. Epub 2012 Jan 4CrossRefPubMed
20.
go back to reference Stamp LK, Chapman PT: Gout and its comorbidities: implications for therapy. Rheumatology (Oxford). 2013, 52 (1): 34-44. 10.1093/rheumatology/kes211. [2012 Sep 3Epub ahead of print]CrossRef Stamp LK, Chapman PT: Gout and its comorbidities: implications for therapy. Rheumatology (Oxford). 2013, 52 (1): 34-44. 10.1093/rheumatology/kes211. [2012 Sep 3Epub ahead of print]CrossRef
21.
go back to reference Roddy E, Mallen C, Hider SL, Jordan KP: Prescription and comorbidity screening following consultation for acute gout in primary care. Rheumatology. 2010, 49 (1): 105-111. 10.1093/rheumatology/kep332.CrossRefPubMed Roddy E, Mallen C, Hider SL, Jordan KP: Prescription and comorbidity screening following consultation for acute gout in primary care. Rheumatology. 2010, 49 (1): 105-111. 10.1093/rheumatology/kep332.CrossRefPubMed
23.
go back to reference Roberts C, Adebajo A, Long S: Improving the quality of care of musculoskeletal conditions in primary care. Rheumatology. 2002, 41: 503-508. 10.1093/rheumatology/41.5.503.CrossRefPubMed Roberts C, Adebajo A, Long S: Improving the quality of care of musculoskeletal conditions in primary care. Rheumatology. 2002, 41: 503-508. 10.1093/rheumatology/41.5.503.CrossRefPubMed
25.
go back to reference Conway R, Coughlan RJ, Carey JJ: Adherence to uric acid treatment guidelines in a rheumatology clinic. Clin Rheumatol. 2012, 31 (12): 1707-1711. 10.1007/s10067-012-2081-6. doi: 10.1007/s10067-012-2081-6CrossRefPubMed Conway R, Coughlan RJ, Carey JJ: Adherence to uric acid treatment guidelines in a rheumatology clinic. Clin Rheumatol. 2012, 31 (12): 1707-1711. 10.1007/s10067-012-2081-6. doi: 10.1007/s10067-012-2081-6CrossRefPubMed
26.
go back to reference Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogli T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarrows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher H, et al: American College of Rheumatology Guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res. 2012, 64 (10): 1431-1446. 10.1002/acr.21772.CrossRef Khanna D, Fitzgerald JD, Khanna PP, Bae S, Singh MK, Neogli T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarrows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher H, et al: American College of Rheumatology Guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Res. 2012, 64 (10): 1431-1446. 10.1002/acr.21772.CrossRef
27.
go back to reference Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogli T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarrows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher H, et al: American College of Rheumatology Guidelines for management of gout. Part 2: therapy and anti-inflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res. 2012, 64 (10): 1447-1461. 10.1002/acr.21773.CrossRef Khanna D, Khanna PP, Fitzgerald JD, Singh MK, Bae S, Neogli T, Pillinger MH, Merill J, Lee S, Prakash S, Kaldas M, Gogia M, Perez-Ruiz F, Taylor W, Lioté F, Choi H, Singh JA, Dalbeth N, Kaplan S, Niyyar V, Jones D, Yarrows SA, Roessler B, Kerr G, King C, Levy G, Furst DE, Edwards NL, Mandell B, Schumacher H, et al: American College of Rheumatology Guidelines for management of gout. Part 2: therapy and anti-inflammatory prophylaxis of acute gouty arthritis. Arthritis Care Res. 2012, 64 (10): 1447-1461. 10.1002/acr.21773.CrossRef
28.
go back to reference Pathman DE, Konrad TR, Freed GL, Freeman VA, Koch GG: The awareness-to-adherence model of the steps to clinical guideline compliance. The case of pediatric vaccine recommendations. Med Care. 1996, 34 (9): 873-889. 10.1097/00005650-199609000-00002.CrossRefPubMed Pathman DE, Konrad TR, Freed GL, Freeman VA, Koch GG: The awareness-to-adherence model of the steps to clinical guideline compliance. The case of pediatric vaccine recommendations. Med Care. 1996, 34 (9): 873-889. 10.1097/00005650-199609000-00002.CrossRefPubMed
29.
go back to reference Lawrence M, Olesen F: Indicators of Quality in Health Care. Eur J Gen Pract. 1997, 3 (3): 103-108. 10.3109/13814789709160336. doi: 10.3109/13814789709160336CrossRef Lawrence M, Olesen F: Indicators of Quality in Health Care. Eur J Gen Pract. 1997, 3 (3): 103-108. 10.3109/13814789709160336. doi: 10.3109/13814789709160336CrossRef
30.
go back to reference Kotter T, Schaefer FA, Scherer M, Blozik E: Involving patients in quality indicator development - a systematic review. Patient preference and adherence. 2013, 7: 259-268. doi: 10.2147/ppa.s39803PubMedPubMedCentral Kotter T, Schaefer FA, Scherer M, Blozik E: Involving patients in quality indicator development - a systematic review. Patient preference and adherence. 2013, 7: 259-268. doi: 10.2147/ppa.s39803PubMedPubMedCentral
32.
go back to reference Maisey S, Steel N, Marsh R, Gillam S, Fleetcroft R, Howe A: Effects of payment for performance in primary care: qualitative interview study. J Health Serv Res Policy. 2008, 13 (3): 133-139. 10.1258/jhsrp.2008.007118.CrossRefPubMed Maisey S, Steel N, Marsh R, Gillam S, Fleetcroft R, Howe A: Effects of payment for performance in primary care: qualitative interview study. J Health Serv Res Policy. 2008, 13 (3): 133-139. 10.1258/jhsrp.2008.007118.CrossRefPubMed
33.
go back to reference Khan NF, Harrison SE, Rose PW: Validity of diagnostic coding within the General Practice Research Database: a systematic review. Br J Gen Pract. 2010, 60 (572): e128-e123. 10.3399/bjgp10X483562.CrossRefPubMedPubMedCentral Khan NF, Harrison SE, Rose PW: Validity of diagnostic coding within the General Practice Research Database: a systematic review. Br J Gen Pract. 2010, 60 (572): e128-e123. 10.3399/bjgp10X483562.CrossRefPubMedPubMedCentral
Metadata
Title
Improvement in the management of gout is vital and overdue: an audit from a UK primary care medical practice
Authors
Elizabeth Cottrell
Valerie Crabtree
John J Edwards
Edward Roddy
Publication date
01-12-2013
Publisher
BioMed Central
Published in
BMC Primary Care / Issue 1/2013
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/1471-2296-14-170

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