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Open Access 01-12-2011 | Review

Selection of the appropriate method for the assessment of insulin resistance

Authors: Anwar Borai, Callum Livingstone, Ibrahim Kaddam, Gordon Ferns

Published in: BMC Medical Research Methodology | Issue 1/2011

Abstract

Insulin resistance is one of the major aggravating factors for metabolic syndrome. There are many methods available for estimation of insulin resistance which range from complex techniques down to simple indices. For all methods of assessing insulin resistance it is essential that their validity and reliability is established before using them as investigations. The reference techniques of hyperinsulinaemic euglycaemic clamp and its alternative the frequently sampled intravenous glucose tolerance test are the most reliable methods available for estimating insulin resistance. However, many simple methods, from which indices can be derived, have been assessed and validated e.g. homeostasis model assessment (HOMA), quantitative insulin sensitivity check index (QUICKI). Given the increasing number of simple indices of IR it may be difficult for clinicians and researchers to select the most appropriate index for their studies. This review therefore provides guidelines and advices which must be considered before proceeding with a study.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2288/11/158/prepub

Title: Selection of the appropriate method for the assessment of insulin resistance
Authors: Anwar Borai
Callum Livingstone
Ibrahim Kaddam
Gordon Ferns
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: BMC Medical Research Methodology / Issue 1/2011
Electronic ISSN: 1471-2288
DOI: https://doi.org/10.1186/1471-2288-11-158

At a glance: The STEP trials

Springer Medicine

Selection of the appropriate method for the assessment of insulin resistance

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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