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Critical Care
Published in: Critical Care 5/2013

Open Access 01-10-2013 | Commentary

Metabolic changes in cardiomyocytes during sepsis

Authors: James J Douglas, Keith R Walley

Published in: Critical Care | Issue 5/2013

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Abstract

Different types of shock induce distinct metabolic changes. The myocardium at rest utilizes free fatty acids as its primary energy source, a mechanism that changes to aerobic glycolysis during sepsis and is in contrast to hemorrhagic shock. The immune system also uses this mechanism, changing its substrate utilization to activate innate and adaptive cells. Cardiomyocytes share a number of features similar to antigen-presenting cells and may use this mechanism to augment the immune response at the reversible expense of cardiac function.
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Metadata
Title
Metabolic changes in cardiomyocytes during sepsis
Authors
James J Douglas
Keith R Walley
Publication date
01-10-2013
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2013
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/1364-8535-17-186

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