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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2015 | Oral presentation

O020. Dysfunctional analgesic mechanisms in migraine patients with ictal cutaneous allodynia

Authors: Antonio Russo, Fabrizio Esposito, Francesca Conte, Laura Marcuccio, Michele Fratello, Giuseppina Caiazzo, Alfonso Giordano, Renata Conforti, Alessandro Tessitore, Gioacchino Tedeschi

Published in: The Journal of Headache and Pain | Special Issue 1/2015

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Excerpt

Approximately two thirds of migraine patients complain of cutaneous allodynia (CA) which is defined as a pain perception evoked by ordinary non-nociceptive skin stimulation in cephalic regions during migraine attacks. CA may be underlied by the sensitization of second-order trigeminovascular neurons, belonging to the trigeminal-thalamo-cortical pathway. In this context, a crucial role seems to be played by supraspinal mechanisms related to the descending pain modulatory system [1]. …
Literature
1.
Bernstein C, Burstein R: Sensitization of the trigeminovascular pathway: perspective and implications to migraine pathophysiology. J Clin Neurol. 2012, 8 (2): 89-99. 10.3988/jcn.2012.8.2.89.PubMedCentralCrossRefPubMed
2.
Russo A, Tessitore A, Esposito F, Marcuccio L, Giordano A, Conforti R, et al: Pain processing in patients with migraine: an event-related fMRI study during trigeminal nociceptive stimulation. J Neurol. 2012, 259 (9): 1903-1912. 10.1007/s00415-012-6438-1.CrossRefPubMed
3.
Schwedt TJ, Chiang CC, Chong CD, Dodick DW: Functional MRI of migraine. Lancet Neurol. 2015, 14 (1): 81-91. 10.1016/S1474-4422(14)70193-0.CrossRefPubMed
Metadata
Title
O020. Dysfunctional analgesic mechanisms in migraine patients with ictal cutaneous allodynia
Authors
Antonio Russo
Fabrizio Esposito
Francesca Conte
Laura Marcuccio
Michele Fratello
Giuseppina Caiazzo
Alfonso Giordano
Renata Conforti
Alessandro Tessitore
Gioacchino Tedeschi
Publication date
01-12-2015
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-16-S1-A157

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