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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2015 | Poster presentation

P032. Coenzyme Q-10 and migraine: a lovable relationship. The experience of a tertiary headache center

Authors: Ennio Pucci, Luca Diamanti, Silvano Cristina, Fabio Antonaci, Alfredo Costa

Published in: The Journal of Headache and Pain | Special Issue 1/2015

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Excerpt

Coenzyme Q-10 (ubiquinone) is a small hydrophobic substance that acts as an electron carrier in the mitochondrial respiratory chain. Its main activity is to protect DNA, proteins and lipids from oxidative stress. In the literature, a role of brain oxidative metabolism in the pathogenesis of migraine has been hypothesized [1]. Few clinical trials are described using coenzyme Q-10 in migraine prophylaxis, even in pediatrics [2‐4]. The aim of this work was to present our experience of migraine prevention, prescribing coenzyme Q-10 to 20 adult patients with migraine without aura. …
Literature
1.
Montagna P, Sacquegna T, Cortelli P, Lugaresi E: Migraine as a defect of brain oxidative metabolism: a hypothesis. J Neurol. 1989, 236 (2): 124-125.CrossRefPubMed
2.
Slater SK, Nelson TD, Kabbouche MA, LeCates SL, Horn P, Segers A, et al: A randomized, double-blinded, placebo-controlled, crossover, add-on study of CoEnzyme Q10 in the prevention of pediatric and adolescent migraine. Cephalalgia. 2011, 31 (8): 897-905.CrossRefPubMed
3.
Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, et al: Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology. 2005, 64 (4): 713-715.CrossRefPubMed
4.
Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL, Silberstein SD: Open label trial of coenzyme Q10 as a migraine preventive. Cephalalgia. 2002, 22 (2): 137-141.CrossRefPubMed
Metadata
Title
P032. Coenzyme Q-10 and migraine: a lovable relationship. The experience of a tertiary headache center
Authors
Ennio Pucci
Luca Diamanti
Silvano Cristina
Fabio Antonaci
Alfredo Costa
Publication date
01-12-2015
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-16-S1-A139

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