Published in:
Open Access
01-12-2014 | Meeting abstract
EHMTI-0338. The enzymes phosphodiesterase 3 and 5 express activity in the trigeminal ganglion and co-localize with calcitonin gene-related peptide
Authors:
JC Nordgaard, LS Kruse, M Moeller, C Kruuse
Published in:
The Journal of Headache and Pain
|
Special Issue 1/2014
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Excerpt
The neuropathology leading to migraine pain has centered on an either a vascular or neuronal origin. Sildenafil, a specific inhibitor of phosphodiesterase 5 (PDE5), was the first compound to induce migraine-like headache in a human headache model without a concomitant artery dilatation. …