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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2014

Open Access 01-12-2014 | Meeting abstract

EHMTI-0093. Investigation of 5-HT2B receptor pathways with relevance to a mouse migraine model

Authors: M Kremser, A Hunfeld, H Lübbert

Published in: The Journal of Headache and Pain | Special Issue 1/2014

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Excerpt

Recent research raises the question whether the serotonin 2B receptor (5-HT2B) plays a role in the pathogenesis of migraine. Clinical studies revealed that the 5-HT2B/2C agonist meta-Chlorophenylpiperazine (mCPP) induces migraine-like headache more likely in migraineurs than in subjects without a history of migraine. We therefore developed an animal model for chronic migraine, where we are able to induce a neurogenic inflammation in the dura mater of hypoxic mice with 5-HT2B agonists. This inflammation can be blocked by specific 5-HT2B inhibitors. …
Metadata
Title
EHMTI-0093. Investigation of 5-HT2B receptor pathways with relevance to a mouse migraine model
Authors
M Kremser
A Hunfeld
H Lübbert
Publication date
01-12-2014
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue Special Issue 1/2014
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/1129-2377-15-S1-F13

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