Published in:
Open Access
01-12-2014 | Meeting abstract
EHMTI-0262. Dysregulation of inflammatory pathways in a familial hemiplegic migraine 1 mouse model after the induction of cortical spreading depression
Authors:
B de Vries, EE Eising, R Shyti, LS Vijfhuizen, LAM Broos, PAC’t Hoen, MD Ferrari, EA Tolner, AMJM van den Maagdenberg
Published in:
The Journal of Headache and Pain
|
Special Issue 1/2014
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Excerpt
Familial Hemiplegic Migraine type 1 (FHM1) is a rare monogenic subtype of migraine with aura caused by mutations in the CACNA1A gene. In FHM1 knock-in mouse models these mutations increase the susceptibility for cortical spreading depression (CSD): the underlying mechanism of the migraine aura. …